Aliases for C1QL4 Gene
Aliases for C1QL4 Gene
External Ids for C1QL4 Gene
- HGNC: 31416
- Entrez Gene: 338761
- Ensembl: ENSG00000186897
- OMIM: 615229
- UniProtKB: Q86Z23
Previous GeneCards Identifiers for C1QL4 Gene
- GC12M048013
- GC12M049726
- GC12M046756
Summaries for C1QL4 Gene
GeneCards Summary for C1QL4 Gene
C1QL4 (Complement C1q Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL1.
UniProtKB/Swiss-Prot for C1QL4 Gene
-
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL4 Gene
Genomics for C1QL4 Gene
GeneHancer (GH) Regulatory Elements for C1QL4 Gene
Promoters and enhancers for C1QL4 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around C1QL4 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the C1QL4 gene promoter:
-
- STAT1beta
- PPAR-gamma2
- S8
- GR
- GR-alpha
- GR-beta
- STAT1
- STAT1alpha
- STAT2
- STAT3
Regulatory Element Products
Genomic Locations for C1QL4 Gene
Genomic Locations for C1QL4 Gene
- chr12:49,332,411-49,337,188
- (GRCh38/hg38)
- Size:
- 4,778 bases
- Orientation:
- Minus strand
- chr12:49,726,200-49,730,971
- (GRCh37/hg19)
- Size:
- 4,772 bases
- Orientation:
- Minus strand
Genomic View for C1QL4 Gene
Genes around C1QL4 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 12q13.12 by Entrez Gene
- 12q13.12 by HGNC
- 12q13.12 by Ensembl
C1QL4 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C1QL4 Gene
Proteins for C1QL4 Gene
-
Protein details for C1QL4 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q86Z23-C1QL4_HUMAN
- Recommended name:
- Complement C1q-like protein 4
- Protein Accession:
- Q86Z23
Protein attributes for C1QL4 Gene
- Size:
- 238 amino acids
- Molecular mass:
- 24909 Da
- Quaternary structure:
-
- Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with ADGRB3.
Protein Expression for C1QL4 Gene
Post-translational modifications for C1QL4 Gene
Other Protein References for C1QL4 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C1QL4
- Invitrogen Antibodies for C1QL4 (AFLGC-C1QL4)
- Search GeneTex for Antibodies for C1QL4
Protein Products
- R&D Systems Proteins and Enzymes for C1QL4 (C1qL4)
-
OriGene Purified Proteins for C1QL4
- Search Origene for MassSpec and Protein Over-expression Lysates for C1QL4
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- Novus Biologicals lysates for C1QL4
- antibodies-online: Search results for 2 available C1QL4 Proteins ranked by validation data
- Compare Top C1QL4 Proteins
-
Quality Products:
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Assay Products
- antibodies-online: Search results for 2 available C1QL4 Elisa Kits ranked by validation data
- Compare Top C1QL4 Elisa Kits
-
Quality Products:
No data available for DME Specific Peptides for C1QL4 Gene
Domains & Families for C1QL4 Gene
Gene Families for C1QL4 Gene
- HGNC:
- Human Protein Atlas (HPA):
-
- Predicted secreted proteins
Protein Domains for C1QL4 Gene
- Blocks:
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for C1QL4 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for C1QL4 Gene
Function for C1QL4 Gene
Molecular function for C1QL4 Gene
- UniProtKB/Swiss-Prot Function:
- May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).
