Aliases for C17orf64 Gene

Aliases for C17orf64 Gene

  • Chromosome 17 Open Reading Frame 64 2 3 5
  • Uncharacterized Protein C17orf64 3 4
  • C17orf64 5

External Ids for C17orf64 Gene

Previous GeneCards Identifiers for C17orf64 Gene

  • GC17P055855
  • GC17P058469
  • GC17P053870

Summaries for C17orf64 Gene

GeneCards Summary for C17orf64 Gene

C17orf64 (Chromosome 17 Open Reading Frame 64) is a Protein Coding gene.

Additional gene information for C17orf64 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C17orf64 Gene

Genomics for C17orf64 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C17orf64 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C17orf64 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C17orf64

Top Transcription factor binding sites by QIAGEN in the C17orf64 gene promoter:
  • CREB
  • deltaCREB
  • ER-alpha
  • FOXF2
  • FOXO1
  • FOXO1a
  • N-Myc
  • NCX
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for C17orf64 Gene

Latest Assembly
chr17:60,392,429-60,431,426
(GRCh38/hg38)
Size:
38,998 bases
Orientation:
Plus strand

Previous Assembly
chr17:58,499,850-58,508,787
(GRCh37/hg19 by Entrez Gene)
Size:
8,938 bases
Orientation:
Plus strand

chr17:58,469,790-58,508,782
(GRCh37/hg19 by Ensembl)
Size:
38,993 bases
Orientation:
Plus strand

Genomic View for C17orf64 Gene

Genes around C17orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf64 Gene

Proteins for C17orf64 Gene

  • Protein details for C17orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WR6-CQ064_HUMAN
    Recommended name:
    Uncharacterized protein C17orf64
    Protein Accession:
    Q86WR6
    Secondary Accessions:
    • Q8IY87

    Protein attributes for C17orf64 Gene

    Size:
    236 amino acids
    Molecular mass:
    27182 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH36356.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305}; Sequence=AAH48806.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};

neXtProt entry for C17orf64 Gene

Post-translational modifications for C17orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C17orf64 Gene

Domains & Families for C17orf64 Gene

Gene Families for C17orf64 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C17orf64 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C17orf64: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C17orf64 Gene

Function for C17orf64 Gene

Phenotypes From GWAS Catalog for C17orf64 Gene

genes like me logo Genes that share phenotypes with C17orf64: view

Animal Models for C17orf64 Gene

MGI Knock Outs for C17orf64:

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf64

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for C17orf64 Gene

Localization for C17orf64 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf64 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf64 Gene

Pathways & Interactions for C17orf64 Gene

PathCards logo

SuperPathways for C17orf64 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C17orf64 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf64 Gene

Drugs & Compounds for C17orf64 Gene

No Compound Related Data Available

Transcripts for C17orf64 Gene

mRNA/cDNA for C17orf64 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf64

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf64 Gene

No ASD Table

Relevant External Links for C17orf64 Gene

GeneLoc Exon Structure for
C17orf64

Expression for C17orf64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C17orf64 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

  • Testis (Reproductive System)

mRNA differential expression in normal tissues according to GTEx for C17orf64 Gene

This gene is overexpressed in Testis (x51.3).

Protein differential expression in normal tissues from HIPED for C17orf64 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf64 Gene



Protein tissue co-expression partners for C17orf64 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C17orf64

SOURCE GeneReport for Unigene cluster for C17orf64 Gene:

Hs.129312
genes like me logo Genes that share expression patterns with C17orf64: view

Primer products for research

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf64 Gene

Orthologs for C17orf64 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf64 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C17H17orf64 30
  • 99.01 (n)
C17orf64 31
  • 98 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C19H17orf64 30
  • 82.04 (n)
C17orf64 31
  • 73 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C9H17orf64 30
  • 81.77 (n)
C17orf64 31
  • 76 (a)
OneToOne
Rat
(Rattus norvegicus)
Mammalia RGD1310166 30
  • 79.4 (n)
Mouse
(Mus musculus)
Mammalia 1700125H20Rik 30 17 31
  • 78.77 (n)
OneToOne
Oppossum
(Monodelphis domestica)
Mammalia C17orf64 31
  • 67 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C17orf64 31
  • 29 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C17orf64 31
  • 61 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C17orf64 31
  • 52 (a)
OneToOne
Species where no ortholog for C17orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C17orf64 Gene

ENSEMBL:
Gene Tree for C17orf64 (if available)
TreeFam:
Gene Tree for C17orf64 (if available)

Paralogs for C17orf64 Gene

(1) SIMAP similar genes for C17orf64 Gene using alignment to 2 proteins:

  • CQ064_HUMAN
  • K7EQ24_HUMAN
genes like me logo Genes that share paralogs with C17orf64: view

No data available for Paralogs for C17orf64 Gene

Variants for C17orf64 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C17orf64 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C17orf64 Gene

Variant ID Type Subtype PubMed ID
dgv3273n100 CNV gain 25217958
nsv519929 CNV loss 19592680
nsv521420 CNV loss 19592680

Variation tolerance for C17orf64 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C17orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf64

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C17orf64 Gene

Disorders for C17orf64 Gene

Additional Disease Information for C17orf64

Genetic Association Database
(GAD)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C17orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf64 Gene

Publications for C17orf64 Gene

  1. The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain. (PMID: 27591891) Mohanty B … Ryan DP (Journal of molecular biology 2016) 2 3
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3

Products for C17orf64 Gene

Sources for C17orf64 Gene