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Aliases for C16orf58 Gene

Aliases for C16orf58 Gene

  • Chromosome 16 Open Reading Frame 58 2 3 5
  • RUS1 Homolog 2 3
  • RUS1 Family Protein C16orf58 3
  • UPF0420 Protein C16orf58 3
  • RUS 3

External Ids for C16orf58 Gene

Previous GeneCards Identifiers for C16orf58 Gene

  • GC16M031409
  • GC16M029061

Summaries for C16orf58 Gene

Entrez Gene Summary for C16orf58 Gene

  • This gene encodes a putative transmembrane protein containing a conserved DUF647 domain that may be involved in protein-protein interaction. The encoded protein is related to a plant protein that participates in ultraviolet B light-sensing during root morphogenesis. [provided by RefSeq, Feb 2013]

GeneCards Summary for C16orf58 Gene

C16orf58 (Chromosome 16 Open Reading Frame 58) is a Protein Coding gene. Diseases associated with C16orf58 include Vesicoureteral Reflux 1 and Acute Cystitis.

Gene Wiki entry for C16orf58 Gene

Additional gene information for C16orf58 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf58 Gene

Genomics for C16orf58 Gene

GeneHancer (GH) Regulatory Elements for C16orf58 Gene

Promoters and enhancers for C16orf58 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J031507 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 670.4 +0.6 561 3.3 SMAD1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 POLR2B ZNF213 C16orf58 ENSG00000260625 GC16P031508 PIR61516 RNF40 ENSG00000260267 LINC02190 SETD1A VN1R64P ENSG00000261648
GH16J031522 Promoter 0.5 EPDnew 650.4 -13.1 -13072 0.1 GC16P031521 C16orf58 SLC5A2 TGFB1I1 CLUHP3 ZNF720 ARMC5 AHSP
GH16J030566 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 102.3 +939.4 939435 6 ZFP64 FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF416 ZNF143 ZNF548 SP3 ZNF688 SETD1A SRCAP ENSG00000260267 NPIPB13 INO80E ZNF764 ZNF747 SMG1P5 SMG1P2
GH16J030956 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 35.9 +551.4 551418 3.4 CLOCK FEZF1 DMAP1 YY1 ZNF213 E2F8 ZNF143 ZNF548 ZNF263 SP3 SETD1A ENSG00000275263 SRCAP INO80E ZNF764 ENSG00000260267 RNF40 ZNF747 SMG1P5 KAT8
GH16J031092 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 39.3 +414.7 414718 4 CLOCK ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF213 ZNF143 SP3 NFYC VKORC1 ENSG00000280160 ENSG00000255439 SETD1A ZNF785 ZNF720 FUS ZNF689 SRCAP ZNF747
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf58 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf58 gene promoter:
  • GATA-1
  • GATA-2
  • LUN-1
  • c-Myb
  • IRF-7A
  • Max
  • c-Myc
  • CHOP-10
  • C/EBPalpha

Genomic Locations for C16orf58 Gene

Genomic Locations for C16orf58 Gene
19,841 bases
Minus strand
19,839 bases
Minus strand

Genomic View for C16orf58 Gene

Genes around C16orf58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf58 Gene

Proteins for C16orf58 Gene

  • Protein details for C16orf58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    RUS1 family protein C16orf58
    Protein Accession:
    Secondary Accessions:
    • Q53GL8
    • Q8NAJ4
    • Q9BVY3
    • Q9H887

    Protein attributes for C16orf58 Gene

    468 amino acids
    Molecular mass:
    51018 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf58 Gene


neXtProt entry for C16orf58 Gene

Post-translational modifications for C16orf58 Gene

  • Ubiquitination at posLast=466466, Lys436, posLast=433433, posLast=376376, and posLast=297297
  • Modification sites at PhosphoSitePlus

Other Protein References for C16orf58 Gene

No data available for DME Specific Peptides for C16orf58 Gene

Domains & Families for C16orf58 Gene

Gene Families for C16orf58 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C16orf58 Gene


Suggested Antigen Peptide Sequences for C16orf58 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the RUS1 family.
  • Belongs to the RUS1 family.
genes like me logo Genes that share domains with C16orf58: view

Function for C16orf58 Gene

Phenotypes From GWAS Catalog for C16orf58 Gene

genes like me logo Genes that share phenotypes with C16orf58: view

Animal Model Products

CRISPR Products

miRNA for C16orf58 Gene

miRTarBase miRNAs that target C16orf58

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf58 Gene

Localization for C16orf58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf58 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf58 gene
Compartment Confidence
nucleus 3
cytosol 3
golgi apparatus 2
plasma membrane 1
cytoskeleton 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Golgi apparatus (2)
  • Nucleoli (2)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C16orf58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane HDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf58: view

