Aliases for C16orf46 Gene

Aliases for C16orf46 Gene

  • Chromosome 16 Open Reading Frame 46 2 3 5
  • Uncharacterized Protein C16orf46 3 4
  • C16orf46 5
  • FLJ32702 2

External Ids for C16orf46 Gene

Previous GeneCards Identifiers for C16orf46 Gene

  • GC16M079653
  • GC16M081087
  • GC16M066843

Summaries for C16orf46 Gene

GeneCards Summary for C16orf46 Gene

C16orf46 (Chromosome 16 Open Reading Frame 46) is a Protein Coding gene.

Additional gene information for C16orf46 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C16orf46 Gene

Genomics for C16orf46 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C16orf46 Gene
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C16orf46 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C16orf46

Top Transcription factor binding sites by QIAGEN in the C16orf46 gene promoter:
  • ATF-2
  • CBF(2)
  • CBF-A
  • CBF-C
  • FOXD1
  • FOXJ2
  • FOXJ2 (long isoform)
  • FOXO4
  • MRF-2
  • NF-kappaB1

Genomic Locations for C16orf46 Gene

Latest Assembly
chr16:81,053,497-81,077,267
(GRCh38/hg38)
Size:
23,771 bases
Orientation:
Minus strand

Previous Assembly
chr16:81,087,102-81,110,843
(GRCh37/hg19 by Entrez Gene)
Size:
23,742 bases
Orientation:
Minus strand

chr16:81,087,102-81,110,872
(GRCh37/hg19 by Ensembl)
Size:
23,771 bases
Orientation:
Minus strand

Genomic View for C16orf46 Gene

Genes around C16orf46 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C16orf46 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C16orf46 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C16orf46 Gene

Proteins for C16orf46 Gene

  • Protein details for C16orf46 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P387-CP046_HUMAN
    Recommended name:
    Uncharacterized protein C16orf46
    Protein Accession:
    Q6P387
    Secondary Accessions:
    • Q96MA7

    Protein attributes for C16orf46 Gene

    Size:
    395 amino acids
    Molecular mass:
    43418 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C16orf46 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C16orf46 Gene

Post-translational modifications for C16orf46 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C16orf46 Gene

Domains & Families for C16orf46 Gene

Gene Families for C16orf46 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C16orf46 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C16orf46: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C16orf46 Gene

Function for C16orf46 Gene

Phenotypes From GWAS Catalog for C16orf46 Gene

genes like me logo Genes that share phenotypes with C16orf46: view

miRNA for C16orf46 Gene

miRTarBase miRNAs that target C16orf46

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf46

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C16orf46 Gene

Localization for C16orf46 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C16orf46 gene
Compartment Confidence
nucleus 5
cytosol 5

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C16orf46 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C16orf46: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C16orf46 Gene

Pathways & Interactions for C16orf46 Gene

PathCards logo

SuperPathways for C16orf46 Gene

No Data Available

Interacting Proteins for C16orf46 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000299578 Q6P387-CP046_HUMAN for C16orf46 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C16orf46 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C16orf46 Gene

Drugs & Compounds for C16orf46 Gene

No Compound Related Data Available

Transcripts for C16orf46 Gene

mRNA/cDNA for C16orf46 Gene

2 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C16orf46

Alternative Splicing Database (ASD) splice patterns (SP) for C16orf46 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:
SP3: - - - -

Relevant External Links for C16orf46 Gene

GeneLoc Exon Structure for
C16orf46

Expression for C16orf46 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C16orf46 Gene

Protein differential expression in normal tissues from HIPED for C16orf46 Gene

This gene is overexpressed in Monocytes (55.3) and Lung (7.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C16orf46 Gene



Protein tissue co-expression partners for C16orf46 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C16orf46

SOURCE GeneReport for Unigene cluster for C16orf46 Gene:

Hs.658684
genes like me logo Genes that share expression patterns with C16orf46: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C16orf46 Gene

Orthologs for C16orf46 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C16orf46 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C16H16orf46 30
  • 98.82 (n)
C16orf46 31
  • 96 (a)
OneToOne
Dog
(Canis familiaris)
Mammalia C5H16orf46 30
  • 82.05 (n)
C16orf46 31
  • 71 (a)
OneToOne
Cow
(Bos Taurus)
Mammalia C18H16orf46 30
  • 79.09 (n)
C16orf46 31
  • 65 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia 1700030J22Rik 30 17 31
  • 69.29 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC687399 30
  • 68.45 (n)
Oppossum
(Monodelphis domestica)
Mammalia C16orf46 31
  • 39 (a)
OneToOne
Platypus
(Ornithorhynchus anatinus)
Mammalia C16orf46 31
  • 37 (a)
OneToOne
Tropical Clawed Frog
(Silurana tropicalis)
Amphibia LOC100487055 30
  • 43.34 (n)
Species where no ortholog for C16orf46 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C16orf46 Gene

ENSEMBL:
Gene Tree for C16orf46 (if available)
TreeFam:
Gene Tree for C16orf46 (if available)

Paralogs for C16orf46 Gene

No data available for Paralogs for C16orf46 Gene

Variants for C16orf46 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C16orf46 Gene

SNP ID Clinical significance and condition Chr 16 pos Variation AA Info Type
rs10459872 - p.Tyr335His
rs12929250 - p.Pro388Ser
rs17855893 - p.Thr77Ser
rs7198494 - p.Ile288Thr
rs9930623 - p.Lys357Glu

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C16orf46 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C16orf46 Gene

Variant ID Type Subtype PubMed ID
dgv356n27 CNV loss 19166990
esv2422360 CNV duplication 17116639
esv2751615 CNV gain 17911159
esv3639307 CNV loss 21293372
esv3639308 CNV loss 21293372
nsv1062724 CNV gain 25217958
nsv1897 CNV deletion 18451855
nsv573338 CNV loss 21841781
nsv573346 CNV loss 21841781

Variation tolerance for C16orf46 Gene

Residual Variation Intolerance Score: 87.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.08; 75.32% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C16orf46 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C16orf46

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C16orf46 Gene

Disorders for C16orf46 Gene

Additional Disease Information for C16orf46

Genetic Association Database
(GAD)
Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform

No disorders were found for C16orf46 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C16orf46 Gene

Publications for C16orf46 Gene

  1. Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study. (PMID: 18951430) Anney RJ … Gill M (American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2008) 3 41
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. (PMID: 30021884) Fasci D … Heck AJR (Molecular & cellular proteomics : MCP 2018) 3
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3

Products for C16orf46 Gene

Sources for C16orf46 Gene