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Aliases for C1QTNF12 Gene

Aliases for C1QTNF12 Gene

  • C1q And TNF Related 12 2 3 5
  • Adipose-Derived Insulin-Sensitizing Factor 2 3 4
  • Complement C1q Tumor Necrosis Factor-Related Protein 12 3 4
  • C1q And Tumor Necrosis Factor Related Protein 12 2 3
  • Family With Sequence Similarity 132 Member A 2 3
  • C1q And TNF Related Protein 12 3 4
  • C1q Domain Containing 2 2 3
  • Adipolin 2 3
  • FAM132A 3 4
  • C1QDC2 3 4
  • CTRP12 3 4
  • Family With Sequence Similarity 132, Member A 2
  • C1q/TNF-Related Protein 12 3
  • Protein FAM132A 3

External Ids for C1QTNF12 Gene

Previous HGNC Symbols for C1QTNF12 Gene

  • C1QDC2
  • FAM132A

Summaries for C1QTNF12 Gene

GeneCards Summary for C1QTNF12 Gene

C1QTNF12 (C1q And TNF Related 12) is a Protein Coding gene. An important paralog of this gene is ERFE.

UniProtKB/Swiss-Prot for C1QTNF12 Gene

  • Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.

Additional gene information for C1QTNF12 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QTNF12 Gene

Genomics for C1QTNF12 Gene

GeneHancer (GH) Regulatory Elements for C1QTNF12 Gene

Promoters and enhancers for C1QTNF12 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01J001127 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 11.9 +118.0 117976 4 FOXA2 ARID4B DMAP1 ZNF48 RAD21 YY1 CREM THAP11 EGR2 MCM3 GC01M001125 SDF4 TTLL10 MXRA8 TTLL10-AS1 ENSG00000230092 B3GALT6 C1QTNF12 UBE2J2 LOC100288379
GH01J001131 Enhancer 1.3 Ensembl ENCODE dbSUPER 11.9 +112.1 112138 6.5 ELF3 PKNOX1 NFRKB BMI1 RAD21 EGR1 SCRT2 ATF7 IKZF2 RUNX3 LINC01342 TTLL10 TTLL10-AS1 SDF4 B3GALT6 C1QTNF12 UBE2J2 C1orf159 GC01M001125 GC01M001138
GH01J001189 Enhancer 0.3 FANTOM5 12 +57.8 57827 0.3 SDF4 B3GALT6 MIR200A MIR200B MIR429 UBE2J2 LINC01786 C1QTNF12 TNFRSF18 HES4
GH01J001235 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 0.4 +7.7 7657 7.9 PKNOX1 FOXA2 MLX ARID4B DMAP1 ZNF48 GLIS2 KLF7 FOS DEK SDF4 ATAD3B B3GALT6 CCNL2 SLC35E2A LOC100129381 FAAP20 SLC35E2B LOC100288379 INTS11
GH01J001249 Enhancer 1 Ensembl ENCODE 0.7 -3.4 -3367 1.6 HDGF PKNOX1 ATF1 IRF4 ZNF335 ARID2 ZNF143 ATF7 RUNX3 CREM ENSG00000260179 B3GALT6 ANKRD65 ATAD3B C1QTNF12 GC01M001138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QTNF12 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C1QTNF12 Gene

Genomic Locations for C1QTNF12 Gene
chr1:1,242,446-1,247,218
(GRCh38/hg38)
Size:
4,773 bases
Orientation:
Minus strand
chr1:1,177,826-1,182,102
(GRCh37/hg19)
Size:
4,277 bases
Orientation:
Minus strand

Genomic View for C1QTNF12 Gene

Genes around C1QTNF12 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QTNF12 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QTNF12 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QTNF12 Gene

Proteins for C1QTNF12 Gene

  • Protein details for C1QTNF12 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T7M4-ADIPL_HUMAN
    Recommended name:
    Adipolin
    Protein Accession:
    Q5T7M4
    Secondary Accessions:
    • Q5EBL5

    Protein attributes for C1QTNF12 Gene

    Size:
    302 amino acids
    Molecular mass:
    32416 Da
    Quaternary structure:
    • Homomultimer; disulfide-linked. May interact with ERFE (By similarity).

