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Aliases for C19orf73 Gene

Aliases for C19orf73 Gene

  • Chromosome 19 Open Reading Frame 73 2 3 5

External Ids for C19orf73 Gene

Previous GeneCards Identifiers for C19orf73 Gene

  • GC19M054315
  • GC19M049621
  • GC19M045997

Summaries for C19orf73 Gene

GeneCards Summary for C19orf73 Gene

C19orf73 (Chromosome 19 Open Reading Frame 73) is a Protein Coding gene.

Additional gene information for C19orf73 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf73 Gene

Genomics for C19orf73 Gene

GeneHancer (GH) Regulatory Elements for C19orf73 Gene

Promoters and enhancers for C19orf73 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I049117 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 550.8 +0.3 332 2.9 CLOCK FEZF1 DMAP1 SLC30A9 ZNF213 ZNF143 SP3 NFYC ZNF610 GLIS1 C19orf73 PPFIA3 NUP62 SNRNP70 IRF3 PRR12 PTOV1-AS2 SNORD35A SNORD35B ALDH16A1
GH19I049148 Promoter/Enhancer 1.8 Ensembl ENCODE dbSUPER 12.4 -31.1 -31089 4.4 HDGF PKNOX1 CLOCK ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 CBX5 SNRNP70 PPFIA3 PRR12 GRWD1 PIH1D1 SNORD35A ALDH16A1 RPL13A PTOV1-AS2 KDELR1
GH19I049142 Promoter/Enhancer 1.5 Ensembl ENCODE dbSUPER 13.2 -23.7 -23677 1.1 HDGF PKNOX1 ATF1 SIN3A RFX5 GLIS2 FOS ATF7 CREM ZBTB2 PPFIA3 C19orf73 LIN7B SNRNP70 NTF4 CGB7 KCNA7 SLC6A16 CD37 CCDC155
GH19I049145 Enhancer 1.4 Ensembl ENCODE dbSUPER 12.7 -27.2 -27242 1.6 CLOCK ATF1 ARNT ARID4B SIN3A ZNF121 GLIS2 ZNF143 ATF7 SP3 SNRNP70 PPFIA3 PRR12 C19orf73 LIN7B KCNA7 NTF4 CGB7 SLC6A16 CD37
GH19I049207 Enhancer 1.3 FANTOM5 Ensembl ENCODE 11.5 -89.2 -89192 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ARID2 FOS ATF7 SNRNP70 PPP1R15A PRR12 CD37 C19orf73 PPFIA3 LIN7B CGB7 NTF4 SLC6A16
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C19orf73 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C19orf73 gene promoter:

Genomic Locations for C19orf73 Gene

Genomic Locations for C19orf73 Gene
chr19:49,118,397-49,119,140
(GRCh38/hg38)
Size:
744 bases
Orientation:
Minus strand
chr19:49,621,654-49,622,397
(GRCh37/hg19)

Genomic View for C19orf73 Gene

Genes around C19orf73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf73 Gene

Proteins for C19orf73 Gene

  • Protein details for C19orf73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVV2-CS073_HUMAN
    Recommended name:
    Putative uncharacterized protein C19orf73
    Protein Accession:
    Q9NVV2
    Secondary Accessions:
    • Q6NSX4

    Protein attributes for C19orf73 Gene

    Size:
    129 amino acids
    Molecular mass:
    13750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf73 Gene

Post-translational modifications for C19orf73 Gene

No Post-translational modifications

Other Protein References for C19orf73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf73 Gene

Domains & Families for C19orf73 Gene

Gene Families for C19orf73 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf73 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C19orf73: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C19orf73 Gene

Function for C19orf73 Gene

Phenotypes From GWAS Catalog for C19orf73 Gene

Gene Ontology (GO) - Molecular Function for C19orf73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C19orf73: view

Phenotypes for C19orf73 Gene

genes like me logo Genes that share phenotypes with C19orf73: view

miRNA for C19orf73 Gene

miRTarBase miRNAs that target C19orf73

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf73 Gene

Localization for C19orf73 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf73 gene
Compartment Confidence
extracellular 2
mitochondrion 2
nucleus 2
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf73 Gene

Pathways & Interactions for C19orf73 Gene

SuperPathways for C19orf73 Gene

No Data Available

Interacting Proteins for C19orf73 Gene

Gene Ontology (GO) - Biological Process for C19orf73 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf73 Gene

Drugs & Compounds for C19orf73 Gene

No Compound Related Data Available

Transcripts for C19orf73 Gene

mRNA/cDNA for C19orf73 Gene

(1) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(32) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C19orf73 Gene

Chromosome 19 open reading frame 73:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf73 Gene

No ASD Table

Relevant External Links for C19orf73 Gene

GeneLoc Exon Structure for
C19orf73
ECgene alternative splicing isoforms for
C19orf73

Expression for C19orf73 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf73 Gene

NURSA nuclear receptor signaling pathways regulating expression of C19orf73 Gene:

C19orf73

SOURCE GeneReport for Unigene cluster for C19orf73 Gene:

Hs.458310
genes like me logo Genes that share expression patterns with C19orf73: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf73 Gene

Orthologs for C19orf73 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C19orf73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf73 33
  • 99.22 (n)
C19orf73 34
  • 98 (a)
OneToOne
Species where no ortholog for C19orf73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C19orf73 Gene

ENSEMBL:
Gene Tree for C19orf73 (if available)
TreeFam:
Gene Tree for C19orf73 (if available)

Paralogs for C19orf73 Gene

No data available for Paralogs for C19orf73 Gene

Variants for C19orf73 Gene

Sequence variations from dbSNP and Humsavar for C19orf73 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000029134 -- 49,118,920(-) C/G/T coding_sequence_variant, missense_variant
rs1001607866 -- 49,120,048(-) C/T upstream_transcript_variant
rs1001989135 -- 49,119,243(-) C/T upstream_transcript_variant
rs1003027372 -- 49,121,037(-) C/T upstream_transcript_variant
rs1003604852 -- 49,118,035(-) C/A downstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf73 Gene

Variant ID Type Subtype PubMed ID
dgv3619n100 CNV gain 25217958
dgv3620n100 CNV gain 25217958
dgv3621n100 CNV gain 25217958
esv2760526 CNV gain 21179565
nsv1060108 CNV gain 25217958
nsv819445 CNV gain 19587683
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv9739 CNV gain+loss 18304495

Variation tolerance for C19orf73 Gene

Residual Variation Intolerance Score: 76.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.44; 28.27% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf73 Gene

Disorders for C19orf73 Gene

Additional Disease Information for C19orf73

No disorders were found for C19orf73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf73 Gene

Publications for C19orf73 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P … Vidal M (Genomics 2007) 3 58
  5. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 4 58

Products for C19orf73 Gene

Sources for C19orf73 Gene

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