Aliases for C18orf25 Gene

Aliases for C18orf25 Gene

  • Chromosome 18 Open Reading Frame 25 2 3 5
  • Uncharacterized Protein C18orf25 3 4
  • ARKadia-Like Protein 1 3 4
  • ARKadia-Like 1 2 3
  • ARKL1 3 4
  • RNF111L1 3
  • Ark2N 3

External Ids for C18orf25 Gene

Previous GeneCards Identifiers for C18orf25 Gene

  • GC18P042049
  • GC18P043753
  • GC18P040611

Summaries for C18orf25 Gene

GeneCards Summary for C18orf25 Gene

C18orf25 (Chromosome 18 Open Reading Frame 25) is a Protein Coding gene. Diseases associated with C18orf25 include La Crosse Encephalitis. An important paralog of this gene is RNF111.

Additional gene information for C18orf25 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C18orf25 Gene

Genomics for C18orf25 Gene

GeneHancer (GH) Regulatory Elements for C18orf25 Gene

Promoters and enhancers for C18orf25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J046172 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 506.6 +0.9 948 3.8 RXRA ZBTB40 ZNF217 CTCF SIN3A NRF1 TCF12 POLR2G SP1 SIX5 C18orf25 HAUS1 ENSG00000267724 EPG5 lnc-ATP5F1A-2
GH18J046199 Enhancer 0.8 ENCODE 20 +26.2 26173 1.4 ZSCAN5C FOS ZNF10 CUX1 CTBP1 FOXA2 OSR2 CEBPG SAP130 FOSL2 C18orf25 lnc-ATP5F1A-4 MF281428-008
GH18J046151 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas 7.5 -17.5 -17453 9.8 JUND PHB2 FOS ZNF10 ZIC2 ZBTB11 AFF1 TARDBP HES1 TOE1 C18orf25 ATP5F1A PSTPIP2 EPG5 RNF165 HSALNG0121307 piR-50443-182
GH18J046211 Enhancer 0.6 ENCODE 13.5 +38.4 38424 1.4 ATF2 MEF2B BATF FOS JUND PRDM6 ZNF664 JUNB JUN ATF7 MF281428-008 C18orf25 lnc-ATP5F1A-4
GH18J046248 Enhancer 1.1 FANTOM5 ENCODE 6.7 +76.5 76463 3.8 ZNF217 ZSCAN5C RBAK JUND ZNF639 EP300 TRIM28 TRIM22 ATF2 ZEB1 PSTPIP2 C18orf25 ATP5F1A EPG5 piR-57460-314 piR-50437-308
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C18orf25 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C18orf25

Top Transcription factor binding sites by QIAGEN in the C18orf25 gene promoter:
  • aMEF-2
  • AML1a
  • CUTL1
  • MEF-2A
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Roaz

Genomic Locations for C18orf25 Gene

Genomic Locations for C18orf25 Gene
93,440 bases
Plus strand
93,437 bases
Plus strand

Genomic View for C18orf25 Gene

Genes around C18orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf25 Gene

Proteins for C18orf25 Gene

  • Protein details for C18orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C18orf25
    Protein Accession:
    Secondary Accessions:
    • A8K123
    • A8KAB6
    • Q5BIX2
    • Q5XG78
    • Q6N058
    • Q86TB5
    • Q8TCQ5

    Protein attributes for C18orf25 Gene

    404 amino acids
    Molecular mass:
    43395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C18orf25 Gene


neXtProt entry for C18orf25 Gene

Post-translational modifications for C18orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf25 Gene

No data available for DME Specific Peptides for C18orf25 Gene

Domains & Families for C18orf25 Gene

Gene Families for C18orf25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C18orf25 Gene

genes like me logo Genes that share domains with C18orf25: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C18orf25 Gene

Function for C18orf25 Gene

Phenotypes From GWAS Catalog for C18orf25 Gene

Gene Ontology (GO) - Molecular Function for C18orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0061630 ubiquitin protein ligase activity IBA 21873635
genes like me logo Genes that share ontologies with C18orf25: view
genes like me logo Genes that share phenotypes with C18orf25: view

Animal Model Products

CRISPR Products

miRNA for C18orf25 Gene

miRTarBase miRNAs that target C18orf25

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf25 Gene

Localization for C18orf25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf25 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 0
cytoskeleton 0
peroxisome 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf25 Gene

