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Aliases for C18orf25 Gene

Aliases for C18orf25 Gene

  • Chromosome 18 Open Reading Frame 25 2 3 5
  • Uncharacterized Protein C18orf25 3 4
  • ARKadia-Like Protein 1 3 4
  • ARKadia-Like 1 2 3
  • ARKL1 3 4
  • RNF111L1 3
  • Ark2N 3

External Ids for C18orf25 Gene

Previous GeneCards Identifiers for C18orf25 Gene

  • GC18P042049
  • GC18P043753
  • GC18P040611

Summaries for C18orf25 Gene

GeneCards Summary for C18orf25 Gene

C18orf25 (Chromosome 18 Open Reading Frame 25) is a Protein Coding gene. An important paralog of this gene is RNF111.

Additional gene information for C18orf25 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf25 Gene

Genomics for C18orf25 Gene

GeneHancer (GH) Regulatory Elements for C18orf25 Gene

Promoters and enhancers for C18orf25 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J046172 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 606.6 +0.8 848 3.2 ZNF652 SP1 ZFX CTCF ELF3 NKRF POLR2A GTF2F1 ZNF687 ZSCAN21 C18orf25 HAUS1 EPG5 ENSG00000267724 GC18P046277
GH18J046199 Enhancer 0.9 ENCODE 20 +26.2 26173 1.4 ELF3 ZNF121 CEBPG BACH1 PPARG PRDM1 SMARCA4 KAT8 DPF2 CEBPA C18orf25 GC18P046277
GH18J046211 Enhancer 0.6 ENCODE 13.4 +38.4 38424 1.4 PRDM1 ATF7 ZNF629 ZSCAN29 RUNX3 ATF2 JUNB BATF JUND JUN C18orf25 GC18P046277
GH18J046204 Enhancer 0.5 ENCODE 17.7 +31.2 31229 1 SCRT2 RUNX3 SCRT1 FEZF1 C18orf25 GC18P046277
GH18J046248 Enhancer 1.2 FANTOM5 ENCODE 6.7 +76.5 76463 3.8 ZSCAN21 JUND SP7 CREM PRDM1 MLLT1 IKZF1 CREB1 ZNF600 PRDM10 ENSG00000267724 IER3IP1 PSTPIP2 C18orf25 ATP5F1A EPG5 GC18P046277
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C18orf25 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C18orf25 gene promoter:
  • aMEF-2
  • AML1a
  • CUTL1
  • MEF-2A
  • Nkx2-5
  • POU2F1
  • POU2F1a
  • Roaz

Genomic Locations for C18orf25 Gene

Genomic Locations for C18orf25 Gene
93,440 bases
Plus strand
93,437 bases
Plus strand

Genomic View for C18orf25 Gene

Genes around C18orf25 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf25 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf25 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf25 Gene

Proteins for C18orf25 Gene

  • Protein details for C18orf25 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C18orf25
    Protein Accession:
    Secondary Accessions:
    • A8K123
    • A8KAB6
    • Q5BIX2
    • Q5XG78
    • Q6N058
    • Q86TB5
    • Q8TCQ5

    Protein attributes for C18orf25 Gene

    404 amino acids
    Molecular mass:
    43395 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C18orf25 Gene


neXtProt entry for C18orf25 Gene

Post-translational modifications for C18orf25 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C18orf25 Gene

No data available for DME Specific Peptides for C18orf25 Gene

Domains & Families for C18orf25 Gene

Gene Families for C18orf25 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C18orf25 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C18orf25: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C18orf25 Gene

Function for C18orf25 Gene

Phenotypes From GWAS Catalog for C18orf25 Gene

Gene Ontology (GO) - Molecular Function for C18orf25 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C18orf25: view
genes like me logo Genes that share phenotypes with C18orf25: view

Animal Model Products

CRISPR Products

miRNA for C18orf25 Gene

miRTarBase miRNAs that target C18orf25

Clone Products

  • Applied Biological Materials (abm): Clones for C18orf25 - Now 50% OFF >
  • * C18orf25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C18orf25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf25 Gene

Localization for C18orf25 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf25 gene
Compartment Confidence
nucleus 3
cytosol 2
extracellular 0
cytoskeleton 0
peroxisome 0
endoplasmic reticulum 0
golgi apparatus 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf25 Gene

Pathways & Interactions for C18orf25 Gene

PathCards logo

SuperPathways for C18orf25 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf25 Gene


No data available for Pathways by source and SIGNOR curated interactions for C18orf25 Gene

Drugs & Compounds for C18orf25 Gene

No Compound Related Data Available

Transcripts for C18orf25 Gene

mRNA/cDNA for C18orf25 Gene

Unigene Clusters for C18orf25 Gene

Chromosome 18 open reading frame 25:
Representative Sequences:

CRISPR Products

Clone Products

  • Applied Biological Materials (abm): Clones for C18orf25 - Now 50% OFF >
  • * C18orf25 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
  • * C18orf25 tags and reporters available: His, HA, Myc, Flag, GFP, RFP, Luciferase - Browse All

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf25 Gene

No ASD Table

Relevant External Links for C18orf25 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C18orf25 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf25 Gene

Protein differential expression in normal tissues from HIPED for C18orf25 Gene

This gene is overexpressed in Lung (18.2), Testis (17.5), Retina (11.8), Blymphocyte (11.1), and Frontal cortex (6.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C18orf25 Gene

Protein tissue co-expression partners for C18orf25 Gene

NURSA nuclear receptor signaling pathways regulating expression of C18orf25 Gene:


SOURCE GeneReport for Unigene cluster for C18orf25 Gene:


Evidence on tissue expression from TISSUES for C18orf25 Gene

  • Nervous system(4.3)
  • Lung(4.2)
  • Lymph node(4.2)
  • Muscle(4.2)
  • Eye(4.1)
genes like me logo Genes that share expression patterns with C18orf25: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf25 Gene

Orthologs for C18orf25 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf25 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18orf25 35
  • 100 (a)
C18H18orf25 34
  • 99.59 (n)
(Canis familiaris)
Mammalia C18orf25 35
  • 98 (a)
C7H18orf25 34
  • 95.46 (n)
(Bos Taurus)
Mammalia C24H18orf25 35
  • 97 (a)
(Mus musculus)
Mammalia 8030462N17Rik 17 35 34
  • 92.23 (n)
(Monodelphis domestica)
Mammalia C18orf25 35
  • 91 (a)
(Rattus norvegicus)
Mammalia RGD1308601 34
  • 90.56 (n)
(Ornithorhynchus anatinus)
Mammalia C18orf25 35
  • 90 (a)
(Gallus gallus)
Aves -- 35
  • 86 (a)
CZH18ORF25 34
  • 82.38 (n)
-- 35
  • 56 (a)
(Anolis carolinensis)
Reptilia C18orf25 35
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf25 34
  • 74.01 (n)
Str.15922 34
African clawed frog
(Xenopus laevis)
Amphibia mgc12909-prov 34
(Danio rerio)
Actinopterygii zgc:77838 34
  • 58.06 (n)
C21H18orf25 35
  • 50 (a)
Species where no ortholog for C18orf25 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf25 Gene

Gene Tree for C18orf25 (if available)
Gene Tree for C18orf25 (if available)

Paralogs for C18orf25 Gene

Paralogs for C18orf25 Gene

(1) SIMAP similar genes for C18orf25 Gene using alignment to 3 proteins:

  • CR025_HUMAN
  • K7ER64_HUMAN Pseudogenes for C18orf25 Gene

genes like me logo Genes that share paralogs with C18orf25: view

Variants for C18orf25 Gene

Sequence variations from dbSNP and Humsavar for C18orf25 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000039705 -- 46,172,436(+) G/A upstream_transcript_variant
rs1000088452 -- 46,249,990(+) C/T intron_variant
rs1000095526 -- 46,258,083(+) T/C intron_variant
rs1000113210 -- 46,200,688(+) T/C intron_variant
rs1000130261 -- 46,207,056(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf25 Gene

Variant ID Type Subtype PubMed ID
esv2675609 CNV deletion 23128226
esv3309689 CNV mobile element insertion 20981092
esv3350079 CNV insertion 20981092
esv3555318 CNV deletion 23714750
esv3642420 CNV gain 21293372
esv3642424 CNV gain 21293372
esv3642429 CNV loss 21293372
nsv1064031 CNV gain 25217958
nsv1110718 CNV insertion 24896259
nsv2278 CNV insertion 18451855
nsv953535 CNV duplication 24416366
nsv960275 CNV duplication 23825009

Variation tolerance for C18orf25 Gene

Residual Variation Intolerance Score: 26.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.29; 40.98% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C18orf25 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf25 Gene

Disorders for C18orf25 Gene

Additional Disease Information for C18orf25

No disorders were found for C18orf25 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf25 Gene

Publications for C18orf25 Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard BS … Muir WJ (Psychiatric genetics 2005) 2 3 4 58
  2. Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2. (PMID: 24216761) Cao JY … Frappier L (Molecular and cellular biology 2014) 2 3 58
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Comparative Protein Interaction Network Analysis Identifies Shared and Distinct Functions for the Human ROCO Proteins. (PMID: 29513927) Tomkins JE … Manzoni C (Proteomics 2018) 3 58

Products for C18orf25 Gene

Sources for C18orf25 Gene

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