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Aliases for C18orf21 Gene

Aliases for C18orf21 Gene

  • Chromosome 18 Open Reading Frame 21 2 3 5
  • HBV X-Transactivated Gene 13 Protein 3 4
  • HBV XAg-Transactivated Protein 13 3 4
  • XTP13 3 4
  • HBV X-Transactivated Protein 13 3
  • UPF0711 Protein C18orf21 3
  • PNAS-124 3
  • PNAS-131 3
  • HsT3108 3

External Ids for C18orf21 Gene

Previous GeneCards Identifiers for C18orf21 Gene

  • GC18P031805
  • GC18P031806
  • GC18P033552
  • GC18P030411

Summaries for C18orf21 Gene

GeneCards Summary for C18orf21 Gene

C18orf21 (Chromosome 18 Open Reading Frame 21) is a Protein Coding gene.

Additional gene information for C18orf21 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C18orf21 Gene

Genomics for C18orf21 Gene

GeneHancer (GH) Regulatory Elements for C18orf21 Gene

Promoters and enhancers for C18orf21 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH18J035967 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 661.1 -1.2 -1225 5.8 MLX DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 ZNF610 GLIS1 C18orf21 LOC105372066 ENSG00000278986 ENSG00000268573 ZNF397 ELP2 RPRD1A GC18M035972 GC18P035965
GH18J035495 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 20.3 -475.0 -475038 3.1 CLOCK MLX FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF416 INO80C ENSG00000267140 ENSG00000268573 ZNF397 ELP2 ZSCAN30 RPRD1A C18orf21 ZNF271P ZNF396
GH18J035289 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 12.6 -681.8 -681789 2.3 MLX ZFP64 DMAP1 YY1 E2F8 ZNF143 SP3 ZNF610 NBN NR2C1 ENSG00000268573 ZSCAN30 ZNF271P ZNF397 C18orf21 ZNF24 GC18M035301 PIR53427
GH18J035037 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 9.8 -931.1 -931086 6.6 HDGF PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MAPRE2 ENSG00000268573 ZNF397 ENSG00000267583 C18orf21 ENSG00000267397 ZNF24 ENSG00000280096
GH18J034976 Promoter/Enhancer 2.1 FANTOM5 Ensembl ENCODE dbSUPER 9.8 -994.1 -994058 3.9 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 MAPRE2 ENSG00000268573 ZNF397 ENSG00000267583 C18orf21 ZNF396 ZNF24 ENSG00000280096
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C18orf21 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C18orf21 gene promoter:
  • GATA-1
  • YY1
  • RP58
  • Pax-4a
  • NF-E2
  • NF-E2 p45
  • Nkx2-2
  • Arnt
  • AhR
  • Evi-1

Genomic Locations for C18orf21 Gene

Genomic Locations for C18orf21 Gene
7,205 bases
Plus strand
7,205 bases
Plus strand

Genomic View for C18orf21 Gene

Genes around C18orf21 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C18orf21 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C18orf21 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C18orf21 Gene

Proteins for C18orf21 Gene

  • Protein details for C18orf21 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0711 protein C18orf21
    Protein Accession:
    Secondary Accessions:
    • Q6GW03
    • Q9BXV6
    • Q9BXW2

    Protein attributes for C18orf21 Gene

    220 amino acids
    Molecular mass:
    24827 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK07541.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAK07547.1; Type=Frameshift; Positions=216; Evidence={ECO:0000305};

    Alternative splice isoforms for C18orf21 Gene


neXtProt entry for C18orf21 Gene

Post-translational modifications for C18orf21 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C18orf21 Gene

Domains & Families for C18orf21 Gene

Gene Families for C18orf21 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C18orf21 Gene


Suggested Antigen Peptide Sequences for C18orf21 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0711 family.
  • Belongs to the UPF0711 family.
genes like me logo Genes that share domains with C18orf21: view

