Aliases for C17orf58 Gene

Aliases for C17orf58 Gene

  • Chromosome 17 Open Reading Frame 58 2 3 5
  • UPF0450 Protein C17orf58 3 4

External Ids for C17orf58 Gene

Previous GeneCards Identifiers for C17orf58 Gene

  • GC17M063418
  • GC17M065987
  • GC17M061371

Summaries for C17orf58 Gene

GeneCards Summary for C17orf58 Gene

C17orf58 (Chromosome 17 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C17orf58 include Hallucinogen Dependence and Cannabis Dependence.

Additional gene information for C17orf58 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C17orf58 Gene

Genomics for C17orf58 Gene

GeneHancer (GH) Regulatory Elements for C17orf58 Gene

Promoters and enhancers for C17orf58 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17J067992 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE CraniofacialAtlas 516.2 +2.4 2367 5.2 ZBTB40 ZNF217 NRF1 POLR2G BCLAF1 JUND PHF8 FOS PHB2 ZNF639 C17orf58 LRRC37A16P NOL11 ENSG00000265055 HELZ BPTF ENSG00000267731 RDM1P3 ENSG00000265100 WIPI1
GH17J067973 Promoter/Enhancer 1 Ensembl ENCODE 12.7 +21.9 21885 2.8 USF1 TEAD4 SAP30 HDAC2 POLR2A MYC CTCF PHF8 ETS1 ZBTB40 ENSG00000279880 SH3GL1P3 C17orf58 WIPI1 RF00017-2518 RN7SL622P lnc-KPNA2-2 BPTF
GH17J068045 Enhancer 0.4 FANTOM5 11.5 -48.5 -48519 0.4 POLR2A ZNF592 C17orf58 KPNA2 piR-58297-216
GH17J067998 Enhancer 0.5 Ensembl 0.7 -2.4 -2417 1.2 CUX1 JUND PKNOX1 ZNF664 HLF MNT ZBTB8A SREBF1 FOXA1 C17orf58 piR-31458-003
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C17orf58 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C17orf58

Top Transcription factor binding sites by QIAGEN in the C17orf58 gene promoter:
  • Oct-B1
  • oct-B2
  • oct-B3
  • Pax-2
  • POU2F1
  • POU2F1a
  • POU2F2
  • POU2F2 (Oct-2.1)
  • POU2F2B
  • POU2F2C

Genomic Locations for C17orf58 Gene

Genomic Locations for C17orf58 Gene
chr17:67,991,099-67,996,784
(GRCh38/hg38)
Size:
5,686 bases
Orientation:
Minus strand
chr17:65,987,217-65,989,765
(GRCh37/hg19)
Size:
2,549 bases
Orientation:
Minus strand

Genomic View for C17orf58 Gene

Genes around C17orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C17orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C17orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C17orf58 Gene

Proteins for C17orf58 Gene

  • Protein details for C17orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q2M2W7-CQ058_HUMAN
    Recommended name:
    UPF0450 protein C17orf58
    Protein Accession:
    Q2M2W7
    Secondary Accessions:
    • A8MQV2

    Protein attributes for C17orf58 Gene

    Size:
    97 amino acids
    Molecular mass:
    11219 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C17orf58 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C17orf58 Gene

Post-translational modifications for C17orf58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C17orf58 Gene

No data available for DME Specific Peptides for C17orf58 Gene

Domains & Families for C17orf58 Gene

Gene Families for C17orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C17orf58 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C17orf58 Gene

GenScript: Design optimal peptide antigens:
  • UPF0450 protein C17orf58 (CQ058_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q2M2W7

UniProtKB/Swiss-Prot:

CQ058_HUMAN :
  • Belongs to the UPF0450 family.
Family:
  • Belongs to the UPF0450 family.
genes like me logo Genes that share domains with C17orf58: view

Function for C17orf58 Gene

Phenotypes From GWAS Catalog for C17orf58 Gene

Phenotypes for C17orf58 Gene

genes like me logo Genes that share phenotypes with C17orf58: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C17orf58 Gene

Localization for C17orf58 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C17orf58 gene
Compartment Confidence
extracellular 2
cytosol 2
plasma membrane 1
peroxisome 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C17orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0062023 collagen-containing extracellular matrix HDA 25037231
genes like me logo Genes that share ontologies with C17orf58: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C17orf58 Gene

Pathways & Interactions for C17orf58 Gene

PathCards logo

SuperPathways for C17orf58 Gene

No Data Available

Interacting Proteins for C17orf58 Gene

;

Gene Ontology (GO) - Biological Process for C17orf58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C17orf58 Gene

Drugs & Compounds for C17orf58 Gene

No Compound Related Data Available

Transcripts for C17orf58 Gene

mRNA/cDNA for C17orf58 Gene

2 REFSEQ mRNAs :
7 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C17orf58

Alternative Splicing Database (ASD) splice patterns (SP) for C17orf58 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for C17orf58 Gene

GeneLoc Exon Structure for
C17orf58

Expression for C17orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C17orf58 Gene

Protein differential expression in normal tissues from HIPED for C17orf58 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C17orf58 Gene



Protein tissue co-expression partners for C17orf58 Gene

- Elite partner

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C17orf58

SOURCE GeneReport for Unigene cluster for C17orf58 Gene:

Hs.90790

Evidence on tissue expression from TISSUES for C17orf58 Gene

  • Nervous system(2.8)
  • Intestine(2.1)
  • Heart(2)
  • Kidney(2)
genes like me logo Genes that share expression patterns with C17orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C17orf58 Gene

Orthologs for C17orf58 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C17orf58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C17H17orf58 30
  • 100 (n)
C17ORF58 31
  • 48 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C17orf58 31
  • 92 (a)
OneToOne
C9H17orf58 30
  • 89 (n)
cow
(Bos Taurus)
Mammalia C19H17orf58 30
  • 88.32 (n)
mouse
(Mus musculus)
Mammalia 1810010H24Rik 17 30
  • 84.54 (n)
rat
(Rattus norvegicus)
Mammalia RGD1565033 30
  • 82.82 (n)
oppossum
(Monodelphis domestica)
Mammalia C17orf58 31
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C17orf58 31
  • 43 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17orf58 31
  • 74 (a)
OneToOne
C17ORF58 30
  • 72.92 (n)
lizard
(Anolis carolinensis)
Reptilia C17orf58 31
  • 48 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.14404 30
Species where no ortholog for C17orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C17orf58 Gene

ENSEMBL:
Gene Tree for C17orf58 (if available)
TreeFam:
Gene Tree for C17orf58 (if available)

Paralogs for C17orf58 Gene

No data available for Paralogs for C17orf58 Gene

Variants for C17orf58 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C17orf58 Gene

SNP ID Clinical significance and condition Chr 17 pos Variation AA Info Type
rs9891146 - p.Ile92Val

Additional dbSNP identifiers (rs#s) for C17orf58 Gene

Structural Variations from Database of Genomic Variants (DGV) for C17orf58 Gene

Variant ID Type Subtype PubMed ID
dgv5754n54 CNV gain 21841781
dgv5755n54 CNV loss 21841781
esv22750 CNV gain 19812545
esv26540 CNV loss 19812545
esv2716136 CNV deletion 23290073
esv3641102 CNV gain 21293372
nsv1118767 CNV deletion 24896259
nsv1120054 OTHER inversion 24896259
nsv436233 CNV deletion 17901297
nsv471405 CNV gain 19718026

Variation tolerance for C17orf58 Gene

Residual Variation Intolerance Score: 42.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.70; 78.62% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C17orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C17orf58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C17orf58 Gene

Disorders for C17orf58 Gene

MalaCards: The human disease database

(2) MalaCards diseases for C17orf58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
hallucinogen dependence
cannabis dependence
  • marijuana abuse
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C17orf58

genes like me logo Genes that share disorders with C17orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C17orf58 Gene

Publications for C17orf58 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 54
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 54
  3. Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver. (PMID: 25037231) Naba A … Hynes RO (BMC cancer 2014) 3 54
  4. DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. (PMID: 16625196) Zody MC … Nusbaum C (Nature 2006) 4 54
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 4 54

Products for C17orf58 Gene

  • Biorbyt antibodies for C17orf58

Sources for C17orf58 Gene