C18orf63 Gene (Protein Coding)

Chromosome 18 Open Reading Frame 63

GC18P074315
GIFtS:
27
See more...

Aliases for C18orf63 Gene

Aliases for C18orf63 Gene

  • Chromosome 18 Open Reading Frame 63 2 3 5
  • Uncharacterized Protein C18orf63 3 4
  • DKFZP781G0119 2 3
  • C18orf63 5

External Ids for C18orf63 Gene

Previous GeneCards Identifiers for C18orf63 Gene

  • GC18P071985

Summaries for C18orf63 Gene

GeneCards Summary for C18orf63 Gene

C18orf63 (Chromosome 18 Open Reading Frame 63) is a Protein Coding gene. Diseases associated with C18orf63 include Ring Dermoid Of Cornea.

Additional gene information for C18orf63 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C18orf63 Gene

Genomics for C18orf63 Gene

GeneHancer (GH) Regulatory Elements Pubs

Download GeneHancer 2017 data
Promoters and enhancers for C18orf63 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH18J074316 Enhancer 1 Ensembl ENCODE 250.7 +1.3 1325 1.7 CEBPA FOXA1 ZFP64 KDM6A CEBPB IRF3 FOXA2 MAFF SMAD4 SAP130 C18orf63 TSHZ1 CYB5A piR-59907-012 HSALNG0122433 DIPK1C
GH18J074288 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE CraniofacialAtlas dbSUPER 11.4 -25.2 -25230 4.9 CHD2 ZBTB10 MXD4 SP1 CEBPA MBD2 CTCF ZEB1 ZIC2 HOMEZ CYB5A ENSG00000286529 lnc-FBXO15-6 ZNF407 C18orf63 lnc-CYB5A-2 ENSG00000260569 TIMM21
GH18J074280 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.1 -32.1 -32138 6.2 CEBPA ETS1 ZIC2 THAP11 ZNF511 SMAD4 SAP130 RXRA ZSCAN9 KMT2B CYB5A C18orf63 lnc-FBXO15-6 ENSG00000260569 TIMM21
GH18J074248 Enhancer 1.3 FANTOM5 ENCODE dbSUPER 8.8 -65.2 -65216 4 CEBPA IKZF1 ZEB1 HOMEZ THAP11 CEBPB MAX MAFF SMAD4 SAP130 CYB5A C18orf63 CNDP2 ENSG00000260569 lnc-FBXO15-6 TIMM21
GH18J074276 Enhancer 0.9 Ensembl ENCODE dbSUPER 11.4 -37.7 -37739 3 RXRA FOXA2 ZNF316 NFE2 JUND HNF4A FOXA1 RCOR1 MAX SP1 CYB5A C18orf63 lnc-FBXO15-6 ENSG00000260569 TIMM21
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C18orf63 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C18orf63

Genomic Locations for C18orf63 Gene

Latest Assembly
chr18:74,315,839-74,359,189
(GRCh38/hg38)
Size:
43,351 bases
Orientation:
Plus strand

Previous Assembly
chr18:71,983,074-72,026,424
(GRCh37/hg19 by Entrez Gene)
Size:
43,351 bases
Orientation:
Plus strand

chr18:71,983,048-72,026,422
(GRCh37/hg19 by Ensembl)
Size:
43,375 bases
Orientation:
Plus strand

Genomic View for C18orf63 Gene

Genes around C18orf63 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf63 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf63 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C18orf63 Gene

Proteins for C18orf63 Gene

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  • Protein details for C18orf63 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q68DL7-CR063_HUMAN
    Recommended name:
    Uncharacterized protein C18orf63
    Protein Accession:
    Q68DL7
    Secondary Accessions:
    • A6NME8

    Protein attributes for C18orf63 Gene

    Size:
    685 amino acids
    Molecular mass:
    77230 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C18orf63 Gene

Protein Expression for C18orf63 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for C18orf63 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf63 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C18orf63 Gene

Domains & Families for C18orf63 Gene

Gene Families for C18orf63 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C18orf63 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C18orf63: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C18orf63 Gene

Function for C18orf63 Gene

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  6. Cell Lines for research

Phenotypes From GWAS Catalog for C18orf63 Gene

Phenotypes for C18orf63 Gene

GenomeRNAi human phenotypes for C18orf63:
genes like me logo Genes that share phenotypes with C18orf63: view

Animal Models for research

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C18orf63

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C18orf63 Gene

Localization for C18orf63 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf63 gene
Compartment Confidence
mitochondrion 2
nucleus 1
cytosol 1
golgi apparatus 1
plasma membrane 0
extracellular 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Mitochondria (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf63 Gene

