Aliases for C16orf54 Gene
Aliases for C16orf54 Gene
External Ids for C16orf54 Gene
- HGNC: 26649
- Entrez Gene: 283897
- Ensembl: ENSG00000185905
- UniProtKB: Q6UWD8
Previous GeneCards Identifiers for C16orf54 Gene
- GC16M029662
- GC16M029663
- GC16M029753
- GC16M027414
Summaries for C16orf54 Gene
GeneCards Summary for C16orf54 Gene
C16orf54 (Chromosome 16 Open Reading Frame 54) is a Protein Coding gene.
Additional gene information for C16orf54 Gene
No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf54 Gene
Genomics for C16orf54 Gene
GeneHancer (GH) Regulatory Elements for C16orf54 Gene
Promoters and enhancers for C16orf54 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association
Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)
GeneHancers around C16orf54 on UCSC Golden Path with GeneCards custom track
- Top Transcription factor binding sites by QIAGEN in the C16orf54 gene promoter:
-
- AML1a
- LCR-F1
- Tal-1
- E47
- E2F-1
- E2F-2
- E2F-3a
- E2F-4
- E2F-5
- E2F
Regulatory Element Products
Genomic Locations for C16orf54 Gene
Genomic Locations for C16orf54 Gene
- chr16:29,742,463-29,746,329
- (GRCh38/hg38)
- Size:
- 3,867 bases
- Orientation:
- Minus strand
- chr16:29,753,784-29,757,340
- (GRCh37/hg19)
- Size:
- 3,557 bases
- Orientation:
- Minus strand
Genomic View for C16orf54 Gene
Genes around C16orf54 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16p11.2 by Entrez Gene
- 16p11.2 by HGNC
- 16p11.2 by Ensembl
C16orf54 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for C16orf54 Gene
Proteins for C16orf54 Gene
-
Protein details for C16orf54 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q6UWD8-CP054_HUMAN
- Recommended name:
- Transmembrane protein C16orf54
- Protein Accession:
- Q6UWD8
- A6NJR6
- Q8NAB0
Protein attributes for C16orf54 Gene
- Size:
- 224 amino acids
- Molecular mass:
- 24360 Da
- Quaternary structure:
- No Data Available
Protein Expression for C16orf54 Gene
Post-translational modifications for C16orf54 Gene
- O-glycosylated with core 1 or possibly core 8 glycans.
- Glycosylation at Thr4
- Ubiquitination at posLast=215215
- Modification sites at PhosphoSitePlus
-
Glycosylation from GlyConnect
- CP054_HUMAN (783)
Other Protein References for C16orf54 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for C16orf54
- Invitrogen Antibodies for C16orf54 (AFLGC-C16orf54)
- Search GeneTex for Antibodies for C16orf54
-
Biorbyt antibodies for C16orf54
Protein Products
-
OriGene Purified Proteins for C16orf54
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- Novus Biologicals proteins for C16orf54
- Search GeneTex for Proteins for C16orf54
Assay Products
No data available for DME Specific Peptides for C16orf54 Gene
Domains & Families for C16orf54 Gene
Gene Families for C16orf54 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Suggested Antigen Peptide Sequences for C16orf54 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for C16orf54 Gene
Function for C16orf54 Gene
Phenotypes From GWAS Catalog for C16orf54 Gene
Phenotypes for C16orf54 Gene
- GenomeRNAi human phenotypes for C16orf54:
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for C16orf54
-
CRISPR Products
-
OriGene CRISPR knockouts for C16orf54
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- Applied Biological Materials CRISPR for C16orf54
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C16orf54
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miRNA for C16orf54 Gene
- miRTarBase miRNAs that target C16orf54
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C16orf54
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Clone Products
- Sino Biological Human cDNA Clone for C16orf54
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- Applied Biological Materials Clones for C16orf54
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for C16orf54
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf54 Gene
Localization for C16orf54 Gene
Subcellular locations from UniProtKB/Swiss-Prot for C16orf54 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| mitochondrion | 1 |
| peroxisome | 1 |
| nucleus | 1 |
| cytosol | 1 |
| golgi apparatus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
No data available for Subcellular locations from the Human Protein Atlas (HPA) for C16orf54 Gene
Transcripts for C16orf54 Gene
mRNA/cDNA for C16orf54 Gene
- (1) REFSEQ mRNAs :
- (5) Additional mRNA sequences :
- (11) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
-
- ENST00000329410 2585 bps (uc002dtp.3)
Unigene Clusters for C16orf54 Gene
CRISPR Products
-
OriGene CRISPR knockouts for C16orf54
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- genomics-online: gRNA clones - Search results for 36 available C16ORF54 gene related products
- Overview of 36 available C16ORF54 gene related products
- Applied Biological Materials CRISPR for C16orf54
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for C16orf54
- GenScript: Design CRISPR guide RNA sequences for C16orf54
miRNA Products
Inhibitory RNA Products
- Origene shrna, sirna, and RNAi products in human, mouse, rat for C16orf54
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- genomics-online: shRNA clones - Search results for 36 available C16ORF54 gene related products
- Overview of 36 available C16ORF54 gene related products
Clone Products
- Sino Biological Human cDNA Clone for C16orf54
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- Applied Biological Materials Clones for C16orf54
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Expression for C16orf54 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
-
Pancreas (Endocrine System)
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
-
Epithelial Cells
- Endocrine Progenitor Cells Dorsal Pancreatic Bud
- Endocrine Progenitor Cells Ventral Pancreatic Bud
-
Blood (Hematopoietic System)
- Granulocytes Peripheral Blood
-
Extraembryonic Mesoderm (Extraembryonic Tissues)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
-
Endothelium (Cardiovascular System)
- Extraembryonic Angioblasts Extraembryonic Capillary Plexus
mRNA differential expression in normal tissues according to GTEx for C16orf54 Gene
This gene is overexpressed in Whole Blood (x38.9).