Pathways & Interactions for C16orf58 Gene

SuperPathways for C16orf58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C16orf58 Gene


No data available for Pathways by source and SIGNOR curated interactions for C16orf58 Gene

Drugs & Compounds for C16orf58 Gene

No Compound Related Data Available

Transcripts for C16orf58 Gene

mRNA/cDNA for C16orf58 Gene

Unigene Clusters for C16orf58 Gene

Chromosome 16 open reading frame 58:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf58

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf58 Gene

No ASD Table

Relevant External Links for C16orf58 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C16orf58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf58 Gene

Protein differential expression in normal tissues from HIPED for C16orf58 Gene

This gene is overexpressed in Nasal epithelium (53.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C16orf58 Gene

Protein tissue co-expression partners for C16orf58 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf58 Gene:


SOURCE GeneReport for Unigene cluster for C16orf58 Gene:


Evidence on tissue expression from TISSUES for C16orf58 Gene

  • Nervous system(4.7)
  • Kidney(4.6)
  • Thyroid gland(4.3)
  • Intestine(2.4)
  • Gall bladder(2.2)
  • Lung(2)
  • Muscle(2)
genes like me logo Genes that share expression patterns with C16orf58: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf58 Gene

Orthologs for C16orf58 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for C16orf58 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C16H16orf58 33
  • 99.43 (n)
C16orf58 34
  • 99 (a)
(Bos Taurus)
Mammalia C25H16orf58 33
  • 88.07 (n)
C16orf58 34
  • 82 (a)
(Canis familiaris)
Mammalia C6H16orf58 33
  • 86.54 (n)
C16orf58 34
  • 68 (a)
(Mus musculus)
Mammalia BC017158 16 34 33
  • 83.98 (n)
(Rattus norvegicus)
Mammalia RGD1310127 33
  • 82.47 (n)
(Ornithorhynchus anatinus)
Mammalia C16orf58 34
  • 70 (a)
(Monodelphis domestica)
Mammalia C16orf58 34
  • 68 (a)
(Anolis carolinensis)
Reptilia C16orf58 34
  • 52 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC101732099 33
  • 61.32 (n)
Str.20322 33
(Danio rerio)
Actinopterygii zgc:162613 33
  • 57.04 (n)
C3H16orf58 34
  • 50 (a)
Dr.12463 33
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.4481 33
fruit fly
(Drosophila melanogaster)
Insecta CG10338 34 33
  • 53.39 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP010020 33
  • 48.69 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons RUS3 33
  • 48.65 (n)
sea squirt
(Ciona savignyi)
Ascidiacea Cin.5264 33
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5264 33
Species where no ortholog for C16orf58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C16orf58 Gene

Gene Tree for C16orf58 (if available)
Gene Tree for C16orf58 (if available)

Paralogs for C16orf58 Gene

No data available for Paralogs for C16orf58 Gene

Variants for C16orf58 Gene

Sequence variations from dbSNP and Humsavar for C16orf58 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs114517938 uncertain-significance, Familial renal glucosuria 31,490,598(-) G/A/C 3_prime_UTR_variant, non_coding_transcript_variant
rs147697689 uncertain-significance, Familial renal glucosuria 31,490,130(-) G/A 3_prime_UTR_variant, non_coding_transcript_variant
rs149525864 uncertain-significance, Familial renal glucosuria 31,490,211(-) G/A/T 3_prime_UTR_variant, non_coding_transcript_variant
rs199521654 uncertain-significance, Familial renal glucosuria 31,489,276(-) T/G downstream_transcript_variant
rs201073991 uncertain-significance, Familial renal glucosuria 31,490,360(-) G/A/C 3_prime_UTR_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf58 Gene

Variant ID Type Subtype PubMed ID
esv3570465 CNV gain 25503493
nsv1060240 CNV gain 25217958
nsv482193 CNV gain 20164927
nsv833194 CNV loss 17160897

Variation tolerance for C16orf58 Gene

Residual Variation Intolerance Score: 58.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.28; 40.80% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf58 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf58 Gene

Disorders for C16orf58 Gene

MalaCards: The human disease database

(4) MalaCards diseases for C16orf58 Gene - From: DISEASES

Disorder Aliases PubMed IDs
vesicoureteral reflux 1
  • vur1
acute cystitis
  • urinary tract infection
ureteral disease
  • ureteral disorders
bladder disease
  • urinary bladder disease
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C16orf58

genes like me logo Genes that share disorders with C16orf58: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C16orf58 Gene

Publications for C16orf58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 58
  5. HIV-host interactome revealed directly from infected cells. (PMID: 27375898) Luo Y … Muesing MA (Nature microbiology 2016) 3 58

Products for C16orf58 Gene

Sources for C16orf58 Gene

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