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Aliases for C19orf66 Gene

Aliases for C19orf66 Gene

  • Chromosome 19 Open Reading Frame 66 2 3 5
  • Repressor Of Yield Of Dengue Virus 2 3
  • RyDEN 3 4
  • Repressor Of Yield Of DENV Protein 3
  • Interferon-Regulated Antiviral 3
  • UPF0515 Protein C19orf66 3
  • IRAV 3

External Ids for C19orf66 Gene

Previous GeneCards Identifiers for C19orf66 Gene

  • GC19P010196
  • GC19P009777

Summaries for C19orf66 Gene

GeneCards Summary for C19orf66 Gene

C19orf66 (Chromosome 19 Open Reading Frame 66) is a Protein Coding gene. Diseases associated with C19orf66 include Dengue Virus.

UniProtKB/Swiss-Prot for C19orf66 Gene

  • Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).

Additional gene information for C19orf66 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf66 Gene

Genomics for C19orf66 Gene

GeneHancer (GH) Regulatory Elements for C19orf66 Gene

Promoters and enhancers for C19orf66 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19I010085 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.5 500 2.5 HDGF ZFP64 ARID4B SIN3A YY1 ZNF143 ATF7 RXRA MXD4 REST C19orf66 ZNF846 RPL10P15 FDX2 ENSG00000267387
GH19I010100 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 10.4 +18.3 18268 8.3 HDGF FOXA2 PKNOX1 SMAD1 MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 PPAN ANGPTL6 PPAN-P2RY11 ZNF699 ILF3 LOC100419831 ZNF317 FBXL12 ZNF559 KRI1
GH19I010197 Enhancer 0.9 Ensembl ENCODE 19.5 +113.6 113589 4.2 GATAD2A ZNF362 L3MBTL2 NR4A1 CEBPB ZMYM3 CEBPG ZNF384 ZBTB40 ZNF316 C19orf66 ANGPTL6 S1PR2 MRPL4 ICAM1 EIF3G P2RY11 SNORD105B SNORD105 PPAN-P2RY11
GH19I010192 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE 9.6 +108.2 108190 3.4 HDGF PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 IRF4 YY1 POLR2B ZNF266 RAVER1 FBXL12 PPAN ILF3 ZNF699 ZNF561 KRI1 EIF3G CDC37
GH19I010110 Promoter/Enhancer 1.7 EPDnew Ensembl ENCODE 9.8 +26.9 26909 5.2 HDGF HNRNPUL1 PKNOX1 SMAD1 SIN3A ZNF48 POLR2B GLIS2 E2F8 ZNF416 P2RY11 GC19P010132 PIR48091 ILF3 ZNF559 ZNF699 ZNF266 ZNF317 FBXL12 LOC100419831
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C19orf66 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C19orf66 gene promoter:

Genomic Locations for C19orf66 Gene

Genomic Locations for C19orf66 Gene
chr19:10,086,119-10,093,252
(GRCh38/hg38)
Size:
7,134 bases
Orientation:
Plus strand
chr19:10,196,798-10,203,928
(GRCh37/hg19)

Genomic View for C19orf66 Gene

Genes around C19orf66 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf66 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf66 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf66 Gene

Proteins for C19orf66 Gene

  • Protein details for C19orf66 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NUL5-RYDEN_HUMAN
    Recommended name:
    Repressor of yield of DENV protein
    Protein Accession:
    Q9NUL5
    Secondary Accessions:
    • A8MQT9
    • Q4G188
    • Q8IYH6
    • Q8N8V1

    Protein attributes for C19orf66 Gene

    Size:
    291 amino acids
    Molecular mass:
    33110 Da
    Quaternary structure:
    • Interacts with PABPC1 (PubMed:26735137). Found in a complex with PABPC1 and LARP1 (PubMed:26735137).

    Alternative splice isoforms for C19orf66 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf66 Gene

Post-translational modifications for C19orf66 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C19orf66 Gene

Domains & Families for C19orf66 Gene

Gene Families for C19orf66 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf66 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf66 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NUL5

UniProtKB/Swiss-Prot:

RYDEN_HUMAN :
  • Belongs to the RyDEN family.
Family:
  • Belongs to the RyDEN family.
genes like me logo Genes that share domains with C19orf66: view

Function for C19orf66 Gene

Molecular function for C19orf66 Gene

UniProtKB/Swiss-Prot Function:
Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus (PubMed:26735137).
UniProtKB/Swiss-Prot Induction:
Up-regulated by interferon (IFN) treatment.

