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Aliases for C16orf70 Gene

Aliases for C16orf70 Gene

  • Chromosome 16 Open Reading Frame 70 2 3 5
  • C16orf6 3 4
  • Chromosome 16 Open Reading Frame 6 2
  • UPF0183 Protein C16orf70 3
  • Lin-10 Homolog 3
  • Lin-10 3
  • LIN10 3

External Ids for C16orf70 Gene

Previous HGNC Symbols for C16orf70 Gene

  • C16orf6
  • LIN10

Previous GeneCards Identifiers for C16orf70 Gene

  • GC16P065703
  • GC16P053017

Summaries for C16orf70 Gene

GeneCards Summary for C16orf70 Gene

C16orf70 (Chromosome 16 Open Reading Frame 70) is a Protein Coding gene.

Additional gene information for C16orf70 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf70 Gene

Genomics for C16orf70 Gene

GeneHancer (GH) Regulatory Elements for C16orf70 Gene

Promoters and enhancers for C16orf70 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J067108 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 650.7 +0.5 480 2.9 HDGF FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 C16orf70 ACD EDC4 CENPT CTCF NAE1 ELMO3 ENSG00000259804 ATP6V0D1 ENSG00000260465
GH16J067527 Promoter/Enhancer 2 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +420.2 420168 4.4 ATF1 FOXA2 ARID4B SIN3A YY1 ZNF121 GLIS2 ZNF143 FOS ATF7 LOC100505942 C16orf70 ATP6V0D1 ZDHHC1 ENKD1 SLC7A6OS NAE1 PSMB10 RIPOR1 LRRC29
GH16J067027 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 11.1 -80.4 -80407 3 HDGF FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 CBFB CTCF EDC4 ENSG00000260465 E2F4 ACD CENPT FBXL8 ENSG00000270165 NAE1
GH16J067239 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 7.8 +134.8 134836 10.3 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF416 ZNF143 SP3 FHOD1 SLC9A5 ATP6V0D1 RN7SKP118 DPEP2NB ELMO3 C16orf86 NAE1 CENPT EDC4
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C16orf70 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf70 gene promoter:

Genomic Locations for C16orf70 Gene

Genomic Locations for C16orf70 Gene
38,642 bases
Plus strand

Genomic View for C16orf70 Gene

Genes around C16orf70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf70 Gene

Proteins for C16orf70 Gene

  • Protein details for C16orf70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0183 protein C16orf70
    Protein Accession:
    Secondary Accessions:
    • Q9HA86

    Protein attributes for C16orf70 Gene

    422 amino acids
    Molecular mass:
    47524 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf70 Gene


neXtProt entry for C16orf70 Gene

Post-translational modifications for C16orf70 Gene

  • Ubiquitination at posLast=231231
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C16orf70 Gene

Domains & Families for C16orf70 Gene

Gene Families for C16orf70 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf70 Gene


Suggested Antigen Peptide Sequences for C16orf70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0183 family.
  • Belongs to the UPF0183 family.
genes like me logo Genes that share domains with C16orf70: view

Function for C16orf70 Gene

Phenotypes From GWAS Catalog for C16orf70 Gene

Gene Ontology (GO) - Molecular Function for C16orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C16orf70: view

Phenotypes for C16orf70 Gene

genes like me logo Genes that share phenotypes with C16orf70: view

Animal Model Products

CRISPR Products

miRNA for C16orf70 Gene

miRTarBase miRNAs that target C16orf70

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf70

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf70 Gene

Localization for C16orf70 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf70 gene
Compartment Confidence
cytosol 4
nucleus 3
mitochondrion 1
peroxisome 1
golgi apparatus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear speckles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C16orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005802 trans-Golgi network IBA --
GO:0030425 dendrite IBA --
GO:0030672 synaptic vesicle membrane IBA --
genes like me logo Genes that share ontologies with C16orf70: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C16orf70 Gene

Pathways & Interactions for C16orf70 Gene

SuperPathways for C16orf70 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C16orf70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043001 Golgi to plasma membrane protein transport IBA --
genes like me logo Genes that share ontologies with C16orf70: view

No data available for Pathways by source and SIGNOR curated interactions for C16orf70 Gene

