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Aliases for C1QL4 Gene

Aliases for C1QL4 Gene

  • Complement C1q Like 4 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 11 3 4
  • Complement Component 1, Q Subcomponent Like 4 2 3
  • C1q/TNF-Related Protein 11 3 4
  • CTRP11 3 4
  • Complement C1q-Like Protein 4 3
  • C1QTNF11 3

External Ids for C1QL4 Gene

Previous GeneCards Identifiers for C1QL4 Gene

  • GC12M048013
  • GC12M049726
  • GC12M046756

Summaries for C1QL4 Gene

GeneCards Summary for C1QL4 Gene

C1QL4 (Complement C1q Like 4) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL1.

UniProtKB/Swiss-Prot for C1QL4 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Additional gene information for C1QL4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C1QL4 Gene

Genomics for C1QL4 Gene

GeneHancer (GH) Regulatory Elements for C1QL4 Gene

Promoters and enhancers for C1QL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH12J049335 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 677.4 +0.5 530 1.9 HDGF ZNF2 ZNF48 ZNF280A GLIS2 ZNF143 KLF7 KLF13 SP3 SP5 C1QL4 GC12P049325 GC12P049321
GH12J049339 Promoter 0.8 EPDnew 650.7 -2.3 -2293 0.1 ZNF335 ZNF366 FEZF1 ZNF600 ZBTB20 ZBTB17 C1QL4 DNAJC22 GC12P049321
GH12J049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 18.4 +70.7 70659 6.6 CLOCK DMAP1 YY1 ZNF213 ZNF143 ZNF263 SP3 NFYC ZFP41 MEF2D TUBA1C ENSG00000258101 DDX23 KMT2D CCNT1 LMBR1L SMARCD1 LOC390314 KANSL2 BCDIN3D
GH12J049321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 20.1 +14.1 14128 2.4 HDGF PKNOX1 SMAD1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B LOC101927267 TROAP CCNT1 KANSL2 DDX23 KMT2D LMBR1L LOC390314 C1QL4 FAM186B
GH12J049621 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -286.5 -286514 3.6 PKNOX1 CLOCK MLX ARID4B SIN3A IRF4 YY1 POLR2B ZNF143 FOS FAM186B PRPF40B FMNL3 RNU6-834P TMBIM6 MCRS1 C1QL4 HIGD1AP9 PIR31660
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C1QL4 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C1QL4 gene promoter:

Genomic Locations for C1QL4 Gene

Genomic Locations for C1QL4 Gene
chr12:49,332,411-49,337,188
(GRCh38/hg38)
Size:
4,778 bases
Orientation:
Minus strand
chr12:49,726,200-49,730,971
(GRCh37/hg19)

Genomic View for C1QL4 Gene

Genes around C1QL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL4 Gene

Proteins for C1QL4 Gene

  • Protein details for C1QL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z23-C1QL4_HUMAN
    Recommended name:
    Complement C1q-like protein 4
    Protein Accession:
    Q86Z23

    Protein attributes for C1QL4 Gene

    Size:
    238 amino acids
    Molecular mass:
    24909 Da
    Quaternary structure:
    • Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with ADGRB3.

neXtProt entry for C1QL4 Gene

Post-translational modifications for C1QL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL4 Gene

Domains & Families for C1QL4 Gene

Gene Families for C1QL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QL4 Gene

Suggested Antigen Peptide Sequences for C1QL4 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C1QL4: view

No data available for UniProtKB/Swiss-Prot for C1QL4 Gene

Function for C1QL4 Gene

Molecular function for C1QL4 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Phenotypes From GWAS Catalog for C1QL4 Gene

Gene Ontology (GO) - Molecular Function for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL4: view
genes like me logo Genes that share phenotypes with C1QL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL4

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL4 Gene

Localization for C1QL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL4 gene
Compartment Confidence
extracellular 4

Gene Ontology (GO) - Cellular Components for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL4 Gene

