Aliases for C15orf62 Gene

Aliases for C15orf62 Gene

  • Chromosome 15 Open Reading Frame 62 2 3 5
  • Uncharacterized Protein C15orf62, Mitochondrial 3 4
  • LOC643338 2
  • C15orf62 5

External Ids for C15orf62 Gene

Previous GeneCards Identifiers for C15orf62 Gene

  • GC15P038853
  • GC15P041062
  • GC15P017910

Summaries for C15orf62 Gene

GeneCards Summary for C15orf62 Gene

C15orf62 (Chromosome 15 Open Reading Frame 62) is a Protein Coding gene. Diseases associated with C15orf62 include Atrial Septal Defect 5. Gene Ontology (GO) annotations related to this gene include GTP-Rho binding. An important paralog of this gene is CDC42EP4.

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C15orf62 Gene

Genomics for C15orf62 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C15orf62 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J040767 Promoter/Enhancer 1.5 Ensembl ENCODE CraniofacialAtlas dbSUPER 250.7 -0.4 -381 4.2 BCLAF1 ZNF600 JUND ZNF10 ZIC2 YY1 CEBPB DEK ELK1 FEZF1 C15orf62 CCDC32 RPAP1 INO80 MGA BAHD1 DNAJC17 IVD ENSG00000259536 HSALNG0105286
GH15J040742 Promoter/Enhancer 1.3 Ensembl ENCODE 12.2 -24.1 -24056 7.4 ZNF654 MYC NCOR1 IKZF1 ZNF600 ZNF592 ZNF10 NFIC ZIC2 YY1 HSALNG0105282 CCDC32 RAD51 C15orf62 ZFYVE19 DNAJC17 RAD51-AS1 SPINT1 RHOV VPS18
GH15J040791 Enhancer 1.2 Ensembl ENCODE dbSUPER 11.8 +24.6 24621 6 IKZF1 JUND CEBPA ATF3 BRCA1 NFIC YY1 CEBPB FEZF1 HOMEZ ZFYVE19 RMDN3 CCDC32 C15orf62 SPINT1 GCHFR RAD51 RAD51-AS1 RHOV RPUSD2
GH15J040589 Promoter/Enhancer 1.2 ENCODE CraniofacialAtlas 9.5 -179.3 -179304 2.6 BCLAF1 ZNF654 IKZF1 ZNF580 ZMYM3 CEBPA YY1 CTCF DEK TRIM22 CCDC32 RAD51 INO80 ENSG00000259211 BAHD1 DNAJC17 RAD51-AS1 RMDN3 GCHFR OIP5
GH15J039932 Promoter/Enhancer 2 EPDnew Ensembl ENCODE CraniofacialAtlas 4.1 -835.4 -835425 3.8 BCLAF1 SP1 ZNF207 MYC ZNF600 IKZF1 ZNF592 POLR2A NFIC YY1 EIF2AK4 FSIP1 C15orf62 SNODB1087 SRP14
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C15orf62 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C15orf62

Top Transcription factor binding sites by QIAGEN in the C15orf62 gene promoter:
  • AREB6
  • C/EBPalpha
  • COMP1
  • CUTL1
  • Egr-2
  • LCR-F1
  • PPAR-gamma1
  • PPAR-gamma2

Genomic Locations for C15orf62 Gene

Latest Assembly
chr15:40,769,980-40,772,449
(GRCh38/hg38)
Size:
2,470 bases
Orientation:
Plus strand

Previous Assembly
chr15:41,062,178-41,064,647
(GRCh37/hg19 by Entrez Gene)
Size:
2,470 bases
Orientation:
Plus strand

chr15:41,062,159-41,064,643
(GRCh37/hg19 by Ensembl)
Size:
2,485 bases
Orientation:
Plus strand

Genomic View for C15orf62 Gene

Genes around C15orf62 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf62 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf62 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf62 Gene

Proteins for C15orf62 Gene

  • Protein details for C15orf62 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A8K5M9-CO062_HUMAN
    Recommended name:
    Uncharacterized protein C15orf62, mitochondrial
    Protein Accession:
    A8K5M9
    Secondary Accessions:
    • A6NK01

    Protein attributes for C15orf62 Gene

    Size:
    175 amino acids
    Molecular mass:
    19679 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf62 Gene

Post-translational modifications for C15orf62 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf62 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf62 Gene

Domains & Families for C15orf62 Gene

Gene Families for C15orf62 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
genes like me logo Genes that share domains with C15orf62: view

No data available for Protein Domains , Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C15orf62 Gene

Function for C15orf62 Gene

Phenotypes From GWAS Catalog for C15orf62 Gene

Gene Ontology (GO) - Molecular Function for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0031267 small GTPase binding IBA --
genes like me logo Genes that share ontologies with C15orf62: view

