Aliases for C17orf97 Gene

Aliases for C17orf97 Gene

  • Chromosome 17 Open Reading Frame 97 2 3 5
  • Ligand Of ATE1 Protein 3 4
  • Protein LIAT1 3 4
  • LIAT1 2 3
  • Ligand Of ATE1 2
  • LOC400566 2
  • C17orf97 5
  • CK20 3

External Ids for C17orf97 Gene

Previous GeneCards Identifiers for C17orf97 Gene

  • GC17P000261

Summaries for C17orf97 Gene

GeneCards Summary for C17orf97 Gene

C17orf97 (Chromosome 17 Open Reading Frame 97) is a Protein Coding gene.

UniProtKB/Swiss-Prot Summary for C17orf97 Gene

Additional gene information for C17orf97 Gene

No data available for Entrez Gene Summary , CIViC Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C17orf97 Gene

Genomics for C17orf97 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C17orf97 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J000409 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE CraniofacialAtlas 700.5 +1.9 1876 6 CTCF RFX1 IKZF1 KDM1A ZNF692 POLR2A ZNF143 PHF21A ZIC2 ZSCAN4 C17orf97 ENSG00000241525 LOC105371430 RFLNB
GH17J000415 Promoter/Enhancer 1 Ensembl ENCODE 50.8 +6.2 6151 2.5 SP1 LARP7 STAT3 ZSCAN4 IKZF2 POLR2A YY1 ZNF37A EED DPF2 C17orf97 ENSG00000241525 LOC105371430 RF00017-2196 RFLNB
GH17J000385 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas dbSUPER 14 -24.4 -24424 1.8 ZBTB33 KDM1A CTCF BACH1 LARP7 ZNF143 ZIC2 RBFOX2 RXRB PATZ1 RPH3AL C17orf97 DOC2B piR-33303-072
GH17J000418 Promoter/Enhancer 1 Ensembl ENCODE 33.6 +9.0 8952 2.5 GATAD2A ZNF512 PRDM1 RXRB CEBPA SOX13 NFE2 FOXA2 EP300 FOXP1 C17orf97 ENSG00000241525 LOC105371430 RF00017-2196 RFLNB
GH17J000599 Enhancer 1.5 FANTOM5 Ensembl ENCODE CraniofacialAtlas 11.8 +192.3 192276 6 RFX1 LEF1 IKZF1 JUND DDX20 PKNOX1 MTA1 DPF2 HDAC1 SOX6 VPS53 RFLNB GEMIN4 ENSG00000241525 C17orf97 TLCD3A piR-54764-255 ENSG00000262708 lnc-FAM57A-6 RF00017-2197
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C17orf97 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C17orf97

Top Transcription factor binding sites by QIAGEN in the C17orf97 gene promoter:
  • c-Myb
  • CUTL1
  • FOXC1
  • FOXJ2
  • FOXJ2 (long isoform)
  • GATA-1
  • HFH-1
  • NCX
  • Nkx2-2

Genomic Locations for C17orf97 Gene

Genomic Locations for C17orf97 Gene
chr17:410,325-431,062
(GRCh38/hg38)
Size:
20,738 bases
Orientation:
Plus strand
chr17:260,118-273,510
(GRCh37/hg19)
Size:
13,393 bases
Orientation:
Plus strand

Genomic View for C17orf97 Gene

Genes around C17orf97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf97 Gene

Proteins for C17orf97 Gene

  • Protein details for C17orf97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQX7-LIAT1_HUMAN
    Recommended name:
    Protein LIAT1
    Protein Accession:
    Q6ZQX7
    Secondary Accessions:
    • A5D8T6
    • Q6NSI2
    • Q6PFW9

    Protein attributes for C17orf97 Gene

    Size:
    453 amino acids
    Molecular mass:
    49656 Da
    Quaternary structure:
    • Interacts with ATE1; it is not a substrate of LIAT1. Interacts with JMJD6 and MRPS14 (By similarity).

    Alternative splice isoforms for C17orf97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C17orf97 Gene

Post-translational modifications for C17orf97 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf97 Gene

No data available for DME Specific Peptides for C17orf97 Gene

Domains & Families for C17orf97 Gene

Gene Families for C17orf97 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C17orf97 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q6ZQX7

UniProtKB/Swiss-Prot:

LIAT1_HUMAN :
  • LIAT1 proteins of some primates, from macaques to humans, contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins of other mammals contain a single copy of this motif. Quantities of these repeats are, in general, different in LIAT1 of different primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, respectively.
Domain:
  • LIAT1 proteins of some primates, from macaques to humans, contain tandem repeats of a 10-residue sequence, whereas LIAT1 proteins of other mammals contain a single copy of this motif. Quantities of these repeats are, in general, different in LIAT1 of different primates. For example, there are 1, 4, 13, 13, 17, and 17 repeats in the gibbon, gorilla, orangutan, bonobo, neanderthal, and human LIAT1, respectively.
genes like me logo Genes that share domains with C17orf97: view

No data available for Suggested Antigen Peptide Sequences for C17orf97 Gene

Function for C17orf97 Gene

Molecular function for C17orf97 Gene

UniProtKB/Swiss-Prot Function:
May be involved in ATE1-mediated N-terminal arginylation.

