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Aliases for C1QTNF4 Gene

Aliases for C1QTNF4 Gene

  • C1q And TNF Related 4 2 3 5
  • Complement-C1q Tumor Necrosis Factor-Related Protein 4 2 3
  • C1q And Tumor Necrosis Factor Related Protein 4 2 3
  • CTRP4 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 4 3
  • ZACRP4 3

External Ids for C1QTNF4 Gene

Previous GeneCards Identifiers for C1QTNF4 Gene

  • GC11M049522
  • GC11M048488
  • GC11M047643
  • GC11M047575
  • GC11M047567
  • GC11M047611
  • GC11M047312
  • GC11M047838
  • GC11M047957
  • GC11M050805
  • GC11M051600
  • GC11M052262
  • GC11M052922
  • GC11M053590
  • GC11M054256

Summaries for C1QTNF4 Gene

GeneCards Summary for C1QTNF4 Gene

C1QTNF4 (C1q And TNF Related 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is C1QTNF8.

UniProtKB/Swiss-Prot for C1QTNF4 Gene

  • May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production.

Additional gene information for C1QTNF4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF4 Gene

Genomics for C1QTNF4 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF4 Gene

Promoters and enhancers for C1QTNF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J047595 Promoter/Enhancer 1 EPDnew ENCODE 650.7 +0.3 284 0.2 BCOR MXI1 POLR2A EZH2 C1QTNF4 GC11M056218
GH11J047594 Promoter 0.5 EPDnew 650.7 0.0 -25 0.1 C1QTNF4 PIR60352
GH11J047424 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 37.1 +168.5 168468 3.7 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B NEUROD1 SIN3A DMAP1 ZNF2 PSMC3 C1QTNF4 FNBP4 NUP160 ENSG00000270060 MADD ARFGAP2 C11orf49 ZNF408 DDB2
GH11J047521 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 43.1 +70.4 70443 4.8 HDGF PKNOX1 FEZF1 ZFP91 ATF7 FOS DEK JUNB GMEB1 SMARCA4 CELF1 C1QTNF4 NUP160 FNBP4 ENSG00000200090 NDUFS3 PTPMT1 AMBRA1 SLC39A13 FAM180B
GH11J047506 Enhancer 1.7 FANTOM5 Ensembl ENCODE dbSUPER 43.7 +81.1 81078 14.4 HDGF PKNOX1 ZFP64 ZNF213 FOS JUNB ZC3H11A REST SREBF1 SMARCA4 ENSG00000270072 NUP160 FNBP4 ENSG00000200090 ENSG00000270060 C1QTNF4 CELF1 DDB2 ZNF408 AMBRA1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1QTNF4 gene promoter:
  • YY1
  • deltaCREB
  • CREB
  • Pax-4a
  • RORalpha1
  • Zic1
  • ZID
  • En-1
  • AP-2alpha
  • AP-2alphaA

Genomic Locations for C1QTNF4 Gene

Genomic Locations for C1QTNF4 Gene
chr11:47,589,664-47,594,659
(GRCh38/hg38)
Size:
4,996 bases
Orientation:
Minus strand
chr11:47,611,216-47,616,211
(GRCh37/hg19)
Size:
4,996 bases
Orientation:
Minus strand

Genomic View for C1QTNF4 Gene

Genes around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF4 Gene

Proteins for C1QTNF4 Gene

  • Protein details for C1QTNF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ3-C1QT4_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 4
    Protein Accession:
    Q9BXJ3
    Secondary Accessions:
    • Q8IV25

    Protein attributes for C1QTNF4 Gene

    Size:
    329 amino acids
    Molecular mass:
    35256 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C1QTNF4 Gene

Post-translational modifications for C1QTNF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF4 Gene

Antibody Products

  • R&D Systems Antibodies for C1QTNF4 (CTRP4/C1qTNF4)
  • Abcam antibodies for C1QTNF4
  • Santa Cruz Biotechnology (SCBT) Antibodies for C1QTNF4

No data available for DME Specific Peptides for C1QTNF4 Gene

Domains & Families for C1QTNF4 Gene

Gene Families for C1QTNF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QTNF4 Gene

Suggested Antigen Peptide Sequences for C1QTNF4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF4: view

No data available for UniProtKB/Swiss-Prot for C1QTNF4 Gene

Function for C1QTNF4 Gene

Molecular function for C1QTNF4 Gene

UniProtKB/Swiss-Prot Function:
May act as a pro-inflammatory cytokine, that induces the activation of NF-kappa-B signaling pathway and up-regulates IL6 production.
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL6.

