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Aliases for C18orf54 Gene

Aliases for C18orf54 Gene

  • Chromosome 18 Open Reading Frame 54 2 3 5
  • Lung Adenoma Susceptibility Protein 2 2 3
  • LAS2 3

External Ids for C18orf54 Gene

Previous GeneCards Identifiers for C18orf54 Gene

  • GC18P050140
  • GC18P051884
  • GC18P048741

Summaries for C18orf54 Gene

GeneCards Summary for C18orf54 Gene

C18orf54 (Chromosome 18 Open Reading Frame 54) is a Protein Coding gene. Diseases associated with C18orf54 include Lung Adenoma.

UniProtKB/Swiss-Prot for C18orf54 Gene

  • Might play a role in cell proliferation.

Additional gene information for C18orf54 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf54 Gene

Genomics for C18orf54 Gene

GeneHancer (GH) Regulatory Elements for C18orf54 Gene

Promoters and enhancers for C18orf54 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J054357 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 650.7 +0.4 447 2.5 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A ZNF2 IRF4 YY1 POLR2B C18orf54 STARD6 POLI MBD2 PIR60000
GH18J054250 Enhancer 1.1 Ensembl ENCODE 16.1 -105.1 -105085 5.5 FOXA2 MLX ARID4B FEZF1 DMAP1 IRF4 ETS1 YY1 ATF7 RUNX3 POLI C18orf54 MBD2 SNORA37 STARD6 GC18P054260
GH18J054259 Enhancer 1.3 FANTOM5 Ensembl ENCODE 10.6 -96.7 -96699 3.5 PKNOX1 FOXA2 ZBTB40 BATF IRF4 EGR1 ATF7 RCOR1 ETV6 FOS GC18P054260 POLI MBD2 SNORA37 C18orf54
GH18J054246 Enhancer 1.1 Ensembl ENCODE dbSUPER 10.3 -110.5 -110546 2.6 FOXA2 EBF1 KMT2B ZNF143 ATF7 IKZF2 RUNX3 SOX5 ZNF687 NANOG POLI MBD2 SNORA37 C18orf54 STARD6 ENSG00000264296 GC18P054260
GH18J054284 Enhancer 1 Ensembl ENCODE 10.8 -72.8 -72761 2.3 PKNOX1 SMAD1 STAT5A BMI1 BATF KLF5 IRF4 ATF7 ETV6 BCLAF1 POLI MBD2 SNORA37 C18orf54 STARD6 GC18M054269 ENSG00000277324
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C18orf54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C18orf54 gene promoter:

Genomic Locations for C18orf54 Gene

Genomic Locations for C18orf54 Gene
27,314 bases
Plus strand

Genomic View for C18orf54 Gene

Genes around C18orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf54 Gene

Proteins for C18orf54 Gene

  • Protein details for C18orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Lung adenoma susceptibility protein 2
    Protein Accession:
    Secondary Accessions:
    • I7HFJ6
    • Q6MZU3
    • Q6ZTL6

    Protein attributes for C18orf54 Gene

    372 amino acids
    Molecular mass:
    41811 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC86570.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf54 Gene


neXtProt entry for C18orf54 Gene

Post-translational modifications for C18orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C18orf54 Gene

Domains & Families for C18orf54 Gene

Gene Families for C18orf54 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C18orf54 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf54: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf54 Gene

Function for C18orf54 Gene

Molecular function for C18orf54 Gene

UniProtKB/Swiss-Prot Function:
Might play a role in cell proliferation.

Gene Ontology (GO) - Molecular Function for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with C18orf54: view
genes like me logo Genes that share phenotypes with C18orf54: view

Animal Model Products

miRNA for C18orf54 Gene

miRTarBase miRNAs that target C18orf54

Clone Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf54 Gene

Localization for C18orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C18orf54 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf54 gene
Compartment Confidence
extracellular 4
nucleus 3
mitochondrion 2
cytosol 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C18orf54: view

Pathways & Interactions for C18orf54 Gene

SuperPathways for C18orf54 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008285 negative regulation of cell proliferation IEA --
genes like me logo Genes that share ontologies with C18orf54: view

No data available for Pathways by source and SIGNOR curated interactions for C18orf54 Gene

Drugs & Compounds for C18orf54 Gene

No Compound Related Data Available

Transcripts for C18orf54 Gene

Unigene Clusters for C18orf54 Gene

Chromosome 18 open reading frame 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf54 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b
SP2: - -

Relevant External Links for C18orf54 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C18orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf54 Gene

mRNA differential expression in normal tissues according to GTEx for C18orf54 Gene

This gene is overexpressed in Testis (x5.8).

NURSA nuclear receptor signaling pathways regulating expression of C18orf54 Gene:


SOURCE GeneReport for Unigene cluster for C18orf54 Gene:

genes like me logo Genes that share expression patterns with C18orf54: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf54 Gene

Orthologs for C18orf54 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf54 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18H18orf54 33
  • 99.31 (n)
C18orf54 34
  • 69 (a)
(Canis familiaris)
Mammalia C1H18orf54 33
  • 86.43 (n)
C18orf54 34
  • 54 (a)
(Mus musculus)
Mammalia 4930503L19Rik 16 34 33
  • 78.44 (n)
(Bos Taurus)
Mammalia C18orf54 34
  • 53 (a)
(Monodelphis domestica)
Mammalia C18orf54 34
  • 35 (a)
(Ornithorhynchus anatinus)
Mammalia C18orf54 34
  • 34 (a)
(Anolis carolinensis)
Reptilia C18orf54 34
  • 31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf54 33
  • 51.6 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.34873 33
(Danio rerio)
Actinopterygii C21H18orf54 34
  • 21 (a)
Species where no ortholog for C18orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf54 Gene

Gene Tree for C18orf54 (if available)
Gene Tree for C18orf54 (if available)

Paralogs for C18orf54 Gene

(4) SIMAP similar genes for C18orf54 Gene using alignment to 2 proteins:

  • J3KS56_HUMAN
genes like me logo Genes that share paralogs with C18orf54: view

No data available for Paralogs for C18orf54 Gene

Variants for C18orf54 Gene

Sequence variations from dbSNP and Humsavar for C18orf54 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000008844 -- 54,381,572(+) A/G 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000032266 -- 54,367,090(+) T/C intron_variant
rs1000124155 -- 54,380,152(+) T/C 3_prime_UTR_variant, intron_variant, non_coding_transcript_variant
rs1000160433 -- 54,357,184(+) A/G upstream_transcript_variant
rs1000249113 -- 54,381,933(+) C/G 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf54 Gene

Variant ID Type Subtype PubMed ID
nsv828245 CNV gain 20364138

Variation tolerance for C18orf54 Gene

Residual Variation Intolerance Score: 88.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.03; 50.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C18orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf54 Gene

Disorders for C18orf54 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C18orf54 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
lung adenoma
  • adenoma of lung
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C18orf54

genes like me logo Genes that share disorders with C18orf54: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C18orf54 Gene

Publications for C18orf54 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 58
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58
  5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3 58

Products for C18orf54 Gene

Sources for C18orf54 Gene

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