Function for C18orf21 Gene

Phenotypes From GWAS Catalog for C18orf21 Gene

Phenotypes for C18orf21 Gene

genes like me logo Genes that share phenotypes with C18orf21: view

Animal Model Products

miRNA for C18orf21 Gene

miRTarBase miRNAs that target C18orf21

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C18orf21 Gene

Localization for C18orf21 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C18orf21 gene
Compartment Confidence
nucleus 2
extracellular 1
mitochondrion 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (2)
  • Plasma membrane (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C18orf21 Gene

Pathways & Interactions for C18orf21 Gene

SuperPathways for C18orf21 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C18orf21 Gene


No data available for Pathways by source and SIGNOR curated interactions for C18orf21 Gene

Drugs & Compounds for C18orf21 Gene

No Compound Related Data Available

Transcripts for C18orf21 Gene

Unigene Clusters for C18orf21 Gene

Chromosome 18 open reading frame 21:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C18orf21 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d
SP1: - - -
SP2: - -
SP4: -
SP5: -

Relevant External Links for C18orf21 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C18orf21 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C18orf21 Gene

Protein differential expression in normal tissues from HIPED for C18orf21 Gene

This gene is overexpressed in Lung (40.0) and Peripheral blood mononuclear cells (20.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C18orf21 Gene

Protein tissue co-expression partners for C18orf21 Gene

NURSA nuclear receptor signaling pathways regulating expression of C18orf21 Gene:


SOURCE GeneReport for Unigene cluster for C18orf21 Gene:

genes like me logo Genes that share expression patterns with C18orf21: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C18orf21 Gene

Orthologs for C18orf21 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C18orf21 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C18H18orf21 33
  • 99.69 (n)
C18ORF21 34
  • 99 (a)
(Bos Taurus)
Mammalia C24H18orf21 33
  • 88.73 (n)
C18orf21 34
  • 85 (a)
(Canis familiaris)
Mammalia C7H18orf21 33
  • 87.48 (n)
C18orf21 34
  • 84 (a)
(Mus musculus)
Mammalia 2700062C07Rik 34 33
  • 79.28 (n)
Gm9182 16
(Rattus norvegicus)
Mammalia MGC116121 33
  • 79.28 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C18orf21 34
  • 49 (a)
(Gallus gallus)
Aves C18ORF21 33
  • 60.79 (n)
C18orf21 34
  • 48 (a)
(Anolis carolinensis)
Reptilia C18orf21 34
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c18orf21 33
  • 54.07 (n)
(Danio rerio)
Actinopterygii si:dkey-184p18.2 33
  • 46.14 (n)
C19H18orf21 (2 of 2) 34
  • 33 (a)
C19H18orf21 (1 of 2) 34
  • 33 (a)
Species where no ortholog for C18orf21 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C18orf21 Gene

Gene Tree for C18orf21 (if available)
Gene Tree for C18orf21 (if available)

Paralogs for C18orf21 Gene Pseudogenes for C18orf21 Gene

genes like me logo Genes that share paralogs with C18orf21: view

No data available for Paralogs for C18orf21 Gene

Variants for C18orf21 Gene

Sequence variations from dbSNP and Humsavar for C18orf21 Gene

SNP ID Clin Chr 18 pos Variation AA Info Type
rs1000292167 -- 35,976,370(+) C/T intron_variant
rs1000738221 -- 35,973,643(+) A/G intron_variant
rs1000980384 -- 35,977,660(+) G/A/C intron_variant
rs1001521634 -- 35,974,866(+) G/A intron_variant
rs1002286945 -- 35,970,876(+) C/T upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C18orf21 Gene

Variant ID Type Subtype PubMed ID
nsv1065113 CNV loss 25217958

Variation tolerance for C18orf21 Gene

Residual Variation Intolerance Score: 67.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.75% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C18orf21 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C18orf21 Gene

Disorders for C18orf21 Gene

Additional Disease Information for C18orf21

No disorders were found for C18orf21 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C18orf21 Gene

Publications for C18orf21 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58

Products for C18orf21 Gene

Sources for C18orf21 Gene

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