neXtProt entry for C1QTNF12 Gene

Post-translational modifications for C1QTNF12 Gene

  • Processed into Adipolin fC1QTNF12 and Adipolin gC1QTNF12 by FURIN. Insulin enhances endogenous C1QTNF12 cleavage.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QTNF12 Gene

No data available for DME Specific Peptides for C1QTNF12 Gene

Domains & Families for C1QTNF12 Gene

Gene Families for C1QTNF12 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QTNF12 Gene

Suggested Antigen Peptide Sequences for C1QTNF12 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T7M4

UniProtKB/Swiss-Prot:

ADIPL_HUMAN :
  • Belongs to the adipolin/erythroferrone family.
Family:
  • Belongs to the adipolin/erythroferrone family.
genes like me logo Genes that share domains with C1QTNF12: view

Function for C1QTNF12 Gene

Molecular function for C1QTNF12 Gene

UniProtKB/Swiss-Prot Function:
Insulin-sensitizing adipocyte-secreted protein (adipokine) that regulates glucose metabolism in liver and adipose tissue. Promotes glucose uptake in adipocytes and suppresses de novo glucose production in hepatocytes via the PI3K-Akt signaling pathway. Administration lead to reduction of blood glucose. Able to attenuate inflammation in fat tissue.
UniProtKB/Swiss-Prot Induction:
By insulin in subcutaneous adipose tissue.

Phenotypes From GWAS Catalog for C1QTNF12 Gene

Gene Ontology (GO) - Molecular Function for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity ISS --
GO:0005515 protein binding IEA --
genes like me logo Genes that share ontologies with C1QTNF12: view
genes like me logo Genes that share phenotypes with C1QTNF12: view

Animal Model Products

Clone Products

  • R&D Systems cDNA Clones for C1QTNF12 (Adipolin/FAM132A)

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QTNF12 Gene

Localization for C1QTNF12 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QTNF12 Gene

Adipolin fC1QTNF12: Secreted.
Adipolin gC1QTNF12: Secreted. Note=In sera is the predominant form. {ECO:0000269 PubMed:22275362}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QTNF12 gene
Compartment Confidence
extracellular 5
plasma membrane 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region ISS --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QTNF12: view

Pathways & Interactions for C1QTNF12 Gene

SuperPathways for C1QTNF12 Gene

No Data Available

Interacting Proteins for C1QTNF12 Gene

Gene Ontology (GO) - Biological Process for C1QTNF12 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010469 regulation of signaling receptor activity IEA --
GO:0010906 regulation of glucose metabolic process IEA --
GO:0035774 positive regulation of insulin secretion involved in cellular response to glucose stimulus IEA --
GO:0045721 negative regulation of gluconeogenesis IEA --
GO:0046324 regulation of glucose import IEA,ISS --
genes like me logo Genes that share ontologies with C1QTNF12: view

No data available for Pathways by source and SIGNOR curated interactions for C1QTNF12 Gene

Drugs & Compounds for C1QTNF12 Gene

No Compound Related Data Available

Transcripts for C1QTNF12 Gene

mRNA/cDNA for C1QTNF12 Gene

(5) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

  • R&D Systems cDNA Clones for C1QTNF12 (Adipolin/FAM132A)

Alternative Splicing Database (ASD) splice patterns (SP) for C1QTNF12 Gene

No ASD Table

Relevant External Links for C1QTNF12 Gene

GeneLoc Exon Structure for
C1QTNF12
ECgene alternative splicing isoforms for
C1QTNF12

Expression for C1QTNF12 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of C1QTNF12 Gene:

C1QTNF12

mRNA Expression by UniProt/SwissProt for C1QTNF12 Gene:

Q5T7M4-ADIPL_HUMAN
Tissue specificity: Predominantly expressed by adipose tissues.
genes like me logo Genes that share expression patterns with C1QTNF12: view

No data available for mRNA expression in normal human tissues , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QTNF12 Gene