Phenotypes From GWAS Catalog for C17orf97 Gene

Phenotypes for C17orf97 Gene

genes like me logo Genes that share phenotypes with C17orf97: view

Animal Models for C17orf97 Gene

MGI Knock Outs for C17orf97:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf97

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C17orf97 Gene

Localization for C17orf97 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf97 gene
Compartment Confidence
nucleus 3
cytosol 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf97 Gene

Pathways & Interactions for C17orf97 Gene

PathCards logo

SuperPathways for C17orf97 Gene

No Data Available

Interacting Proteins for C17orf97 Gene

Selected Interacting proteins: Q6ZQX7-LIAT1_HUMAN for C17orf97 Gene via MINT IID

Symbol External ID(s) Details
JMJD6

Gene Ontology (GO) - Biological Process for C17orf97 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016598 protein arginylation IEA,ISS --
genes like me logo Genes that share ontologies with C17orf97: view

No data available for Pathways by source and SIGNOR curated interactions for C17orf97 Gene

Drugs & Compounds for C17orf97 Gene

No Compound Related Data Available

Transcripts for C17orf97 Gene

mRNA/cDNA for C17orf97 Gene

1 REFSEQ mRNAs :
6 NCBI additional mRNA sequence :
5 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf97

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf97 Gene

No ASD Table

Relevant External Links for C17orf97 Gene

GeneLoc Exon Structure for
C17orf97

Expression for C17orf97 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C17orf97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Lung (Respiratory System)

mRNA differential expression in normal tissues according to GTEx for C17orf97 Gene

This gene is overexpressed in Testis (x11.8).

Protein differential expression in normal tissues from HIPED for C17orf97 Gene

This gene is overexpressed in Testis (35.3), Ovary (19.2), and Blymphocyte (14.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf97 Gene



Protein tissue co-expression partners for C17orf97 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C17orf97

SOURCE GeneReport for Unigene cluster for C17orf97 Gene:

Hs.499607

Evidence on tissue expression from TISSUES for C17orf97 Gene

  • Stomach(4.1)
genes like me logo Genes that share expression patterns with C17orf97: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf97 Gene

Orthologs for C17orf97 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C17orf97 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C17H17orf97 30
  • 96.79 (n)
C17orf97 31
  • 95 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C9H17orf97 30
  • 75.25 (n)
C17orf97 31
  • 69 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700016K19Rik 30 17 31
  • 74.59 (n)
OneToOne
Cow
(Bos Taurus)
Mammalia C19H17orf97 30
  • 73.62 (n)
C17orf97 31
  • 68 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1565611 30
  • 73.43 (n)
Species where no ortholog for C17orf97 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C17orf97 Gene

ENSEMBL:
Gene Tree for C17orf97 (if available)
TreeFam:
Gene Tree for C17orf97 (if available)

Paralogs for C17orf97 Gene

No data available for Paralogs for C17orf97 Gene

Variants for C17orf97 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C17orf97 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs35229416 - p.Asp220Glu
rs4581766 - p.Glu56Lys

Additional dbSNP identifiers (rs#s) for C17orf97 Gene

Structural Variations from Database of Genomic Variants (DGV) for C17orf97 Gene

Variant ID Type Subtype PubMed ID
dgv3070n100 CNV gain 25217958
dgv3071n100 CNV gain 25217958
dgv3072n100 CNV gain 25217958
dgv5386n54 CNV gain 21841781
esv1210692 CNV deletion 17803354
esv2422420 CNV duplication 17116639
esv2715298 CNV deletion 23290073
esv2715301 CNV deletion 23290073
esv2715302 CNV deletion 23290073
esv2761938 CNV gain 21179565
esv3639622 CNV gain 21293372
esv3639624 CNV gain 21293372
esv3892944 CNV gain 25118596
esv998391 CNV deletion 20482838
nsv457627 CNV gain 19166990
nsv573947 CNV gain 21841781
nsv573948 CNV gain 21841781
nsv827849 CNV gain 20364138

Variation tolerance for C17orf97 Gene

Residual Variation Intolerance Score: 87.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.30; 85.19% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C17orf97 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf97

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf97 Gene

Disorders for C17orf97 Gene

No disorders were found for C17orf97 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf97 Gene

Publications for C17orf97 Gene

  1. Liat1, an arginyltransferase-binding protein whose evolution among primates involved changes in the numbers of its 10-residue repeats. (PMID: 25369936) Brower CS … Varshavsky A (Proceedings of the National Academy of Sciences of the United States of America 2014) 2 3 4
  2. A Y2H-seq approach defines the human protein methyltransferase interactome. (PMID: 23455924) Weimann M … Stelzl U (Nature methods 2013) 3
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4

Products for C17orf97 Gene

Sources for C17orf97 Gene