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Aliases for C1QTNF2 Gene

Aliases for C1QTNF2 Gene

  • C1q And TNF Related 2 2 3 5
  • C1q And Tumor Necrosis Factor Related Protein 2 2 3
  • CTRP2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 2 3
  • Complement-C1q Tumor Necrosis Factor-Related Protein 2 3
  • Zacrp2 3

External Ids for C1QTNF2 Gene

Previous GeneCards Identifiers for C1QTNF2 Gene

  • GC05M159893
  • GC05M159710
  • GC05M159755
  • GC05M159707
  • GC05M154868

Summaries for C1QTNF2 Gene

GeneCards Summary for C1QTNF2 Gene

C1QTNF2 (C1q And TNF Related 2) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding and receptor binding. An important paralog of this gene is C1QTNF7.

Additional gene information for C1QTNF2 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF2 Gene

Genomics for C1QTNF2 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF2 Gene

Promoters and enhancers for C1QTNF2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH05I160369 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 550.8 +0.1 95 2 NFXL1 ZNF335 EGR1 EGR2 ZNF263 ZNF362 USF2 ZNF398 RAD51 ZNF341 C1QTNF2 CCNJL
GH05I160008 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 37 +361.1 361133 2.3 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 IRF4 YY1 TTC1 GC05P160010 ENSG00000199398 ZBED8 PWWP2A EBF1 C1QTNF2 LINC02202 RNF145 ENSG00000223908
GH05I160311 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 18.7 +58.3 58284 1.9 NFIB ZNF76 SIN3A ZNF2 ZNF48 ZEB1 ZNF335 GLIS2 ZNF366 EGR2 CCNJL C1QTNF2 SNRPEP1 GC05P160291
GH05I160361 Enhancer 1.1 Ensembl ENCODE dbSUPER 25.3 +7.3 7257 4.4 MEIS2 MAX EGR1 VEZF1 CBFA2T2 CREM STAT1 L3MBTL2 BHLHE40 USF2 C1QTNF2 CCNJL
GH05I160356 Enhancer 0.7 Ensembl ENCODE dbSUPER 26.6 +13.0 13012 2.9 ZNF143 C1QTNF2 ZBED8 CCNJL
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1QTNF2 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1QTNF2 gene promoter:

Genomic Locations for C1QTNF2 Gene

Genomic Locations for C1QTNF2 Gene
chr5:160,347,751-160,370,652
(GRCh38/hg38)
Size:
22,902 bases
Orientation:
Minus strand
chr5:159,774,758-159,797,648
(GRCh37/hg19)

Genomic View for C1QTNF2 Gene

Genes around C1QTNF2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF2 Gene

Proteins for C1QTNF2 Gene

  • Protein details for C1QTNF2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BXJ5-C1QT2_HUMAN
    Recommended name:
    Complement C1q tumor necrosis factor-related protein 2
    Protein Accession:
    Q9BXJ5

    Protein attributes for C1QTNF2 Gene

    Size:
    285 amino acids
    Molecular mass:
    29952 Da
    Quaternary structure:
    • May interact with ERFE.
    SequenceCaution:
    • Sequence=AAH11699.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH54506.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for C1QTNF2 Gene

Post-translational modifications for C1QTNF2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF2 Gene

No data available for DME Specific Peptides for C1QTNF2 Gene

Domains & Families for C1QTNF2 Gene

Gene Families for C1QTNF2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Suggested Antigen Peptide Sequences for C1QTNF2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QTNF2: view

No data available for UniProtKB/Swiss-Prot for C1QTNF2 Gene

Function for C1QTNF2 Gene

Phenotypes From GWAS Catalog for C1QTNF2 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005102 receptor binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

Phenotypes for C1QTNF2 Gene

genes like me logo Genes that share phenotypes with C1QTNF2: view

Animal Models for C1QTNF2 Gene

MGI Knock Outs for C1QTNF2:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QTNF2

miRNA for C1QTNF2 Gene

miRTarBase miRNAs that target C1QTNF2

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QTNF2 Gene

Localization for C1QTNF2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF2 gene
Compartment Confidence
extracellular 3
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Centrosome (2)
  • Golgi apparatus (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