Phenotypes From GWAS Catalog for C19orf66 Gene

Gene Ontology (GO) - Molecular Function for C19orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding IDA 26735137
GO:0005515 protein binding IPI 21044950
genes like me logo Genes that share ontologies with C19orf66: view
genes like me logo Genes that share phenotypes with C19orf66: view

Animal Model Products

miRNA for C19orf66 Gene

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C19orf66 Gene

Localization for C19orf66 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf66 Gene

Cytoplasm. Nucleus. Note=Predominantly found in the cytoplasm. {ECO:0000269 PubMed:26735137}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf66 gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C19orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA,IEA 26735137
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IEA,IDA 26735137
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C19orf66: view

Pathways & Interactions for C19orf66 Gene

SuperPathways for C19orf66 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf66 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0034340 response to type I interferon IDA 26735137
GO:0034341 response to interferon-gamma IDA 26735137
GO:0034342 response to type III interferon IDA 26735137
GO:0045071 negative regulation of viral genome replication IMP 26735137
GO:0051607 defense response to virus IDA,IEA 26735137
genes like me logo Genes that share ontologies with C19orf66: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf66 Gene

Drugs & Compounds for C19orf66 Gene

No Compound Related Data Available

Transcripts for C19orf66 Gene

Unigene Clusters for C19orf66 Gene

Chromosome 19 open reading frame 66:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf66 Gene

ExUns: 1 ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c · 8d ^ 9 ^ 10
SP1: -
SP2: - - -
SP3: -
SP4: -
SP5: - - -
SP6:
SP7: -
SP8:

Relevant External Links for C19orf66 Gene

GeneLoc Exon Structure for
C19orf66
ECgene alternative splicing isoforms for
C19orf66

Expression for C19orf66 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf66 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf66 Gene

This gene is overexpressed in Liver (x6.7).

Protein differential expression in normal tissues from HIPED for C19orf66 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (14.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf66 Gene



Protein tissue co-expression partners for C19orf66 Gene

NURSA nuclear receptor signaling pathways regulating expression of C19orf66 Gene:

C19orf66

SOURCE GeneReport for Unigene cluster for C19orf66 Gene:

Hs.655613

Evidence on tissue expression from TISSUES for C19orf66 Gene

  • Liver(4.5)
  • Pancreas(4.1)
  • Nervous system(2.3)
genes like me logo Genes that share expression patterns with C19orf66: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf66 Gene

Orthologs for C19orf66 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf66 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C19ORF66 34
  • 100 (a)
OneToOne
C19H19orf66 33
  • 97.14 (n)
dog
(Canis familiaris)
Mammalia C19orf66 34
  • 95 (a)
OneToOne
C20H19orf66 33
  • 90.96 (n)
cow
(Bos Taurus)
Mammalia C7H19orf66 33 34
  • 91.21 (n)
rat
(Rattus norvegicus)
Mammalia LOC500956 33
  • 85.28 (n)
mouse
(Mus musculus)
Mammalia A230050P20Rik 33 16 34
  • 84.94 (n)
oppossum
(Monodelphis domestica)
Mammalia C19orf66 34
  • 57 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C19orf66 34
  • 52 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf66 33
  • 61.22 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:171711 33
  • 58.24 (n)
C3H19orf66 34
  • 46 (a)
OneToOne
Species where no ortholog for C19orf66 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf66 Gene

ENSEMBL:
Gene Tree for C19orf66 (if available)
TreeFam:
Gene Tree for C19orf66 (if available)

Paralogs for C19orf66 Gene

No data available for Paralogs for C19orf66 Gene

Variants for C19orf66 Gene

Sequence variations from dbSNP and Humsavar for C19orf66 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000367573 -- 10,089,145(+) A/G 5_prime_UTR_variant, coding_sequence_variant, intron_variant, missense_variant
rs1000752628 -- 10,090,129(+) C/G downstream_transcript_variant, genic_downstream_transcript_variant, intron_variant
rs1000814936 -- 10,088,935(+) G/A intron_variant
rs1001175014 -- 10,090,977(+) T/C genic_downstream_transcript_variant, intron_variant
rs1001496709 -- 10,085,716(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf66 Gene

Variant ID Type Subtype PubMed ID
nsv2414 CNV insertion 18451855
nsv458355 CNV loss 19166990
nsv578606 CNV loss 21841781
nsv833743 CNV loss 17160897

Variation tolerance for C19orf66 Gene

Residual Variation Intolerance Score: 57.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.63; 13.52% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf66 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf66

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf66 Gene

Disorders for C19orf66 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C19orf66 Gene - From: GeneCards

Disorder Aliases PubMed IDs
dengue virus
  • dengue virus, susceptibility to
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C19orf66

genes like me logo Genes that share disorders with C19orf66: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C19orf66 Gene

Publications for C19orf66 Gene

  1. Characterization of RyDEN (C19orf66) as an Interferon-Stimulated Cellular Inhibitor against Dengue Virus Replication. (PMID: 26735137) Suzuki Y … Yamamoto N (PLoS pathogens 2016) 2 3 4 58
  2. IRAV (FLJ11286), an Interferon-Stimulated Gene with Antiviral Activity against Dengue Virus, Interacts with MOV10. (PMID: 27974568) Balinsky CA … Zoon KC (Journal of virology 2017) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A … Stelzl U (Molecular systems biology 2015) 3 58
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58

Products for C19orf66 Gene

Sources for C19orf66 Gene

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