Aliases for C1QTNF7 Gene

Aliases for C1QTNF7 Gene

  • C1q And TNF Related 7 2 3 5
  • CTRP7 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 7 3 4
  • C1q And Tumor Necrosis Factor Related Protein 7 2 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 7 3
  • C1QTNF7 5
  • ZACRP7 3

External Ids for C1QTNF7 Gene

Previous GeneCards Identifiers for C1QTNF7 Gene

  • GC04P015156
  • GC04P015283
  • GC04P015029
  • GC04P015092
  • GC04P015017
  • GC04P014691

Summaries for C1QTNF7 Gene

GeneCards Summary for C1QTNF7 Gene

C1QTNF7 (C1q And TNF Related 7) is a Protein Coding gene. Diseases associated with C1QTNF7 include Conduct Disorder. An important paralog of this gene is C1QTNF2.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QTNF7 Gene

Genomics for C1QTNF7 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1QTNF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04J015339 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 +1.1 1059 2.6 NFIA GATA2 CEBPB C1QTNF7 CC2D2A C1QTNF7-AS1 lnc-CC2D2A-1 HSALNG0033040
GH04J015000 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -335.7 -335717 7.4 BCLAF1 ZNF207 IKZF1 MYC ZNF600 POLR2A NFIC ZIC2 ZBTB10 YY1 CPEB2 CPEB2-DT C1QTNF7 LINC00504 C1QTNF7-AS1
GH04J015478 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 7.6 +140.0 139958 2.4 ZNF600 ZNF654 MYC IKZF1 ZNF10 POLR2A ZIC2 YY1 MXD4 REST CC2D2A FAM200B FBXL5 C1QTNF7 ENSG00000273133 piR-38524 HSALNG0033040
GH04J015400 Enhancer 0.7 ENCODE dbSUPER 20 +61.9 61903 3.1 CEBPB GABPA SPI1 POLR2A REST MAX CTCF EGR1 EP300 C1QTNF7 C1QTNF7-AS1 lnc-CC2D2A-1 ENSG00000251379 CC2D2A HSALNG0033040
GH04J015450 Enhancer 0.7 Ensembl ENCODE 20.9 +111.8 111782 3.2 CEBPB TCF7L2 SPI1 JUND POLR2A EP300 FOS C1QTNF7 C1QTNF7-AS1 ENSG00000251379 piR-37895-110 CC2D2A HSALNG0033040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF7 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QTNF7

Top Transcription factor binding sites by QIAGEN in the C1QTNF7 gene promoter:
  • c-Rel
  • ITF-2
  • Lhx3a
  • LHX3b
  • Lmo2
  • POU3F2
  • S8
  • Sox5
  • STAT5B
  • Tal-1beta

Genomic Locations for C1QTNF7 Gene

Latest Assembly
chr4:15,339,818-15,446,169
(GRCh38/hg38)
Size:
106,352 bases
Orientation:
Plus strand

Previous Assembly
chr4:15,341,612-15,447,791
(GRCh37/hg19 by Entrez Gene)
Size:
106,180 bases
Orientation:
Plus strand

chr4:15,341,442-15,447,790
(GRCh37/hg19 by Ensembl)
Size:
106,349 bases
Orientation:
Plus strand

Genomic View for C1QTNF7 Gene

Genes around C1QTNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF7 Gene

Proteins for C1QTNF7 Gene

  • Protein details for C1QTNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ2-C1QT7_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 7
    Protein Accession:
    Q9BXJ2
    Secondary Accessions:
    • B2RBT3
    • J3KPW3

    Protein attributes for C1QTNF7 Gene

    Size:
    289 amino acids
    Molecular mass:
    30683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF7 Gene

Post-translational modifications for C1QTNF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1QTNF7 Gene

Domains & Families for C1QTNF7 Gene

Gene Families for C1QTNF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for C1QTNF7 Gene

InterPro:
Blocks:
  • Collagen triple helix repeat
  • Complement C1q protein

Suggested Antigen Peptide Sequences for C1QTNF7 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q tumor necrosis factor-related protein 7 (C1QT7_HUMAN)
genes like me logo Genes that share domains with C1QTNF7: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QTNF7 Gene

