Free for academic non-profit institutions. Other users need a Commercial license
Aliases for C18orf21 Gene
Aliases for C18orf21 Gene
External Ids for C18orf21 Gene
- HGNC: 28802
- Entrez Gene: 83608
- Ensembl: ENSG00000141428
- UniProtKB: Q32NC0
Previous GeneCards Identifiers for C18orf21 Gene
- GC18P031805
- GC18P031806
- GC18P033552
- GC18P030411
Summaries for C18orf21 Gene
GeneCards Summary for C18orf21 Gene
C18orf21 (Chromosome 18 Open Reading Frame 21) is a Protein Coding gene.
Additional gene information for C18orf21 Gene
- HGNC(28802)
- Entrez Gene(83608)
- Ensembl(ENSG00000141428)
- UniProtKB(Q32NC0)
- Open Targets Platform(ENSG00000141428)
- Monarch Initiative
- Search for C18orf21 at DataMed
- Search for C18orf21 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C18orf21 Gene
Genomics for C18orf21 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for C18orf21 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around C18orf21 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C18orf21
- Top Transcription factor binding sites by QIAGEN in the C18orf21 gene promoter:
-
- AhR
- Arnt
- Evi-1
- GATA-1
- NF-E2
- NF-E2 p45
- Nkx2-2
- Pax-4a
- RP58
- YY1
Genomic Locations for C18orf21 Gene
Genomic Locations for C18orf21 Gene
- chr18:35,971,878-35,979,287
- (GRCh38/hg38)
- Size:
- 7,410 bases
- Orientation:
- Plus strand
- chr18:33,552,046-33,559,250
- (GRCh37/hg19)
- Size:
- 7,205 bases
- Orientation:
- Plus strand
Genomic View for C18orf21 Gene
Genes around C18orf21 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 18q12.2 by HGNC
- 18q12.2 by Entrez Gene
- 18q12.2 by Ensembl
C18orf21 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C18orf21 Gene
Proteins for C18orf21 Gene
-
Protein details for C18orf21 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q32NC0-CR021_HUMAN
- Recommended name:
- UPF0711 protein C18orf21
- Protein Accession:
- Q32NC0
- Q6GW03
- Q9BXV6
- Q9BXW2
Protein attributes for C18orf21 Gene
- Size:
- 220 amino acids
- Molecular mass:
- 24827 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07547.1; Type=Frameshift; Evidence={ECO:0000305};
Protein Expression for C18orf21 Gene
Post-translational modifications for C18orf21 Gene
Other Protein References for C18orf21 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C18orf21
- Invitrogen Antibodies for C18orf21 (AFLGC-C18orf21)
- antibodies-online: Show 7 available C18ORF21 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for C18orf21
- Search Origene for MassSpec and Protein Over-expression Lysates for C18orf21
- Origene Custom Protein Services for C18orf21
- Novus Biologicals proteins for C18orf21
No data available for DME Specific Peptides for C18orf21 Gene
Domains & Families for C18orf21 Gene
Gene Families for C18orf21 Gene
- Human Protein Atlas (HPA):
-
- Predicted intracellular proteins
Suggested Antigen Peptide Sequences for C18orf21 Gene
- GenScript: Design optimal peptide antigens:
-
- HBV XAg-transactivated protein 13 (CR021_HUMAN)
- C18orf21 protein (Q8TBS0_HUMAN)
Graphical View of Domain Structure for InterPro Entry
Q32NC0- Family:
-
- Belongs to the UPF0711 family.
Function for C18orf21 Gene
Phenotypes From GWAS Catalog for C18orf21 Gene
Phenotypes for C18orf21 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C18orf21 - Select products 50% OFF >
- * C18orf21 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C18orf21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C18orf21
-
Santa Cruz Biotechnology (SCBT) CRISPR for C18orf21
miRNA for C18orf21 Gene
- miRTarBase miRNAs that target C18orf21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C18orf21
- Browse OriGene Inhibitory RNA Products For C18orf21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C18orf21
Clone Products
- Applied Biological Materials (abm): Clones for C18orf21 - Select products 50% OFF >
- * C18orf21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C18orf21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C18orf21
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf21 Gene
Localization for C18orf21 Gene
| Compartment | Confidence |
|---|---|
| nucleus | 2 |
| extracellular | 1 |
| mitochondrion | 0 |
| golgi apparatus | 0 |
- Nucleoli (2)
- Plasma membrane (2)
No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf21 Gene
Pathways & Interactions for C18orf21 Gene
Interacting Proteins for C18orf21 Gene
GPS-Prot Interaction Network for C18orf21
No data available for Pathways by source and SIGNOR curated interactions for C18orf21 Gene
Transcripts for C18orf21 Gene
mRNA/cDNA for C18orf21 Gene
- 4 REFSEQ mRNAs :
- 12 NCBI additional mRNA sequence :
- 8 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000592875 985 nts (view in UCSC)
- ENST00000269194 703 nts (view in UCSC)
- ENST00000587719 581 nts (view in UCSC)
- ENST00000587873 656 nts (view in UCSC)
- ENST00000593210 185 nts (view in UCSC)
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C18orf21 - Select products 50% OFF >
- * C18orf21 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C18orf21
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C18orf21
-
Santa Cruz Biotechnology (SCBT) CRISPR for C18orf21
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C18orf21
- Browse OriGene Inhibitory RNA Products For C18orf21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C18orf21
Clone Products
- Applied Biological Materials (abm): Clones for C18orf21 - Select products 50% OFF >
