Free for academic non-profit institutions. Other users need a Commercial license

Aliases for C19orf81 Gene

Aliases for C19orf81 Gene

  • Chromosome 19 Open Reading Frame 81 2 3 5

External Ids for C19orf81 Gene

Previous GeneCards Identifiers for C19orf81 Gene

  • GC19P051153

Summaries for C19orf81 Gene

GeneCards Summary for C19orf81 Gene

C19orf81 (Chromosome 19 Open Reading Frame 81) is a Protein Coding gene.

Additional gene information for C19orf81 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf81 Gene

Genomics for C19orf81 Gene

GeneHancer (GH) Regulatory Elements for C19orf81 Gene

Promoters and enhancers for C19orf81 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I050650 Promoter 0.7 EPDnew 550.4 +16.6 16562 0.1 ATF1 PRDM10 NR2C2 C19orf81 GC19M050639 SYT3
GH19I050383 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 18.8 -248.1 -248143 3.2 HDGF PKNOX1 CLOCK SMAD1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 POLD1 C19orf81 PTOV1-AS2 NUP62 PNKP SNORD35A SNORD35B IRF3 ALDH16A1 SIGLEC17P
GH19I050657 Promoter/Enhancer 1.6 Ensembl ENCODE 16.1 +26.2 26194 2.9 HDGF PKNOX1 SMAD1 ARNT SIN3A YBX1 ZNF2 ZBTB7B POLR2B FOS SYT3 POLD1 NUP62 PTOV1-AS2 IRF3 ZNF175 PNKP ENSG00000268047 ZNF473 CTU1
GH19I051121 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 5.1 +493.4 493368 10.3 PKNOX1 ATF1 FOXA2 TCF12 FOS ATF7 RXRA MBD2 MEF2D ATF4 SIGLEC9 ZNF613 ZNF841 ZNF577 POLD1 SIGLEC18P KLK11 CTU1 C19orf81 SIGLEC10
GH19I051131 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +499.5 499540 1.4 HDAC1 ATF1 RAD21 ZBTB40 YY1 TCF12 ZNF766 ATF7 RXRA ZBTB11 SIGLEC9 CTU1 SIGLEC10 C19orf81 SIGLEC17P SIGLEC7 CD33 SIGLEC12 ENSG00000267990
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C19orf81 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C19orf81 Gene

Genomic Locations for C19orf81 Gene
chr19:50,632,767-50,659,310
(GRCh38/hg38)
Size:
26,544 bases
Orientation:
Plus strand
chr19:51,152,702-51,162,567
(GRCh37/hg19)

Genomic View for C19orf81 Gene

Genes around C19orf81 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf81 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf81 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf81 Gene

Proteins for C19orf81 Gene

  • Protein details for C19orf81 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    C9J6K1-CS081_HUMAN
    Recommended name:
    Putative uncharacterized protein C19orf81
    Protein Accession:
    C9J6K1

    Protein attributes for C19orf81 Gene

    Size:
    198 amino acids
    Molecular mass:
    22444 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf81 Gene

Post-translational modifications for C19orf81 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf81 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf81 Gene

Domains & Families for C19orf81 Gene

Gene Families for C19orf81 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf81 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf81: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf81 Gene

Function for C19orf81 Gene

Phenotypes From GWAS Catalog for C19orf81 Gene

Phenotypes for C19orf81 Gene

MGI mutant phenotypes for C19orf81:
inferred from 1 alleles
GenomeRNAi human phenotypes for C19orf81:
genes like me logo Genes that share phenotypes with C19orf81: view

Animal Models for C19orf81 Gene

MGI Knock Outs for C19orf81:

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf81 Gene

Localization for C19orf81 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf81 gene
Compartment Confidence
extracellular 2
cytoskeleton 2
cytosol 2
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Aggresome (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf81 Gene

Pathways & Interactions for C19orf81 Gene

SuperPathways for C19orf81 Gene

No Data Available

Interacting Proteins for C19orf81 Gene

Gene Ontology (GO) - Biological Process for C19orf81 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf81 Gene

Drugs & Compounds for C19orf81 Gene

No Compound Related Data Available

Transcripts for C19orf81 Gene

mRNA/cDNA for C19orf81 Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(22) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C19orf81 Gene

Chromosome 19 open reading frame 81:
Representative Sequences:

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf81 Gene

No ASD Table

Relevant External Links for C19orf81 Gene

GeneLoc Exon Structure for
C19orf81
ECgene alternative splicing isoforms for
C19orf81

Expression for C19orf81 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf81 Gene

mRNA differential expression in normal tissues according to GTEx for C19orf81 Gene

This gene is overexpressed in Testis (x8.2), Pituitary (x7.9), and Brain - Cerebellar Hemisphere (x4.5).

Protein differential expression in normal tissues from HIPED for C19orf81 Gene

This gene is overexpressed in Plasma (62.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C19orf81 Gene



Protein tissue co-expression partners for C19orf81 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C19orf81 Gene:

C19orf81

SOURCE GeneReport for Unigene cluster for C19orf81 Gene:

Hs.531650
genes like me logo Genes that share expression patterns with C19orf81: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf81 Gene

Orthologs for C19orf81 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf81 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19orf81 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1H19orf81 33
  • 86.82 (n)
C19orf81 34
  • 77 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C18H19orf81 33
  • 85.45 (n)
C19orf81 34
  • 72 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700008O03Rik 33 16 34
  • 78.8 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C19orf81 34
  • 51 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf81 34
  • 64 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 14 (a)
OneToOne
Species where no ortholog for C19orf81 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf81 Gene

ENSEMBL:
Gene Tree for C19orf81 (if available)
TreeFam:
Gene Tree for C19orf81 (if available)

Paralogs for C19orf81 Gene

No data available for Paralogs for C19orf81 Gene

Variants for C19orf81 Gene

Sequence variations from dbSNP and Humsavar for C19orf81 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000525401 -- 50,648,096(+) A/G upstream_transcript_variant
rs1000625630 -- 50,653,855(+) G/A intron_variant
rs1000641858 -- 50,652,573(+) C/T intron_variant
rs1000796545 -- 50,658,724(+) C/T intron_variant
rs1001187942 -- 50,658,916(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf81 Gene

Variant ID Type Subtype PubMed ID
esv3574587 CNV gain 25503493
nsv1072893 CNV deletion 25765185
nsv1140251 OTHER inversion 24896259
nsv579950 CNV loss 21841781
nsv828583 CNV loss 20364138
nsv953605 CNV deletion 24416366

Variation tolerance for C19orf81 Gene

Gene Damage Index Score: 1.77; 33.51% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf81 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf81

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf81 Gene

Disorders for C19orf81 Gene

Additional Disease Information for C19orf81

No disorders were found for C19orf81 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf81 Gene

Publications for C19orf81 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for C19orf81 Gene

Sources for C19orf81 Gene

Content
Loading form....