Function for C1QTNF7 Gene

Phenotypes From GWAS Catalog for C1QTNF7 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF7: view
genes like me logo Genes that share phenotypes with C1QTNF7: view

Animal Models for C1QTNF7 Gene

MGI Knock Outs for C1QTNF7:

Animal Models for research

  • Taconic Biosciences Mouse Models for C1QTNF7

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF7

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF7 Gene

Localization for C1QTNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF7 gene
Compartment Confidence
extracellular 4
plasma membrane 1
nucleus 1
endoplasmic reticulum 1
mitochondrion 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1QTNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF7: view

Pathways & Interactions for C1QTNF7 Gene

PathCards logo

SuperPathways for C1QTNF7 Gene

No Data Available

Interacting Proteins for C1QTNF7 Gene

Gene Ontology (GO) - Biological Process for C1QTNF7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF7 Gene

Drugs & Compounds for C1QTNF7 Gene

No Compound Related Data Available

Transcripts for C1QTNF7 Gene

mRNA/cDNA for C1QTNF7 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF7

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5:
SP6:

Relevant External Links for C1QTNF7 Gene

GeneLoc Exon Structure for
C1QTNF7

Expression for C1QTNF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF7 Gene

This gene is overexpressed in Artery - Tibial (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF7 Gene

This gene is overexpressed in Pancreas (35.6), Prostate (15.8), Gallbladder (7.1), and Urinary Bladder (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF7 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QTNF7

SOURCE GeneReport for Unigene cluster for C1QTNF7 Gene:

Hs.153714
genes like me logo Genes that share expression patterns with C1QTNF7: view

Primer products for research

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF7 Gene

Orthologs for C1QTNF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF7 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C1QTNF7 29 30
  • 99.77 (n)
OneToOne
Dog
(Canis familiaris)
Mammalia C1QTNF7 29 30
  • 92.45 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia C1QTNF7 29 30
  • 91.93 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia C1qtnf7 29
  • 89.39 (n)
Mouse
(Mus musculus)
Mammalia C1qtnf7 29 16 30
  • 87.95 (n)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF7 30
  • 85 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C1QTNF7 29 30
  • 80.16 (n)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C1QTNF7 30
  • 81 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c1qtnf7 29
  • 73.08 (n)
Zebrafish
(Danio rerio)
Actinopterygii CABZ01048675.1 30
  • 67 (a)
OneToOne
LOC564609 29
  • 64.79 (n)
Species where no ortholog for C1QTNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1QTNF7 Gene

ENSEMBL:
Gene Tree for C1QTNF7 (if available)
TreeFam:
Gene Tree for C1QTNF7 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QTNF7: view image
Alliance of Genome Resources:
Additional Orthologs for C1QTNF7

Paralogs for C1QTNF7 Gene

(8) SIMAP similar genes for C1QTNF7 Gene using alignment to 2 proteins:

  • C1QT7_HUMAN
  • J3KPK0_HUMAN
genes like me logo Genes that share paralogs with C1QTNF7: view

Variants for C1QTNF7 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C1QTNF7 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF7 Gene

Variant ID Type Subtype PubMed ID
esv2623009 CNV insertion 19546169
esv2759227 CNV gain+loss 17122850
esv3599738 CNV loss 21293372

Variation tolerance for C1QTNF7 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF7
Leiden Open Variation Database (LOVD)
C1QTNF7

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QTNF7 Gene

Disorders for C1QTNF7 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1QTNF7 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
conduct disorder
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1QTNF7

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with C1QTNF7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF7 Gene

Publications for C1QTNF7 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick DM … Bierut L (Molecular psychiatry 2011) 3 40
  2. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PMID: 19344414) Cerhan JR … Slager SL (British journal of haematology 2009) 3 40
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Implications of C1q/TNF-related protein superfamily in patients with coronary artery disease. (PMID: 31965030) Zhang Y … Wang Y (Scientific reports 2020) 3
  5. ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas. (PMID: 30232004) Abraham CG … Espinosa JM (Cell reports 2018) 3

Products for C1QTNF7 Gene

Sources for C1QTNF7 Gene