Pathways & Interactions for C1QTNF2 Gene

SuperPathways for C1QTNF2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QTNF2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000187 activation of MAPK activity IEA --
GO:0045725 positive regulation of glycogen biosynthetic process IEA --
GO:0046321 positive regulation of fatty acid oxidation IEA --
GO:0046326 positive regulation of glucose import IEA --
GO:0051260 protein homooligomerization IEA --
genes like me logo Genes that share ontologies with C1QTNF2: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF2 Gene

Drugs & Compounds for C1QTNF2 Gene

No Compound Related Data Available

Transcripts for C1QTNF2 Gene

mRNA/cDNA for C1QTNF2 Gene

Unigene Clusters for C1QTNF2 Gene

C1q and tumor necrosis factor related protein 2:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF2 Gene

No ASD Table

Relevant External Links for C1QTNF2 Gene

GeneLoc Exon Structure for
C1QTNF2
ECgene alternative splicing isoforms for
C1QTNF2

Expression for C1QTNF2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QTNF2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QTNF2 Gene

This gene is overexpressed in Artery - Aorta (x6.9), Artery - Coronary (x4.3), and Artery - Tibial (x4.1).

Protein differential expression in normal tissues from HIPED for C1QTNF2 Gene

This gene is overexpressed in Tlymphocyte (39.2), Monocytes (14.6), and Blymphocyte (8.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for C1QTNF2 Gene



Protein tissue co-expression partners for C1QTNF2 Gene

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF2 Gene:

C1QTNF2

SOURCE GeneReport for Unigene cluster for C1QTNF2 Gene:

Hs.110062

Evidence on tissue expression from TISSUES for C1QTNF2 Gene

  • Muscle(4.2)
  • Nervous system(4.1)
genes like me logo Genes that share expression patterns with C1QTNF2: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF2 Gene

Orthologs for C1QTNF2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QTNF2 33 34
  • 98.99 (n)
dog
(Canis familiaris)
Mammalia C1QTNF2 33 34
  • 90.76 (n)
cow
(Bos Taurus)
Mammalia C1QTNF2 33 34
  • 89.47 (n)
mouse
(Mus musculus)
Mammalia C1qtnf2 33 16 34
  • 88 (n)
rat
(Rattus norvegicus)
Mammalia C1qtnf2 33
  • 86.51 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C1QTNF2 34
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QTNF2 34
  • 76 (a)
OneToOne
chicken
(Gallus gallus)
Aves C1QTNF2 33 34
  • 72.65 (n)
lizard
(Anolis carolinensis)
Reptilia C1QTNF2 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100490036 33
  • 66.07 (n)
zebrafish
(Danio rerio)
Actinopterygii c1qtnf2 33 34
  • 63.47 (n)
Species where no ortholog for C1QTNF2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF2 Gene

ENSEMBL:
Gene Tree for C1QTNF2 (if available)
TreeFam:
Gene Tree for C1QTNF2 (if available)

Paralogs for C1QTNF2 Gene

(9) SIMAP similar genes for C1QTNF2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C1QTNF2: view

Variants for C1QTNF2 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF2 Gene

SNP ID Clin Chr 05 pos Variation AA Info Type
rs1000159859 -- 160,361,491(-) A/G intron_variant
rs1000228363 -- 160,351,974(-) G/A/T intron_variant
rs1000247378 -- 160,358,140(-) G/A intron_variant
rs1000536667 -- 160,350,742(-) C/T intron_variant
rs1000545708 -- 160,357,262(-) T/C intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF2 Gene

Variant ID Type Subtype PubMed ID
esv2730977 CNV deletion 23290073
esv3607367 CNV gain 21293372
esv3607370 CNV gain 21293372
nsv1015634 CNV gain 25217958
nsv473554 CNV novel sequence insertion 20440878

Variation tolerance for C1QTNF2 Gene

Residual Variation Intolerance Score: 46.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.06; 37.83% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF2 Gene

Disorders for C1QTNF2 Gene

Additional Disease Information for C1QTNF2

No disorders were found for C1QTNF2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF2 Gene

Publications for C1QTNF2 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for C1QTNF2 Gene

Sources for C1QTNF2 Gene

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