Phenotypes From GWAS Catalog for C1QL4 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0042802 | identical protein binding | IEA | -- |
Phenotypes for C1QL4 Gene
Animal Model Products
-
Taconic Biosciences Mouse Models for C1QL4
- Cyagen custom Knockout/knockin (KOKI) mouse models for C1QL4
-
CRISPR Products
-
OriGene CRISPR knockouts for C1QL4
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- Applied Biological Materials CRISPR for C1QL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1QL4
- GenScript: Design CRISPR guide RNA sequences for C1QL4
miRNA Products
Inhibitory RNA Products
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Clone Products
- Sino Biological Human cDNA Clone for C1QL4
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- genomics-online: cdna clones - Search results for available C1QL4 gene related products
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- Applied Biological Materials Clones for C1QL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for C1QL4 (C1qL4)
Cell Line Products
-
Horizon Cell Lines for C1QL4
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL4 Gene
Localization for C1QL4 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C1QL4 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 4 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
| GO:0005581 | collagen trimer | IEA | -- |
| GO:0005615 | extracellular space | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL4 Gene
Pathways & Interactions for C1QL4 Gene
No Data Available
Interacting Proteins for C1QL4 Gene
GPS-Prot Interaction Network for C1QL4
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0045599 | negative regulation of fat cell differentiation | IEA | -- |
| GO:0048147 | negative regulation of fibroblast proliferation | IEA | -- |
| GO:0070373 | negative regulation of ERK1 and ERK2 cascade | IEA | -- |
No data available for Pathways by source and SIGNOR curated interactions for C1QL4 Gene
Transcripts for C1QL4 Gene
mRNA/cDNA for C1QL4 Gene
- (2) REFSEQ mRNAs :
- (2) Additional mRNA sequences :
- (12) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000334221 2071 bps (uc001rtz.2)
Unigene Clusters for C1QL4 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C1QL4
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- Applied Biological Materials CRISPR for C1QL4
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C1QL4
- GenScript: Design CRISPR guide RNA sequences for C1QL4
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C1QL4
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Clone Products
- Sino Biological Human cDNA Clone for C1QL4
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- genomics-online: cdna clones - Search results for available C1QL4 gene related products
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- Applied Biological Materials Clones for C1QL4
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
- R&D Systems cDNA Clones for C1QL4 (C1qL4)
Expression for C1QL4 Gene
mRNA differential expression in normal tissues according to GTEx for C1QL4 Gene
This gene is overexpressed in Testis (x16.8), Brain - Hypothalamus (x6.1), and Vagina (x5.0).
This gene is overexpressed in Platelet (69.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL4 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C1QL4 Gene:
C1QL4SOURCE GeneReport for Unigene cluster for C1QL4 Gene:
Hs.380386mRNA Expression by UniProt/SwissProt for C1QL4 Gene:
Q86Z23-C1QL4_HUMAN
Tissue specificity:
Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.
Primer Products
-
OriGene qPCR primer pairs for C1QL4
- genomics-online: primer clones - Search results for available C1QL4 gene related products
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL4 Gene
Orthologs for C1QL4 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C1QL4 34 33 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | C1QL4 34 |
|
OneToOne | |
| dog (Canis familiaris) |
Mammalia | C1QL4 34 33 |
|
OneToOne | |
| mouse (Mus musculus) |
Mammalia | C1ql4 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | C1ql4 33 |
|
||
| cow (Bos Taurus) |
Mammalia | C1QL4 34 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | C1QL4 34 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | c1ql4 33 |
|
||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.12905 33 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | C1QL4 (1 of 2) 34 |
|
OneToMany | |
| C1QL4 (2 of 2) 34 |
|
OneToMany | |||
| LOC567540 33 |
|
||||
| fruit fly (Drosophila melanogaster) |
Insecta | Capr 34 |
|
OneToMany |
- Species where no ortholog for C1QL4 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Evolution for C1QL4 Gene
- ENSEMBL:
- Gene Tree for C1QL4 (if available)
- TreeFam:
- Gene Tree for C1QL4 (if available)
- Aminode:
- Evolutionary constrained regions (ECRs) for C1QL4: view image
Paralogs for C1QL4 Gene
Variants for C1QL4 Gene
| SNP ID | Clin | Chr 12 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1001323712 | -- | 49,336,550(-) | T/C | 5_prime_UTR_variant | |
| rs1001857741 | -- | 49,332,265(-) | C/T | downstream_transcript_variant | |
| rs1001862892 | -- | 49,332,237(-) | G/A | downstream_transcript_variant | |
| rs1001928640 | -- | 49,337,794(-) | A/G | upstream_transcript_variant | |
| rs1002096807 | -- | 49,332,476(-) | G/A | 3_prime_UTR_variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1497n100 | CNV | gain | 25217958 |
| nsv1134226 | CNV | deletion | 24896259 |
| nsv826368 | CNV | gain | 20364138 |
| nsv832405 | CNV | gain | 17160897 |
| nsv952175 | CNV | deletion | 24416366 |
Residual Variation Intolerance Score:
58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.43;
28.06% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C1QL4 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C1QL4
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL4 Gene
Disorders for C1QL4 Gene
Additional Disease Information for C1QL4
No disorders were found for C1QL4 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL4 Gene
Publications for C1QL4 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
- C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. (PMID: 23449976) Wei Z … Wong GW (The Journal of biological chemistry 2013) 4 58
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58
Products for C1QL4 Gene
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- genomics-online: cdna clones - Search results for available C1QL4 gene related products
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Sources for C1QL4 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt