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Aliases for C19orf25 Gene

Aliases for C19orf25 Gene

  • Chromosome 19 Open Reading Frame 25 2 3 5
  • UPF0449 Protein C19orf25 3

External Ids for C19orf25 Gene

Previous GeneCards Identifiers for C19orf25 Gene

  • GC19M001425
  • GC19M001426
  • GC19M001247
  • GC19M001473

Summaries for C19orf25 Gene

GeneCards Summary for C19orf25 Gene

C19orf25 (Chromosome 19 Open Reading Frame 25) is a Protein Coding gene.

Gene Wiki entry for C19orf25 Gene

Additional gene information for C19orf25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C19orf25 Gene

Genomics for C19orf25 Gene

GeneHancer (GH) Regulatory Elements for C19orf25 Gene

Promoters and enhancers for C19orf25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH19J001478 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 650.7 +0.4 444 2 HDGF PKNOX1 CLOCK SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 C19orf25 TMEM259 SF3A2 LOC100288123 TCF3 MED16 GRIN3B DAZAP1 PTBP1 CIRBP
GH19J001442 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.2 +35.1 35065 3.6 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 DMAP1 ZNF2 YY1 POLR2B APC2 SF3A2 RNA5SP462 C19orf24 DAZAP1 C19orf25 REEP6 PCSK4 CIRBP GRIN3B
GH19J001382 Promoter/Enhancer 2.4 EPDnew Ensembl ENCODE dbSUPER 10.7 +95.5 95530 2.2 MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 NDUFS7 TRF-GAA1-6 TRN-GTT2-6 PIR60227 PIR43938 SF3A2 CIRBP TMEM259 DAZAP1 LOC100288123
GH19J001236 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 6 +222.7 222697 41.1 CLOCK MLX ZFP64 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 CIRBP C19orf24 MIDN CBARP ATP5F1D SF3A2 TCF3 TMEM259 LOC100288123 MIER2
GH19J001441 Enhancer 0.9 ENCODE dbSUPER 12.2 +37.3 37341 0.6 ARNT TAL1 INSM2 HIC1 GLIS2 POLR2A NCOR1 PATZ1 NFATC1 RBM22 ENSG00000268798 C19orf25 PCSK4 REEP6 APC2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C19orf25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C19orf25 gene promoter:
  • YY1
  • Spz1
  • Max
  • c-Myc
  • SREBP-1a
  • LUN-1
  • AML1a
  • SREBP-1c
  • SREBP-1b
  • E47

Genomic Locations for C19orf25 Gene

Genomic Locations for C19orf25 Gene
18,414 bases
Minus strand
18,414 bases
Minus strand

Genomic View for C19orf25 Gene

Genes around C19orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C19orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C19orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C19orf25 Gene

Proteins for C19orf25 Gene

  • Protein details for C19orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0449 protein C19orf25
    Protein Accession:
    Secondary Accessions:
    • B3KQN6
    • Q8N9R7
    • Q8WV94

    Protein attributes for C19orf25 Gene

    118 amino acids
    Molecular mass:
    12878 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C19orf25 Gene


neXtProt entry for C19orf25 Gene

Post-translational modifications for C19orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Boster Bio Antibodies for C19orf25
  • Santa Cruz Biotechnology (SCBT) Antibodies for C19orf25

No data available for DME Specific Peptides for C19orf25 Gene

Domains & Families for C19orf25 Gene

Gene Families for C19orf25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C19orf25 Gene


Suggested Antigen Peptide Sequences for C19orf25 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0449 family.
  • Belongs to the UPF0449 family.
genes like me logo Genes that share domains with C19orf25: view

Function for C19orf25 Gene

Phenotypes From GWAS Catalog for C19orf25 Gene

Gene Ontology (GO) - Molecular Function for C19orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C19orf25: view
genes like me logo Genes that share phenotypes with C19orf25: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C19orf25 Gene

Localization for C19orf25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C19orf25 gene
Compartment Confidence
nucleus 3
cytoskeleton 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Intermediate filaments (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C19orf25 Gene

Pathways & Interactions for C19orf25 Gene

SuperPathways for C19orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C19orf25 Gene


