Aliases for C1QTNF9 Gene

Aliases for C1QTNF9 Gene

  • C1q And TNF Related 9 2 3 5
  • Complement C1q And Tumor Necrosis Factor-Related Protein 9A 3 4
  • Complement C1q And Tumor Necrosis Factor-Related Protein 9 3 4
  • C1q And Tumor Necrosis Factor Related Protein 9 2 3
  • C1QTNF9A 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 9A 3
  • Complement C1q Tumor Necrosis Factor-Related Protein 9 3
  • CTRP9 3
  • AQL1 3

External Ids for C1QTNF9 Gene

Previous GeneCards Identifiers for C1QTNF9 Gene

  • GC13P023779
  • GC13P024881
  • GC13P005695

Summaries for C1QTNF9 Gene

GeneCards Summary for C1QTNF9 Gene

C1QTNF9 (C1q And TNF Related 9) is a Protein Coding gene. Diseases associated with C1QTNF9 include Bleeding Disorder, Platelet-Type, 14 and Pyruvate Dehydrogenase E1-Alpha Deficiency. Gene Ontology (GO) annotations related to this gene include hormone activity. An important paralog of this gene is C1QTNF9B.

UniProtKB/Swiss-Prot Summary for C1QTNF9 Gene

  • Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.

Additional gene information for C1QTNF9 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QTNF9 Gene

Genomics for C1QTNF9 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF9 Gene

Promoters and enhancers for C1QTNF9 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH13J024306 Promoter/Enhancer 0.9 EPDnew Ensembl 512.8 -0.2 -165 2 FOS FOXA2 SPI1 FOXA1 JUND NFIB AGO2 GATA3 FOXA3 CEBPB C1QTNF9 SPATA13 C1QTNF9B MIPEP PARP4 SPATA13-AS1 ENSG00000273167
GH13J024308 Promoter 0.4 EPDnew 500.7 +1.5 1498 0.1 AGO2 C1QTNF9 C1QTNF9-AS1 ENSG00000273167
GH13J024309 Promoter 0.3 EPDnew 500.7 +2.4 2395 0.1 C1QTNF9 C1QTNF9-AS1 ENSG00000273167
GH13J024311 Enhancer 0.3 Ensembl 500.7 +1.3 1335 0.2 AGO2 C1QTNF9 C1QTNF9-AS1 ENSG00000273167
GH13J023888 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 43.2 -418.5 -418465 3.4 ZBTB40 ZNF217 EP300 CTCF TCF12 SIN3A POLR2G USF1 SP1 PHF8 MIPEP PCOTH lnc-C1QTNF9B-2 C1QTNF9 piR-43105-132
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF9 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QTNF9

Top Transcription factor binding sites by QIAGEN in the C1QTNF9 gene promoter:
  • AhR
  • Arnt
  • E2F
  • E2F-1
  • E2F-2
  • GATA-2
  • Ik-2
  • Lmo2
  • PPAR-alpha
  • STAT5A

Genomic Locations for C1QTNF9 Gene

Genomic Locations for C1QTNF9 Gene
chr13:24,307,166-24,322,535
(GRCh38/hg38)
Size:
15,370 bases
Orientation:
Plus strand
chr13:24,881,304-24,896,673
(GRCh37/hg19)
Size:
15,370 bases
Orientation:
Plus strand

Genomic View for C1QTNF9 Gene

Genes around C1QTNF9 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF9 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF9 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF9 Gene

Proteins for C1QTNF9 Gene

  • Protein details for C1QTNF9 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C862-C1T9A_HUMAN
    Recommended name:
    Complement C1q and tumor necrosis factor-related protein 9A
    Protein Accession:
    P0C862
    Secondary Accessions:
    • A2A3T6
    • Q0VGC5
    • Q5VX65
    • Q5VX66
    • Q8IUU4

    Protein attributes for C1QTNF9 Gene

    Size:
    333 amino acids
    Molecular mass:
    34681 Da
    Quaternary structure:
    • Multimers (predominantly trimers). Interacts with ADIPOQ via the C1q domain to form a heterotrimeric complex (By similarity). Interacts with CTRP9B. Forms heterotrimers and heterooligomeric complexes with CTRP9B.

neXtProt entry for C1QTNF9 Gene

Post-translational modifications for C1QTNF9 Gene

  • Glycosylation at Lys73 and Lys127
  • Modification sites at PhosphoSitePlus

Other Protein References for C1QTNF9 Gene

No data available for DME Specific Peptides for C1QTNF9 Gene

Domains & Families for C1QTNF9 Gene

Gene Families for C1QTNF9 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins
  • Transporters

Protein Domains for C1QTNF9 Gene

Suggested Antigen Peptide Sequences for C1QTNF9 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q tumor necrosis factor-related protein 9 (C1T9A_HUMAN)
genes like me logo Genes that share domains with C1QTNF9: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QTNF9 Gene

Function for C1QTNF9 Gene

Molecular function for C1QTNF9 Gene

UniProtKB/Swiss-Prot Function:
Probable adipokine. Activates AMPK, AKT, and p44/42 MAPK signaling pathways.