Pathways & Interactions for C1QL4 Gene

SuperPathways for C1QL4 Gene

No Data Available

Interacting Proteins for C1QL4 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000335285%0d%0a9606.ENSP00000222572%0d%0a
Selected Interacting proteins: Q86Z23-C1QL4_HUMAN ENSP00000335285 for C1QL4 Gene via IID STRING

Gene Ontology (GO) - Biological Process for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation IEA --
GO:0048147 negative regulation of fibroblast proliferation IEA --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL4 Gene

Drugs & Compounds for C1QL4 Gene

No Compound Related Data Available

Transcripts for C1QL4 Gene

mRNA/cDNA for C1QL4 Gene

(12) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C1QL4 Gene

Complement component 1, q subcomponent-like 4:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL4

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL4 Gene

No ASD Table

Relevant External Links for C1QL4 Gene

GeneLoc Exon Structure for
C1QL4
ECgene alternative splicing isoforms for
C1QL4

Expression for C1QL4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C1QL4 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL4 Gene

This gene is overexpressed in Testis (x16.8), Brain - Hypothalamus (x6.1), and Vagina (x5.0).

Protein differential expression in normal tissues from HIPED for C1QL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL4 Gene



Protein tissue co-expression partners for C1QL4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C1QL4 Gene:

C1QL4

SOURCE GeneReport for Unigene cluster for C1QL4 Gene:

Hs.380386

mRNA Expression by UniProt/SwissProt for C1QL4 Gene:

Q86Z23-C1QL4_HUMAN
Tissue specificity: Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with C1QL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL4 Gene

Orthologs for C1QL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QL4 34 33
  • 99.86 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QL4 34
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL4 34 33
  • 92.3 (n)
OneToOne
mouse
(Mus musculus)
Mammalia C1ql4 16 34 33
  • 87.85 (n)
rat
(Rattus norvegicus)
Mammalia C1ql4 33
  • 86.07 (n)
cow
(Bos Taurus)
Mammalia C1QL4 34
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C1QL4 34
  • 79 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql4 33
  • 69.24 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.12905 33
zebrafish
(Danio rerio)
Actinopterygii C1QL4 (1 of 2) 34
  • 74 (a)
OneToMany
C1QL4 (2 of 2) 34
  • 74 (a)
OneToMany
LOC567540 33
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
Insecta Capr 34
  • 4 (a)
OneToMany
Species where no ortholog for C1QL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL4 Gene

ENSEMBL:
Gene Tree for C1QL4 (if available)
TreeFam:
Gene Tree for C1QL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QL4: view image

Paralogs for C1QL4 Gene

(7) SIMAP similar genes for C1QL4 Gene using alignment to 1 proteins:

  • C1QL4_HUMAN
genes like me logo Genes that share paralogs with C1QL4: view

Variants for C1QL4 Gene

Sequence variations from dbSNP and Humsavar for C1QL4 Gene

SNP ID Clin Chr 12 pos Variation AA Info Type
rs1001323712 -- 49,336,550(-) T/C 5_prime_UTR_variant
rs1001857741 -- 49,332,265(-) C/T downstream_transcript_variant
rs1001862892 -- 49,332,237(-) G/A downstream_transcript_variant
rs1001928640 -- 49,337,794(-) A/G upstream_transcript_variant
rs1002096807 -- 49,332,476(-) G/A 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for C1QL4 Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
nsv1134226 CNV deletion 24896259
nsv826368 CNV gain 20364138
nsv832405 CNV gain 17160897
nsv952175 CNV deletion 24416366

Variation tolerance for C1QL4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL4 Gene

Disorders for C1QL4 Gene

Additional Disease Information for C1QL4

No disorders were found for C1QL4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C1QL4 Gene

Publications for C1QL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  4. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. (PMID: 23449976) Wei Z … Wong GW (The Journal of biological chemistry 2013) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C1QL4 Gene

Sources for C1QL4 Gene

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