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Aliases for C16orf71 Gene

Aliases for C16orf71 Gene

  • Chromosome 16 Open Reading Frame 71 2 3 5

External Ids for C16orf71 Gene

Previous GeneCards Identifiers for C16orf71 Gene

  • GC16P004725
  • GC16P004786

Summaries for C16orf71 Gene

GeneCards Summary for C16orf71 Gene

C16orf71 (Chromosome 16 Open Reading Frame 71) is a Protein Coding gene.

Additional gene information for C16orf71 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf71 Gene

Genomics for C16orf71 Gene

GeneHancer (GH) Regulatory Elements for C16orf71 Gene

Promoters and enhancers for C16orf71 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16I004733 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 550.8 +0.1 123 2.4 HDGF PKNOX1 MLX ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 E2F8 ANKS3 C16orf71 ZNF500 CREBBP UBN1 EEF2KMT LOC102724927 MGRN1 GC16P004728 ENSG00000266994
GH16I004765 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE 12.2 +33.2 33191 4.2 HDGF MLX ZFP64 ARID4B SIN3A DMAP1 YBX1 ZNF2 YY1 POLR2B ZNF500 SEPT12 ROGDI ANKS3 C16orf71 UBN1 GLYR1 SMIM22 SEC14L5 CDIP1
GH16I003870 Enhancer 1.1 Ensembl ENCODE 14.1 -862.9 -862876 1.3 ATF1 ZNF473 ZNF493 ZSCAN4 ZNF76 YBX1 RAD21 ZNF366 KLF7 ZNF391 ZNF75A ANKS3 ZNF213-AS1 TIGD7 C16orf71 CLUAP1 ZNF200 FLYWCH2 ZNF174 MTCO1P28
GH16I004010 Enhancer 1.4 FANTOM5 Ensembl ENCODE 5.1 -720.2 -720221 6.4 FOXA2 FEZF1 DMAP1 ZNF2 BRCA1 ZNF48 YY1 ZNF121 FOS RXRA ADCY9 CREBBP C16orf71 CDIP1 CORO7 GC16M004019 GC16M003975
GH16I004020 Enhancer 1.1 Ensembl ENCODE 5.1 -713.0 -712962 1.3 ELF3 CLOCK FOXA2 MLX NFIB ARID4B SIN3A DMAP1 ZNF48 ZSCAN9 CREBBP ADCY9 C16orf71 CDIP1 GC16M004019 GC16M003975
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C16orf71 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf71 gene promoter:

Genomic Locations for C16orf71 Gene

Genomic Locations for C16orf71 Gene
chr16:4,734,272-4,749,396
(GRCh38/hg38)
Size:
15,125 bases
Orientation:
Plus strand
chr16:4,784,273-4,799,397
(GRCh37/hg19)

Genomic View for C16orf71 Gene

Genes around C16orf71 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf71 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf71 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf71 Gene

Proteins for C16orf71 Gene

  • Protein details for C16orf71 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IYS4-CP071_HUMAN
    Recommended name:
    Uncharacterized protein C16orf71
    Protein Accession:
    Q8IYS4
    Secondary Accessions:
    • Q8NCV0

    Protein attributes for C16orf71 Gene

    Size:
    520 amino acids
    Molecular mass:
    55682 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf71 Gene

Post-translational modifications for C16orf71 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C16orf71 Gene

No data available for DME Specific Peptides for C16orf71 Gene

Domains & Families for C16orf71 Gene

Gene Families for C16orf71 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf71 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf71: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C16orf71 Gene

Function for C16orf71 Gene

Phenotypes From GWAS Catalog for C16orf71 Gene

genes like me logo Genes that share phenotypes with C16orf71: view

miRNA for C16orf71 Gene

miRTarBase miRNAs that target C16orf71

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf71 Gene

Localization for C16orf71 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf71 gene
Compartment Confidence
nucleus 3
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nuclear speckles (1)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C16orf71 Gene

Pathways & Interactions for C16orf71 Gene

SuperPathways for C16orf71 Gene

No Data Available

Interacting Proteins for C16orf71 Gene

Gene Ontology (GO) - Biological Process for C16orf71 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf71 Gene

Drugs & Compounds for C16orf71 Gene

No Compound Related Data Available

Transcripts for C16orf71 Gene

Unigene Clusters for C16orf71 Gene

Chromosome 16 open reading frame 71:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf71 Gene

No ASD Table

Relevant External Links for C16orf71 Gene

GeneLoc Exon Structure for
C16orf71
ECgene alternative splicing isoforms for
C16orf71

Expression for C16orf71 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf71 Gene

mRNA differential expression in normal tissues according to GTEx for C16orf71 Gene

This gene is overexpressed in Testis (x34.6).

Protein differential expression in normal tissues from HIPED for C16orf71 Gene

This gene is overexpressed in Testis (65.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf71 Gene



Protein tissue co-expression partners for C16orf71 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf71 Gene:

C16orf71

SOURCE GeneReport for Unigene cluster for C16orf71 Gene:

Hs.602738
genes like me logo Genes that share expression patterns with C16orf71: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf71 Gene

Orthologs for C16orf71 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf71 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf71 33
  • 99.04 (n)
C16orf71 34
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H16orf71 33
  • 71.59 (n)
C16orf71 34
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC360479 33
  • 65.71 (n)
cow
(Bos Taurus)
Mammalia C25H16ORF71 34
  • 52 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4930451G09Rik 34
  • 48 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C16orf71 34
  • 32 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C16orf71 34
  • 31 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C16orf71 34
  • 24 (a)
OneToOne
Species where no ortholog for C16orf71 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf71 Gene

ENSEMBL:
Gene Tree for C16orf71 (if available)
TreeFam:
Gene Tree for C16orf71 (if available)

Paralogs for C16orf71 Gene

No data available for Paralogs for C16orf71 Gene

Variants for C16orf71 Gene

Sequence variations from dbSNP and Humsavar for C16orf71 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000036408 -- 4,736,763(+) T/C intron_variant
rs1000044339 -- 4,742,390(+) A/T intron_variant
rs1000086207 -- 4,735,769(+) G/T intron_variant
rs1000418376 -- 4,742,131(+) C/G intron_variant
rs1000546627 -- 4,732,601(+) G/C upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf71 Gene

Variant ID Type Subtype PubMed ID
esv2657180 CNV deletion 23128226
esv3637702 CNV loss 21293372
esv3637704 CNV gain 21293372
nsv1046986 CNV gain 25217958
nsv1050237 CNV loss 25217958
nsv571302 CNV gain 21841781

Variation tolerance for C16orf71 Gene

Residual Variation Intolerance Score: 82.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.74; 78.81% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf71 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf71

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf71 Gene

Disorders for C16orf71 Gene

Additional Disease Information for C16orf71

No disorders were found for C16orf71 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf71 Gene

Publications for C16orf71 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  2. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. The sequence and analysis of duplication-rich human chromosome 16. (PMID: 15616553) Martin J … Pennacchio LA (Nature 2004) 4 58

Products for C16orf71 Gene

Sources for C16orf71 Gene

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