Aliases for C1QL2 Gene

Aliases for C1QL2 Gene

  • Complement C1q Like 2 2 3 5
  • C1q And Tumor Necrosis Factor-Related Protein 10 3 4
  • Complement Component 1, Q Subcomponent-Like 2 2 3
  • Complement C1q-Like Protein 2 3 4
  • C1q/TNF-Related Protein 10 3 4
  • CTRP10 3 4
  • C1q And Tumor Necrosis Factor Related Protein 10 2
  • C1q-Domain Containing Protein 3
  • C1QTNF10 3

External Ids for C1QL2 Gene

Previous GeneCards Identifiers for C1QL2 Gene

  • GC02M120009
  • GC02M119630
  • GC02M119914
  • GC02M112238

Summaries for C1QL2 Gene

GeneCards Summary for C1QL2 Gene

C1QL2 (Complement C1q Like 2) is a Protein Coding gene. Diseases associated with C1QL2 include Carey-Fineman-Ziter Syndrome. Gene Ontology (GO) annotations related to this gene include identical protein binding. An important paralog of this gene is C1QL3.

UniProtKB/Swiss-Prot Summary for C1QL2 Gene

  • May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Additional gene information for C1QL2 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C1QL2 Gene

Genomics for C1QL2 Gene

GeneHancer (GH) Regulatory Elements for C1QL2 Gene

Promoters and enhancers for C1QL2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02J119158 Promoter 0.9 EPDnew 500.7 +0.1 85 0.1 ZIC2 ZBTB26 ZNF341 EZH2 CTCF KLF9 SMC3 ZBTB17 ZFHX2 ZNF335 C1QL2 piR-48222-188
GH02J119159 Promoter 0.8 Ensembl 508.2 +0.4 394 0.2 ZIC2 ZBTB26 ZNF341 EZH2 ZBTB17 ZNF335 SIN3A RNF2 CHD1 MAZ C1QL2 piR-48222-188
GH02J119157 Enhancer 0.4 Ensembl 509.2 +1.4 1394 0.2 EZH2 RNF2 SUZ12 C1QL2 piR-48222-188
GH02J119156 Enhancer 0.3 ENCODE 500.7 +2.0 1995 0.2 EZH2 SUZ12 C1QL2 piR-48222-188
GH02J119485 Enhancer 1.8 VISTA Ensembl ENCODE CraniofacialAtlas dbSUPER 4.6 -328.6 -328605 11.8 EP300 FOXK2 ZNF217 NCOR1 JUND KDM6A ZNF623 TGIF2 SMARCC2 SKI ENSG00000231013 SCTR CFAP221 C1QL2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C1QL2 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C1QL2

Top Transcription factor binding sites by QIAGEN in the C1QL2 gene promoter:
  • c-Myb
  • Evi-1
  • NRSF form 1
  • NRSF form 2
  • POU2F1
  • SREBP-1a
  • SREBP-1b
  • SREBP-1c

Genomic Locations for C1QL2 Gene

Genomic Locations for C1QL2 Gene
chr2:119,156,243-119,158,895
(GRCh38/hg38)
Size:
2,653 bases
Orientation:
Minus strand
chr2:119,913,819-119,916,471
(GRCh37/hg19)
Size:
2,653 bases
Orientation:
Minus strand

Genomic View for C1QL2 Gene

Genes around C1QL2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C1QL2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C1QL2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C1QL2 Gene

Proteins for C1QL2 Gene

  • Protein details for C1QL2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z5L3-C1QL2_HUMAN
    Recommended name:
    Complement C1q-like protein 2
    Protein Accession:
    Q7Z5L3

    Protein attributes for C1QL2 Gene

    Size:
    287 amino acids
    Molecular mass:
    29468 Da
    Quaternary structure:
    • Forms homotrimers which can further assemble to form higher-order oligomeric complexes. Interacts with ADGRB3. May interact with ERFE. Forms heterooligomers with C1QL3 and C1QL4, when proteins are coexpressed; this interaction does not occur after secretion.

neXtProt entry for C1QL2 Gene

Post-translational modifications for C1QL2 Gene

No Post-translational modifications

Other Protein References for C1QL2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C1QL2 Gene

Domains & Families for C1QL2 Gene

Gene Families for C1QL2 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C1QL2 Gene

Blocks:
  • Complement C1q protein
  • Collagen triple helix repeat
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C1QL2 Gene

GenScript: Design optimal peptide antigens:
  • C1QL2 protein (A4VCH9_HUMAN)
  • Complement C1q-like protein 2 (C1QL2_HUMAN)
genes like me logo Genes that share domains with C1QL2: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C1QL2 Gene

Function for C1QL2 Gene

Molecular function for C1QL2 Gene

UniProtKB/Swiss-Prot Function:
May regulate the number of excitatory synapses that are formed on hippocampus neurons. Has no effect on inhibitory synapses (By similarity).

