Aliases for C1QTNF6 Gene

Aliases for C1QTNF6 Gene

  • C1q And TNF Related 6 2 3 5
  • CTRP6 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 6 3 4
  • C1q And Tumor Necrosis Factor Related Protein 6 2 3
  • ZACRP6 2 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 6 3
  • C1QTNF6 5
  • CTFP6 3

External Ids for C1QTNF6 Gene

Previous GeneCards Identifiers for C1QTNF6 Gene

  • GC22M034190
  • GC22M035819
  • GC22M035900
  • GC22M037576
  • GC22M020541

Summaries for C1QTNF6 Gene

GeneCards Summary for C1QTNF6 Gene

C1QTNF6 (C1q And TNF Related 6) is a Protein Coding gene. Diseases associated with C1QTNF6 include Type 1 Diabetes Mellitus 8 and Autoimmune Polyendocrine Syndrome, Type Ii. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is C1QTNF8.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QTNF6 Gene

Genomics for C1QTNF6 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1QTNF6 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF6 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QTNF6

Top Transcription factor binding sites by QIAGEN in the C1QTNF6 gene promoter:
  • AhR
  • AML1a
  • AREB6
  • COUP
  • E47
  • HNF-4alpha1
  • PPAR-gamma1
  • PPAR-gamma2
  • Tal-1

Genomic Locations for C1QTNF6 Gene

Genomic Locations for C1QTNF6 Gene
19,258 bases
Minus strand
19,220 bases
Minus strand

Genomic View for C1QTNF6 Gene

Genes around C1QTNF6 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF6 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF6 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF6 Gene

Proteins for C1QTNF6 Gene

  • Protein details for C1QTNF6 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 6
    Protein Accession:
    Secondary Accessions:
    • Q5H9G8
    • Q6ZRM7

    Protein attributes for C1QTNF6 Gene

    278 amino acids
    Molecular mass:
    30861 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF6 Gene


neXtProt entry for C1QTNF6 Gene

Post-translational modifications for C1QTNF6 Gene

  • Glycosylation at Asn91
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C1QTNF6 Gene

Domains & Families for C1QTNF6 Gene

Gene Families for C1QTNF6 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C1QTNF6 Gene

  • Collagen triple helix repeat
  • Collagen helix repeat
  • Complement C1q protein

Suggested Antigen Peptide Sequences for C1QTNF6 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q tumor necrosis factor-related protein 6 (C1QT6_HUMAN)
genes like me logo Genes that share domains with C1QTNF6: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QTNF6 Gene

Function for C1QTNF6 Gene

Phenotypes From GWAS Catalog for C1QTNF6 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view
genes like me logo Genes that share phenotypes with C1QTNF6: view

Animal Models for C1QTNF6 Gene

MGI Knock Outs for C1QTNF6:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF6

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF6

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF6 Gene

Localization for C1QTNF6 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF6 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF6 gene
Compartment Confidence
extracellular 3
plasma membrane 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
peroxisome 0
cytosol 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1QTNF6 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C1QTNF6: view

Pathways & Interactions for C1QTNF6 Gene

PathCards logo

SuperPathways for C1QTNF6 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF6 Gene


No data available for Pathways by source and SIGNOR curated interactions for C1QTNF6 Gene

Drugs & Compounds for C1QTNF6 Gene

No Compound Related Data Available

Transcripts for C1QTNF6 Gene

mRNA/cDNA for C1QTNF6 Gene

16 NCBI additional mRNA sequence :
7 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF6

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF6 Gene

ExUns: 1 ^ 2a · 2b ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b · 5c · 5d · 5e ^ 6
SP1: - - -
SP2: -
SP3: - - - -
SP5: - - -

Relevant External Links for C1QTNF6 Gene

GeneLoc Exon Structure for

Expression for C1QTNF6 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF6 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF6 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C1QTNF6 Gene

Protein tissue co-expression partners for C1QTNF6 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QTNF6

SOURCE GeneReport for Unigene cluster for C1QTNF6 Gene:

genes like me logo Genes that share expression patterns with C1QTNF6: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF6 Gene

Orthologs for C1QTNF6 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF6 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1QTNF6 30 31
  • 99.04 (n)
(Canis familiaris)
Mammalia C1QTNF6 30 31
  • 82.7 (n)
(Bos Taurus)
Mammalia C1QTNF6 30 31
  • 81.93 (n)
(Rattus norvegicus)
Mammalia C1qtnf6 30
  • 76.49 (n)
(Mus musculus)
Mammalia C1qtnf6 30 17 31
  • 75.8 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 53 (a)
(Gallus gallus)
Aves C1QTNF6 30
  • 63.99 (n)
-- 31
  • 56 (a)
(Anolis carolinensis)
Reptilia -- 31
  • 55 (a)
(Danio rerio)
Actinopterygii c1qtnf6a 30 31
  • 64.36 (n)
CABZ01084570.1 31
  • 49 (a)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 16 (a)
Species where no ortholog for C1QTNF6 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C1QTNF6 Gene

Gene Tree for C1QTNF6 (if available)
Gene Tree for C1QTNF6 (if available)
Evolutionary constrained regions (ECRs) for C1QTNF6: view image

Paralogs for C1QTNF6 Gene

(5) SIMAP similar genes for C1QTNF6 Gene using alignment to 2 proteins:

  • F8WC87_HUMAN
genes like me logo Genes that share paralogs with C1QTNF6: view

Variants for C1QTNF6 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QTNF6 Gene

SNP ID Clinical significance and condition Chr 22 pos Variation AA Info Type
715888 Benign: not provided 37,185,417(-) T/C SYNONYMOUS_VARIANT
774971 Benign: not provided 37,185,231(-) G/A SYNONYMOUS_VARIANT
rs17812681 - p.Arg226His
rs17812699 - p.Pro138Leu
rs229526 - p.Pro42Arg

Additional dbSNP identifiers (rs#s) for C1QTNF6 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF6 Gene

Variant ID Type Subtype PubMed ID
esv34015 CNV loss 18971310
nsv829203 CNV loss 20364138

Variation tolerance for C1QTNF6 Gene

Residual Variation Intolerance Score: 79.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.72; 97.87% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF6 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF6 Gene

Disorders for C1QTNF6 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C1QTNF6 Gene - From: DISEASES

Disorder Aliases PubMed IDs
type 1 diabetes mellitus 8
  • diabetes mellitus, insulin-dependent, 8
autoimmune polyendocrine syndrome, type ii
  • aps2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1QTNF6

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
genes like me logo Genes that share disorders with C1QTNF6: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF6 Gene

Publications for C1QTNF6 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4
  2. Novel associations for hypothyroidism include known autoimmune risk loci. (PMID: 22493691) Eriksson N … Do CB (PloS one 2012) 3 41
  3. Genetic susceptibility to type 2 diabetes is associated with reduced prostate cancer risk. (PMID: 20203524) Pierce BL … Ahsan H (Human heredity 2010) 3 41
  4. Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo. (PMID: 20410501) Jin Y … Spritz RA (The New England journal of medicine 2010) 3 41
  5. Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes. (PMID: 19430480) Barrett JC … Type 1 Diabetes Genetics Consortium (Nature genetics 2009) 3 41

Products for C1QTNF6 Gene

  • Signalway Proteins for C1QTNF6

Sources for C1QTNF6 Gene