Aliases for C16orf91 Gene

Aliases for C16orf91 Gene

  • Chromosome 16 Open Reading Frame 91 2 3 5
  • Cattle Cerebrum And Skeletal Muscle-Specific Protein 1 Family Member 2 3
  • Protein CCSMST1 3 4
  • Up-Regulated In Lung Cancer 5 3
  • CCSMST1 3
  • URLC5 3
  • Gs103 3

External Ids for C16orf91 Gene

Previous GeneCards Identifiers for C16orf91 Gene

  • GC16M001411
  • GC16M001469
  • GC16M001396
  • GC16M001433
  • GC16M001438
  • GC16M001492
  • GC16M001498
  • GC16M001514
  • GC16M001443
  • GC16M001451
  • GC16M001457
  • GC16M001463
  • GC16M001468
  • GC16M001473
  • GC16M001479
  • GC16M001482

Summaries for C16orf91 Gene

GeneCards Summary for C16orf91 Gene

C16orf91 (Chromosome 16 Open Reading Frame 91) is a Protein Coding gene.

Additional gene information for C16orf91 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C16orf91 Gene

Genomics for C16orf91 Gene

GeneHancer (GH) Regulatory Elements for C16orf91 Gene

Promoters and enhancers for C16orf91 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf91 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C16orf91

Top Transcription factor binding sites by QIAGEN in the C16orf91 gene promoter:
  • AML1a
  • AREB6
  • Arnt
  • FOXL1
  • NF-1
  • NF-1/L
  • Pax-5
  • PPAR-gamma1
  • PPAR-gamma2
  • YY1

Genomic Locations for C16orf91 Gene

Genomic Locations for C16orf91 Gene
1,057 bases
Minus strand
9,601 bases
Minus strand

Genomic View for C16orf91 Gene

Genes around C16orf91 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf91 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf91 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf91 Gene

Proteins for C16orf91 Gene

  • Protein details for C16orf91 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein CCSMST1
    Protein Accession:
    Secondary Accessions:
    • Q96RZ0

    Protein attributes for C16orf91 Gene

    132 amino acids
    Molecular mass:
    15004 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAK61280.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=EAW85657.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for C16orf91 Gene

Post-translational modifications for C16orf91 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf91 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf91 Gene

Domains & Families for C16orf91 Gene

Gene Families for C16orf91 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C16orf91 Gene


Suggested Antigen Peptide Sequences for C16orf91 Gene

GenScript: Design optimal peptide antigens:
  • Protein CCSMST1 (CSMT1_HUMAN)

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CCSMST1 family.
  • Belongs to the CCSMST1 family.
genes like me logo Genes that share domains with C16orf91: view

Function for C16orf91 Gene

genes like me logo Genes that share phenotypes with C16orf91: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf91

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf91 Gene

Localization for C16orf91 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf91 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf91 gene
Compartment Confidence
mitochondrion 2
nucleus 2
plasma membrane 1
endoplasmic reticulum 1
cytosol 1

Gene Ontology (GO) - Cellular Components for C16orf91 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf91: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C16orf91 Gene

Pathways & Interactions for C16orf91 Gene

PathCards logo

SuperPathways for C16orf91 Gene

No Data Available

Interacting Proteins for C16orf91 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000413100 Q4G0I0-CSMT1_HUMAN for C16orf91 Gene via STRING IID


Gene Ontology (GO) - Biological Process for C16orf91 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf91 Gene

Drugs & Compounds for C16orf91 Gene

No Compound Related Data Available

Transcripts for C16orf91 Gene

mRNA/cDNA for C16orf91 Gene

7 NCBI additional mRNA sequence :
2 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf91

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf91 Gene

No ASD Table

Relevant External Links for C16orf91 Gene

GeneLoc Exon Structure for

Expression for C16orf91 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C16orf91 Gene

Protein differential expression in normal tissues from HIPED for C16orf91 Gene

This gene is overexpressed in Adrenal (37.7), Bone (12.5), and Peripheral blood mononuclear cells (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C16orf91 Gene

Protein tissue co-expression partners for C16orf91 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C16orf91

SOURCE GeneReport for Unigene cluster for C16orf91 Gene:

genes like me logo Genes that share expression patterns with C16orf91: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf91 Gene

Orthologs for C16orf91 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C16orf91 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16orf91 31
  • 97 (a)
(Bos Taurus)
Mammalia C25H16orf91 30
  • 75.76 (n)
  • 48 (a)
(Rattus norvegicus)
Mammalia RGD1565784 30
  • 73.99 (n)
(Mus musculus)
Mammalia BC003965 17 31 30
  • 73.74 (n)
(Canis familiaris)
Mammalia C6H16orf91 30
  • 70.11 (n)
C16orf91 31
  • 44 (a)
(Monodelphis domestica)
Mammalia C16orf91 31
  • 43 (a)
Species where no ortholog for C16orf91 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf91 Gene

Gene Tree for C16orf91 (if available)
Gene Tree for C16orf91 (if available)

Paralogs for C16orf91 Gene

(1) SIMAP similar genes for C16orf91 Gene using alignment to 1 proteins:

  • H3BP47_HUMAN
genes like me logo Genes that share paralogs with C16orf91: view

No data available for Paralogs for C16orf91 Gene

Variants for C16orf91 Gene

Additional dbSNP identifiers (rs#s) for C16orf91 Gene

Structural Variations from Database of Genomic Variants (DGV) for C16orf91 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2762143 CNV gain 21179565
nsv1046314 CNV loss 25217958
nsv457331 CNV loss 19166990
nsv471066 CNV loss 18288195
nsv571160 CNV loss 21841781
nsv819259 CNV gain 19587683
nsv819844 CNV gain 19587683
nsv952899 CNV deletion 24416366

Variation tolerance for C16orf91 Gene

Residual Variation Intolerance Score: 66.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.55% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf91 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C16orf91 Gene

Disorders for C16orf91 Gene

Additional Disease Information for C16orf91

No disorders were found for C16orf91 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf91 Gene

Publications for C16orf91 Gene

  1. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels RJ … Higgs DR (Human molecular genetics 2001) 3 4 54
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 54
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 54

Products for C16orf91 Gene

Sources for C16orf91 Gene