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Aliases for C16orf96 Gene

Aliases for C16orf96 Gene

  • Chromosome 16 Open Reading Frame 96 2 3 5
  • Uncharacterized Protein C16orf96 3 4

External Ids for C16orf96 Gene

Previous GeneCards Identifiers for C16orf96 Gene

  • GC16P004607

Summaries for C16orf96 Gene

GeneCards Summary for C16orf96 Gene

C16orf96 (Chromosome 16 Open Reading Frame 96) is a Protein Coding gene. An important paralog of this gene is QRICH2.

Additional gene information for C16orf96 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf96 Gene

Genomics for C16orf96 Gene

GeneHancer (GH) Regulatory Elements for C16orf96 Gene

Promoters and enhancers for C16orf96 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J004536 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 600.7 -0.5 -518 2.6 ZNF652 SP1 ELF3 MNT CBFA2T2 NKRF POLR2A ZNF121 CEBPG RERE CDIP1 C16orf96 NMRAL1 ZNF500 CREBBP HMOX2 MGRN1 PPL ENSG00000278434
GH16J004533 Enhancer 0.8 ENCODE dbSUPER 0.7 -3.6 -3632 2.7 IKZF1 CREB1 IKZF2 EED ZFHX2 BATF EBF1 ZNF362 EGR2 ENSG00000278434 NMRAL1 HMOX2 MGRN1 C16orf96 CDIP1
GH16J004548 Enhancer 0.9 Ensembl ENCODE 0.4 +10.2 10192 1 CTCF ZNF384 PRDM1 RAD21 REST TRIM22 NFE2 RUNX3 MAFG SMC3 NMRAL1 HMOX2 MGRN1 CDIP1 ENSG00000261789 C16orf96
GH16J004585 Enhancer 0.9 Ensembl ENCODE 0.3 +46.5 46538 3.3 CTCF ZNF548 RAD21 ZNF600 ZIC2 REST CBFB RUNX3 TFDP1 SAP130 GC16P004586 CREBBP ZNF500 MGRN1 HMOX2 GC16M004577 C16orf96
GH16J004593 Enhancer 0.7 Ensembl ENCODE 0.2 +54.7 54692 2 ZIC2 SCRT2 POLR2A SIN3A MYC MAX HMOX2 MGRN1 GC16P004586 UBALD1 C16orf96
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf96 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C16orf96 Gene

Genomic Locations for C16orf96 Gene
62,006 bases
Plus strand
44,225 bases
Plus strand

Genomic View for C16orf96 Gene

Genes around C16orf96 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf96 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf96 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf96 Gene

Proteins for C16orf96 Gene

  • Protein details for C16orf96 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C16orf96
    Protein Accession:
    Secondary Accessions:
    • C9JH24

    Protein attributes for C16orf96 Gene

    1141 amino acids
    Molecular mass:
    125041 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf96 Gene

Post-translational modifications for C16orf96 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf96 Gene

No data available for DME Specific Peptides for C16orf96 Gene

Domains & Families for C16orf96 Gene

Gene Families for C16orf96 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf96 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf96: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf96 Gene

Function for C16orf96 Gene

Phenotypes From GWAS Catalog for C16orf96 Gene

Phenotypes for C16orf96 Gene

genes like me logo Genes that share phenotypes with C16orf96: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf96

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C16orf96 Gene

Localization for C16orf96 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf96 gene
Compartment Confidence
cytosol 3
plasma membrane 1
nucleus 1
cytoskeleton 0
mitochondrion 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C16orf96 Gene

Pathways & Interactions for C16orf96 Gene

PathCards logo

SuperPathways for C16orf96 Gene

No Data Available

Interacting Proteins for C16orf96 Gene

Selected Interacting proteins: A6NNT2-CP096_HUMAN for C16orf96 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C16orf96 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf96 Gene

Drugs & Compounds for C16orf96 Gene

No Compound Related Data Available

Transcripts for C16orf96 Gene

mRNA/cDNA for C16orf96 Gene

(1) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for C16orf96 Gene

Chromosome 16 open reading frame 96:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf96

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf96 Gene

No ASD Table

Relevant External Links for C16orf96 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf96 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf96 Gene

mRNA differential expression in normal tissues according to GTEx for C16orf96 Gene

This gene is overexpressed in Testis (x28.0).

Protein differential expression in normal tissues from HIPED for C16orf96 Gene

This gene is overexpressed in Heart (32.3) and Lung (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf96 Gene

NURSA nuclear receptor signaling pathways regulating expression of C16orf96 Gene:


SOURCE GeneReport for Unigene cluster for C16orf96 Gene:

genes like me logo Genes that share expression patterns with C16orf96: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf96 Gene

Orthologs for C16orf96 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf96 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf96 34
  • 98.57 (n)
C16orf96 35
  • 97 (a)
(Canis familiaris)
Mammalia C6H16orf96 34
  • 76.27 (n)
C16orf96 35
  • 50 (a)
(Rattus norvegicus)
Mammalia LOC100361104 34
  • 66.14 (n)
(Mus musculus)
Mammalia 4930562C15Rik 17 35 34
  • 66.02 (n)
(Monodelphis domestica)
Mammalia C16orf96 35
  • 36 (a)
(Gallus gallus)
Aves LOC768955 34
  • 50.66 (n)
Species where no ortholog for C16orf96 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf96 Gene

Gene Tree for C16orf96 (if available)
Gene Tree for C16orf96 (if available)

Paralogs for C16orf96 Gene

Paralogs for C16orf96 Gene

genes like me logo Genes that share paralogs with C16orf96: view

Variants for C16orf96 Gene

Sequence variations from dbSNP and Humsavar for C16orf96 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000006921 -- 4,571,351(+) A/G intron_variant
rs1000046113 -- 4,537,465(+) G/A upstream_transcript_variant
rs1000064970 -- 4,549,846(+) C/G genic_upstream_transcript_variant, intron_variant
rs1000110160 -- 4,542,030(+) G/C genic_upstream_transcript_variant, intron_variant
rs1000115649 -- 4,576,524(+) G/A/C coding_sequence_variant, missense_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf96 Gene

Variant ID Type Subtype PubMed ID
esv32558 CNV gain 17666407
esv3581944 CNV loss 25503493
esv3637698 CNV loss 21293372
nsv1046986 CNV gain 25217958
nsv1160333 CNV deletion 26073780

Variation tolerance for C16orf96 Gene

Gene Damage Index Score: 10.00; 90.01% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf96 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf96 Gene

Disorders for C16orf96 Gene

Additional Disease Information for C16orf96

No disorders were found for C16orf96 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf96 Gene

Publications for C16orf96 Gene

  1. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 3 4 58
  2. Systematic Analysis of Human Protein Phosphatase Interactions and Dynamics. (PMID: 28330616) Yadav L … Varjosalo M (Cell systems 2017) 3 58
  3. ABCE1 is a highly conserved RNA silencing suppressor. (PMID: 25659154) Kärblane K … Sarmiento C (PloS one 2015) 3 58
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 58

Products for C16orf96 Gene

Sources for C16orf96 Gene

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