Aliases for C16orf72 Gene

Aliases for C16orf72 Gene

  • Chromosome 16 Open Reading Frame 72 2 3 5
  • UPF0472 Protein C16orf72 3 4
  • PRO0149 3

External Ids for C16orf72 Gene

Previous GeneCards Identifiers for C16orf72 Gene

  • GC16P009094
  • GC16P009185
  • GC16P009106

Summaries for C16orf72 Gene

GeneCards Summary for C16orf72 Gene

C16orf72 (Chromosome 16 Open Reading Frame 72) is a Protein Coding gene.

Additional gene information for C16orf72 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C16orf72 Gene

Genomics for C16orf72 Gene

GeneHancer (GH) Regulatory Elements for C16orf72 Gene

Promoters and enhancers for C16orf72 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf72 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf72 gene promoter:
  • ATF-2
  • c-Myb
  • CREB
  • deltaCREB
  • Hlf
  • Lmo2
  • NF-kappaB1
  • STAT1
  • STAT5B
  • XBP-1

Genomic Locations for C16orf72 Gene

Genomic Locations for C16orf72 Gene
chr16:9,091,644-9,121,635
(GRCh38/hg38)
Size:
29,992 bases
Orientation:
Plus strand
chr16:9,185,505-9,215,497
(GRCh37/hg19)
Size:
29,993 bases
Orientation:
Plus strand

Genomic View for C16orf72 Gene

Genes around C16orf72 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf72 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf72 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf72 Gene

Proteins for C16orf72 Gene

  • Protein details for C16orf72 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CZ0-CP072_HUMAN
    Recommended name:
    UPF0472 protein C16orf72
    Protein Accession:
    Q14CZ0

    Protein attributes for C16orf72 Gene

    Size:
    275 amino acids
    Molecular mass:
    30926 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf72 Gene

Post-translational modifications for C16orf72 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf72 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf72 Gene

Domains & Families for C16orf72 Gene

Gene Families for C16orf72 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf72 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf72 Gene

GenScript: Design optimal peptide antigens:
  • UPF0472 protein C16orf72 (CP072_HUMAN)

Graphical View of Domain Structure for InterPro Entry

Q14CZ0

UniProtKB/Swiss-Prot:

CP072_HUMAN :
  • Belongs to the UPF0472 family.
Family:
  • Belongs to the UPF0472 family.
genes like me logo Genes that share domains with C16orf72: view

Function for C16orf72 Gene

Phenotypes From GWAS Catalog for C16orf72 Gene

Gene Ontology (GO) - Molecular Function for C16orf72 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 24722188
genes like me logo Genes that share ontologies with C16orf72: view
genes like me logo Genes that share phenotypes with C16orf72: view

Animal Model Products

CRISPR Products

miRNA for C16orf72 Gene

miRTarBase miRNAs that target C16orf72

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf72 Gene

Localization for C16orf72 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf72 gene
Compartment Confidence
nucleus 3
cytosol 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf72 Gene

Pathways & Interactions for C16orf72 Gene

PathCards logo

SuperPathways for C16orf72 Gene

No Data Available

Interacting Proteins for C16orf72 Gene

Gene Ontology (GO) - Biological Process for C16orf72 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf72 Gene

Drugs & Compounds for C16orf72 Gene

No Compound Related Data Available

Transcripts for C16orf72 Gene

mRNA/cDNA for C16orf72 Gene

(1) REFSEQ mRNAs :
(11) Additional mRNA sequences :
(489) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf72 Gene

No ASD Table

Relevant External Links for C16orf72 Gene

GeneLoc Exon Structure for
C16orf72
ECgene alternative splicing isoforms for
C16orf72

Expression for C16orf72 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf72 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf72 Gene

This gene is overexpressed in Whole Blood (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of C16orf72 Gene:

C16orf72

SOURCE GeneReport for Unigene cluster for C16orf72 Gene:

Hs.221497

Evidence on tissue expression from TISSUES for C16orf72 Gene

  • Nervous system(2.7)
genes like me logo Genes that share expression patterns with C16orf72: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf72 Gene

Orthologs for C16orf72 Gene

This gene was present in the common ancestor of animals.

