Aliases for C1QTNF4 Gene

Aliases for C1QTNF4 Gene

  • C1q And TNF Related 4 2 3 5
  • Complement C1q Tumor Necrosis Factor-Related Protein 4 3 4
  • Complement-C1q Tumor Necrosis Factor-Related Protein 4 2 3
  • C1q And Tumor Necrosis Factor Related Protein 4 2 3
  • C1q/TNF-Related Protein 4 3 4
  • CTRP4 3 4
  • ZACRP4 3

External Ids for C1QTNF4 Gene

Previous GeneCards Identifiers for C1QTNF4 Gene

  • GC11M049522
  • GC11M048488
  • GC11M047643
  • GC11M047575
  • GC11M047567
  • GC11M047611
  • GC11M047312
  • GC11M047838
  • GC11M047957
  • GC11M055821
  • GC11M056046
  • GC11M056191
  • GC11M050805
  • GC11M051600
  • GC11M052262
  • GC11M052922
  • GC11M053590
  • GC11M054256
  • GC11M054922
  • GC11M055624

Summaries for C1QTNF4 Gene

GeneCards Summary for C1QTNF4 Gene

C1QTNF4 (C1q And TNF Related 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include cytokine activity. An important paralog of this gene is C1QTNF8.

UniProtKB/Swiss-Prot Summary for C1QTNF4 Gene

  • May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).

Additional gene information for C1QTNF4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QTNF4 Gene

Genomics for C1QTNF4 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF4 Gene

Promoters and enhancers for C1QTNF4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH11J047595 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE CraniofacialAtlas 526.8 +0.1 87 1 EZH2 SMC3 ZBTB17 MXI1 PHF8 BCOR ZNF335 ZBTB7A VEZF1 ZNF366 C1QTNF4 FAM180B
GH11J047592 Promoter 0.6 Ensembl 500.7 +1.5 1510 0.2 RBM25 CHD4 ZMYM3 ESRRA C1QTNF4 FAM180B
GH11J047424 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 37.1 +168.2 168220 3.7 ZBTB40 ZNF217 EP300 TCF12 NRF1 POLR2G SP1 NCOR1 PHF8 SIX5 PSMC3 lnc-RAPSN-1 C1QTNF4 MADD ARFGAP2 C11orf49 KBTBD4 FNBP4 ACP2 ENSG00000255197
GH11J047522 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE dbSUPER 43.1 +69.7 69696 3.8 JUND FOS TRIM28 MYC JUN ZEB1 ZNF341 OSR2 NCOR1 DEK CELF1 C1QTNF4 NDUFS3 PTPMT1 FAM180B ENSG00000231880 RNU5E-10P C11orf49 HQ292159 ENSG00000270072
GH11J047506 Promoter/Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 42.2 +85.6 85599 4.9 ZNF623 RFX1 CTBP1 TRIM22 BCL11A NCOR1 ZNF384 MYNN CEBPB RBBP5 C1QTNF4 CELF1 NDUFS3 PTPMT1 FAM180B KBTBD4 ENSG00000231880 RNU5E-10P MTCH2 FNBP4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QTNF4

Top Transcription factor binding sites by QIAGEN in the C1QTNF4 gene promoter:
  • AP-2alpha
  • AP-2alphaA
  • CREB
  • deltaCREB
  • En-1
  • Pax-4a
  • RORalpha1
  • YY1
  • Zic1
  • ZID

Genomic Locations for C1QTNF4 Gene

Genomic Locations for C1QTNF4 Gene
chr11:47,589,664-47,594,411
(GRCh38/hg38)
Size:
4,748 bases
Orientation:
Minus strand
chr11:47,611,216-47,616,211
(GRCh37/hg19)
Size:
4,996 bases
Orientation:
Minus strand

Genomic View for C1QTNF4 Gene

Genes around C1QTNF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF4 Gene

Proteins for C1QTNF4 Gene

  • Protein details for C1QTNF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ3-C1QT4_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 4
    Protein Accession:
    Q9BXJ3
    Secondary Accessions:
    • Q8IV25

    Protein attributes for C1QTNF4 Gene

    Size:
    329 amino acids
    Molecular mass:
    35256 Da
    Quaternary structure:
    • Homomultimer. Forms trimers, hexamers and high molecular weight oligomers (By similarity).

neXtProt entry for C1QTNF4 Gene

Post-translational modifications for C1QTNF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF4 Gene

No data available for DME Specific Peptides for C1QTNF4 Gene

Domains & Families for C1QTNF4 Gene

Gene Families for C1QTNF4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QTNF4 Gene

Blocks:
  • Complement C1q protein
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1QTNF4 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q tumor necrosis factor-related protein 4 (C1QT4_HUMAN)
genes like me logo Genes that share domains with C1QTNF4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QTNF4 Gene

Function for C1QTNF4 Gene

Molecular function for C1QTNF4 Gene

UniProtKB/Swiss-Prot Function:
May be involved in the regulation of the inflammatory network. Its role as pro- or anti-inflammatory seems to be context dependent (PubMed:21658842, PubMed:27086950). Seems to have some role in regulating food intake and energy balance when administered in the brain. This effect is sustained over a two-day period, and it is accompanied by decreased expression of orexigenic neuropeptides in the hypothalamus 3 h post-injection (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated by IL6.

