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Aliases for C17orf77 Gene
Aliases for C17orf77 Gene
External Ids for C17orf77 Gene
- HGNC: 26480
- Entrez Gene: 146723
- Ensembl: ENSG00000182352
- UniProtKB: Q96MU5
Previous GeneCards Identifiers for C17orf77 Gene
- GC17P070093
- GC17P072581
- GC17P067990
- GC17P074586
- GC17P074597
- GC17P074609
Summaries for C17orf77 Gene
GeneCards Summary for C17orf77 Gene
C17orf77 (Chromosome 17 Open Reading Frame 77) is a Protein Coding gene.
Additional gene information for C17orf77 Gene
- HGNC(26480)
- Entrez Gene(146723)
- Ensembl(ENSG00000182352)
- UniProtKB(Q96MU5)
- Open Targets Platform(ENSG00000182352)
- Search for C17orf77 at DataMed
- Search for C17orf77 at HumanCyc
No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C17orf77 Gene
Genomics for C17orf77 Gene
GeneHancer (GH) Regulatory Elements Pubs
Promoters and enhancers for C17orf77 Gene
| GeneHancer (GH) Identifier | GH Type | GH Score |
GH Sources | Gene Association Score | Total Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites |
Gene Targets |
|---|---|---|---|---|---|---|---|---|---|---|
| GH17J074568 | Promoter/Enhancer | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 0.4 | -15.1 | -15074 | 1.6 | ZBTB33 YBX1 ZNF629 ZSCAN4 REST ZNF747 ZNF600 MNT KLF9 ZNF211 | CD300E NAT9 CD300C NUP85 CD300LB NT5C CD300LD ENSG00000246731 HID1 CASKIN2 | |
| GH17J074579 | Enhancer | 0.5 | Ensembl | 0.7 | -4.7 | -4678 | 1.2 | GABPA NR2C2 SPI1 ZBTB40 GABPB1 NR2C1 | C17orf77 RF00951-057 CD300H CD300LD | |
| GH17J074593 | Promoter | 0.4 | EPDnew | 0.4 | +7.6 | 7608 | 0.1 | SPI1 | CD300LD C17orf77 ENSG00000261222 LOC101928343 CD300E | |
| GH17J074592 | Promoter | 0.4 | Ensembl | 0.4 | +7.4 | 7422 | 0.2 | SPI1 | CD300LD SUMO2 C17orf77 piR-51845-001 | |
| GH17J074581 | Enhancer | 0.2 | FANTOM5 | 0.7 | -3.4 | -3390 | 0.1 | RF00951-057 CD300LD RAB37 SLC9A3R1 C17orf77 CD300H |
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication |
Request up-to-date GeneHancer data (full dataset)
GeneHancers around C17orf77 on the GeneHancer Hub at the UCSC Golden Path
Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C17orf77
- Top Transcription factor binding sites by QIAGEN in the C17orf77 gene promoter:
-
- AML1a
- AREB6
- Bach1
- FOXF2
- HNF-4alpha1
- HNF-4alpha2
- LCR-F1
- SRF
- SRF (504 AA)
- USF1
Genomic Locations for C17orf77 Gene
Genomic Locations for C17orf77 Gene
- chr17:74,584,679-74,594,209
- (GRCh38/hg38)
- Size:
- 9,531 bases
- Orientation:
- Plus strand
- chr17:72,580,818-72,590,348
- (GRCh37/hg19)
- Size:
- 9,531 bases
- Orientation:
- Plus strand
Genomic View for C17orf77 Gene
Genes around C17orf77 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 17q25.1 by HGNC
- 17q25.1 by Entrez Gene
- 17q25.1 by Ensembl
C17orf77 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C17orf77 Gene
Proteins for C17orf77 Gene
-
Protein details for C17orf77 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96MU5-CQ077_HUMAN
- Recommended name:
- Uncharacterized protein C17orf77
- Protein Accession:
- Q96MU5
Protein attributes for C17orf77 Gene
- Size:
- 243 amino acids
- Molecular mass:
- 26264 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AK056444; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
Post-translational modifications for C17orf77 Gene
Other Protein References for C17orf77 Gene
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for C17orf77
- antibodies-online: Show 18 available C17ORF77 Antibodies ranked by validation data
Protein Products
-
OriGene Purified Proteins for C17orf77
- Search Origene for MassSpec and Protein Over-expression Lysates for C17orf77
- Origene Custom Protein Services for C17orf77