Phenotypes From GWAS Catalog for C1QL2 Gene

Gene Ontology (GO) - Molecular Function for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042802 identical protein binding IEA --
genes like me logo Genes that share ontologies with C1QL2: view
genes like me logo Genes that share phenotypes with C1QL2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for C1QL2

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL2

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C1QL2 Gene

Localization for C1QL2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C1QL2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C1QL2 gene
Compartment Confidence
extracellular 4
plasma membrane 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for C1QL2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005581 collagen trimer IEA --
GO:0032991 protein-containing complex IEA --
genes like me logo Genes that share ontologies with C1QL2: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C1QL2 Gene

Pathways & Interactions for C1QL2 Gene

PathCards logo

SuperPathways for C1QL2 Gene

No Data Available

Interacting Proteins for C1QL2 Gene

;

Gene Ontology (GO) - Biological Process for C1QL2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C1QL2 Gene

Drugs & Compounds for C1QL2 Gene

No Compound Related Data Available

Transcripts for C1QL2 Gene

mRNA/cDNA for C1QL2 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C1QL2

Alternative Splicing Database (ASD) splice patterns (SP) for C1QL2 Gene

No ASD Table

Relevant External Links for C1QL2 Gene

GeneLoc Exon Structure for
C1QL2

Expression for C1QL2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C1QL2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C1QL2 Gene

This gene is overexpressed in Brain - Hippocampus (x8.2), Brain - Amygdala (x6.9), Brain - Cortex (x5.8), Brain - Frontal Cortex (BA9) (x5.8), Brain - Anterior cingulate cortex (BA24) (x5.4), and Brain - Hypothalamus (x5.2).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C1QL2

SOURCE GeneReport for Unigene cluster for C1QL2 Gene:

Hs.433493
genes like me logo Genes that share expression patterns with C1QL2: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C1QL2 Gene

Orthologs for C1QL2 Gene

This gene was present in the common ancestor of animals.

Orthologs for C1QL2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C1QL2 31 30
  • 99.39 (n)
OneToOne
dog
(Canis familiaris)
Mammalia C1QL2 31 30
  • 90.82 (n)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C1QL2 31
  • 89 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C1QL2 31 30
  • 88.85 (n)
OneToOne
mouse
(Mus musculus)
Mammalia C1ql2 17 31 30
  • 86.53 (n)
rat
(Rattus norvegicus)
Mammalia C1ql2 30
  • 85.6 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 31
  • 1 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia C1QL2 31
  • 96 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii c1ql2 31 30
  • 73.79 (n)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Capr 31
  • 5 (a)
OneToMany
Species where no ortholog for C1QL2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C1QL2 Gene

ENSEMBL:
Gene Tree for C1QL2 (if available)
TreeFam:
Gene Tree for C1QL2 (if available)
Aminode:
Evolutionary constrained regions (ECRs) for C1QL2: view image

Paralogs for C1QL2 Gene

(7) SIMAP similar genes for C1QL2 Gene using alignment to 2 proteins:

  • C1QL2_HUMAN
  • A4VCH9_HUMAN
genes like me logo Genes that share paralogs with C1QL2: view

Variants for C1QL2 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C1QL2 Gene

SNP ID Clinical significance and condition Chr 02 pos Variation AA Info Type
778000 Benign: not provided 119,158,174(-) G/T SYNONYMOUS_VARIANT

Additional dbSNP identifiers (rs#s) for C1QL2 Gene

Structural Variations from Database of Genomic Variants (DGV) for C1QL2 Gene

Variant ID Type Subtype PubMed ID
nsv459119 CNV gain 19166990
nsv582783 CNV gain 21841781
nsv582784 CNV gain 21841781
nsv829637 CNV gain 20364138
nsv954802 CNV deletion 24416366

Variation tolerance for C1QL2 Gene

Residual Variation Intolerance Score: 48.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.82; 17.17% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C1QL2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C1QL2

SNP Genotyping and Copy Number Assay Products

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C1QL2 Gene

Disorders for C1QL2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C1QL2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
carey-fineman-ziter syndrome
  • cfzs
- elite association - COSMIC cancer census association via MalaCards
Search C1QL2 in MalaCards View complete list of genes associated with diseases

Additional Disease Information for C1QL2

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
genes like me logo Genes that share disorders with C1QL2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C1QL2 Gene

Publications for C1QL2 Gene

  1. Molecular, biochemical and functional characterizations of C1q/TNF family members: adipose-tissue-selective expression patterns, regulation by PPAR-gamma agonist, cysteine-mediated oligomerizations, combinatorial associations and metabolic functions. (PMID: 18783346) Wong GW … Lodish HF (The Biochemical journal 2008) 2 3 54
  2. Genetic loci associated with circulating levels of very long-chain saturated fatty acids. (PMID: 25378659) Lemaitre RN … Friedlander Y (Journal of lipid research 2015) 3 54
  3. New genetic associations detected in a host response study to hepatitis B vaccine. (PMID: 20237496) Davila S … Seielstad M (Genes and immunity 2010) 3 54
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 4 54
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C1QL2 Gene

Sources for C1QL2 Gene