Orthologs for C1QTNF12 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C1QTNF12 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia FAM132A 34 33
  • 79.07 (n)
OneToOne
cow
(Bos Taurus)
Mammalia FAM132A 34 33
  • 76.11 (n)
OneToOne
rat
(Rattus norvegicus)
Mammalia Fam132a 33
  • 75 (n)
mouse
(Mus musculus)
Mammalia Fam132a 34 33
  • 74.55 (n)
OneToOne
C1qtnf12 16
platypus
(Ornithorhynchus anatinus)
Mammalia FAM132A 34
  • 66 (a)
OneToOne
chicken
(Gallus gallus)
Aves FAM132A 34 33
  • 62.21 (n)
OneToOne
lizard
(Anolis carolinensis)
Reptilia FAM132A 34
  • 55 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia fam132a 33
  • 58.19 (n)
Str.12517 33
zebrafish
(Danio rerio)
Actinopterygii fam132a 34 33
  • 58.7 (n)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.12580 33
Species where no ortholog for C1QTNF12 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QTNF12 Gene

ENSEMBL:
Gene Tree for C1QTNF12 (if available)
TreeFam:
Gene Tree for C1QTNF12 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QTNF12: view image

Paralogs for C1QTNF12 Gene

Paralogs for C1QTNF12 Gene

genes like me logo Genes that share paralogs with C1QTNF12: view

Variants for C1QTNF12 Gene

Sequence variations from dbSNP and Humsavar for C1QTNF12 Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000190648 -- 1,242,027(-) G/A downstream_transcript_variant
rs1000299631 -- 1,246,338(-) C/T intron_variant
rs1000399684 -- 1,246,105(-) A/C intron_variant
rs1000645879 -- 1,241,945(-) C/T
rs1000680997 -- 1,244,586(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QTNF12 Gene

Variant ID Type Subtype PubMed ID
dgv10n106 CNV deletion 24896259
dgv2n67 CNV gain 20364138
esv3584991 CNV gain 21293372
nsv1003578 CNV gain 25217958
nsv10161 CNV gain+loss 18304495
nsv1074016 CNV deletion 25765185
nsv1160772 CNV duplication 26073780
nsv455661 CNV loss 19166990
nsv469848 CNV gain 16826518
nsv470680 CNV loss 18288195
nsv482937 CNV loss 15286789
nsv517709 CNV gain+loss 19592680
nsv544947 CNV loss 21841781
nsv544964 CNV loss 21841781
nsv544965 CNV loss 21841781
nsv950452 CNV deletion 24416366

Variation tolerance for C1QTNF12 Gene

Gene Damage Index Score: 8.31; 85.26% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QTNF12 Gene

Human Gene Mutation Database (HGMD)
C1QTNF12
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QTNF12

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QTNF12 Gene

Disorders for C1QTNF12 Gene

Additional Disease Information for C1QTNF12

No disorders were found for C1QTNF12 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QTNF12 Gene

Publications for C1QTNF12 Gene

  1. Insulin regulates the novel adipokine adipolin/CTRP12: in vivo and ex vivo effects. (PMID: 24492466) Tan BK … Randeva HS (The Journal of endocrinology 2014) 3 4 58
  2. Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism. (PMID: 21849507) Enomoto T … Ouchi N (The Journal of biological chemistry 2011) 2 3 58
  3. Circulating C1q complement/TNF-related protein (CTRP) 1, CTRP9, CTRP12 and CTRP13 concentrations in Type 2 diabetes mellitus: In vivo regulation by glucose. (PMID: 28207876) Bai B … Chen J (PloS one 2017) 3 58
  4. The Effect of Coenzyme Q10 Supplementation on Circulating Levels of Novel Adipokine Adipolin/CTRP12 in Overweight and Obese Patients with Type 2 Diabetes. (PMID: 27657997) Mehrdadi P … Hosseinzadeh-Attar MJ (Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 2017) 3 58
  5. Circulatory changes of the novel adipokine adipolin/CTRP12 in response to metformin treatment and an oral glucose challenge in humans. (PMID: 24612181) Tan BK … Randeva HS (Clinical endocrinology 2014) 3 58

Products for C1QTNF12 Gene

Sources for C1QTNF12 Gene

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