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C17orf77 Gene(Protein Coding)

Chromosome 17 Open Reading Frame 77

GCID:
GC17P074586
GIFtS:
28
Genes Participants
UDN Logo

Aliases for C17orf77 Gene

Aliases for C17orf77 Gene

  • Chromosome 17 Open Reading Frame 77 2 3 5
  • Uncharacterized Protein C17orf77 3

External Ids for C17orf77 Gene

Previous GeneCards Identifiers for C17orf77 Gene

  • GC17P070093
  • GC17P072581
  • GC17P067990

Summaries for C17orf77 Gene

GeneCards Summary for C17orf77 Gene

C17orf77 (Chromosome 17 Open Reading Frame 77) is a Protein Coding gene.

Additional gene information for C17orf77 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf77 Gene

Genomics for C17orf77 Gene

Products:

  1. Regulatory Element

GeneHancer (GH) Regulatory Elements for C17orf77 Gene

Promoters and enhancers for C17orf77 Gene
GeneHancer (GH) Identifier GH Type GH
Score		 GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites		 Gene Targets
GH17J074592 Promoter/Enhancer 0.8 EPDnew Ensembl 0.4 +7.5 7522 0.4 SPI1 CD300LD SUMO2 PIR53017 C17orf77
GH17J074581 Enhancer 0.2 FANTOM5 0.7 -3.4 -3390 0.1 CD300LD RAB37 SLC9A3R1 C17orf77 PIR40961
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C17orf77 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C17orf77 gene promoter:

Genomic Locations for C17orf77 Gene

Genomic Locations for C17orf77 Gene
chr17:74,584,679-74,594,209
(GRCh38/hg38)
Size:
9,531 bases
Orientation:
Plus strand
chr17:72,580,818-72,590,348
(GRCh37/hg19)

Genomic View for C17orf77 Gene

Genes around C17orf77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf77 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for C17orf77 Gene

Proteins for C17orf77 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for C17orf77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96MU5-CQ077_HUMAN
    Recommended name:
    Uncharacterized protein C17orf77
    Protein Accession:
    Q96MU5

    Protein attributes for C17orf77 Gene

    Size:
    243 amino acids
    Molecular mass:
    26264 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AK056444; Type=Erroneous termination; Positions=207; Note=Translated as Cys.; Evidence={ECO:0000305};

neXtProt entry for C17orf77 Gene

Post-translational modifications for C17orf77 Gene

  • Glycosylation at posLast=136136
  • Modification sites at PhosphoSitePlus

Other Protein References for C17orf77 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C17orf77 Gene

Domains & Families for C17orf77 Gene

Protein Domains for C17orf77 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf77: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf77 Gene

Function for C17orf77 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
genes like me logo Genes that share phenotypes with C17orf77: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf77 Gene

Localization for C17orf77 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C17orf77 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf77 gene
Compartment Confidence
extracellular 3
nucleus 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C17orf77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C17orf77: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C17orf77 Gene

Pathways & Interactions for C17orf77 Gene

SuperPathways for C17orf77 Gene

PathCards logo More details on SuperPathways for C17orf77
No Data Available

Interacting Proteins for C17orf77 Gene

Gene Ontology (GO) - Biological Process for C17orf77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf77 Gene

Drugs & Compounds for C17orf77 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for C17orf77 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for C17orf77 Gene

(5) Selected AceView cDNA sequences:
(1) Additional mRNA sequences :
(2) REFSEQ mRNAs :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
(3) RNA Central transcripts :

Unigene Clusters for C17orf77 Gene

Chromosome 17 open reading frame 77:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf77 Gene

No ASD Table

Relevant External Links for C17orf77 Gene

GeneLoc Exon Structure for
C17orf77
ECgene alternative splicing isoforms for
C17orf77

Expression for C17orf77 Gene

Products:

  1. Primer
  2. Gene Expression Assay

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf77 Gene

mRNA expression in normal human tissues for C17orf77 Gene
mRNA expression by GTEx for C17orf77 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf77 Gene

This gene is overexpressed in Breast - Mammary Tissue (x26.1), Colon - Transverse (x11.2), Small Intestine - Terminal Ileum (x10.4), and Cervix - Ectocervix (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of C17orf77 Gene:

C17orf77

SOURCE GeneReport for Unigene cluster for C17orf77 Gene:

Hs.350775
genes like me logo Genes that share expression patterns with C17orf77: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf77 Gene

Orthologs for C17orf77 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C17orf77 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia C17H17orf77 33
  • 98.12 (n)
C17orf77 34
  • 95 (a)
 OneToOne
Species where no ortholog for C17orf77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf77 Gene

ENSEMBL:
Gene Tree for C17orf77 (if available)
TreeFam:
Gene Tree for C17orf77 (if available)

Paralogs for C17orf77 Gene

No data available for Paralogs for C17orf77 Gene

Variants for C17orf77 Gene

Products:

  1. SNP Genotyping and Copy Number Assay

Sequence variations from dbSNP and Humsavar for C17orf77 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000238531 -- 74,589,102(+) C/G intron_variant
rs1000650393 -- 74,585,147(+) G/T intron_variant
rs1000765123 -- 74,584,916(+) T/A genic_upstream_transcript_variant, splice_donor_variant, upstream_transcript_variant
rs1001324339 -- 74,594,035(+) A/G 3_prime_UTR_variant
rs1001522897 -- 74,583,591(+) T/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C17orf77 Gene

Variant ID Type Subtype PubMed ID
dgv3282n100 CNV gain 25217958
dgv372n27 CNV gain 19166990
dgv5768n54 CNV gain 21841781
dgv5774n54 CNV gain 21841781
esv2751770 CNV gain 17911159
esv2761978 CNV gain 21179565
esv33995 CNV loss 17666407
esv3573820 CNV gain 25503493
esv3641230 CNV gain 21293372
esv3641244 CNV gain 21293372
nsv517569 CNV gain+loss 19592680

Variation tolerance for C17orf77 Gene

Residual Variation Intolerance Score: 94.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.14; 75.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C17orf77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf77 Gene

Disorders for C17orf77 Gene

Additional Disease Information for C17orf77

ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C17orf77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf77 Gene

Publications for C17orf77 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58

Products for C17orf77 Gene

Sources for C17orf77 Gene

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