- Novus Biologicals lysates for C17orf77
No data available for DME Specific Peptides for C17orf77 Gene
Domains & Families for C17orf77 Gene
No data available for Gene Families , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C17orf77 Gene
Function for C17orf77 Gene
Phenotypes for C17orf77 Gene
- GenomeRNAi human phenotypes for C17orf77:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C17orf77 - Select products 50% OFF >
- * C17orf77 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C17orf77
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C17orf77
-
Santa Cruz Biotechnology (SCBT) CRISPR for C17orf77
miRNA for C17orf77 Gene
- miRTarBase miRNAs that target C17orf77
-
- hsa-miR-148b-3p (MIRT019426)
- hsa-miR-3613-3p (MIRT644604)
- hsa-miR-5003-3p (MIRT644605)
- hsa-miR-548b-3p (MIRT644606)
- hsa-miR-3133 (MIRT644607)
- hsa-miR-5582-3p (MIRT644608)
- hsa-miR-548x-3p (MIRT644609)
- hsa-miR-548j-3p (MIRT644610)
- hsa-miR-548aq-3p (MIRT644611)
- hsa-miR-548am-3p (MIRT644612)
- hsa-miR-548aj-3p (MIRT644613)
- hsa-miR-548ah-3p (MIRT644614)
- hsa-miR-548ae-3p (MIRT644615)
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C17orf77
- Browse OriGene Inhibitory RNA Products For C17orf77
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf77
Clone Products
- Applied Biological Materials (abm): Clones for C17orf77 - Select products 50% OFF >
- * C17orf77 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C17orf77
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C17orf77
Cell Line Products
-
Horizon Cell Lines for C17orf77
No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf77 Gene
Localization for C17orf77 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C17orf77 Gene
- Secreted.
| Compartment | Confidence |
|---|---|
| extracellular | 3 |
| cytosol | 1 |
| nucleus | 0 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005576 | extracellular region | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for C17orf77 Gene
Transcripts for C17orf77 Gene
mRNA/cDNA for C17orf77 Gene
- 2 REFSEQ mRNAs :
- 2 NCBI additional mRNA sequence :
- 3 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :
-
- ENST00000524389 641 nts (view in UCSC)
- ENST00000392620 2525 nts (view in UCSC)
- ENST00000328023 2470 nts (view in UCSC)
- 3 RNACentral transcripts :
- 1 LNCipedia transcripts :
- 1 LncBook transcripts :
CRISPR Products
- Applied Biological Materials (abm): CRISPR Clones for C17orf77 - Select products 50% OFF >
- * C17orf77 CRISPR as ready-to-use vector or virus: ORF | Lenti- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
-
OriGene CRISPR knockouts for C17orf77
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C17orf77
-
Santa Cruz Biotechnology (SCBT) CRISPR for C17orf77
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C17orf77
- Browse OriGene Inhibitory RNA Products For C17orf77
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf77
Clone Products
- Applied Biological Materials (abm): Clones for C17orf77 - Select products 50% OFF >
- * C17orf77 as ready-to-use vector or virus: ORF | Lenti- | Retro- | Adeno- | AAV- | Protein Vector - Browse All
- * Gene synthesis, site-directed mutagenesis, subcloning, and more services - Browse All
- Sino Biological Human cDNA Clone for C17orf77
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C17orf77
Relevant External Links for C17orf77 Gene
- GeneLoc Exon Structure for
- C17orf77
Expression for C17orf77 Gene
mRNA differential expression in normal tissues according to GTEx for C17orf77 Gene
This gene is overexpressed in Breast - Mammary Tissue (x26.1), Colon - Transverse (x11.2), Small Intestine - Terminal Ileum (x10.4), and Cervix - Ectocervix (x5.2).
Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C17orf77
SOURCE GeneReport for Unigene cluster for C17orf77 Gene:
Hs.350775Primer Products
-
OriGene qPCR primer pairs for C17orf77
Gene Expression Assay Products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf77 Gene
Orthologs for C17orf77 Gene
This gene was present in the common ancestor of human and chimp.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| Chimpanzee (Pan troglodytes) |
Mammalia | C17H17orf77 30 |
|
||
| C17orf77 31 |
|
OneToOne |
- Species where no ortholog for C17orf77 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Eremothecium gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- Alpha proteobacteria (Wolbachia pipientis)
- Amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- Baker's yeast (Saccharomyces cerevisiae)
- Barley (Hordeum vulgare)
- Beta proteobacteria (Neisseria meningitidis)
- Bread mold (Neurospora crassa)
- Chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- Common water flea (Daphnia pulex)
- Corn (Zea mays)
- Cow (Bos Taurus)
- Dog (Canis familiaris)
- E. coli (Escherichia coli)
- Filamentous fungi (Aspergillus nidulans)
- Firmicute Bacteria (Streptococcus pneumoniae)
- Fission Yeast (Schizosaccharomyces pombe)
- Fruit Fly (Drosophila melanogaster)
- Green Algae (Chlamydomonas reinhardtii)
- Honey Bee (Apis mellifera)
- K. Lactis Yeast (Kluyveromyces lactis)
- Lizard (Anolis carolinensis)
- Loblloly Pine (Pinus taeda)
- Malaria Parasite (Plasmodium falciparum)
- Medicago Trunc (Medicago Truncatula)
- Moss (Physcomitrella patens)
- Mouse (Mus musculus)
- Oppossum (Monodelphis domestica)
- Orangutan (Pongo pygmaeus)
- Pig (Sus scrofa)
- Platypus (Ornithorhynchus anatinus)
- Rainbow Trout (Oncorhynchus mykiss)
- Rat (Rattus norvegicus)
- Rice (Oryza sativa)
- Rice Blast Fungus (Magnaporthe grisea)
- Schistosome Parasite (Schistosoma mansoni)
- Sea Anemone (Nematostella vectensis)
- Sea Vase (Ciona intestinalis)
- Sea Squirt (Ciona savignyi)
- Sea Urchin (Strongylocentrotus purpuratus)
- Sorghum (Sorghum bicolor)
- Soybean (Glycine max)
- Stem Rust Fungus (Puccinia graminis)
- Sugarcane (Saccharum officinarum)
- Thale Cress (Arabidopsis thaliana)
- Tomato (Lycopersicon esculentum)
- Toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- Tropical Clawed Frog (Silurana tropicalis)
- Wheat (Triticum aestivum)
- Worm (Caenorhabditis elegans)
- Zebrafish (Danio rerio)
Paralogs for C17orf77 Gene
No data available for Paralogs for C17orf77 Gene
Variants for C17orf77 Gene
Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C17orf77 Gene
| SNP ID | Clinical significance and condition | Chr 17 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs493430 | - | p.Arg47Ser |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv3282n100 | CNV | gain | 25217958 |
| dgv372n27 | CNV | gain | 19166990 |
| dgv5768n54 | CNV | gain | 21841781 |
| dgv5774n54 | CNV | gain | 21841781 |
| esv2751770 | CNV | gain | 17911159 |
| esv2761978 | CNV | gain | 21179565 |
| esv33995 | CNV | loss | 17666407 |
| esv3573820 | CNV | gain | 25503493 |
| esv3641230 | CNV | gain | 21293372 |
| esv3641244 | CNV | gain | 21293372 |
| nsv517569 | CNV | gain+loss | 19592680 |
Residual Variation Intolerance Score:
94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
6.14;
75.65% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C17orf77 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C17orf77
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf77 Gene
Disorders for C17orf77 Gene
Additional Disease Information for C17orf77
No disorders were found for C17orf77 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf77 Gene
Publications for C17orf77 Gene
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
- DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
ExternalLinks
Products for C17orf77 Gene
- Custom Antibody ServicesOriGene Antibodies for C17orf77
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for C17orf77
- Search Origene for MassSpec and Protein Over-expression Lysates for C17orf77
- Origene Custom Protein Services for C17orf77
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C17orf77
- Browse OriGene Inhibitory RNA Products For C17orf77
- OriGene qPCR primer pairs for C17orf77
- OriGene CRISPR knockouts for C17orf77
- OriGene ORF clones in human for C17orf77
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For C17orf77
- Sino Biological Human cDNA Clone for C17orf77