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C15orf62

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf62 Gene

Localization for C15orf62 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf62 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf62 gene
Compartment Confidence
plasma membrane 3
cytoskeleton 3
mitochondrion 3
nucleus 2
cytosol 0

Gene Ontology (GO) - Cellular Components for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA 21873635
GO:0005739 mitochondrion IEA --
GO:0005856 cytoskeleton IBA 21873635
GO:0005886 plasma membrane IBA 21873635
genes like me logo Genes that share ontologies with C15orf62: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C15orf62 Gene

Pathways & Interactions for C15orf62 Gene

PathCards logo

SuperPathways for C15orf62 Gene

No Data Available

Interacting Proteins for C15orf62 Gene

Gene Ontology (GO) - Biological Process for C15orf62 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction IBA 21873635
GO:0008360 regulation of cell shape IBA 21873635
GO:0030838 positive regulation of actin filament polymerization IBA 21873635
GO:0031274 positive regulation of pseudopodium assembly IBA 21873635
genes like me logo Genes that share ontologies with C15orf62: view

No data available for Pathways by source and SIGNOR curated interactions for C15orf62 Gene

Drugs & Compounds for C15orf62 Gene

No Compound Related Data Available

Transcripts for C15orf62 Gene

mRNA/cDNA for C15orf62 Gene

1 REFSEQ mRNAs :
5 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Inhibitory RNAs for research

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C15orf62

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf62 Gene

No ASD Table

Relevant External Links for C15orf62 Gene

GeneLoc Exon Structure for
C15orf62

Expression for C15orf62 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C15orf62 Gene

mRNA expression in normal human tissues for C15orf62 Gene

Protein differential expression in normal tissues from HIPED for C15orf62 Gene

This gene is overexpressed in Plasma (47.4) and Heart (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C15orf62 Gene



Protein tissue co-expression partners for C15orf62 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C15orf62

SOURCE GeneReport for Unigene cluster for C15orf62 Gene:

Hs.631715
genes like me logo Genes that share expression patterns with C15orf62: view

Primer products for research

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf62 Gene

Orthologs for C15orf62 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf62 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C15H15orf62 29
  • 99.62 (n)
Dog
(Canis familiaris)
Mammalia C15orf62 30
  • 89 (a)
OneToOne
C30H15orf62 29
  • 88.95 (n)
Cow
(Bos Taurus)
Mammalia C10H15orf62 29
  • 86.27 (n)
C15orf62 30
  • 85 (a)
OneToOne
Mouse
(Mus musculus)
Mammalia Gm14137 29 16 30
  • 85.33 (n)
OneToOne
Rat
(Rattus norvegicus)
Mammalia LOC691418 29
  • 84.95 (n)
Oppossum
(Monodelphis domestica)
Mammalia C15orf62 30
  • 80 (a)
OneToOne
Chicken
(Gallus gallus)
Aves C5H15ORF62 29
  • 54.17 (n)
C15orf62 30
  • 38 (a)
OneToOne
Lizard
(Anolis carolinensis)
Reptilia C15orf62 30
  • 33 (a)
OneToOne
Species where no ortholog for C15orf62 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C15orf62 Gene

ENSEMBL:
Gene Tree for C15orf62 (if available)
TreeFam:
Gene Tree for C15orf62 (if available)
Alliance of Genome Resources:
Additional Orthologs for C15orf62

Paralogs for C15orf62 Gene

Paralogs for C15orf62 Gene

genes like me logo Genes that share paralogs with C15orf62: view

Variants for C15orf62 Gene

dbSNP identifiers (rs#s) for variants without ClinVar clinical significance for C15orf62 Gene

All consequence types are included: molecular consequences (e.g. missense, synonymous), and location-based (e.g. intron, upstream).

Structural Variations from Database of Genomic Variants (DGV) for C15orf62 Gene

Variant ID Type Subtype PubMed ID
nsv827306 CNV loss 20364138

Variation tolerance for C15orf62 Gene

Gene Damage Index Score: 2.09; 38.25% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf62 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf62
Leiden Open Variation Database (LOVD)
C15orf62

SNP Genotyping and Copy Number Assays for research

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C15orf62 Gene

Disorders for C15orf62 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C15orf62 Gene - From: COP

Disorder Aliases PubMed IDs
atrial septal defect 5
  • asd5
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C15orf62

Human Genome Epidemiology Navigator
(HuGE)
Atlas
ATLAS of Genetics and Cytogenetics in Oncology and Haematology
Open Targets Platform
Open Targets Platform
genes like me logo Genes that share disorders with C15orf62: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C15orf62 Gene

Publications for C15orf62 Gene

  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey SD … DREAM investigators (Diabetes care 2010) 3 40
  2. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud PJ … BRIGHT Consortium (American journal of human genetics 2009) 3

Products for C15orf62 Gene

Sources for C15orf62 Gene