C1QL4 Gene (Protein Coding)

Complement C1q Like 4

GC12M049332
GIFtS:
33

Aliases for C1QL4 Gene

Aliases for C1QL4 Gene

  • Complement C1q Like 4 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 11 3 4
  • Complement Component 1, Q Subcomponent Like 4 2 3
  • Complement C1q-Like Protein 4 3 4
  • C1q/TNF-Related Protein 11 3 4
  • CTRP11 3 4
  • C1QTNF11 3

External Ids for C1QL4 Gene

Previous GeneCards Identifiers for C1QL4 Gene

  • GC12M048013
  • GC12M049726
  • GC12M046756

Summaries for C1QL4 Gene

GeneCards Summary for C1QL4 Gene

C1QL4 (Complement C1q Like 4) is a Protein Coding gene. Diseases associated with C1QL4 include Carey-Fineman-Ziter Syndrome. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL1.

UniProtKB/Swiss-Prot Summary for C1QL4 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Additional gene information for C1QL4 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QL4 Gene

Genomics for C1QL4 Gene

GeneHancer (GH) Regulatory Elements for C1QL4 Gene

Promoters and enhancers for C1QL4 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH12J049335 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 527.3 +0.2 187 1.6 HNRNPK EP300 CTCF PHB2 ZNF639 ZNF10 ZIC2 AFF1 GABPA ZBTB26 C1QL4 CCNT1 LOC390314 DDX23 KANSL2 LIMA1 KMT2D LMBR1L SMARCD1 LOC101927267
GH12J049339 Promoter/Enhancer 0.9 EPDnew Ensembl 500.7 -2.5 -2512 0.6 NFIC ZBTB17 ZNF335 MAX FEZF1 ZNF398 RNF2 ZNF366 SUZ12 ZBTB20 C1QL4 TUBA1A DNAJC22
GH12J049263 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 18.4 +70.7 70682 6.6 HNRNPK FOXK2 ZBTB40 ZNF217 TCF12 MYC NRF1 POLR2G USF1 SP1 TUBA1C ENSG00000258101 LMBR1L DDX23 CCNT1 KANSL2 KMT2D LOC390314 SMARCD1 BCDIN3D
GH12J049321 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 20.2 +13.9 13888 3 ZNF217 TCF12 SIN3A NRF1 POLR2G SP1 PHB2 ZNF639 POLR2A CLOCK LOC101927267 TROAP KANSL2 CCNT1 DDX23 C1QL4 KMT2D LOC390314 ENSG00000257964 LIMA1
GH12J049621 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 9.8 -286.4 -286370 3.9 HNRNPK EP300 CTCF TCF12 NRF1 POLR2G SP1 PHF8 ZFX ZNF639 FAM186B PRPF40B FMNL3 RNU6-834P TMBIM6 MCRS1 C1QL4 lnc-KCNH3-4 lnc-FAM186B-4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QL4 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QL4

Top Transcription factor binding sites by QIAGEN in the C1QL4 gene promoter:
  • GR
  • GR-alpha
  • GR-beta
  • PPAR-gamma2
  • S8
  • STAT1
  • STAT1alpha
  • STAT1beta
  • STAT2
  • STAT3

Genomic Locations for C1QL4 Gene

Genomic Locations for C1QL4 Gene
chr12:49,332,409-49,337,188
(GRCh38/hg38)
Size:
4,780 bases
Orientation:
Minus strand
chr12:49,726,200-49,730,971
(GRCh37/hg19)
Size:
4,772 bases
Orientation:
Minus strand

Genomic View for C1QL4 Gene

Genes around C1QL4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL4 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C1QL4 Gene

Proteins for C1QL4 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C1QL4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86Z23-C1QL4_HUMAN
    Recommended name:
    Complement C1q-like protein 4
    Protein Accession:
    Q86Z23

    Protein attributes for C1QL4 Gene

    Size:
    238 amino acids
    Molecular mass:
    24909 Da
    Quaternary structure:
    • Forms homooligomers, predominantly dimers or trimers. Forms heterooligomers with C1QL1, C1QL2 and C1QL3, when proteins are coexpressed; this interaction does not occur after secretion. Interacts with ADGRB3.

neXtProt entry for C1QL4 Gene

Protein Expression for C1QL4 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C1QL4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL4 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL4 Gene

Domains & Families for C1QL4 Gene

Gene Families for C1QL4 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QL4 Gene

Blocks:
  • Complement C1q protein
  • Collagen triple helix repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1QL4 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q-like protein 4 (C1QL4_HUMAN)
genes like me logo Genes that share domains with C1QL4: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QL4 Gene

Function for C1QL4 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for C1QL4 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). May inhibit adipocyte differentiation at an early stage of the process (By similarity).