Drugs & Compounds for C16orf70 Gene

No Compound Related Data Available

Transcripts for C16orf70 Gene

mRNA/cDNA for C16orf70 Gene

Unigene Clusters for C16orf70 Gene

Chromosome 16 open reading frame 70:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf70

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf70 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13 ^ 14 ^ 15 ^ 16 ^ 17
SP1: - -
SP2: - - -
SP3: -

Relevant External Links for C16orf70 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf70 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf70 Gene

Protein differential expression in normal tissues from HIPED for C16orf70 Gene

This gene is overexpressed in Frontal cortex (13.0), Testis (8.0), Ovary (7.2), Retina (6.8), and Placenta (6.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C16orf70 Gene

Protein tissue co-expression partners for C16orf70 Gene

NURSA nuclear receptor signaling pathways regulating expression of C16orf70 Gene:


SOURCE GeneReport for Unigene cluster for C16orf70 Gene:

genes like me logo Genes that share expression patterns with C16orf70: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf70 Gene

Orthologs for C16orf70 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf70 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16ORF70 34
  • 100 (a)
C16H16orf70 33
  • 97.38 (n)
(Canis familiaris)
Mammalia C16orf70 34
  • 99 (a)
C5H16orf70 33
  • 94.71 (n)
(Bos Taurus)
Mammalia C16orf70 34
  • 97 (a)
C18H16orf70 33
  • 92.42 (n)
(Monodelphis domestica)
Mammalia C16orf70 34
  • 95 (a)
(Ornithorhynchus anatinus)
Mammalia C16orf70 34
  • 94 (a)
(Rattus norvegicus)
Mammalia RGD621098 33
  • 92.18 (n)
(Mus musculus)
Mammalia D230025D16Rik 16 34 33
  • 92.02 (n)
(Gallus gallus)
Aves C11H16ORF70 34 33
  • 83.57 (n)
(Anolis carolinensis)
Reptilia C16orf70 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100494115 33
  • 77.22 (n)
(Danio rerio)
Actinopterygii C18H16orf70 34
  • 87 (a)
si:dkey-102f14.5 33
  • 76.35 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003820 33
  • 58.66 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG7083 34 33
  • 57.17 (n)
(Caenorhabditis elegans)
Secernentea T01G9.2 34 33
  • 46.38 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G51130 33
  • 49.86 (n)
(Oryza sativa)
Liliopsida Os06g0714000 33
  • 49.28 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 61 (a)
CSA.1238 34
  • 59 (a)
Cin.69 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.69 33
Species where no ortholog for C16orf70 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C16orf70 Gene

Gene Tree for C16orf70 (if available)
Gene Tree for C16orf70 (if available)

Paralogs for C16orf70 Gene Pseudogenes for C16orf70 Gene

genes like me logo Genes that share paralogs with C16orf70: view

No data available for Paralogs for C16orf70 Gene

Variants for C16orf70 Gene

Sequence variations from dbSNP and Humsavar for C16orf70 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000009000 -- 67,144,934(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000016733 -- 67,143,471(+) T/C genic_downstream_transcript_variant, intron_variant
rs1000235212 -- 67,137,808(+) C/T genic_downstream_transcript_variant, intron_variant
rs1000357581 -- 67,108,909(+) A/G upstream_transcript_variant
rs1000369818 -- 67,115,923(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf70 Gene

Variant ID Type Subtype PubMed ID
esv3638878 CNV loss 21293372
nsv509627 CNV insertion 20534489
nsv524363 CNV loss 19592680
nsv827707 CNV loss 20364138
nsv952044 CNV deletion 24416366

Variation tolerance for C16orf70 Gene

Residual Variation Intolerance Score: 20.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.10; 38.34% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf70 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf70 Gene

Disorders for C16orf70 Gene

Additional Disease Information for C16orf70

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C16orf70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf70 Gene

Publications for C16orf70 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 44 58
  2. Association between genetic variants in VEGF, ERCC3 and occupational benzene haematotoxicity. (PMID: 19773279) Hosgood HD … Lan Q (Occupational and environmental medicine 2009) 3 44 58
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58

Products for C16orf70 Gene

Sources for C16orf70 Gene

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