Orthologs for C16orf72 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C25H16ORF72 33
  • 100 (a)
OneToOne
C25H16orf72 32
  • 97.7 (n)
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf72 32
  • 99.24 (n)
C16orf72 33
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1810013L24Rik 17 33 32
  • 97.09 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf72 33
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1309748 32
  • 96.24 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf72 33
  • 95 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C16orf72 33
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves C16orf72 33
  • 94 (a)
OneToOne
LOC416639 32
  • 88.03 (n)
lizard
(Anolis carolinensis)
Reptilia C16orf72 33
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c16orf72 32
  • 84.38 (n)
Str.5950 32
African clawed frog
(Xenopus laevis)
Amphibia MGC68553 32
zebrafish
(Danio rerio)
Actinopterygii C3H16orf72 33
  • 83 (a)
OneToOne
zgc:77849 32
  • 75.63 (n)
wufb59e09 32
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3294 32
fruit fly
(Drosophila melanogaster)
Insecta CG4768 33
  • 32 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.11201 33
  • 44 (a)
OneToOne
Species where no ortholog for C16orf72 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf72 Gene

ENSEMBL:
Gene Tree for C16orf72 (if available)
TreeFam:
Gene Tree for C16orf72 (if available)

Paralogs for C16orf72 Gene

Pseudogenes.org Pseudogenes for C16orf72 Gene

genes like me logo Genes that share paralogs with C16orf72: view

No data available for Paralogs for C16orf72 Gene

Variants for C16orf72 Gene

Sequence variations from dbSNP and Humsavar for C16orf72 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000030161 -- 9,099,861(+) T/A intron_variant
rs1000100711 -- 9,103,139(+) C/G/T coding_sequence_variant, missense_variant, stop_gained
rs1000142569 -- 9,117,643(+) A/G 3_prime_UTR_variant, genic_downstream_transcript_variant
rs1000146903 -- 9,111,615(+) C/A 3_prime_UTR_variant, intron_variant
rs1000177771 -- 9,094,849(+) C/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf72 Gene

Variant ID Type Subtype PubMed ID
dgv2725n100 CNV gain 25217958
dgv2726n100 CNV gain 25217958
esv3892788 CNV gain 25118596
nsv1040937 CNV gain 25217958
nsv1070322 CNV deletion 25765185
nsv457400 CNV gain 19166990
nsv457401 CNV gain 19166990
nsv457402 CNV gain 19166990
nsv519065 CNV gain 19592680
nsv525864 CNV loss 19592680
nsv571430 CNV gain 21841781
nsv571431 CNV gain 21841781
nsv571432 CNV gain 21841781
nsv952918 CNV duplication 24416366

Variation tolerance for C16orf72 Gene

Residual Variation Intolerance Score: 59% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.91; 48.86% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf72 Gene

Human Gene Mutation Database (HGMD)
C16orf72
SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf72

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf72 Gene

Disorders for C16orf72 Gene

Additional Disease Information for C16orf72

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C16orf72 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf72 Gene

Publications for C16orf72 Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3 56
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 56
  3. Control of a neuronal morphology program by an RNA-binding zinc finger protein, Unkempt. (PMID: 25737280) Murn J … Shi Y (Genes & development 2015) 3 56
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 56
  5. Quantitative Lys-ϵ-Gly-Gly (diGly) proteomics coupled with inducible RNAi reveals ubiquitin-mediated proteolysis of DNA damage-inducible transcript 4 (DDIT4) by the E3 ligase HUWE1. (PMID: 25147182) Thompson JW … Luchansky SJ (The Journal of biological chemistry 2014) 3 56

Products for C16orf72 Gene

Sources for C16orf72 Gene