- * C18orf21 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C18orf21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C18orf21
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | · | 6d |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | ||||||||||||||||||
| SP2: | - | - | |||||||||||||||||||
| SP3: | |||||||||||||||||||||
| SP4: | - | ||||||||||||||||||||
| SP5: | - |
Relevant External Links for C18orf21 Gene
- GeneLoc Exon Structure for
- C18orf21
Expression for C18orf21 Gene
This gene is overexpressed in Lung (40.0) and Peripheral blood mononuclear cells (20.0).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C18orf21 Gene
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C18orf21
SOURCE GeneReport for Unigene cluster for C18orf21 Gene:
Hs.37883Primer Products
-
OriGene qPCR primer pairs for C18orf21
-
OriGene qPCR primer pairs and template standards for C18orf21
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf21 Gene
Orthologs for C18orf21 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C18H18orf21 30 |
|
||
| C18ORF21 31 |
|
OneToOne | |||
| Cow (Bos Taurus) |
Mammalia | C24H18orf21 30 |
|
||
| C18orf21 31 |
|
OneToOne | |||
| Dog (Canis familiaris) |
Mammalia | C7H18orf21 30 |
|
||
| C18orf21 31 |
|
OneToOne | |||
| Mouse (Mus musculus) |
Mammalia | 2700062C07Rik 30 17 31 |
|
OneToOne | |
| Gm9182 17 |
|
|
|||
| Rat (Rattus norvegicus) |
Mammalia | MGC116121 30 |
|
||
| Oppossum (Monodelphis domestica) |
Mammalia | -- 31 |
|
OneToMany | |
| -- 31 |
|
OneToMany | |||
| Platypus (Ornithorhynchus anatinus) |
Mammalia | C18orf21 31 |
|
OneToOne | |
| Chicken (Gallus gallus) |
Aves | C18ORF21 30 |
|
||
| C18orf21 31 |
|
OneToOne | |||
| Lizard (Anolis carolinensis) |
Reptilia | C18orf21 31 |
|
OneToOne | |
| Tropical Clawed Frog (Silurana tropicalis) |
Amphibia | c18orf21 30 |
|
||
| Zebrafish (Danio rerio) |
Actinopterygii | si:dkey-184p18.2 30 |
|
||
| C19H18orf21 (2 of 2) 31 |
|
OneToMany | |||
| C19H18orf21 (1 of 2) 31 |
|
OneToMany |
- Species where no ortholog for C18orf21 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Rainbow Trout (Oncorhynchus mykiss)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
Paralogs for C18orf21 Gene
Pseudogenes.org Pseudogenes for C18orf21 Gene
No data available for Paralogs for C18orf21 Gene
Variants for C18orf21 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C18orf21 Gene
| SNP ID | Clinical significance and condition | Chr 18 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs2276314 | - | p.Thr132Ala |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| nsv1065113 | CNV | loss | 25217958 |
Residual Variation Intolerance Score:
67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.24;
24.75% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C18orf21 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C18orf21
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf21 Gene
Disorders for C18orf21 Gene
Additional Disease Information for C18orf21
No disorders were found for C18orf21 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf21 Gene
Publications for C18orf21 Gene
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3
- Quantitative mapping of RNA-mediated nuclear estrogen receptor β interactome in human breast cancer cells. (PMID: 29509190) Giurato G … Tarallo R (Scientific data 2018) 3
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
- The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3
ExternalLinks
Products for C18orf21 Gene
- Browse OriGene Antibodies
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C18orf21
- Search Origene for MassSpec and Protein Over-expression Lysates for C18orf21
- Origene Custom Protein Services for C18orf21
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C18orf21
- Browse OriGene Inhibitory RNA Products For C18orf21
- OriGene qPCR primer pairs for C18orf21
- OriGene qPCR primer pairs and template standards for C18orf21
- OriGene CRISPR knockouts for C18orf21
- OriGene ORF clones in human for C18orf21
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C18orf21
- Sino Biological Human cDNA Clone for C18orf21
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse cDNA Clones
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals Antibodies for C18orf21
- Novus Biologicals proteins for C18orf21
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- Invitrogen Antibodies for C18orf21 (AFLGC-C18orf21)
- VectorBuilder Custom and pre-made DNA vectors for C18orf21 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for C18orf21 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for C18orf21 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for C18orf21 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for C18orf21
- antibodies-online: Show 7 available C18ORF21 Antibodies ranked by validation data
- antibodies-online: Search results for available C18ORF21 related products ranked by validation data
- antibodies-online: Search results for available C18ORF21 related products ranked by validation data
- Browse Santa Cruz Biotechnology (SCBT) Antibodies
- Search Santa Cruz Biotechnology (SCBT) for C18orf21 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for C18orf21
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C18orf21
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C18orf21
- Search GeneCopoeia for miRNA 3'UTR Target clone products for C18orf21
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C18orf21
Sources for C18orf21 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB