Aliases for C19orf67 Gene

Aliases for C19orf67 Gene

  • Chromosome 19 Open Reading Frame 67 2 3 5
  • UPF0575 Protein C19orf67 3 4
  • UPF0575 Protein C19orf67-Like 3

External Ids for C19orf67 Gene

Previous GeneCards Identifiers for C19orf67 Gene

  • GC19M014055
  • GC19M014191

Summaries for C19orf67 Gene

GeneCards Summary for C19orf67 Gene

C19orf67 (Chromosome 19 Open Reading Frame 67) is a Protein Coding gene.

Additional gene information for C19orf67 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C19orf67 Gene

Genomics for C19orf67 Gene

GeneHancer (GH) Regulatory Elements for C19orf67 Gene

Promoters and enhancers for C19orf67 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J014085 Promoter/Enhancer 1.3 Ensembl CraniofacialAtlas dbSUPER 500.7 +0.3 280 1.2 NRF1 POLR2G HES1 MYC CTBP1 FOXA2 ZNF263 ZKSCAN1 SAP130 MAX C19orf67 ENSG00000288239-001 RF00017-2838 PRKACA LOC100507373 RF00017-2839
GH19J014227 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.5 -142.6 -142625 1.4 RBAK ZNF639 ZNF354C ZNF623 ZNF510 ZNF341 ZNF266 ZBTB11 ZNF426 OVOL3 CCDC130 MRI1 ZNF333 SNRPGP15 RFX1 DCAF15 NOTCH3 DDX39A SYDE1 C19orf67
GH19J014080 Promoter/Enhancer 2.3 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 0.7 +4.4 4374 3 FOXK2 ZBTB40 ZNF217 SIN3A NRF1 USF1 POLR2G SP1 PHF8 SIX5 PRKACA PALM3 ZSWIM4 ADGRL1 CCDC130 RFX1 PKN1 DCAF15 DNAJB1 C19orf67
GH19J014076 Promoter 0.6 Ensembl 0.4 +9.2 9174 0.2 GLIS1 KLF1 FOS ZNF316 ZNF770 RF00017-2839 C19orf67 ENSG00000288239-001 RF00017-2838
GH19J014078 Enhancer 0.2 FANTOM5 0.4 +7.3 7274 0.2 NANOS3 PRKACA MIR181C MIR181D C19orf57 CC2D1A ZSWIM4 CCDC130 RFX1 PKN1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C19orf67 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C19orf67

Top Transcription factor binding sites by QIAGEN in the C19orf67 gene promoter:
  • E47
  • HSF1short
  • ITF-2
  • LUN-1
  • p53
  • POU3F1
  • STAT1
  • STAT3
  • Tal-1beta

Genomic Locations for C19orf67 Gene

Genomic Locations for C19orf67 Gene
chr19:14,081,601-14,085,875
(GRCh38/hg38)
Size:
4,275 bases
Orientation:
Minus strand
chr19:14,191,952-14,196,687
(GRCh37/hg19)
Size:
4,736 bases
Orientation:
Minus strand

Genomic View for C19orf67 Gene

Genes around C19orf67 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf67 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf67 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf67 Gene

Proteins for C19orf67 Gene

  • Protein details for C19orf67 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NJJ6-CS067_HUMAN
    Recommended name:
    UPF0575 protein C19orf67
    Protein Accession:
    A6NJJ6

    Protein attributes for C19orf67 Gene

    Size:
    358 amino acids
    Molecular mass:
    39779 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf67 Gene

Post-translational modifications for C19orf67 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf67 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf67 Gene

Domains & Families for C19orf67 Gene

Gene Families for C19orf67 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf67 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf67 Gene

GenScript: Design optimal peptide antigens:
  • UPF0575 protein C19orf67 (CS067_HUMAN)

Graphical View of Domain Structure for InterPro Entry

A6NJJ6

UniProtKB/Swiss-Prot:

CS067_HUMAN :
  • Belongs to the UPF0575 family.
Family:
  • Belongs to the UPF0575 family.
genes like me logo Genes that share domains with C19orf67: view

Function for C19orf67 Gene

genes like me logo Genes that share phenotypes with C19orf67: view

Animal Models for C19orf67 Gene

MGI Knock Outs for C19orf67:

Animal Model Products

CRISPR Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf67 Gene

Localization for C19orf67 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf67 gene
Compartment Confidence
extracellular 1
peroxisome 1
nucleus 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C19orf67 Gene

Pathways & Interactions for C19orf67 Gene

PathCards logo

SuperPathways for C19orf67 Gene

No Data Available

Interacting Proteins for C19orf67 Gene

;

Gene Ontology (GO) - Biological Process for C19orf67 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf67 Gene

Drugs & Compounds for C19orf67 Gene

No Compound Related Data Available

Transcripts for C19orf67 Gene

mRNA/cDNA for C19orf67 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf67 Gene

No ASD Table

Relevant External Links for C19orf67 Gene

GeneLoc Exon Structure for
C19orf67

Expression for C19orf67 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf67 Gene

mRNA differential expression in normal tissues according to GTEx for C19orf67 Gene

This gene is overexpressed in Testis (x31.4).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C19orf67

genes like me logo Genes that share expression patterns with C19orf67: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf67 Gene

Orthologs for C19orf67 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf67 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19H19orf67 30
  • 99.35 (n)
C19orf67 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C19orf67 31
  • 90 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C19orf67 31
  • 89 (a)
OneToOne
C7H19orf67 30
  • 85.33 (n)
mouse
(Mus musculus)
Mammalia 1700067K01Rik 17 31 30
  • 81.67 (n)
rat
(Rattus norvegicus)
Mammalia LOC686013 30
  • 78.97 (n)
oppossum
(Monodelphis domestica)
Mammalia C19orf67 31
  • 66 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf67 31
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii si:ch211-214c7.5 30
  • 52.69 (n)
C1H19orf67 31
  • 35 (a)
OneToOne
Species where no ortholog for C19orf67 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf67 Gene

ENSEMBL:
Gene Tree for C19orf67 (if available)
TreeFam:
Gene Tree for C19orf67 (if available)

Paralogs for C19orf67 Gene

No data available for Paralogs for C19orf67 Gene

Variants for C19orf67 Gene

Additional dbSNP identifiers (rs#s) for C19orf67 Gene

Structural Variations from Database of Genomic Variants (DGV) for C19orf67 Gene

Variant ID Type Subtype PubMed ID
dgv49n68 CNV loss 17160897
nsv578642 CNV gain 21841781
nsv828452 CNV loss 20364138
nsv828454 CNV gain 20364138
nsv833761 CNV loss 17160897
nsv953980 CNV deletion 24416366

Variation tolerance for C19orf67 Gene

Gene Damage Index Score: 1.52; 29.61% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf67 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf67

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C19orf67 Gene

Disorders for C19orf67 Gene

Additional Disease Information for C19orf67

No disorders were found for C19orf67 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf67 Gene

Publications for C19orf67 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4 54

Products for C19orf67 Gene

Sources for C19orf67 Gene