Phenotypes From GWAS Catalog for C1QTNF4 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF4: view
genes like me logo Genes that share phenotypes with C1QTNF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF4 Gene

Localization for C1QTNF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF4 gene
Compartment Confidence
extracellular 4
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IEA,IDA 21658842
genes like me logo Genes that share ontologies with C1QTNF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QTNF4 Gene

Pathways & Interactions for C1QTNF4 Gene

SuperPathways for C1QTNF4 Gene

No Data Available

Interacting Proteins for C1QTNF4 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000302274%0d%0a9606.ENSP00000373153%0d%0a9606.ENSP00000299421%0d%0a9606.ENSP00000324944%0d%0a
Selected Interacting proteins: Q9BXJ3-C1QT4_HUMAN ENSP00000302274 for C1QTNF4 Gene via UniProtKB STRING IID

Gene Ontology (GO) - Biological Process for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0032755 positive regulation of interleukin-6 production IDA 21658842
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway IDA 21658842
GO:1901224 positive regulation of NIK/NF-kappaB signaling IDA 21658842
GO:1904469 positive regulation of tumor necrosis factor secretion IDA 21658842
genes like me logo Genes that share ontologies with C1QTNF4: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF4 Gene

Drugs & Compounds for C1QTNF4 Gene

No Compound Related Data Available

Transcripts for C1QTNF4 Gene

mRNA/cDNA for C1QTNF4 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QTNF4 Gene

C1q and tumor necrosis factor related protein 4:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF4 Gene

No ASD Table

Relevant External Links for C1QTNF4 Gene

GeneLoc Exon Structure for
C1QTNF4
ECgene alternative splicing isoforms for
C1QTNF4

Expression for C1QTNF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.4), Brain - Putamen (basal ganglia) (x6.7), and Brain - Caudate (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF4 Gene

This gene is overexpressed in Serum (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF4 Gene



Protein tissue co-expression partners for C1QTNF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF4 Gene:

C1QTNF4

SOURCE GeneReport for Unigene cluster for C1QTNF4 Gene:

Hs.662633

mRNA Expression by UniProt/SwissProt for C1QTNF4 Gene:

Q9BXJ3-C1QT4_HUMAN
Tissue specificity: Widely expressed at low levels.

Evidence on tissue expression from TISSUES for C1QTNF4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C1QTNF4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF4 Gene

Orthologs for C1QTNF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF4 34 33
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1QTNF4 34 33
  • 92.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia C1qtnf4 16 34 33
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf4 33
  • 87.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF4 34
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC137014 34
  • 24 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves C1QTNF4 34 33
  • 64.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QTNF4 34
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf4 33
  • 64.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26293 33
zebrafish
(Danio rerio)
Actinopterygii c1qtnf4 34 33
  • 66.15 (n)
OneToOne
wufi33h02 33
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToMany
Species where no ortholog for C1QTNF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF4 Gene

ENSEMBL:
Gene Tree for C1QTNF4 (if available)
TreeFam:
Gene Tree for C1QTNF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QTNF4: view image

Paralogs for C1QTNF4 Gene

Paralogs for C1QTNF4 Gene

genes like me logo Genes that share paralogs with C1QTNF4: view

Variants for C1QTNF4 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF4 Gene

SNP ID Clin Chr 11 pos Variation AA Info Type
rs1000508382 -- 47,596,730(-) C/T upstream_transcript_variant
rs1000518136 -- 47,591,342(-) G/T intron_variant
rs1000560398 -- 47,596,445(-) A/T upstream_transcript_variant
rs1001120002 -- 47,589,324(-) C/T downstream_transcript_variant
rs1001178393 -- 47,596,963(-) A/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF4 Gene

Variant ID Type Subtype PubMed ID
esv3579504 CNV loss 25503493
nsv509405 CNV insertion 20534489
nsv825872 CNV gain 20364138
nsv825873 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for C1QTNF4 Gene

Gene Damage Index Score: 2.62; 45.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF4 Gene

Disorders for C1QTNF4 Gene

Additional Disease Information for C1QTNF4

No disorders were found for C1QTNF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF4 Gene

Publications for C1QTNF4 Gene

  1. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells. (PMID: 21658842) Li Q … Wang L (Cancer letters 2011) 3 4 58
  2. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao WA … Aebersold R (Nature methods 2005) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. (PMID: 24366864) Byerly MS … Wong GW (The Journal of biological chemistry 2014) 3 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C1QTNF4 Gene

Sources for C1QTNF4 Gene

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