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Aliases for C16orf89 Gene

Aliases for C16orf89 Gene

  • Chromosome 16 Open Reading Frame 89 2 3 5

External Ids for C16orf89 Gene

Previous GeneCards Identifiers for C16orf89 Gene

  • GC16M005035
  • GC16M005098

Summaries for C16orf89 Gene

Entrez Gene Summary for C16orf89 Gene

  • This gene is expressed predominantly in the thyroid. Based on expression patterns similar to thyroid transcription factors and proteins, this gene may function in the development and function of the thyroid. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

GeneCards Summary for C16orf89 Gene

C16orf89 (Chromosome 16 Open Reading Frame 89) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein homodimerization activity.

Additional gene information for C16orf89 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf89 Gene

Genomics for C16orf89 Gene

GeneHancer (GH) Regulatory Elements for C16orf89 Gene

Promoters and enhancers for C16orf89 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I005064 Promoter/Enhancer 1.4 EPDnew ENCODE 574.7 +0.8 777 1.3 FOXA2 NFIB ZSCAN4 ZNF133 MZF1 FEZF1 ZNF2 ZNF335 SCRT2 KLF7 C16orf89 ZNF500 ALG1 NAGPA
GH16I005066 Promoter 0.7 EPDnew 555.8 0.0 -18 0.1 ZIC2 EZH2 C16orf89 ENSG00000260882 ALG1
GH16I005032 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 12.8 +31.1 31097 5 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 NAGPA ALG1 ZNF500 C16orf89 CDIP1 PPL NAGPA-AS1
GH16I005041 Enhancer 0.8 ENCODE dbSUPER 14.1 +24.3 24310 0.2 NR2F1 DPF2 ATF2 JUND IKZF1 FOS RUNX3 IKZF2 C16orf89 ALG1 NAGPA NAGPA-AS1
GH16I005043 Enhancer 0.8 ENCODE dbSUPER 14.1 +24.1 24090 0.2 DPF2 BATF ATF2 JUND IKZF1 FOS PRDM1 IKZF2 C16orf89 NAGPA ALG1 NAGPA-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C16orf89 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf89 gene promoter:

Genomic Locations for C16orf89 Gene

Genomic Locations for C16orf89 Gene
23,374 bases
Minus strand

Genomic View for C16orf89 Gene

Genes around C16orf89 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf89 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf89 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf89 Gene

Proteins for C16orf89 Gene

  • Protein details for C16orf89 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0764 protein C16orf89
    Protein Accession:
    Secondary Accessions:
    • B4DUM5
    • Q8N2I3
    • Q8N4T1

    Protein attributes for C16orf89 Gene

    402 amino acids
    Molecular mass:
    45391 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=AAH33681.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAQ88847.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11494.1; Type=Miscellaneous discrepancy; Note=Aberrant splicing.; Evidence={ECO:0000305}; Sequence=EAW85244.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for C16orf89 Gene


neXtProt entry for C16orf89 Gene

Post-translational modifications for C16orf89 Gene

No data available for DME Specific Peptides for C16orf89 Gene

Domains & Families for C16orf89 Gene

Gene Families for C16orf89 Gene

Human Protein Atlas (HPA):
  • Predicted secreted proteins

Protein Domains for C16orf89 Gene


Suggested Antigen Peptide Sequences for C16orf89 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0764 family.
  • Belongs to the UPF0764 family.
genes like me logo Genes that share domains with C16orf89: view

Function for C16orf89 Gene

Gene Ontology (GO) - Molecular Function for C16orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IPI 20578903
genes like me logo Genes that share ontologies with C16orf89: view
genes like me logo Genes that share phenotypes with C16orf89: view

Animal Models for C16orf89 Gene

MGI Knock Outs for C16orf89:

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for C16orf89 Gene

Localization for C16orf89 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf89 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf89 gene
Compartment Confidence
extracellular 5
cytosol 5
plasma membrane 1
mitochondrion 1
nucleus 1
endoplasmic reticulum 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C16orf89 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA 20578903
GO:0016020 membrane IDA 20578903
GO:0070062 extracellular exosome HDA,IDA 19056867
genes like me logo Genes that share ontologies with C16orf89: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C16orf89 Gene

Pathways & Interactions for C16orf89 Gene

SuperPathways for C16orf89 Gene

No Data Available

Interacting Proteins for C16orf89 Gene

Selected Interacting proteins: Q6UX73-CP089_HUMAN for C16orf89 Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C16orf89 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf89 Gene

Drugs & Compounds for C16orf89 Gene

No Compound Related Data Available

Transcripts for C16orf89 Gene

Unigene Clusters for C16orf89 Gene

Chromosome 16 open reading frame 89:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf89 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9a · 9b
SP1: -
SP2: - -
SP3: - - -

Relevant External Links for C16orf89 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf89 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf89 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf89 Gene

This gene is overexpressed in Thyroid (x11.9), Stomach (x4.9), and Lung (x4.6).