Phenotypes From GWAS Catalog for C1QL4 Gene

Gene Ontology (GO) - Molecular Function for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL4: view
genes like me logo Genes that share phenotypes with C1QL4: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL4

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL4 Gene

Localization for C1QL4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL4 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL4 gene
Compartment Confidence
extracellular 4
plasma membrane 1
nucleus 1

Gene Ontology (GO) - Cellular Components for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0005615 extracellular space IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL4 Gene

Pathways & Interactions for C1QL4 Gene

PathCards logo

SuperPathways for C1QL4 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C1QL4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045599 negative regulation of fat cell differentiation IEA --
GO:0048147 negative regulation of fibroblast proliferation IEA --
GO:0070373 negative regulation of ERK1 and ERK2 cascade IEA --
genes like me logo Genes that share ontologies with C1QL4: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL4 Gene

Drugs & Compounds for C1QL4 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C1QL4 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for C1QL4 Gene

1 REFSEQ mRNAs :
2 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL4

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL4 Gene

No ASD Table

Relevant External Links for C1QL4 Gene

GeneLoc Exon Structure for
C1QL4

Expression for C1QL4 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QL4 Gene

mRNA expression in normal human tissues for C1QL4 Gene
mRNA expression by GTEx for C1QL4 GenemRNA expression by BioGPS for C1QL4 Gene

mRNA differential expression in normal tissues according to GTEx for C1QL4 Gene

This gene is overexpressed in Testis (x16.8), Brain - Hypothalamus (x6.1), and Vagina (x5.0).

Protein differential expression in normal tissues from HIPED for C1QL4 Gene

This gene is overexpressed in Platelet (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL4 Gene



Protein tissue co-expression partners for C1QL4 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QL4

SOURCE GeneReport for Unigene cluster for C1QL4 Gene:

Hs.380386

mRNA Expression by UniProt/SwissProt for C1QL4 Gene:

Q86Z23-C1QL4_HUMAN
Tissue specificity: Highest expression levels in testis and adipose tissue, lower levels in skeletal muscle and kidney.
genes like me logo Genes that share expression patterns with C1QL4: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL4 Gene

Orthologs for C1QL4 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C1QL4 31 30
  • 99.86 (n)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia C1QL4 31
  • 97 (a)
 OneToOne
dog
(Canis familiaris)
 Mammalia C1QL4 31 30
  • 92.3 (n)
 OneToOne
mouse
(Mus musculus)
 Mammalia C1ql4 17 31 30
  • 87.85 (n)
rat
(Rattus norvegicus)
 Mammalia C1ql4 30
  • 86.07 (n)
cow
(Bos Taurus)
 Mammalia C1QL4 31
  • 83 (a)
 OneToOne
lizard
(Anolis carolinensis)
 Reptilia C1QL4 31
  • 79 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia c1ql4 30
  • 69.24 (n)
African clawed frog
(Xenopus laevis)
 Amphibia Xl.12905 30
zebrafish
(Danio rerio)
 Actinopterygii C1QL4 (1 of 2) 31
  • 74 (a)
 OneToMany
C1QL4 (2 of 2) 31
  • 74 (a)
 OneToMany
LOC567540 30
  • 67.3 (n)
fruit fly
(Drosophila melanogaster)
 Insecta Capr 31
  • 4 (a)
 OneToMany
Species where no ortholog for C1QL4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL4 Gene

ENSEMBL:
Gene Tree for C1QL4 (if available)
TreeFam:
Gene Tree for C1QL4 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QL4: view image

Paralogs for C1QL4 Gene

Paralogs for C1QL4 Gene

(7) SIMAP similar genes for C1QL4 Gene using alignment to 1 proteins:

  • C1QL4_HUMAN
genes like me logo Genes that share paralogs with C1QL4: view

Variants for C1QL4 Gene

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  1. SNP Genotyping and Copy Number Assay

Additional dbSNP identifiers (rs#s) for C1QL4 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QL4 Gene

Variant ID Type Subtype PubMed ID
dgv1497n100 CNV gain 25217958
nsv1134226 CNV deletion 24896259
nsv826368 CNV gain 20364138
nsv832405 CNV gain 17160897
nsv952175 CNV deletion 24416366

Variation tolerance for C1QL4 Gene

Residual Variation Intolerance Score: 58.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.43; 28.06% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QL4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL4

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QL4 Gene

Disorders for C1QL4 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1QL4 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carey-fineman-ziter syndrome
  • cfzs
- elite association - COSMIC cancer census association via MalaCards
Search C1QL4 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for C1QL4

ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C1QL4: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QL4 Gene

Publications for C1QL4 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 54
  4. C1q/tumor necrosis factor-related protein 11 (CTRP11), a novel adipose stroma-derived regulator of adipogenesis. (PMID: 23449976) Wei Z … Wong GW (The Journal of biological chemistry 2013) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

ExternalLinks

View latest publications for C1QL4 gene in Mastermind

Products for C1QL4 Gene

Sources for C1QL4 Gene