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Aliases for C16orf54 Gene

Aliases for C16orf54 Gene

  • Chromosome 16 Open Reading Frame 54 2 3 5
  • Transmembrane Protein C16orf54 3

External Ids for C16orf54 Gene

Previous GeneCards Identifiers for C16orf54 Gene

  • GC16M029662
  • GC16M029663
  • GC16M029753
  • GC16M027414

Summaries for C16orf54 Gene

GeneCards Summary for C16orf54 Gene

C16orf54 (Chromosome 16 Open Reading Frame 54) is a Protein Coding gene.

Additional gene information for C16orf54 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C16orf54 Gene

Genomics for C16orf54 Gene

GeneHancer (GH) Regulatory Elements for C16orf54 Gene

Promoters and enhancers for C16orf54 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH16J029742 Promoter/Enhancer 2.2 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 659 +1.2 1197 5.4 HDGF BMI1 BATF KLF5 IRF4 ZNF207 ETV6 BCLAF1 IKZF2 RUNX3 C16orf54 ENSG00000260719 RN7SKP127 TBX6 YPEL3 MYLPF CORO1A PPP4C GC16M029747
GH16J029700 Enhancer 1.4 FANTOM5 Ensembl ENCODE 15 +44.4 44405 3.6 ARID4B ZBTB7B ARID2 ZNF143 ZFP91 ATF7 RUNX3 DEK NFKBIZ REST NPIPB12 NPIPB13 C16orf54 MVP DOC2A ENSG00000198106 INO80E NPIPB11 ENSG00000260853 ENSG00000235560
GH16J029828 Promoter/Enhancer 1.6 EPDnew Ensembl ENCODE 10.9 -83.7 -83701 3.4 FOXA2 MLX ARID4B DMAP1 ETS1 YY1 SLC30A9 RXRA SP5 REST MVP CDIPTOSP CDIPT C16orf92 FAM57B DOC2A TMEM219 INO80E HIRIP3 C16orf54
GH16J030697 Promoter/Enhancer 1.6 Ensembl ENCODE 9.7 -952.8 -952806 3.8 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 SP3 SRCAP LOC730183 ZNF785 SETD1A FUS ENSG00000260267 TAOK2 ENSG00000260304 ENSG00000260114 BCL7C
GH16J030398 Enhancer 1.3 Ensembl ENCODE 9.7 -654.1 -654066 3.8 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 ZBTB7B IRF4 YY1 PIR39668 GC16P030401 ZNF785 ENSG00000260114 TBC1D10B SPN PYCARD SMG1P5 CD2BP2 FUS
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C16orf54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C16orf54 gene promoter:

Genomic Locations for C16orf54 Gene

Genomic Locations for C16orf54 Gene
chr16:29,742,463-29,746,329
(GRCh38/hg38)
Size:
3,867 bases
Orientation:
Minus strand
chr16:29,753,784-29,757,340
(GRCh37/hg19)

Genomic View for C16orf54 Gene

Genes around C16orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf54 Gene

Proteins for C16orf54 Gene

  • Protein details for C16orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWD8-CP054_HUMAN
    Recommended name:
    Transmembrane protein C16orf54
    Protein Accession:
    Q6UWD8
    Secondary Accessions:
    • A6NJR6
    • Q8NAB0

    Protein attributes for C16orf54 Gene

    Size:
    224 amino acids
    Molecular mass:
    24360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C16orf54 Gene

Post-translational modifications for C16orf54 Gene

  • O-glycosylated with core 1 or possibly core 8 glycans.
  • Glycosylation at Thr4
  • Ubiquitination at posLast=215215
  • Modification sites at PhosphoSitePlus
  • Glycosylation from GlyConnect
    • CP054_HUMAN (783)

Other Protein References for C16orf54 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C16orf54 Gene

Domains & Families for C16orf54 Gene

Gene Families for C16orf54 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for C16orf54 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for C16orf54 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C16orf54: view