This gene is overexpressed in CD8 Tcells (17.3), Plasma (11.5), Peripheral blood mononuclear cells (10.9), Monocytes (8.5), NK cells (7.6), and Platelet (7.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf54 Gene
- Elite partner
NURSA nuclear receptor signaling pathways regulating expression of C16orf54 Gene:
C16orf54SOURCE GeneReport for Unigene cluster for C16orf54 Gene:
Hs.331095Evidence on tissue expression from TISSUES for C16orf54 Gene
- Spleen(4.2)
Primer Products
-
OriGene qPCR primer pairs for C16orf54
- genomics-online: primer clones - Search results for 36 available C16ORF54 gene related products
- Overview of 36 available C16ORF54 gene related products
Gene Expression Assay Products
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf54 Gene
Orthologs for C16orf54 Gene
This gene was present in the common ancestor of mammals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | C16H16orf54 33 |
|
||
| C16orf54 34 |
|
OneToOne | |||
| cow (Bos Taurus) |
Mammalia | C25H16orf54 33 |
|
||
| C16orf54 34 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | C6H16orf54 33 |
|
||
| C16orf54 34 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | AI467606 16 34 33 |
|
||
| rat (Rattus norvegicus) |
Mammalia | LOC308990 33 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | C16orf54 34 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | -- 34 |
|
OneToMany | |
| -- 34 |
|
OneToMany |
- Species where no ortholog for C16orf54 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- lizard (Anolis carolinensis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
- zebrafish (Danio rerio)
Paralogs for C16orf54 Gene
No data available for Paralogs for C16orf54 Gene
Variants for C16orf54 Gene
| SNP ID | Clin | Chr 16 pos | Variation | AA Info | Type |
|---|---|---|---|---|---|
| rs1000595169 | -- | 29,743,035(-) | C/T | 3_prime_UTR_variant | |
| rs1000639186 | -- | 29,746,141(-) | G/A | upstream_transcript_variant | |
| rs1000755061 | -- | 29,746,404(-) | T/A | upstream_transcript_variant | |
| rs1000985062 | -- | 29,747,297(-) | T/C | upstream_transcript_variant | |
| rs1001253009 | -- | 29,745,771(-) | C/T | intron_variant |
Gene Damage Index Score:
2.08;
38.11% of all genes are more intolerant (likely to be disease-causing)
Additional Variant Information for C16orf54 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- C16orf54
SNP Genotyping and Copy Number Assay Products
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf54 Gene
Disorders for C16orf54 Gene
Additional Disease Information for C16orf54
No disorders were found for C16orf54 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf54 Gene
Publications for C16orf54 Gene
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
- Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
- Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. (PMID: 26439863) Matheson NJ … Lehner PJ (Cell host & microbe 2015) 3 58
Products for C16orf54 Gene
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- Invitrogen Antibodies for C16orf54 (AFLGC-C16orf54)
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- Search GeneCopoeia for CRISPR/Cas9 clones, lentivirus and AAV products for C16orf54
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- Biorbyt antibodies for C16orf54
Sources for C16orf54 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
- (120) Genetics Home Reference
- (121) MeSH
- (122) MedlinePlus
- (123) CDC
- (124) NINDS
- (125) NCBI Bookshelf
- (126) ClinVar
- (127) Gene Damage Index
- (128) ViGene Biosciences
- (129) HPO
- (130) UDN
- (131) VISTA
- (132) FANTOM5
- (133) ENCODE
- (134) ProSci
- (135) Horizon
- (136) NURSA
- (137) IID
- (138) Cyagen
- (139) VectorBuilder
- (140) SNPedia
- (141) BRCA Exchange
- (142) St John's Lab
- (143) CIViC
- (144) ProteoGenix
- (145) dbSUPER
- (146) TISSUES
- (147) Gene ORGANizer
- (148) abm
- (149) CrownBio
- (150) Human Protein Atlas
- (151) GWAS Catalog
- (152) Monarch Initiative
- (153) DataMed
- (154) HumanCyc
- (155) genomics-online
- (156) UCNEbase
- (157) EPDnew
- (158) Applied Biosystems
- (159) GlyConnect
- (160) Aminode
- (161) GeneCopoeia
- (162) GPS-Prot
- (163) RNACentral
- (164) LncRNADisease
- (165) LOVD
- (166) miR2Disease
- (167) DiseaseEnhancer
- (168) Boster Bio
- (169) Biorbyt