The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided ... See more...

Aliases for C19orf33 Gene

Aliases for C19orf33 Gene

  • Chromosome 19 Open Reading Frame 33 2 3 5
  • Hepatocyte Growth Factor Activator Inhibitor Type 2-Related Small Protein 2 3 4
  • H2RSP 2 3 4
  • Immortalization Up-Regulated Protein 3 4
  • Immortalization-Upregulated Protein 2 3
  • HAI-2 Related Small Protein 2 3
  • IMUP-1 2 3
  • IMUP-2 2 3
  • IMUP 2 3
  • HAI-2-Related Small Protein 4
  • C19orf33 5

External Ids for C19orf33 Gene

Previous GeneCards Identifiers for C19orf33 Gene

  • GC19P043489
  • GC19P043490
  • GC19P038794
  • GC19P035242

Summaries for C19orf33 Gene

Entrez Gene Summary for C19orf33 Gene

  • The protein encoded by this gene has been shown to be upregulated in SV40-immortalized fibroblasts as well as in endometrial carcinoma cells. The encoded protein is found primarily in the nucleus. This protein may play a role in placental development and diseases such as pre-eclampsia. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]

GeneCards Summary for C19orf33 Gene

C19orf33 (Chromosome 19 Open Reading Frame 33) is a Protein Coding gene. Diseases associated with C19orf33 include Eclampsia and Pre-Eclampsia. Gene Ontology (GO) annotations related to this gene include double-stranded DNA binding and single-stranded DNA binding. An important paralog of this gene is ENSG00000267748.

Additional gene information for C19orf33 Gene

No data available for CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C19orf33 Gene

Genomics for C19orf33 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C19orf33 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C19orf33 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C19orf33

Top Transcription factor binding sites by QIAGEN in the C19orf33 gene promoter:
  • CP2
  • E47
  • GATA-1
  • GATA-2
  • GATA-3
  • NF-E2
  • NF-E2 p45
  • Pax-6
  • Tal-1

Genomic Locations for C19orf33 Gene

Genomic Locations for C19orf33 Gene
chr19:38,304,164-38,305,006
(GRCh38/hg38)
Size:
843 bases
Orientation:
Plus strand
chr19:38,794,801-38,795,649
(GRCh37/hg19)
Size:
849 bases
Orientation:
Plus strand

Genomic View for C19orf33 Gene

Genes around C19orf33 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf33 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf33 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf33 Gene

Proteins for C19orf33 Gene

  • Protein details for C19orf33 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9GZP8-IMUP_HUMAN
    Recommended name:
    Immortalization up-regulated protein
    Protein Accession:
    Q9GZP8
    Secondary Accessions:
    • Q0P6G2
    • Q96H58
    • Q9HCR4

    Protein attributes for C19orf33 Gene

    Size:
    106 amino acids
    Molecular mass:
    10897 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C19orf33 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C19orf33 Gene

Post-translational modifications for C19orf33 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C19orf33 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C19orf33 Gene

Domains & Families for C19orf33 Gene

Gene Families for C19orf33 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf33 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C19orf33 Gene

GenScript: Design optimal peptide antigens:
  • Hepatocyte growth factor activator inhibitor type 2-related small protein (IMUP_HUMAN)
genes like me logo Genes that share domains with C19orf33: view

No data available for Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C19orf33 Gene

Function for C19orf33 Gene

Phenotypes From GWAS Catalog for C19orf33 Gene

genes like me logo Genes that share phenotypes with C19orf33: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C19orf33

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf33 Gene

Localization for C19orf33 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C19orf33 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf33 gene
Compartment Confidence
nucleus 5
plasma membrane 4
cytosol 4
extracellular 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoplasm (3)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C19orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 11606055
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with C19orf33: view

Pathways & Interactions for C19orf33 Gene

PathCards logo

SuperPathways for C19orf33 Gene

No Data Available

Interacting Proteins for C19orf33 Gene

Gene Ontology (GO) - Biological Process for C19orf33 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
genes like me logo Genes that share ontologies with C19orf33: view

No data available for Pathways by source and SIGNOR curated interactions for C19orf33 Gene

Drugs & Compounds for C19orf33 Gene

No Compound Related Data Available

Transcripts for C19orf33 Gene

mRNA/cDNA for C19orf33 Gene

3 REFSEQ mRNAs :
8 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C19orf33

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf33 Gene

No ASD Table

Relevant External Links for C19orf33 Gene

GeneLoc Exon Structure for
C19orf33

Expression for C19orf33 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C19orf33 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C19orf33 Gene

This gene is overexpressed in Esophagus - Mucosa (x10.5).

Protein differential expression in normal tissues from HIPED for C19orf33 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (20.7), Cervix (19.4), and Amniocyte (9.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf33 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C19orf33

SOURCE GeneReport for Unigene cluster for C19orf33 Gene:

Hs.631544

Evidence on tissue expression from TISSUES for C19orf33 Gene

  • Lung(4.3)
  • Pancreas(4.1)
  • Skin(2.4)
genes like me logo Genes that share expression patterns with C19orf33: view

No data available for Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf33 Gene

Orthologs for C19orf33 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C19orf33 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C19ORF33 31
  • 98 (a)
OneToMany
Species where no ortholog for C19orf33 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C19orf33 Gene

ENSEMBL:
Gene Tree for C19orf33 (if available)
TreeFam:
Gene Tree for C19orf33 (if available)

Paralogs for C19orf33 Gene

Paralogs for C19orf33 Gene

genes like me logo Genes that share paralogs with C19orf33: view

Variants for C19orf33 Gene

Additional dbSNP identifiers (rs#s) for C19orf33 Gene

Structural Variations from Database of Genomic Variants (DGV) for C19orf33 Gene

Variant ID Type Subtype PubMed ID
nsv833822 CNV loss 17160897

Variation tolerance for C19orf33 Gene

Residual Variation Intolerance Score: 47.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.09; 87.67% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf33 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C19orf33

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C19orf33 Gene

Disorders for C19orf33 Gene

MalaCards: The human disease database

(8) MalaCards diseases for C19orf33 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
eclampsia
  • eclampsia in puerperium
pre-eclampsia
  • toxemia of pregnancy
cardiovascular syphilis
  • syphilis, cardiovascular
cephalosporin allergy
leukorrhea
  • discharge - leukorrhea
- elite association - COSMIC cancer census association via MalaCards
genes like me logo Genes that share disorders with C19orf33: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C19orf33 Gene

Publications for C19orf33 Gene

  1. Identification of cDNAs encoding two novel nuclear proteins, IMUP-1 and IMUP-2, upregulated in SV40-immortalized human fibroblasts. (PMID: 11080599) Kim JK … Kato S (Gene 2000) 2 3 4 23
  2. Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes. (PMID: 11606055) Itoh H … Koono M (Biochemical and biophysical research communications 2001) 3 4 23
  3. Increased immortalization-upregulated protein 2 (IMUP-2) by hypoxia induces apoptosis of the trophoblast and pre-eclampsia. (PMID: 20432246) Jeon SY … Kim GJ (Journal of cellular biochemistry 2010) 3 23
  4. Imup-1 and imup-2 overexpression in endometrial carcinoma in Korean and Japanese populations. (PMID: 18507030) Kim SJ … Kim JK (Anticancer research 2008) 3 23
  5. Enhanced expression of hepatocyte growth factor activator inhibitor type 2-related small peptide at the invasive front of colon cancers. (PMID: 16809422) Uchiyama S … Kataoka H (Gut 2007) 3 23

Products for C19orf33 Gene

  • Signalway Proteins for C19orf33

Sources for C19orf33 Gene