Protein differential expression in normal tissues from HIPED for C16orf89 Gene

This gene is overexpressed in Urine (53.7) and Cerebrospinal fluid (11.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf89 Gene

Protein tissue co-expression partners for C16orf89 Gene

NURSA nuclear receptor signaling pathways regulating expression of C16orf89 Gene:


SOURCE GeneReport for Unigene cluster for C16orf89 Gene:


mRNA Expression by UniProt/SwissProt for C16orf89 Gene:

Tissue specificity: Predominantly expressed in thyroid tissue.

Evidence on tissue expression from TISSUES for C16orf89 Gene

  • Thyroid gland(4.5)
  • Intestine(4.2)
  • Muscle(4.2)
  • Stomach(2)
genes like me logo Genes that share expression patterns with C16orf89: view

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf89 Gene

Orthologs for C16orf89 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf89 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf89 33
  • 98.79 (n)
C16orf89 34
  • 88 (a)
(Bos Taurus)
Mammalia C25H16orf89 33
  • 83.24 (n)
C16orf89 34
  • 70 (a)
(Canis familiaris)
Mammalia C6H16orf89 33
  • 82.98 (n)
C16orf89 34
  • 69 (a)
(Mus musculus)
Mammalia AU021092 33 16 34
  • 78.02 (n)
(Rattus norvegicus)
Mammalia RGD1565166 33
  • 77.95 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 52 (a)
-- 34
  • 43 (a)
(Ornithorhynchus anatinus)
Mammalia C16orf89 34
  • 46 (a)
(Gallus gallus)
Aves C14H16ORF89 33
  • 60.31 (n)
C16orf89 34
  • 43 (a)
(Danio rerio)
Actinopterygii si:ch211-76l23.7 33
  • 50.8 (n)
C3H16orf89 34
  • 34 (a)
Species where no ortholog for C16orf89 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf89 Gene

Gene Tree for C16orf89 (if available)
Gene Tree for C16orf89 (if available)

Paralogs for C16orf89 Gene

(19) SIMAP similar genes for C16orf89 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C16orf89: view

No data available for Paralogs for C16orf89 Gene

Variants for C16orf89 Gene

Sequence variations from dbSNP and Humsavar for C16orf89 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000098359 -- 5,046,010(-) C/T intron_variant
rs1000295240 -- 5,057,951(-) C/T intron_variant
rs1000461395 -- 5,067,344(-) G/GCG upstream_transcript_variant
rs1000503720 -- 5,044,826(-) A/C 3_prime_UTR_variant, coding_sequence_variant, intron_variant, synonymous_variant
rs1000587852 -- 5,045,605(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf89 Gene

Variant ID Type Subtype PubMed ID
dgv477e199 CNV deletion 23128226
esv2422516 CNV deletion 17116639
esv25186 CNV gain 19812545
esv2760069 CNV gain+loss 17122850
esv34300 CNV gain 17911159
esv3637713 CNV gain 21293372
esv3637714 CNV gain 21293372
esv3637716 CNV loss 21293372
esv3637717 CNV loss 21293372
esv3892762 CNV gain 25118596
nsv1038475 CNV gain 25217958
nsv1039432 CNV loss 25217958
nsv1042612 CNV loss 25217958
nsv1046986 CNV gain 25217958
nsv1052766 CNV loss 25217958
nsv1722 CNV deletion 18451855
nsv428318 CNV gain 18775914
nsv457360 CNV loss 19166990
nsv571303 CNV loss 21841781
nsv817715 CNV gain 17921354
nsv827532 CNV loss 20364138
nsv9340 CNV loss 18304495

Variation tolerance for C16orf89 Gene

Residual Variation Intolerance Score: 72.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.03; 80.20% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf89 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf89 Gene

Disorders for C16orf89 Gene

Additional Disease Information for C16orf89

No disorders were found for C16orf89 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf89 Gene

Publications for C16orf89 Gene

  1. Initial characterization of C16orf89, a novel thyroid-specific gene. (PMID: 20578903) Afink GB … Ris-Stalpers C (Thyroid : official journal of the American Thyroid Association 2010) 2 3 4 58
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  3. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 58
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M … Moll S (Journal of proteomics 2013) 3 58
  5. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. (PMID: 23533145) Principe S … Drake RR (Proteomics 2013) 3 58

Products for C16orf89 Gene

Sources for C16orf89 Gene

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