- Browse Sino Biological Recombinant Proteins
- Browse Sino Biological Cell Lysates
- Browse Sino Biological Antibodies
- Browse Sino Biological Assays
- Browse ELISA Kits
- Browse CRO Services
- High-throughput Antibody Production Service
- Protein Production Service
- Epitope Tag Antibodies & Reporter Protein Antibodies
- Lentiviral ORF Clones
- Novus Biologicals lysates for C17orf77
- Browse Antibodies
- Browse Peptides and Proteins
- Browse Lysates
- Browse ELISA Kits
- VectorBuilder Custom and pre-made DNA vectors for C17orf77 (ie. gene expression, shRNA knockdown, CRISPR)
- VectorBuilder Viral vectors for C17orf77 (ie. lentivirus, AAV, adenovirus)
- VectorBuilder CRISPR vectors for C17orf77 (ie. knockout, knockin, CRISPRa, CRISPRi)
- VectorBuilder Virus packaging for C17orf77 CRISPR vectors (ie. lentivirus, AAV, adenovirus)
- VectorBuilder Stable cell line generation for C17orf77
- antibodies-online: Show 18 available C17ORF77 Antibodies ranked by validation data
- antibodies-online: Search results for available C17ORF77 related products ranked by validation data
- antibodies-online: Search results for available C17ORF77 related products ranked by validation data
- Horizon Cell Lines for C17orf77
- Browse GeneCopoeia Cell Lines
- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C17orf77
- Search GeneCopoeia for ORF cDNA, lentivirus, AAV viral particles and/or promoter clone products for C17orf77
- Search GeneCopoeia for miRNA 3'UTR Target clone products for C17orf77
- Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf77
Sources for C17orf77 Gene
- (1) GeneCards
- (2) HGNC
- (3) NCBI Entrez Gene
- (4) UniProtKB/Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) Cell Signaling Technology
- (12) GO
- (13) UniProtKB/TrEMBL
- (14) InterPro
- (15) ProtoNet
- (16) Blocks
- (17) MGI
- (18) IUBMB
- (19) KEGG
- (20) MINT
- (21) STRING
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) ASD
- (28) SAGE
- (29) SOURCE
- (30) HomoloGene
- (31) PanEnsembl
- (32) euGenes
- (33) SGD
- (34) FlyBase
- (35) WormBase
- (36) Pseudogene
- (37) DGV
- (38) dbSNP
- (39) GenAtlas
- (40) HGMD
- (41) GAD
- (42) BGMUT
- (43) HuGE
- (44) Atlas
- (45) GenBank
- (46) HORDE
- (47) HUGE
- (48) IMGT
- (49) Leiden
- (50) miRBase
- (51) DME
- (52) OriGene
- (53) PubMed
- (54) R&D Systems
- (55) TGDB
- (56) Tocris
- (57) Abcam
- (58) Novus Biologicals
- (59) ProSpec
- (60) Sino Biological
- (61) GenScript
- (62) Qiagen
- (63) OCA
- (64) Proteopedia
- (65) MOPED
- (66) neXtProt
- (67) Reactome
- (68) GeneGo (Thomson Reuters)
- (69) DISEASES
- (70) SIMAP
- (71) GenomeRNAi
- (72) LifeMap
- (73) miRTarBase
- (74) MalaCards
- (75) Invitrogen
- (76) BitterDB
- (77) ESI-BIO
- (78) RefSeq
- (79) BioSystems
- (80) MaxQB
- (81) IUPHAR
- (82) BioGPS
- (83) Illumina
- (84) COMPARTMENTS
- (85) HOMER
- (86) PaxDb
- (87) ApexBio
- (88) Addgene
- (89) antibodies-online
- (90) CYP
- (91) NONCODE
- (92) TreeFam
- (93) PathCards
- (94) GeneReviews
- (95) GeneTex
- (96) Taconic Biosciences
- (97) GTEx
- (98) ProteomicsDB
- (99) SCBT
- (100) DGIdb
- (101) ClinicalTrials
- (102) RVIS
- (103) SIGNOR
- (104) diseasecard
- (105) NIH Rare Diseases
- (106) Orphanet
- (107) UMLS
- (108) GTR
- (109) Disease Ontology
- (110) Genetics Home Reference
- (111) MeSH
- (112) MedlinePlus
- (113) CDC
- (114) NINDS
- (115) NCBI Bookshelf
- (116) ClinVar
- (117) Gene Damage Index
- (118) HPO
- (119) UDN
- (120) VISTA
- (121) FANTOM5
- (122) ENCODE
- (123) ProSci
- (124) Horizon
- (125) The Signaling Pathways Project (SPP)
- (126) IID
- (127) VectorBuilder
- (128) SNPedia
- (129) BRCA Exchange
- (130) CIViC
- (131) ProteoGenix
- (132) dbSUPER
- (133) TISSUES
- (134) Gene ORGANizer
- (135) abm
- (136) Human Protein Atlas
- (137) GWAS Catalog
- (138) Monarch Initiative
- (139) DataMed
- (140) HumanCyc
- (141) UCNEbase
- (142) EPDnew
- (143) Applied Biosystems
- (144) GlyConnect
- (145) Aminode
- (146) GeneCopoeia
- (147) GPS-Prot
- (148) RNACentral
- (149) LncRNADisease
- (150) LOVD
- (151) miR2Disease
- (152) DiseaseEnhancer
- (153) Boster Bio
- (154) Biorbyt
- (155) Biocompare
- (156) Mastermind
- (157) CTD^2 Dashboard
- (158) CraniofacialAtlas
- (159) GeneImprint
- (160) Synthego
- (161) ENA
- (162) GtRNAdb
- (163) LncBase
- (164) LncBook
- (165) LNCipedia
- (166) Modomics
- (167) PDBe
- (168) Rfam
- (169) SILVA
- (170) snOPY
- (171) SRPDB
- (172) GENCODE
- (173) TarBase
- (174) Signalway Antibody
- (175) Open Targets Platform
- (176) 5SRRNADB
- (177) snoDB
- (178) MirGeneDB