Pathways & Interactions for C18orf63 Gene

PathCards logo

SuperPathways for C18orf63 Gene

No Data Available

Interacting Proteins for C18orf63 Gene

STRING Interaction Network Preview (showing top 5 STRING interactants - click image to see top 25)
STRING Interaction Network
Selected Interacting proteins: ENSP00000464330 Q68DL7-CR063_HUMAN for C18orf63 Gene via STRING IID

GPS-Prot Interaction Network for C18orf63

Gene Ontology (GO) - Biological Process for C18orf63 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C18orf63 Gene

Drugs & Compounds for C18orf63 Gene

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No Compound Related Data Available

Transcripts for C18orf63 Gene

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mRNA/cDNA for C18orf63 Gene

1 REFSEQ mRNAs :
1 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C18orf63

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf63 Gene

No ASD Table

Relevant External Links for C18orf63 Gene

GeneLoc Exon Structure for
C18orf63

Expression for C18orf63 Gene

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mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C18orf63 Gene

mRNA expression in normal human tissues for C18orf63 Gene
mRNA expression by GTEx for C18orf63 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf63 Gene

This gene is overexpressed in Testis (x50.3).

Protein differential expression in normal tissues from HIPED for C18orf63 Gene

This gene is overexpressed in Rectum (18.1), Gallbladder (10.8), Prostate (7.0), and Platelet (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C18orf63 Gene



Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C18orf63

SOURCE GeneReport for Unigene cluster for C18orf63 Gene:

Hs.465414
genes like me logo Genes that share expression patterns with C18orf63: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf63 Gene

Orthologs for C18orf63 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf63 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
 Mammalia C18H18orf63 30
  • 99.08 (n)
C18orf63 31
  • 98 (a)
 OneToOne
Dog
(Canis familiaris)
 Mammalia C1H18orf63 30
  • 82.89 (n)
C18orf63 31
  • 71 (a)
 OneToOne
Cow
(Bos Taurus)
 Mammalia C24H18orf63 30
  • 80.56 (n)
C18orf63 31
  • 68 (a)
 OneToOne
Mouse
(Mus musculus)
 Mammalia Gm17266 30 17
  • 74.78 (n)
Rat
(Rattus norvegicus)
 Mammalia LOC100359752 30
  • 73.95 (n)
Oppossum
(Monodelphis domestica)
 Mammalia C18orf63 31
  • 52 (a)
 OneToOne
Platypus
(Ornithorhynchus anatinus)
 Mammalia C18orf63 31
  • 46 (a)
 OneToOne
Chicken
(Gallus gallus)
 Aves C2H18orf63 30
  • 57.27 (n)
C18orf63 31
  • 39 (a)
 OneToOne
Lizard
(Anolis carolinensis)
 Reptilia C18orf63 31
  • 47 (a)
 OneToOne
Zebrafish
(Danio rerio)
 Actinopterygii C24H18orf63 31
  • 34 (a)
 OneToOne
Species where no ortholog for C18orf63 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)

Evolution for C18orf63 Gene

ENSEMBL:
Gene Tree for C18orf63 (if available)
TreeFam:
Gene Tree for C18orf63 (if available)

Paralogs for C18orf63 Gene

No data available for Paralogs for C18orf63 Gene

Variants for C18orf63 Gene

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dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C18orf63 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C18orf63 Gene

Variant ID Type Subtype PubMed ID
dgv3401n100 CNV gain 25217958
esv2659011 CNV deletion 23128226
esv3643111 CNV loss 21293372
esv3643113 CNV loss 21293372
esv3643114 CNV gain 21293372
nsv1057441 CNV gain 25217958
nsv1065204 CNV loss 25217958
nsv2356 CNV insertion 18451855
nsv819427 CNV loss 19587683

Variation tolerance for C18orf63 Gene

Gene Damage Index Score: 4.13; 61.38% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C18orf63 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C18orf63

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C18orf63 Gene

Disorders for C18orf63 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C18orf63 Gene - From: COP

Disorder Aliases PubMed IDs
ring dermoid of cornea
  • rdc
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C18orf63

Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with C18orf63: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C18orf63 Gene

Publications for C18orf63 Gene

  1. VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation. (PMID: 29507755) Yue Y … Liu J (Cell discovery 2018) 3
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4
  3. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C … Lander ES (Nature 2005) 4

ExternalLinks

View latest publications for C18orf63 gene in Mastermind

Products for C18orf63 Gene

Sources for C18orf63 Gene