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Aliases for C16orf78 Gene

Aliases for C16orf78 Gene

  • Chromosome 16 Open Reading Frame 78 2 3 5
  • Uncharacterized Protein C16orf78 3

External Ids for C16orf78 Gene

Previous GeneCards Identifiers for C16orf78 Gene

  • GC16P047966
  • GC16P049407
  • GC16P035297

Summaries for C16orf78 Gene

GeneCards Summary for C16orf78 Gene

C16orf78 (Chromosome 16 Open Reading Frame 78) is a Protein Coding gene.

Additional gene information for C16orf78 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf78 Gene

Genomics for C16orf78 Gene

GeneHancer (GH) Regulatory Elements for C16orf78 Gene

Promoters and enhancers for C16orf78 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J049373 Promoter 0.5 EPDnew 650.7 0.0 -23 0.1 C16orf78 GC16P049335
GH16J049281 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 1.3 -91.8 -91762 1.1 RB1 ZNF335 ZNF766 GLIS2 ZNF143 FOS ATF7 PHF21A ZBTB11 USF2 CBLN1 LOC102724859 C16orf78 GC16P049294
GH16J049122 Enhancer 0.2 FANTOM5 10.1 -251.0 -250990 0.1 LOC105371241 C16orf78 ENSG00000261421
GH16J049366 Enhancer 0.5 ENCODE 0.4 -5.8 -5829 2.3 SP1 USF1 EBF1 SPI1 C16orf78 GC16P049335
GH16J049383 Enhancer 0.4 ENCODE 0.4 +9.3 9317 0.2 CTCF ZNF143 C16orf78 GC16P049397 LOC105371244
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf78 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf78 gene promoter:
  • HNF-1A
  • HNF-1
  • TBP
  • Nkx5-1
  • Brachyury
  • IRF-7A
  • LHX3b
  • Lhx3a
  • p53
  • NRSF form 2

Genomic Locations for C16orf78 Gene

Genomic Locations for C16orf78 Gene
25,624 bases
Plus strand
25,609 bases
Plus strand

Genomic View for C16orf78 Gene

Genes around C16orf78 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf78 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf78 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf78 Gene

Proteins for C16orf78 Gene

  • Protein details for C16orf78 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C16orf78
    Protein Accession:

    Protein attributes for C16orf78 Gene

    265 amino acids
    Molecular mass:
    30819 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf78 Gene

Post-translational modifications for C16orf78 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf78 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf78 Gene

Domains & Families for C16orf78 Gene

Gene Families for C16orf78 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf78 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf78: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf78 Gene

Function for C16orf78 Gene

Phenotypes From GWAS Catalog for C16orf78 Gene

genes like me logo Genes that share phenotypes with C16orf78: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C16orf78 Gene

Localization for C16orf78 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf78 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for C16orf78 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus HDA 21630459
genes like me logo Genes that share ontologies with C16orf78: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from the Human Protein Atlas (HPA) for C16orf78 Gene

Pathways & Interactions for C16orf78 Gene

SuperPathways for C16orf78 Gene

No Data Available

Interacting Proteins for C16orf78 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000299191 Q8WTQ4-CP078_HUMAN for C16orf78 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C16orf78 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf78 Gene

Drugs & Compounds for C16orf78 Gene

No Compound Related Data Available

Transcripts for C16orf78 Gene

mRNA/cDNA for C16orf78 Gene

(1) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(13) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C16orf78 Gene

Chromosome 16 open reading frame 78:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf78 Gene

No ASD Table

Relevant External Links for C16orf78 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf78 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf78 Gene

mRNA differential expression in normal tissues according to GTEx for C16orf78 Gene

This gene is overexpressed in Testis (x52.2).

Protein differential expression in normal tissues from HIPED for C16orf78 Gene

This gene is overexpressed in Plasma (68.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf78 Gene

Protein tissue co-expression partners for C16orf78 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf78 Gene:


SOURCE GeneReport for Unigene cluster for C16orf78 Gene:

genes like me logo Genes that share expression patterns with C16orf78: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf78 Gene

Orthologs for C16orf78 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf78 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16orf78 34
  • 98 (a)
C16H16orf78 33
  • 97.73 (n)
(Canis familiaris)
Mammalia C2H16orf78 33
  • 70.74 (n)
C16orf78 34
  • 59 (a)
(Bos Taurus)
Mammalia C18H16orf78 34 33
  • 69.55 (n)
(Mus musculus)
Mammalia 4933402J07Rik 16 34 33
  • 65.87 (n)
(Rattus norvegicus)
Mammalia LOC680913 33
  • 65.07 (n)
(Ornithorhynchus anatinus)
Mammalia C16orf78 34
  • 34 (a)
(Anolis carolinensis)
Reptilia C16orf78 34
  • 24 (a)
Species where no ortholog for C16orf78 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf78 Gene

Gene Tree for C16orf78 (if available)
Gene Tree for C16orf78 (if available)

Paralogs for C16orf78 Gene

No data available for Paralogs for C16orf78 Gene

Variants for C16orf78 Gene

Sequence variations from dbSNP and Humsavar for C16orf78 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000052412 -- 49,378,961(+) G/A intron_variant
rs1000221764 -- 49,391,482(+) T/A intron_variant
rs1000303338 -- 49,397,206(+) C/T intron_variant
rs1000403878 -- 49,378,746(+) C/A intron_variant
rs1000409744 -- 49,396,816(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf78 Gene

Variant ID Type Subtype PubMed ID
esv3306707 CNV mobile element insertion 20981092
esv3308343 CNV mobile element insertion 20981092
esv3357346 CNV insertion 20981092
esv3430901 CNV insertion 20981092
nsv1803 CNV insertion 18451855
nsv833221 CNV loss 17160897
nsv833222 CNV loss 17160897

Variation tolerance for C16orf78 Gene

Residual Variation Intolerance Score: 73% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.88; 67.47% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf78 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf78 Gene

Disorders for C16orf78 Gene

Additional Disease Information for C16orf78

No disorders were found for C16orf78 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf78 Gene

Publications for C16orf78 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. The protein interaction landscape of the human CMGC kinase group. (PMID: 23602568) Varjosalo M … Gstaiger M (Cell reports 2013) 3 58
  3. A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants. (PMID: 22219177) Tao S … Sun J (Carcinogenesis 2012) 3 58
  4. Protein array based interactome analysis of amyloid-β indicates an inhibition of protein translation. (PMID: 21244100) Virok DP … Fülöp L (Journal of proteome research 2011) 3 58
  5. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S … Oliva R (Proteomics 2011) 3 58

Products for C16orf78 Gene

Sources for C16orf78 Gene

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