Phenotypes From GWAS Catalog for C1QTNF9 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
GO:0005515 protein binding IEA,IPI 19666007
GO:0042802 identical protein binding IPI 19666007
genes like me logo Genes that share ontologies with C1QTNF9: view
genes like me logo Genes that share phenotypes with C1QTNF9: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF9

CRISPR Products

miRNA for C1QTNF9 Gene

miRTarBase miRNAs that target C1QTNF9

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF9

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C1QTNF9 Gene

Localization for C1QTNF9 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF9 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF9 gene
Compartment Confidence
extracellular 4
mitochondrion 2
cytosol 2
plasma membrane 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1QTNF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF9: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QTNF9 Gene

Pathways & Interactions for C1QTNF9 Gene

PathCards logo

SuperPathways for C1QTNF9 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF9 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
genes like me logo Genes that share ontologies with C1QTNF9: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF9 Gene

Drugs & Compounds for C1QTNF9 Gene

No Compound Related Data Available

Transcripts for C1QTNF9 Gene

mRNA/cDNA for C1QTNF9 Gene

3 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF9

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF9 Gene

No ASD Table

Relevant External Links for C1QTNF9 Gene

GeneLoc Exon Structure for
C1QTNF9

Expression for C1QTNF9 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF9 Gene

Protein differential expression in normal tissues from HIPED for C1QTNF9 Gene

This gene is overexpressed in Pancreatic juice (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF9 Gene



Protein tissue co-expression partners for C1QTNF9 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QTNF9

SOURCE GeneReport for Unigene cluster for C1QTNF9 Gene:

Hs.362854

mRNA Expression by UniProt/SwissProt for C1QTNF9 Gene:

P0C862-C1T9A_HUMAN
Tissue specificity: Expressed predominantly in adipose tissue.

Evidence on tissue expression from TISSUES for C1QTNF9 Gene

  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C1QTNF9: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF9 Gene

Orthologs for C1QTNF9 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF9 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF9 30
  • 98.9 (n)
-- 31
  • 98 (a)
ManyToMany
-- 31
  • 98 (a)
ManyToMany
dog
(Canis familiaris)
Mammalia -- 31
  • 89 (a)
OneToMany
mouse
(Mus musculus)
Mammalia C1qtnf9 31
  • 85 (a)
OneToMany
cow
(Bos Taurus)
Mammalia C1QTNF9 31
  • 85 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 74 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 31
  • 64 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 31
  • 61 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii c1qtnf9 31 30
  • 58.82 (n)
OneToMany
Species where no ortholog for C1QTNF9 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF9 Gene

ENSEMBL:
Gene Tree for C1QTNF9 (if available)
TreeFam:
Gene Tree for C1QTNF9 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QTNF9: view image

Paralogs for C1QTNF9 Gene

Variants for C1QTNF9 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QTNF9 Gene

SNP ID Clinical significance and condition Chr 13 pos Variation AA Info Type
rs1974332 - p.Leu6Phe
rs3751357 - p.Met219Val
rs4589405 - p.Val301Met

Additional dbSNP identifiers (rs#s) for C1QTNF9 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF9 Gene

Variant ID Type Subtype PubMed ID
dgv1615n100 CNV gain 25217958
dgv3084n54 CNV gain 21841781
esv2422202 CNV duplication 17116639
esv2422502 CNV duplication 17116639
esv2751136 CNV loss 17911159
esv2751137 CNV gain 17911159
esv2761200 CNV gain+loss 21179565
esv3580576 CNV loss 25503493
esv3582215 CNV gain 25503493
esv3631540 CNV gain 21293372
esv3892310 CNV gain 25118596
esv3892311 CNV gain 25118596
esv5325 OTHER complex 18987735
nsv1044867 CNV gain 25217958
nsv1078303 OTHER inversion 25765185
nsv1140246 OTHER inversion 24896259
nsv1151909 OTHER inversion 26484159
nsv455837 CNV gain 19166990
nsv455842 CNV gain 19166990
nsv525965 CNV gain 19592680
nsv561292 CNV loss 21841781
nsv561342 CNV gain 21841781
nsv832567 CNV loss 17160897
nsv983562 CNV duplication 23825009

Variation tolerance for C1QTNF9 Gene

Residual Variation Intolerance Score: 94.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.90; 89.76% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF9 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF9

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF9 Gene

Disorders for C1QTNF9 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C1QTNF9 Gene - From: DISEASES

- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1QTNF9

genes like me logo Genes that share disorders with C1QTNF9: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF9 Gene

Publications for C1QTNF9 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 54
  2. Identification and characterization of CTRP9, a novel secreted glycoprotein, from adipose tissue that reduces serum glucose in mice and forms heterotrimers with adiponectin. (PMID: 18787108) Wong GW … Lodish HF (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2009) 2 3 54
  3. CTRP8 and CTRP9B are novel proteins that hetero-oligomerize with C1q/TNF family members. (PMID: 19666007) Peterson JM … Wong GW (Biochemical and biophysical research communications 2009) 3 4 54
  4. Effects of a single bout of high-intensity interval exercise on C1q/TNF-related proteins. (PMID: 29953821) Kon M … Nakagaki K (Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme 2019) 3 54
  5. Role of CTRP3, CTRP9 and MCP-1 for the evaluation of T2DM associated coronary artery disease in Egyptian postmenopausal females. (PMID: 30557342) Ahmed SF … El-Mesallamy HO (PloS one 2018) 3 54

Products for C1QTNF9 Gene

Sources for C1QTNF9 Gene