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Aliases for C17orf64 Gene

Aliases for C17orf64 Gene

  • Chromosome 17 Open Reading Frame 64 2 3 5
  • Uncharacterized Protein C17orf64 3

External Ids for C17orf64 Gene

Previous GeneCards Identifiers for C17orf64 Gene

  • GC17P055855
  • GC17P058469
  • GC17P053870

Summaries for C17orf64 Gene

GeneCards Summary for C17orf64 Gene

C17orf64 (Chromosome 17 Open Reading Frame 64) is a Protein Coding gene.

Additional gene information for C17orf64 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C17orf64 Gene

Genomics for C17orf64 Gene

GeneHancer (GH) Regulatory Elements for C17orf64 Gene

Promoters and enhancers for C17orf64 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J060387 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 650.7 -1.3 -1257 6.5 DMAP1 YY1 ZNF213 E2F8 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 USP32 C17orf64 GC17P060389 NDUFB8P2 PPM1D TUBD1 HEATR6 RPL32P32 RPS6KB1 CA4
GH17J060422 Promoter 0.5 EPDnew 661.8 +30.1 30050 0.1 C17orf64 USP32 HMGN2P42
GH17J060356 Enhancer 1.3 Ensembl ENCODE dbSUPER 12.2 -36.0 -35959 0.9 HDGF PKNOX1 FOXA2 ARID4B ATF7 RXRA NFIL3 ATF4 RCOR2 ETV4 C17orf64 USP32 HEATR6 GC17M060371 ENSG00000271626
GH17J060420 Promoter/Enhancer 1.3 Ensembl ENCODE 11.8 +29.1 29106 1.4 PKNOX1 ARID4B SIN3A KLF5 ZNF48 RAD21 ZNF207 ZNF143 RUNX3 SMARCA5 USP32 C17orf64 LOC105371850
GH17J060357 Enhancer 1.2 Ensembl ENCODE dbSUPER 12.2 -35.0 -34958 1.1 FOXA2 ZEB1 ZNF335 ZNF121 ZNF366 FOS ATF7 BCLAF1 CEBPB ZEB2 C17orf64 USP32 HEATR6 ENSG00000275860 GC17M060371 ENSG00000271626
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C17orf64 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C17orf64 gene promoter:
  • NCX
  • FOXF2
  • deltaCREB
  • CREB
  • ER-alpha
  • PPAR-gamma1
  • PPAR-gamma2
  • FOXO1a
  • FOXO1
  • N-Myc

Genomic Locations for C17orf64 Gene

Genomic Locations for C17orf64 Gene
38,998 bases
Plus strand
38,998 bases
Plus strand

Genomic View for C17orf64 Gene

Genes around C17orf64 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf64 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf64 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf64 Gene

Proteins for C17orf64 Gene

  • Protein details for C17orf64 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C17orf64
    Protein Accession:
    Secondary Accessions:
    • Q8IY87

    Protein attributes for C17orf64 Gene

    236 amino acids
    Molecular mass:
    27182 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH36356.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAH48806.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

neXtProt entry for C17orf64 Gene

Post-translational modifications for C17orf64 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf64 Gene

No data available for DME Specific Peptides for C17orf64 Gene

Domains & Families for C17orf64 Gene

Gene Families for C17orf64 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C17orf64 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C17orf64: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C17orf64 Gene

Function for C17orf64 Gene

genes like me logo Genes that share phenotypes with C17orf64: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf64 Gene

Localization for C17orf64 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf64 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C17orf64 Gene

Pathways & Interactions for C17orf64 Gene

SuperPathways for C17orf64 Gene

No Data Available

Interacting Proteins for C17orf64 Gene

Gene Ontology (GO) - Biological Process for C17orf64 Gene


No data available for Pathways by source and SIGNOR curated interactions for C17orf64 Gene

Drugs & Compounds for C17orf64 Gene

No Compound Related Data Available

Transcripts for C17orf64 Gene

mRNA/cDNA for C17orf64 Gene

(6) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(19) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C17orf64 Gene

Chromosome 17 open reading frame 64:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf64 Gene

No ASD Table

Relevant External Links for C17orf64 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C17orf64 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C17orf64 Gene

mRNA differential expression in normal tissues according to GTEx for C17orf64 Gene

This gene is overexpressed in Testis (x51.3).

Protein differential expression in normal tissues from HIPED for C17orf64 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf64 Gene

Protein tissue co-expression partners for C17orf64 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C17orf64 Gene:


SOURCE GeneReport for Unigene cluster for C17orf64 Gene:

genes like me logo Genes that share expression patterns with C17orf64: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf64 Gene

Orthologs for C17orf64 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf64 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C17H17orf64 33
  • 99.01 (n)
C17orf64 34
  • 98 (a)
(Bos Taurus)
Mammalia C19H17orf64 33
  • 82.04 (n)
C17orf64 34
  • 73 (a)
(Canis familiaris)
Mammalia C9H17orf64 33
  • 81.77 (n)
C17orf64 34
  • 76 (a)
(Rattus norvegicus)
Mammalia RGD1310166 33
  • 79.4 (n)
(Mus musculus)
Mammalia 1700125H20Rik 16 34 33
  • 78.77 (n)
(Monodelphis domestica)
Mammalia C17orf64 34
  • 67 (a)
(Ornithorhynchus anatinus)
Mammalia C17orf64 34
  • 29 (a)
(Gallus gallus)
Aves C17orf64 34
  • 61 (a)
(Anolis carolinensis)
Reptilia C17orf64 34
  • 52 (a)
Species where no ortholog for C17orf64 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf64 Gene

Gene Tree for C17orf64 (if available)
Gene Tree for C17orf64 (if available)

Paralogs for C17orf64 Gene

(1) SIMAP similar genes for C17orf64 Gene using alignment to 2 proteins:

  • CQ064_HUMAN
  • K7EQ24_HUMAN
genes like me logo Genes that share paralogs with C17orf64: view

No data available for Paralogs for C17orf64 Gene

Variants for C17orf64 Gene

Sequence variations from dbSNP and Humsavar for C17orf64 Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000013402 -- 60,420,196(+) G/T upstream_transcript_variant
rs1000358498 -- 60,420,088(+) ATTTTA/ upstream_transcript_variant
rs1000468956 -- 60,426,367(+) A/G intron_variant
rs1000585884 -- 60,422,137(+) C/T genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000691460 -- 60,421,726(+) ACTACA/ 5_prime_UTR_variant, genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C17orf64 Gene

Variant ID Type Subtype PubMed ID
dgv3273n100 CNV gain 25217958
nsv519929 CNV loss 19592680
nsv521420 CNV loss 19592680

Variation tolerance for C17orf64 Gene

Residual Variation Intolerance Score: 45.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.29; 62.78% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C17orf64 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf64 Gene

Disorders for C17orf64 Gene

Additional Disease Information for C17orf64

No disorders were found for C17orf64 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C17orf64 Gene

Publications for C17orf64 Gene

  1. The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain. (PMID: 27591891) Mohanty B … Ryan DP (Journal of molecular biology 2016) 2 3 58
  2. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 58
  3. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C17orf64 Gene

Sources for C17orf64 Gene

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