Aliases for C1QTNF3 Gene

Aliases for C1QTNF3 Gene

  • C1q And TNF Related 3 2 3 5
  • CTRP3 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 3 3 4
  • Collagenous Repeat-Containing Sequence 26 KDa Protein 3 4
  • C1q And Tumor Necrosis Factor Related Protein 3 2 3
  • Secretory Protein CORS26 3 4
  • Cartonectin 2 3
  • CORS26 3 4
  • Collagenous Repeat-Containing Sequence Of 26-KDa 3
  • 2310005P21Rik 2
  • C1ATNF3 3
  • CORS-26 3
  • C1QTNF3 5
  • Cors-26 2
  • CORCS 3
  • Corcs 2
  • CORS 3
  • Cors 2

External Ids for C1QTNF3 Gene

Previous GeneCards Identifiers for C1QTNF3 Gene

  • GC05M033966
  • GC05M034479
  • GC05M034065
  • GC05M034053
  • GC05M033987

Summaries for C1QTNF3 Gene

GeneCards Summary for C1QTNF3 Gene

C1QTNF3 (C1q And TNF Related 3) is a Protein Coding gene. Diseases associated with C1QTNF3 include Bleeding Disorder, Platelet-Type, 14 and Chromosome 5P13 Duplication Syndrome. An important paralog of this gene is C1QTNF3-AMACR.

Gene Wiki entry for C1QTNF3 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QTNF3 Gene

Genomics for C1QTNF3 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C1QTNF3 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05J034243 Promoter/Enhancer 1.6 Ensembl ENCODE CraniofacialAtlas 250.7 +0.3 291 4.5 FEZF1 CEBPA FOXA1 MNT SIX4 ZEB1 ELF1 THAP11 CEBPB ARNT C1QTNF3 ENSG00000286543 lnc-C1QTNF3-AMACR-2 ENSG00000215158 ENSG00000215156 BRIX1 HSALNG0041078 AMACR
GH05J034042 Promoter/Enhancer 0.7 EPDnew ENCODE 250.1 +201.0 200973 2.9 REST NR2F2 C1QTNF3 AMACR HSALNG0041064 lnc-RXFP3-1 C1QTNF3-AMACR
GH05J034175 Promoter 0.3 EPDnew 250.2 +68.7 68738 0.1 piR-31826-002 FJ601678-019 C1QTNF3 piR-59338-001 LOC643373 ENSG00000215158 lnc-C1QTNF3-AMACR-2 AMACR
GH05J034064 Promoter 0.3 EPDnew 250.1 +180.4 180443 0.1 HSALNG0041066 C1QTNF3 AF480515 AMACR C1QTNF3-AMACR
GH05J034006 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 2.5 +236.1 236075 4.5 TBP ZBTB10 MXD4 FEZF1 CEBPA MNT DEK SMAD5 HES1 MBD2 AMACR BRIX1 TTC23L ENSG00000215158 C1QTNF3 piR-41405-009 C1QTNF3-AMACR
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF3 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QTNF3

Top Transcription factor binding sites by QIAGEN in the C1QTNF3 gene promoter:
  • E2F
  • E2F-1
  • E2F-2
  • E2F-3a
  • E2F-4
  • E2F-5
  • HNF-4alpha1
  • Pax-4a
  • POU2F1
  • POU2F1a

Genomic Locations for C1QTNF3 Gene

Latest Assembly
226,867 bases
Minus strand

Previous Assembly
(GRCh37/hg19 by Entrez Gene)
226,867 bases
Minus strand

(GRCh37/hg19 by Ensembl)
24,385 bases
Minus strand

Genomic View for C1QTNF3 Gene

Genes around C1QTNF3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF3 Gene

Proteins for C1QTNF3 Gene

  • Protein details for C1QTNF3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 3
    Protein Accession:
    Secondary Accessions:
    • Q0VAN4
    • Q542Y2
    • Q6MZN1
    • Q96KY1

    Protein attributes for C1QTNF3 Gene

    246 amino acids
    Molecular mass:
    26994 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C1QTNF3 Gene


neXtProt entry for C1QTNF3 Gene

Post-translational modifications for C1QTNF3 Gene

Other Protein References for C1QTNF3 Gene

No data available for DME Specific Peptides for C1QTNF3 Gene

Domains & Families for C1QTNF3 Gene

Gene Families for C1QTNF3 Gene

Human Protein Atlas (HPA):
  • Plasma proteins
  • Predicted secreted proteins

Protein Domains for C1QTNF3 Gene

  • Collagen triple helix repeat
  • Complement C1q protein

Suggested Antigen Peptide Sequences for C1QTNF3 Gene

GenScript: Design optimal peptide antigens:
  • Secretory protein CORS26 (C1QT3_HUMAN)
  • cDNA, FLJ78820, highly similar to Homo sapiens C1q and tumor necrosis factor related protein 3 (C1QTNF3), transcript variant 2, mRNA (Q0VAN4_HUMAN)
  • cDNA PSEC0232 fis, clone HEMBA1006549, moderately similar to Complement-c1q tumor necrosis factor-related protein 3 (Q542Y2_HUMAN)
genes like me logo Genes that share domains with C1QTNF3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QTNF3 Gene

Function for C1QTNF3 Gene

Phenotypes From GWAS Catalog for C1QTNF3 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0005515 protein binding IPI 32814053
GO:0042802 identical protein binding IPI 16213490
genes like me logo Genes that share ontologies with C1QTNF3: view
genes like me logo Genes that share phenotypes with C1QTNF3: view

Animal Models for C1QTNF3 Gene

MGI Knock Outs for C1QTNF3:

Animal Models for research

  • Taconic Biosciences Mouse Models for C1QTNF3

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF3

Clone products for research

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF3 Gene

Localization for C1QTNF3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF3 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0016020 membrane HDA 19946888
GO:0070062 extracellular exosome HDA 19199708
genes like me logo Genes that share ontologies with C1QTNF3: view

Pathways & Interactions for C1QTNF3 Gene

PathCards logo

SuperPathways for C1QTNF3 Gene

No Data Available

Interacting Proteins for C1QTNF3 Gene

Gene Ontology (GO) - Biological Process for C1QTNF3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001819 positive regulation of cytokine production IDA 18421280
GO:0010629 negative regulation of gene expression IDA --
GO:0032715 negative regulation of interleukin-6 production IDA 16213490
GO:0035356 cellular triglyceride homeostasis IDA 20739398
GO:0045444 fat cell differentiation IEP 20739398
genes like me logo Genes that share ontologies with C1QTNF3: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF3 Gene

Drugs & Compounds for C1QTNF3 Gene

No Compound Related Data Available

Transcripts for C1QTNF3 Gene

mRNA/cDNA for C1QTNF3 Gene

16 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QTNF3

Clone products for research

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF3 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c · 5d ^ 6a · 6b · 6c ^ 7a · 7b
SP1: - - - -
SP2: - - - -
SP4: -
SP5: - - - - -
SP6: - - - - - -
SP7: - -
SP8: - -

Relevant External Links for C1QTNF3 Gene

GeneLoc Exon Structure for

Expression for C1QTNF3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QTNF3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for C1QTNF3 Gene

This gene is overexpressed in Fetal gut (25.9), Breast (13.2), Bone marrow mesenchymal stem cell (10.3), and Vitreous humor (9.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QTNF3 Gene

Protein tissue co-expression partners for C1QTNF3 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QTNF3

SOURCE GeneReport for Unigene cluster for C1QTNF3 Gene:


mRNA Expression by UniProt/SwissProt for C1QTNF3 Gene:

Tissue specificity: Expressed in colon and small intestine.

Evidence on tissue expression from TISSUES for C1QTNF3 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with C1QTNF3: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF3 Gene

Orthologs for C1QTNF3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C1QTNF3 30
  • 99.9 (n)
-- 31
  • 78 (a)
(Canis familiaris)
Mammalia -- 31
  • 97 (a)
C1QTNF3 30
  • 93.21 (n)
(Bos Taurus)
Mammalia C1QTNF3 30 31
  • 92.44 (n)
(Monodelphis domestica)
Mammalia -- 31
  • 91 (a)
(Mus musculus)
Mammalia C1qtnf3 30 17 31
  • 90.91 (n)
(Rattus norvegicus)
Mammalia C1qtnf3 30
  • 90.49 (n)
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 79 (a)
(Gallus gallus)
Aves -- 31
  • 87 (a)
C1QTNF3 30
  • 78.7 (n)
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia c1qtnf3 30
  • 71.02 (n)
Sea Squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 30 (a)
Species where no ortholog for C1QTNF3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C1QTNF3 Gene

Gene Tree for C1QTNF3 (if available)
Gene Tree for C1QTNF3 (if available)
Evolutionary constrained regions (ECRs) for C1QTNF3: view image

Paralogs for C1QTNF3 Gene

(4) SIMAP similar genes for C1QTNF3 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C1QTNF3: view

Variants for C1QTNF3 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C1QTNF3 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF3 Gene

Variant ID Type Subtype PubMed ID
nsv507243 OTHER sequence alteration 20534489
nsv519240 CNV gain 19592680
nsv522715 CNV gain 19592680
nsv830255 CNV loss 17160897

Variation tolerance for C1QTNF3 Gene

Residual Variation Intolerance Score: 25.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.95; 19.72% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QTNF3 Gene

Disorders for C1QTNF3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for C1QTNF3 Gene - From: COP and GCD

Disorder Aliases PubMed IDs
bleeding disorder, platelet-type, 14
  • bdplt14
chromosome 5p13 duplication syndrome
  • 5p13 microduplication syndrome
type 2 diabetes mellitus
  • t2d
cone-rod dystrophy 2
  • cord2
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C1QTNF3

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with C1QTNF3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QTNF3 Gene

Publications for C1QTNF3 Gene

  1. Effects of the new C1q/TNF-related protein (CTRP-3) "cartonectin" on the adipocytic secretion of adipokines. (PMID: 18421280) Wölfing B … Schäffler A (Obesity (Silver Spring, Md.) 2008) 2 3 23
  2. Genomic organization, promoter, amino acid sequence, chromosomal localization, and expression of the human gene for CORS-26 (collagenous repeat-containing sequence of 26-kDa protein). (PMID: 14654242) Schäffler A … Müller-Ladner U (Biochimica et biophysica acta 2003) 3 4 23
  3. C1q/TNF-related protein-3 (CTRP3), a novel adipokine that regulates hepatic glucose output. (PMID: 20952387) Peterson JM … Wong GW (The Journal of biological chemistry 2010) 3 4
  4. Maternal genes and facial clefts in offspring: a comprehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PMID: 20634891) Jugessur A … Murray JC (PloS one 2010) 3 41
  5. Plasma levels of leptin, omentin, collagenous repeat-containing sequence of 26-kDa protein (CORS-26) and adiponectin before and after oral glucose uptake in slim adults. (PMID: 17311679) Wurm S … Buechler C (Cardiovascular diabetology 2007) 3 23

Products for C1QTNF3 Gene

Sources for C1QTNF3 Gene