C19orf38 Gene (Protein Coding)

Chromosome 19 Open Reading Frame 38

GC19P010837
GIFtS:
28
See more...

Aliases for C19orf38 Gene

Aliases for C19orf38 Gene

  • Chromosome 19 Open Reading Frame 38 2 3 5
  • Highly Expressed In Immature Dendritic Cell Transcript 1 2 3
  • Protein HIDE1 3 4
  • HIDE1 2 3
  • C19orf38 5

External Ids for C19orf38 Gene

Previous GeneCards Identifiers for C19orf38 Gene

  • GC19P010821
  • GC19P010961
  • GC19P010537
  • GC19P010947

Summaries for C19orf38 Gene

GeneCards Summary for C19orf38 Gene

C19orf38 (Chromosome 19 Open Reading Frame 38) is a Protein Coding gene.

Additional gene information for C19orf38 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C19orf38 Gene

Genomics for C19orf38 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for C19orf38 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH19J010834 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE CraniofacialAtlas 250.7 -0.6 -557 2.8 TBP ZBTB10 SP1 NR2C1 MNT SMAD5 MBD2 ZNF217 POLR2A BHLHE40 C19orf38 HSALNG0123968 TMED1 KRI1 DNMT1 ILF3 ZNF491 ZNF627 ZNF441 RAVER1
GH19J010848 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 250.4 +12.2 12243 2 POLR2A ZNF189 ZNF121 C19orf38 MK280144-320 HIKESHIP2 CARM1 lnc-TIMM29-1
GH19J011086 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.8 +255.8 255812 11 ZSCAN16 CHD2 TBP ZBTB10 SP1 BCL11A MXD4 FEZF1 CEBPA FOXA1 LDLR ZNF491 ZNF441 FDX2 ILF3 ZNF823 ELAVL3 ZNF788P C19orf38 ZNF844
GH19J010423 Promoter/Enhancer 1.7 FANTOM5 Ensembl ENCODE 17.4 -411.8 -411842 3 ZSCAN16 SP1 ZBTB10 BCL11A MNT IKZF1 IRF2 MBD2 CTCF ZEB1 PDE4A C19orf38 KRI1 ICAM1 SMARCA4 ZNF266 DNMT1 RAVER1 PPAN TYK2
GH19J010808 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 11.9 -22.1 -22070 11.6 MNT IKZF1 BHLHE40 CTCF ZIC2 ZNF623 ZNF395 REST MAX VEZF1 KRI1 ILF3 TIMM29 ZNF441 PPAN ZNF627 C19orf38 FBXL12 EIF3G ILF3-DT
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C19orf38 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C19orf38

Top Transcription factor binding sites by QIAGEN in the C19orf38 gene promoter:
  • AML1a
  • Egr-3
  • HOXA5
  • LCR-F1
  • MAZR
  • NRSF form 2
  • p53
  • RORalpha1
  • ZIC2
  • ZID

Genomic Locations for C19orf38 Gene

Latest Assembly
chr19:10,836,558-10,869,796
(GRCh38/hg38)
Size:
33,239 bases
Orientation:
Plus strand

Previous Assembly
chr19:10,959,091-10,980,466
(GRCh37/hg19 by Entrez Gene)
Size:
21,376 bases
Orientation:
Plus strand

chr19:10,947,251-10,980,466
(GRCh37/hg19 by Ensembl)
Size:
33,216 bases
Orientation:
Plus strand

Genomic View for C19orf38 Gene

Genes around C19orf38 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf38 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf38 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C19orf38 Gene

Proteins for C19orf38 Gene

Products:

  1. Antibodies for research
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  3. Assay products for research

  • Protein details for C19orf38 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8MVS5-HIDE1_HUMAN
    Recommended name:
    Protein HIDE1
    Protein Accession:
    A8MVS5
    Secondary Accessions:
    • B2RXI3

    Protein attributes for C19orf38 Gene

    Size:
    230 amino acids
    Molecular mass:
    24753 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C19orf38 Gene

Protein Expression for C19orf38 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C19orf38 Gene

  • Glycosylation at Asn48, Asn73, and Asn97
  • Modification sites at PhosphoSitePlus

Other Protein References for C19orf38 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf38 Gene

Domains & Families for C19orf38 Gene

Gene Families for C19orf38 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C19orf38 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf38 Gene

GenScript: Design optimal peptide antigens:
  • Protein HIDE1 (HIDE1_HUMAN)
genes like me logo Genes that share domains with C19orf38: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C19orf38 Gene