Phenotypes From GWAS Catalog for C1QTNF4 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005125 cytokine activity IEA --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF4: view
genes like me logo Genes that share phenotypes with C1QTNF4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF4

CRISPR Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF4 Gene

Localization for C1QTNF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF4 gene
Compartment Confidence
extracellular 5
cytoskeleton 1
mitochondrion 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005615 extracellular space IDA,IEA 21658842
genes like me logo Genes that share ontologies with C1QTNF4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QTNF4 Gene

Pathways & Interactions for C1QTNF4 Gene

PathCards logo

SuperPathways for C1QTNF4 Gene

No Data Available

Interacting Proteins for C1QTNF4 Gene

STRING Interaction Network Preview (showing top 4 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000302274 Q9BXJ3-C1QT4_HUMAN for C1QTNF4 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for C1QTNF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007165 signal transduction IEA --
GO:0032755 positive regulation of interleukin-6 production IDA 21658842
GO:0070105 positive regulation of interleukin-6-mediated signaling pathway IDA 21658842
GO:1901224 positive regulation of NIK/NF-kappaB signaling IDA 21658842
GO:1904469 positive regulation of tumor necrosis factor secretion IDA 21658842
genes like me logo Genes that share ontologies with C1QTNF4: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF4 Gene

Drugs & Compounds for C1QTNF4 Gene

No Compound Related Data Available

Transcripts for C1QTNF4 Gene

mRNA/cDNA for C1QTNF4 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF4 Gene

No ASD Table

Relevant External Links for C1QTNF4 Gene

GeneLoc Exon Structure for
C1QTNF4

Expression for C1QTNF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF4 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (x7.4), Brain - Putamen (basal ganglia) (x6.7), and Brain - Caudate (basal ganglia) (x5.6).

Protein differential expression in normal tissues from HIPED for C1QTNF4 Gene

This gene is overexpressed in Serum (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF4 Gene



Protein tissue co-expression partners for C1QTNF4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QTNF4

SOURCE GeneReport for Unigene cluster for C1QTNF4 Gene:

Hs.662633

mRNA Expression by UniProt/SwissProt for C1QTNF4 Gene:

Q9BXJ3-C1QT4_HUMAN
Tissue specificity: Widely expressed at low levels (PubMed:21658842). Highest levels in adipocyte tissue and brain (PubMed:24366864).

Evidence on tissue expression from TISSUES for C1QTNF4 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C1QTNF4: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF4 Gene

Orthologs for C1QTNF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF4 31 30
  • 99.19 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1QTNF4 31 30
  • 92.99 (n)
OneToOne
mouse
(Mus musculus)
Mammalia C1qtnf4 17 31 30
  • 90.52 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf4 30
  • 87.65 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF4 31
  • 72 (a)
OneToOne
cow
(Bos Taurus)
Mammalia MGC137014 31
  • 24 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia -- 31
  • 23 (a)
ManyToMany
chicken
(Gallus gallus)
Aves C1QTNF4 31 30
  • 64.56 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QTNF4 31
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1qtnf4 30
  • 64.02 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26293 30
zebrafish
(Danio rerio)
Actinopterygii c1qtnf4 31 30
  • 66.15 (n)
OneToOne
wufi33h02 30
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 37 (a)
OneToMany
Species where no ortholog for C1QTNF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF4 Gene

ENSEMBL:
Gene Tree for C1QTNF4 (if available)
TreeFam:
Gene Tree for C1QTNF4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QTNF4: view image

Paralogs for C1QTNF4 Gene

Variants for C1QTNF4 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QTNF4 Gene

SNP ID Clinical significance and condition Chr 11 pos Variation AA Info Type
rs1418830230 - p.Gly301Asp
VAR_081086 - p.His198Gln

Additional dbSNP identifiers (rs#s) for C1QTNF4 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF4 Gene

Variant ID Type Subtype PubMed ID
esv3579504 CNV loss 25503493
nsv509405 CNV insertion 20534489
nsv825872 CNV gain 20364138
nsv825873 CNV gain 20364138
nsv832142 CNV loss 17160897

Variation tolerance for C1QTNF4 Gene

Gene Damage Index Score: 2.62; 45.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF4 Gene

Disorders for C1QTNF4 Gene

Additional Disease Information for C1QTNF4

No disorders were found for C1QTNF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF4 Gene

Publications for C1QTNF4 Gene

  1. Whole-Exome Sequencing Identifies Novel Variants that Co-segregates with Autosomal Recessive Retinal Degeneration in a Pakistani Pedigree. (PMID: 29721947) Biswas P … Ayyagari R (Advances in experimental medicine and biology 2018) 3 4 54
  2. C1q/TNF-related protein 4 (CTRP4) is a unique secreted protein with two tandem C1q domains that functions in the hypothalamus to modulate food intake and body weight. (PMID: 24366864) Byerly MS … Wong GW (The Journal of biological chemistry 2014) 3 4 54
  3. Identification of C1qTNF-related protein 4 as a potential cytokine that stimulates the STAT3 and NF-κB pathways and promotes cell survival in human cancer cells. (PMID: 21658842) Li Q … Wang L (Cancer letters 2011) 3 4 54
  4. Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. (PMID: 16094384) Tao WA … Aebersold R (Nature methods 2005) 2 3 54
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54

Products for C1QTNF4 Gene

Sources for C1QTNF4 Gene