Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C1QTNF7 Gene

Aliases for C1QTNF7 Gene

  • C1q And TNF Related 7 2 3 5
  • C1q And Tumor Necrosis Factor Related Protein 7 2 3
  • CTRP7 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 7 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 7 3
  • ZACRP7 3

External Ids for C1QTNF7 Gene

Previous GeneCards Identifiers for C1QTNF7 Gene

  • GC04P015156
  • GC04P015029
  • GC04P015092
  • GC04P015017
  • GC04P014691

Summaries for C1QTNF7 Gene

GeneCards Summary for C1QTNF7 Gene

C1QTNF7 (C1q And TNF Related 7) is a Protein Coding gene. An important paralog of this gene is C1QTNF2.

Additional gene information for C1QTNF7 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF7 Gene

Genomics for C1QTNF7 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF7 Gene

Promoters and enhancers for C1QTNF7 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH04I015374 Promoter/Enhancer 1.4 EPDnew Ensembl ENCODE dbSUPER 567.7 +34.8 34827 1.2 C1QTNF7 LOC101929095 ENSG00000251379 GC04P015410
GH04I015413 Promoter/Enhancer 0.7 EPDnew Ensembl 550.2 +74.2 74183 0.4 C1QTNF7 GC04P015410 ENSG00000251379 LOC101929095
GH04I015339 Promoter 0.5 EPDnew 550.8 +0.2 151 0.1 C1QTNF7 GC04P015410 LOC101929095
GH04I015340 Enhancer 0.4 ENCODE dbSUPER 550.8 +1.5 1498 0.8 C1QTNF7 LOC101929095 GC04P015410
GH04I015400 Enhancer 0.9 Ensembl ENCODE dbSUPER 20 +62.0 61975 3.2 ELK4 POLR2A MAX CEBPB REST GABPA C1QTNF7 LOC101929095 GC04P015410 ENSG00000251379
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1QTNF7 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1QTNF7 gene promoter:

Genomic Locations for C1QTNF7 Gene

Genomic Locations for C1QTNF7 Gene
chr4:15,339,818-15,446,169
(GRCh38/hg38)
Size:
106,352 bases
Orientation:
Plus strand
chr4:15,341,442-15,447,791
(GRCh37/hg19)

Genomic View for C1QTNF7 Gene

Genes around C1QTNF7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF7 Gene

Proteins for C1QTNF7 Gene

  • Protein details for C1QTNF7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ2-C1QT7_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 7
    Protein Accession:
    Q9BXJ2
    Secondary Accessions:
    • B2RBT3
    • J3KPW3

    Protein attributes for C1QTNF7 Gene

    Size:
    289 amino acids
    Molecular mass:
    30683 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QTNF7 Gene

Post-translational modifications for C1QTNF7 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C1QTNF7 Gene

Domains & Families for C1QTNF7 Gene

Gene Families for C1QTNF7 Gene

HGNC:
Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1QTNF7 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF7: view

No data available for UniProtKB/Swiss-Prot for C1QTNF7 Gene

Function for C1QTNF7 Gene

Phenotypes From GWAS Catalog for C1QTNF7 Gene

genes like me logo Genes that share phenotypes with C1QTNF7: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF7

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF7 Gene

Localization for C1QTNF7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF7 gene
Compartment Confidence
extracellular 4
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1QTNF7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QTNF7: view

Pathways & Interactions for C1QTNF7 Gene

SuperPathways for C1QTNF7 Gene

No Data Available

Interacting Proteins for C1QTNF7 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295297%0d%0a9606.ENSP00000409279%0d%0a9606.ENSP00000366434%0d%0a9606.ENSP00000403852%0d%0a
Selected Interacting proteins: ENSP00000295297 Q9BXJ2-C1QT7_HUMAN for C1QTNF7 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C1QTNF7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF7 Gene

Drugs & Compounds for C1QTNF7 Gene

No Compound Related Data Available

Transcripts for C1QTNF7 Gene

Unigene Clusters for C1QTNF7 Gene

C1q and tumor necrosis factor related protein 7:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF7 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b · 8c · 8d
SP1: - - - - - - -
SP2: - - - -
SP3: - - -
SP4: - -
SP5:
SP6:

Relevant External Links for C1QTNF7 Gene

GeneLoc Exon Structure for
C1QTNF7
ECgene alternative splicing isoforms for
C1QTNF7

Expression for C1QTNF7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF7 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF7 Gene

This gene is overexpressed in Artery - Tibial (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF7 Gene

This gene is overexpressed in Pancreas (35.6), Prostate (15.8), Gallbladder (7.1), and Urinary Bladder (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF7 Gene



NURSA nuclear receptor signaling pathways regulating expression of C1QTNF7 Gene:

C1QTNF7

SOURCE GeneReport for Unigene cluster for C1QTNF7 Gene:

Hs.153714
genes like me logo Genes that share expression patterns with C1QTNF7: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF7 Gene

Orthologs for C1QTNF7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF7 33 34
  • 99.77 (n)
dog
(Canis familiaris)
Mammalia C1QTNF7 33 34
  • 92.45 (n)
cow
(Bos Taurus)
Mammalia C1QTNF7 33 34
  • 91.93 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf7 33
  • 89.39 (n)
mouse
(Mus musculus)
Mammalia C1qtnf7 33 16 34
  • 87.95 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF7 34
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1QTNF7 33 34
  • 80.16 (n)
lizard
(Anolis carolinensis)
Reptilia C1QTNF7 34
  • 81 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf7 33
  • 73.08 (n)
zebrafish
(Danio rerio)
Actinopterygii CABZ01048675.1 34
  • 67 (a)
OneToOne
LOC564609 33
  • 64.79 (n)
Species where no ortholog for C1QTNF7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF7 Gene

ENSEMBL:
Gene Tree for C1QTNF7 (if available)
TreeFam:
Gene Tree for C1QTNF7 (if available)

Paralogs for C1QTNF7 Gene

(8) SIMAP similar genes for C1QTNF7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF7: view

Variants for C1QTNF7 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF7 Gene

SNP ID Clin Chr 04 pos Variation AA Info Type
rs1000000807 -- 15,386,328(+) C/T genic_upstream_transcript_variant, intron_variant
rs1000006891 -- 15,439,985(+) A/G intron_variant
rs1000014567 -- 15,431,719(+) T/C intron_variant
rs10000232 -- 15,355,667(+) A/C genic_upstream_transcript_variant, intron_variant
rs1000027096 -- 15,354,384(+) T/C genic_upstream_transcript_variant, intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF7 Gene

Variant ID Type Subtype PubMed ID
esv2623009 CNV insertion 19546169
esv2759227 CNV gain+loss 17122850
esv3599738 CNV loss 21293372

Variation tolerance for C1QTNF7 Gene

Residual Variation Intolerance Score: 35% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.64; 31.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF7 Gene

Disorders for C1QTNF7 Gene

Additional Disease Information for C1QTNF7

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C1QTNF7 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF7 Gene

Publications for C1QTNF7 Gene

  1. Genome-wide association study of conduct disorder symptomatology. (PMID: 20585324) Dick DM … Bierut L (Molecular psychiatry 2011) 3 44 58
  2. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PMID: 19344414) Cerhan JR … Slager SL (British journal of haematology 2009) 3 44 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y … Ge F (Molecular & cellular proteomics : MCP 2013) 3 58
  5. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X … REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology Donor Study-II Component International (PloS one 2013) 3 58

Products for C1QTNF7 Gene

Sources for C1QTNF7 Gene

Content
Loading form....