Function for C19orf38 Gene

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  1. Animal Models for research
  2. CRISPR products for research
  3. miRNA products for research
  4. Inhibitory RNAs for research
  5. Clone products for research
  6. Cell Lines for research

Phenotypes From GWAS Catalog for C19orf38 Gene

Gene Ontology (GO) - Molecular Function for C19orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 32296183
genes like me logo Genes that share ontologies with C19orf38: view

Phenotypes for C19orf38 Gene

MGI mutant phenotypes for C19orf38:
inferred from 1 alleles
genes like me logo Genes that share phenotypes with C19orf38: view

Animal Models for C19orf38 Gene

MGI Knock Outs for C19orf38:

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C19orf38

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf38 Gene

Localization for C19orf38 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf38 Gene

Membrane. Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf38 gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 0
lysosome 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (1)
  • Golgi apparatus (1)
  • Plasma membrane (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C19orf38 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C19orf38: view

Pathways & Interactions for C19orf38 Gene

PathCards logo

SuperPathways for C19orf38 Gene

No Data Available

Interacting Proteins for C19orf38 Gene

Selected Interacting proteins: A8MVS5-HIDE1_HUMAN for C19orf38 Gene via UniProtKB IID

GPS-Prot Interaction Network for C19orf38

Gene Ontology (GO) - Biological Process for C19orf38 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C19orf38 Gene

Drugs & Compounds for C19orf38 Gene

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  1. Drug products for research
No Compound Related Data Available

Transcripts for C19orf38 Gene

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  2. miRNA products for research
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mRNA/cDNA for C19orf38 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C19orf38

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf38 Gene

No ASD Table

Relevant External Links for C19orf38 Gene

GeneLoc Exon Structure for
C19orf38

Expression for C19orf38 Gene

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  1. Primer products for research
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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf38 Gene

mRNA expression in normal human tissues for C19orf38 Gene
mRNA expression by BioGPS for C19orf38 GenemRNA expression by GTEx for C19orf38 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf38 Gene

This gene is overexpressed in Whole Blood (x41.7).

Protein differential expression in normal tissues from HIPED for C19orf38 Gene

This gene is overexpressed in Monocytes (35.9), Testis (19.9), and Peripheral blood mononuclear cells (8.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C19orf38 Gene



Protein tissue co-expression partners for C19orf38 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C19orf38

SOURCE GeneReport for Unigene cluster for C19orf38 Gene:

Hs.440535
genes like me logo Genes that share expression patterns with C19orf38: view

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf38 Gene

Orthologs for C19orf38 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C19orf38 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C19orf38 31
  • 97 (a)
 OneToOne
C19H19orf38 30
  • 91.33 (n)
Dog
(Canis familiaris)
 Mammalia C20H19orf38 30
  • 80.79 (n)
C19orf38 31
  • 75 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia C7H19orf38 30
  • 80.27 (n)
C19orf38 31
  • 73 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia AB124611 30 17 31
  • 78.13 (n)
 OneToOne
Rat
(Rattus norvegicus)
 Mammalia LOC691141 30
  • 77.52 (n)
Oppossum
(Monodelphis domestica)
 Mammalia C19orf38 31
  • 53 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia C19orf38 31
  • 44 (a)
 OneToOne
Species where no ortholog for C19orf38 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C19orf38 Gene

ENSEMBL:
Gene Tree for C19orf38 (if available)
TreeFam:
Gene Tree for C19orf38 (if available)

Paralogs for C19orf38 Gene

No data available for Paralogs for C19orf38 Gene

Variants for C19orf38 Gene

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  1. SNP Genotyping and Copy Number Assays for research

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C19orf38 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C19orf38 Gene

Variant ID Type Subtype PubMed ID
esv3583244 CNV loss 25503493
esv3643659 CNV loss 21293372
nsv1123220 CNV deletion 24896259
nsv1160584 CNV deletion 26073780
nsv2416 CNV insertion 18451855
nsv833748 CNV loss 17160897

Variation tolerance for C19orf38 Gene

Gene Damage Index Score: 4.05; 60.64% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf38 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf38

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C19orf38 Gene

Disorders for C19orf38 Gene

Additional Disease Information for C19orf38

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C19orf38 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf38 Gene

Publications for C19orf38 Gene

  1. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J … Lucas SM (Nature 2004) 3 4
  2. A reference map of the human binary protein interactome. (PMID: 32296183) Luck K … Calderwood MA (Nature 2020) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

ExternalLinks

View latest publications for C19orf38 gene in Mastermind

Products for C19orf38 Gene

Sources for C19orf38 Gene