Aliases for C1QL3 Gene

Aliases for C1QL3 Gene

  • Complement C1q Like 3 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 13 3 4
  • Complement Component 1, Q Subcomponent-Like 3 2 3
  • Complement C1q-Like Protein 3 3 4
  • C1q/TNF-Related Protein 13 3 4
  • CTRP13 3 4
  • C1QTNF13 3
  • C1ql 3
  • K100 3

External Ids for C1QL3 Gene

Previous GeneCards Identifiers for C1QL3 Gene

  • GC10M016558
  • GC10M016594
  • GC10M016561

Summaries for C1QL3 Gene

GeneCards Summary for C1QL3 Gene

C1QL3 (Complement C1q Like 3) is a Protein Coding gene. Diseases associated with C1QL3 include Intermittent Explosive Disorder. An important paralog of this gene is C1QL1.

UniProtKB/Swiss-Prot Summary for C1QL3 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Additional gene information for C1QL3 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QL3 Gene

Genomics for C1QL3 Gene

GeneHancer (GH) Regulatory Elements for C1QL3 Gene

Promoters and enhancers for C1QL3 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH10J016521 Promoter 1.2 EPDnew Ensembl 519.3 +1.0 1005 2 CTCF ZNF10 ZBTB26 EZH2 ZBTB17 ZNF384 PHF8 ZNF335 HIC1 ZNF18 C1QL3 ENSG00000287925 lnc-C1QL3-1
GH10J016440 Promoter/Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.7 +81.4 81391 2.3 POLR2A ZNF76 FOS CEBPB FOSL1 BATF HDAC2 SNIP1 SMAD5 PRDM6 PTER C1QL3 RF00017-604
GH10J016509 Enhancer 0.4 Ensembl 21.9 +11.8 11805 0.4 ZNF316 MAFF FOSL2 MAFK FOS C1QL3 lnc-C1QL3-1 RF00754 PTER
GH10J016470 Enhancer 0.8 Ensembl ENCODE 11 +51.2 51204 2.4 TRIM24 PBX2 TCF12 EGR1 VEZF1 DPF2 MEIS2 GABPB1 TEAD4 ARID1B PTER C1QL3 RF00017-604 RNU2-18P RF00004-013
GH10J016386 Enhancer 0.8 Ensembl ENCODE 11.1 +134.8 134844 1.3 POLR2A HDAC2 YY1 NANOG TCF12 SMARCA4 JUND TAF1 GTF2F1 EP300 lnc-C1QL3-2 C1QL3 RSU1 RF01210-045
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QL3 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QL3

Top Transcription factor binding sites by QIAGEN in the C1QL3 gene promoter:
  • AhR
  • Bach1
  • C/EBPbeta
  • Gfi-1
  • GR
  • GR-alpha
  • Pbx1a
  • RFX1
  • S8
  • XBP-1

Genomic Locations for C1QL3 Gene

Genomic Locations for C1QL3 Gene
chr10:16,513,734-16,522,005
(GRCh38/hg38)
Size:
8,272 bases
Orientation:
Minus strand
chr10:16,555,742-16,564,004
(GRCh37/hg19)
Size:
8,263 bases
Orientation:
Minus strand

Genomic View for C1QL3 Gene

Genes around C1QL3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL3 Gene

Proteins for C1QL3 Gene

  • Protein details for C1QL3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5VWW1-C1QL3_HUMAN
    Recommended name:
    Complement C1q-like protein 3
    Protein Accession:
    Q5VWW1
    Secondary Accessions:
    • A0PJY4
    • A0PJY5

    Protein attributes for C1QL3 Gene

    Size:
    255 amino acids
    Molecular mass:
    26719 Da
    Quaternary structure:
    • Forms homooligomers. Interacts with ADGRB3. Interacts with C1QL2 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

    Alternative splice isoforms for C1QL3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C1QL3 Gene

Post-translational modifications for C1QL3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C1QL3 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL3 Gene

Domains & Families for C1QL3 Gene

Gene Families for C1QL3 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QL3 Gene

Blocks:
  • Complement C1q protein
  • Collagen triple helix repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1QL3 Gene

GenScript: Design optimal peptide antigens:
  • Complement C1q-like protein 3 (C1QL3_HUMAN)
genes like me logo Genes that share domains with C1QL3: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QL3 Gene

Function for C1QL3 Gene

Molecular function for C1QL3 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity). Plays a role in glucose homeostasis. Via AMPK signaling pathway, stimulates glucose uptake in adipocytes, myotubes and hepatocytes and enhances insulin-stimulated glucose uptake. In a hepatoma cell line, reduces the expression of gluconeogenic enzymes G6PC and PCK1 and hence decreases de novo glucose production (By similarity).

Phenotypes From GWAS Catalog for C1QL3 Gene

Gene Ontology (GO) - Molecular Function for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL3: view
genes like me logo Genes that share phenotypes with C1QL3: view

Animal Models for C1QL3 Gene

MGI Knock Outs for C1QL3:

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL3

CRISPR Products

miRNA for C1QL3 Gene

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL3

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C1QL3 Gene

Localization for C1QL3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL3 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL3 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1
mitochondrion 1
nucleus 1
cytosol 1
lysosome 1

Gene Ontology (GO) - Cellular Components for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
genes like me logo Genes that share ontologies with C1QL3: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL3 Gene

Pathways & Interactions for C1QL3 Gene

PathCards logo

SuperPathways for C1QL3 Gene

No Data Available

Interacting Proteins for C1QL3 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 6)
STRING Interaction Network
Selected Interacting proteins: ENSP00000298943 Q5VWW1-C1QL3_HUMAN for C1QL3 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for C1QL3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0050807 regulation of synapse organization IEA --
genes like me logo Genes that share ontologies with C1QL3: view

No data available for Pathways by source and SIGNOR curated interactions for C1QL3 Gene

Drugs & Compounds for C1QL3 Gene

No Compound Related Data Available

Transcripts for C1QL3 Gene

mRNA/cDNA for C1QL3 Gene

1 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL3

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL3 Gene

No ASD Table

Relevant External Links for C1QL3 Gene

GeneLoc Exon Structure for
C1QL3

Expression for C1QL3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QL3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL3 Gene

This gene is overexpressed in Brain - Anterior cingulate cortex (BA24) (x13.9), Brain - Frontal Cortex (BA9) (x9.7), and Brain - Cortex (x5.3).

Protein differential expression in normal tissues from HIPED for C1QL3 Gene

This gene is overexpressed in Adipocyte (35.1) and Frontal cortex (33.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C1QL3 Gene



Protein tissue co-expression partners for C1QL3 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QL3

SOURCE GeneReport for Unigene cluster for C1QL3 Gene:

Hs.676792

mRNA Expression by UniProt/SwissProt for C1QL3 Gene:

Q5VWW1-C1QL3_HUMAN
Tissue specificity: Highly expressed in adipose tissue, with expression levels at least 2 orders of magnitude higher than in other tissues, including brain and kidney.

Evidence on tissue expression from TISSUES for C1QL3 Gene

  • Nervous system(4.9)
  • Lung(4.5)
  • Intestine(4.3)
  • Skin(4.3)
  • Eye(4.2)
  • Blood(3.7)
  • Liver(3.6)
  • Kidney(3.4)
  • Pancreas(3.2)
  • Heart(2.5)
  • Muscle(2.1)
genes like me logo Genes that share expression patterns with C1QL3: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL3 Gene

Orthologs for C1QL3 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL3 Gene

Organism Taxonomy Gene Similarity Type Details
platypus
(Ornithorhynchus anatinus)
Mammalia C1QL3 31
  • 100 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QL3 31
  • 100 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C1QL3 31 30
  • 99.74 (n)
OneToOne
cow
(Bos Taurus)
Mammalia C1QL3 31 30
  • 95.29 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL3 30
  • 95.29 (n)
mouse
(Mus musculus)
Mammalia C1ql3 17 31 30
  • 93.2 (n)
rat
(Rattus norvegicus)
Mammalia C1ql3 30
  • 92.55 (n)
lizard
(Anolis carolinensis)
Reptilia C1QL3 31
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1ql3 30
  • 81.74 (n)
zebrafish
(Danio rerio)
Actinopterygii c1ql3a 31 30
  • 77.68 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Capr 31
  • 5 (a)
OneToMany
Species where no ortholog for C1QL3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL3 Gene

ENSEMBL:
Gene Tree for C1QL3 (if available)
TreeFam:
Gene Tree for C1QL3 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QL3: view image

Paralogs for C1QL3 Gene

(11) SIMAP similar genes for C1QL3 Gene using alignment to 2 proteins:

  • C1QL3_HUMAN
  • L8EC65_HUMAN
genes like me logo Genes that share paralogs with C1QL3: view

Variants for C1QL3 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QL3 Gene

SNP ID Clinical significance and condition Chr 10 pos Variation AA Info Type
780849 Benign: not provided 16,520,610(-) G/A SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for C1QL3 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QL3 Gene

Variant ID Type Subtype PubMed ID
nsv1046833 CNV gain 25217958
nsv25020 CNV deletion 16902084
nsv831797 CNV loss 17160897

Variation tolerance for C1QL3 Gene

Residual Variation Intolerance Score: 31.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.01; 0.30% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QL3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL3

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL3 Gene

Disorders for C1QL3 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1QL3 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intermittent explosive disorder
  • explosive personality disorder
- elite association - COSMIC cancer census association via MalaCards
Search C1QL3 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for C1QL3

genes like me logo Genes that share disorders with C1QL3: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QL3 Gene

Publications for C1QL3 Gene

  1. Metabolic regulation by C1q/TNF-related protein-13 (CTRP13): activation OF AMP-activated protein kinase and suppression of fatty acid-induced JNK signaling. (PMID: 21378161) Wei Z … Wong GW (The Journal of biological chemistry 2011) 2 3 4 54
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P … Rogers J (Nature 2004) 3 4 54
  3. CTRP13 inhibits atherosclerosis via autophagy-lysosome-dependent degradation of CD36. (PMID: 30222079) Wang C … Huang K (FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019) 3 54
  4. Complement 1q-like-3 protein inhibits insulin secretion from pancreatic β-cells via the cell adhesion G protein-coupled receptor BAI3. (PMID: 30228187) Gupta R … Bhatnagar S (The Journal of biological chemistry 2018) 3 54
  5. Lower circulating levels of CTRP12 and CTRP13 in polycystic ovarian syndrome: Irrespective of obesity. (PMID: 30540803) Shanaki M … Vatannejad A (PloS one 2018) 3 54

Products for C1QL3 Gene

Sources for C1QL3 Gene