No data available for UniProtKB/Swiss-Prot for C16orf54 Gene

Function for C16orf54 Gene

Phenotypes From GWAS Catalog for C16orf54 Gene

genes like me logo Genes that share phenotypes with C16orf54: view

Animal Model Products

miRNA for C16orf54 Gene

miRTarBase miRNAs that target C16orf54

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf54 Gene

Localization for C16orf54 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C16orf54 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf54 gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
peroxisome 1
nucleus 1
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for C16orf54 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C16orf54: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C16orf54 Gene

Pathways & Interactions for C16orf54 Gene

SuperPathways for C16orf54 Gene

No Data Available

Interacting Proteins for C16orf54 Gene

Gene Ontology (GO) - Biological Process for C16orf54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf54 Gene

Drugs & Compounds for C16orf54 Gene

No Compound Related Data Available

Transcripts for C16orf54 Gene

mRNA/cDNA for C16orf54 Gene

(11) Selected AceView cDNA sequences:
(5) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C16orf54 Gene

Chromosome 16 open reading frame 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf54 Gene

No ASD Table

Relevant External Links for C16orf54 Gene

GeneLoc Exon Structure for
C16orf54
ECgene alternative splicing isoforms for
C16orf54

Expression for C16orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C16orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C16orf54 Gene

This gene is overexpressed in Whole Blood (x38.9).

Protein differential expression in normal tissues from HIPED for C16orf54 Gene

This gene is overexpressed in CD8 Tcells (17.3), Plasma (11.5), Peripheral blood mononuclear cells (10.9), Monocytes (8.5), NK cells (7.6), and Platelet (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf54 Gene



Protein tissue co-expression partners for C16orf54 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of C16orf54 Gene:

C16orf54

SOURCE GeneReport for Unigene cluster for C16orf54 Gene:

Hs.331095

Evidence on tissue expression from TISSUES for C16orf54 Gene

  • Spleen(4.2)
genes like me logo Genes that share expression patterns with C16orf54: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf54 Gene

Orthologs for C16orf54 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C16orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C16H16orf54 33
  • 99.26 (n)
C16orf54 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C25H16orf54 33
  • 82.26 (n)
C16orf54 34
  • 78 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C6H16orf54 33
  • 81.55 (n)
C16orf54 34
  • 69 (a)
OneToOne
mouse
(Mus musculus)
Mammalia AI467606 16 34 33
  • 76.53 (n)
rat
(Rattus norvegicus)
Mammalia LOC308990 33
  • 76.38 (n)
oppossum
(Monodelphis domestica)
Mammalia C16orf54 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 47 (a)
OneToMany
-- 34
  • 45 (a)
OneToMany
Species where no ortholog for C16orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C16orf54 Gene

ENSEMBL:
Gene Tree for C16orf54 (if available)
TreeFam:
Gene Tree for C16orf54 (if available)

Paralogs for C16orf54 Gene

No data available for Paralogs for C16orf54 Gene

Variants for C16orf54 Gene

Sequence variations from dbSNP and Humsavar for C16orf54 Gene

SNP ID Clin Chr 16 pos Variation AA Info Type
rs1000595169 -- 29,743,035(-) C/T 3_prime_UTR_variant
rs1000639186 -- 29,746,141(-) G/A upstream_transcript_variant
rs1000755061 -- 29,746,404(-) T/A upstream_transcript_variant
rs1000985062 -- 29,747,297(-) T/C upstream_transcript_variant
rs1001253009 -- 29,745,771(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C16orf54 Gene

Variant ID Type Subtype PubMed ID
dgv34n68 CNV loss 17160897
nsv1063706 CNV gain 25217958
nsv833186 CNV loss 17160897

Variation tolerance for C16orf54 Gene

Gene Damage Index Score: 2.08; 38.11% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf54 Gene

Disorders for C16orf54 Gene

Additional Disease Information for C16orf54

No disorders were found for C16orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf54 Gene

Publications for C16orf54 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef. (PMID: 26439863) Matheson NJ … Lehner PJ (Cell host & microbe 2015) 3 58

Products for C16orf54 Gene

Sources for C16orf54 Gene

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