No data available for Pathways by source and SIGNOR curated interactions for C19orf25 Gene

Drugs & Compounds for C19orf25 Gene

No Compound Related Data Available

Transcripts for C19orf25 Gene

mRNA/cDNA for C19orf25 Gene

Unigene Clusters for C19orf25 Gene

Chromosome 19 open reading frame 25:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C19orf25 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e
SP1: - - -
SP2: - -
SP3: -
SP4: - -
SP5: -
SP6: - -

Relevant External Links for C19orf25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C19orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C19orf25 Gene

Protein differential expression in normal tissues from HIPED for C19orf25 Gene

This gene is overexpressed in Bone (28.0) and Peripheral blood mononuclear cells (21.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C19orf25 Gene

NURSA nuclear receptor signaling pathways regulating expression of C19orf25 Gene:


SOURCE GeneReport for Unigene cluster for C19orf25 Gene:


Evidence on tissue expression from TISSUES for C19orf25 Gene

  • Nervous system(3.6)
genes like me logo Genes that share expression patterns with C19orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C19orf25 Gene

Orthologs for C19orf25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C19orf25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C19H19orf25 33
  • 98.87 (n)
C19orf25 34
  • 55 (a)
(Canis familiaris)
Mammalia C20H19orf25 33
  • 79.66 (n)
(Bos Taurus)
Mammalia C7H19orf25 34 33
  • 75.71 (n)
(Mus musculus)
Mammalia 2310011J03Rik 16 34 33
  • 74.04 (n)
(Rattus norvegicus)
Mammalia RGD1359127 33
  • 74.04 (n)
(Monodelphis domestica)
Mammalia C19orf25 34
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia C19orf25 34
  • 38 (a)
(Gallus gallus)
Aves C19orf25 34
  • 51 (a)
(Anolis carolinensis)
Reptilia C19orf25 34
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c19orf25 33
  • 52.75 (n)
(Danio rerio)
Actinopterygii C11H19orf25 (1 of 2) 34
  • 43 (a)
C11H19orf25 (2 of 2) 34
  • 36 (a)
Species where no ortholog for C19orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C19orf25 Gene

Gene Tree for C19orf25 (if available)
Gene Tree for C19orf25 (if available)

Paralogs for C19orf25 Gene

(23) SIMAP similar genes for C19orf25 Gene using alignment to 7 proteins:

  • CS025_HUMAN
  • E7EP72_HUMAN
  • K7EK56_HUMAN
  • K7ER12_HUMAN
genes like me logo Genes that share paralogs with C19orf25: view

No data available for Paralogs for C19orf25 Gene

Variants for C19orf25 Gene

Sequence variations from dbSNP and Humsavar for C19orf25 Gene

SNP ID Clin Chr 19 pos Variation AA Info Type
rs1000338202 -- 1,474,357(-) A/G 3_prime_UTR_variant
rs1000757303 -- 1,480,835(-) C/A upstream_transcript_variant
rs1000945533 -- 1,473,629(-) G/A 3_prime_UTR_variant
rs1001080316 -- 1,477,832(-) C/A intron_variant
rs1001231958 -- 1,480,913(-) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C19orf25 Gene

Variant ID Type Subtype PubMed ID
esv2758743 CNV gain+loss 17122850
esv32942 CNV gain+loss 17666407
nsv1113954 CNV deletion 24896259
nsv470105 CNV gain 18288195
nsv470106 CNV loss 18288195
nsv578279 CNV gain 21841781
nsv578295 CNV gain 21841781
nsv817811 CNV loss 17921354
nsv833705 CNV loss 17160897
nsv953942 CNV deletion 24416366

Variation tolerance for C19orf25 Gene

Gene Damage Index Score: 0.81; 16.95% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C19orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C19orf25 Gene

Disorders for C19orf25 Gene

Additional Disease Information for C19orf25

No disorders were found for C19orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C19orf25 Gene

Publications for C19orf25 Gene

  1. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  2. ZW10 links mitotic checkpoint signaling to the structural kinetochore. (PMID: 15824131) Kops GJ … Cleveland DW (The Journal of cell biology 2005) 2 3 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C19orf25 Gene

Sources for C19orf25 Gene

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