Pathways & Interactions for C18orf25 Gene

PathCards logo

SuperPathways for C18orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006511 ubiquitin-dependent protein catabolic process IBA 21873635
GO:0016567 protein ubiquitination IEA --
genes like me logo Genes that share ontologies with C18orf25: view

No data available for Pathways by source and SIGNOR curated interactions for C18orf25 Gene

Drugs & Compounds for C18orf25 Gene

No Compound Related Data Available

Transcripts for C18orf25 Gene

mRNA/cDNA for C18orf25 Gene

15 NCBI additional mRNA sequence :
6 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf25 Gene

No ASD Table

Relevant External Links for C18orf25 Gene

GeneLoc Exon Structure for

Expression for C18orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C18orf25 Gene

Protein differential expression in normal tissues from HIPED for C18orf25 Gene

This gene is overexpressed in Lung (18.2), Testis (17.5), Retina (11.8), Blymphocyte (11.1), and Frontal cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C18orf25 Gene

Protein tissue co-expression partners for C18orf25 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C18orf25

SOURCE GeneReport for Unigene cluster for C18orf25 Gene:


Evidence on tissue expression from TISSUES for C18orf25 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
  • Muscle(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with C18orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf25 Gene

Orthologs for C18orf25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18orf25 31
  • 100 (a)
C18H18orf25 30
  • 99.59 (n)
(Canis familiaris)
Mammalia C18orf25 31
  • 98 (a)
C7H18orf25 30
  • 95.46 (n)
(Bos Taurus)
Mammalia C24H18orf25 31
  • 97 (a)
(Mus musculus)
Mammalia 8030462N17Rik 17 31 30
  • 92.23 (n)
(Monodelphis domestica)
Mammalia C18orf25 31
  • 91 (a)
(Rattus norvegicus)
Mammalia RGD1308601 30
  • 90.56 (n)
(Ornithorhynchus anatinus)
Mammalia C18orf25 31
  • 90 (a)
(Gallus gallus)
Aves -- 31
  • 86 (a)
CZH18ORF25 30
  • 82.38 (n)
-- 31
  • 56 (a)
(Anolis carolinensis)
Reptilia C18orf25 31
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf25 30
  • 74.01 (n)
Str.15922 30
African clawed frog
(Xenopus laevis)
Amphibia mgc12909-prov 30
(Danio rerio)
Actinopterygii zgc:77838 30
  • 58.06 (n)
C21H18orf25 31
  • 50 (a)
Species where no ortholog for C18orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf25 Gene

Gene Tree for C18orf25 (if available)
Gene Tree for C18orf25 (if available)

Paralogs for C18orf25 Gene

Paralogs for C18orf25 Gene

(1) SIMAP similar genes for C18orf25 Gene using alignment to 3 proteins:

  • CR025_HUMAN
  • K7ER64_HUMAN Pseudogenes for C18orf25 Gene

genes like me logo Genes that share paralogs with C18orf25: view

Variants for C18orf25 Gene

Additional dbSNP identifiers (rs#s) for C18orf25 Gene

Structural Variations from Database of Genomic Variants (DGV) for C18orf25 Gene

Variant ID Type Subtype PubMed ID
esv2675609 CNV deletion 23128226
esv3309689 CNV mobile element insertion 20981092
esv3350079 CNV insertion 20981092
esv3555318 CNV deletion 23714750
esv3642420 CNV gain 21293372
esv3642424 CNV gain 21293372
esv3642429 CNV loss 21293372
nsv1064031 CNV gain 25217958
nsv1110718 CNV insertion 24896259
nsv2278 CNV insertion 18451855
nsv953535 CNV duplication 24416366
nsv960275 CNV duplication 23825009

Variation tolerance for C18orf25 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C18orf25 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C18orf25 Gene

Disorders for C18orf25 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C18orf25 Gene - From: DISEASES

Disorder Aliases PubMed IDs
la crosse encephalitis
  • california encephalitis
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C18orf25

genes like me logo Genes that share disorders with C18orf25: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C18orf25 Gene

Publications for C18orf25 Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard BS … Muir WJ (Psychiatric genetics 2005) 2 3 4 54
  2. Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2. (PMID: 24216761) Cao JY … Frappier L (Molecular and cellular biology 2014) 2 3 54
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 54
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  5. The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. (PMID: 29845934) Faust TB … Frankel AD (eLife 2018) 3 54

Products for C18orf25 Gene

Sources for C18orf25 Gene