Aliases for C15orf61 Gene

Aliases for C15orf61 Gene

  • Chromosome 15 Open Reading Frame 61 2 3 5
  • Uncharacterized Protein C15orf61 3 4

External Ids for C15orf61 Gene

Previous GeneCards Identifiers for C15orf61 Gene

  • GC15P065600
  • GC15P067813
  • GC15P044649

Summaries for C15orf61 Gene

GeneCards Summary for C15orf61 Gene

C15orf61 (Chromosome 15 Open Reading Frame 61) is a Protein Coding gene.

Additional gene information for C15orf61 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C15orf61 Gene

Genomics for C15orf61 Gene

GeneHancer (GH) Regulatory Elements for C15orf61 Gene

Promoters and enhancers for C15orf61 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J067520 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE CraniofacialAtlas 500.7 +0.7 670 3.6 EP300 ZBTB40 ZNF217 SIN3A NRF1 TCF12 USF1 POLR2G GTF2E2 PHF8 IQCH-AS1 C15orf61 MAP2K5
GH15J067548 Enhancer 1.1 Ensembl ENCODE 11.6 +27.8 27770 4.2 EP300 ZSCAN5C JUND FOS ZNF639 ZNF10 ZIC2 ZBTB11 TRIM28 CTBP1 SKOR1 IQCH-AS1 PIAS1 C15orf61 LOC101929076 RNU6-1 IQCH MAP2K5 ENSG00000270964 NONHSAG017251.2-001
GH15J067510 Enhancer 1 Ensembl ENCODE 5.7 -9.8 -9831 2.6 JUND FOS ZIC2 MYC OSR2 WT1 ZSCAN18 ZNF76 IRF1 MAX IQCH-AS1 MAP2K5 C15orf61 lnc-IQCH-2 lnc-IQCH-3
GH15J067493 Enhancer 0.4 Ensembl 11 -26.9 -26930 1.6 ZNF18 MITF USF2 ZNF549 IQCH-AS1 C15orf61 MAP2K5 lnc-IQCH-3 piR-45012-202 IQCH
GH15J067967 Promoter/Enhancer 1.4 FANTOM5 ENCODE CraniofacialAtlas 1.6 +447.3 447311 1.5 USF1 ZBTB26 RFX1 ZNF341 SP2 ZBTB17 POLR2A PBX2 ZFHX2 ZNF335 PIAS1 LOC101929076 RNU6-1 SKOR1 ENSG00000260657 C15orf61 ENSG00000261702 lnc-CALML4-5 HSALNG0106777
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C15orf61 on UCSC Golden Path with GeneCards custom track

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C15orf61

Top Transcription factor binding sites by QIAGEN in the C15orf61 gene promoter:
  • AP-1
  • ATF-2
  • c-Jun
  • IRF-1
  • Nkx2-5
  • POU3F2
  • RSRFC4

Genomic Locations for C15orf61 Gene

Genomic Locations for C15orf61 Gene
chr15:67,521,131-67,530,146
(GRCh38/hg38)
Size:
9,016 bases
Orientation:
Plus strand
chr15:67,813,406-67,819,641
(GRCh37/hg19)
Size:
6,236 bases
Orientation:
Plus strand

Genomic View for C15orf61 Gene

Genes around C15orf61 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf61 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf61 Gene

Proteins for C15orf61 Gene

  • Protein details for C15orf61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NNL5-CO061_HUMAN
    Recommended name:
    Uncharacterized protein C15orf61
    Protein Accession:
    A6NNL5
    Secondary Accessions:
    • B4DFB2

    Protein attributes for C15orf61 Gene

    Size:
    157 amino acids
    Molecular mass:
    18091 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf61 Gene

Post-translational modifications for C15orf61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf61 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf61 Gene

Domains & Families for C15orf61 Gene

Gene Families for C15orf61 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C15orf61 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C15orf61: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C15orf61 Gene

Function for C15orf61 Gene

Phenotypes From GWAS Catalog for C15orf61 Gene

genes like me logo Genes that share phenotypes with C15orf61: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf61 Gene

Localization for C15orf61 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C15orf61 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf61 gene
Compartment Confidence
extracellular 3
mitochondrion 1
peroxisome 1
cytosol 1
nucleus 0
endoplasmic reticulum 0

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoli (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C15orf61 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C15orf61: view

Pathways & Interactions for C15orf61 Gene

PathCards logo

SuperPathways for C15orf61 Gene

No Data Available

Interacting Proteins for C15orf61 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
STRING Interaction Network
Selected Interacting proteins: ENSP00000342254 A6NNL5-CO061_HUMAN for C15orf61 Gene via STRING IID

;

Gene Ontology (GO) - Biological Process for C15orf61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf61 Gene

Drugs & Compounds for C15orf61 Gene

No Compound Related Data Available

Transcripts for C15orf61 Gene

mRNA/cDNA for C15orf61 Gene

1 REFSEQ mRNAs :
4 NCBI additional mRNA sequence :
4 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf61 Gene

No ASD Table

Relevant External Links for C15orf61 Gene

GeneLoc Exon Structure for
C15orf61

Expression for C15orf61 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C15orf61 Gene

Protein differential expression in normal tissues from HIPED for C15orf61 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf61 Gene



Protein tissue co-expression partners for C15orf61 Gene

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C15orf61

SOURCE GeneReport for Unigene cluster for C15orf61 Gene:

Hs.438385

Evidence on tissue expression from TISSUES for C15orf61 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with C15orf61: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf61 Gene

Orthologs for C15orf61 Gene

This gene was present in the common ancestor of animals.

Orthologs for C15orf61 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf61 30
  • 99.57 (n)
C15orf61 31
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C30H15orf61 30
  • 94.48 (n)
C15orf61 31
  • 94 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C15orf61 31
  • 94 (a)
OneToOne
C10H15orf61 30
  • 93.84 (n)
mouse
(Mus musculus)
Mammalia 2300009A05Rik 17 31 30
  • 92.57 (n)
rat
(Rattus norvegicus)
Mammalia RGD1309779 30
  • 91.51 (n)
chicken
(Gallus gallus)
Aves C10H15orf61 30
  • 80.48 (n)
C15orf61 31
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100488454 30
  • 65.37 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:162898 30
  • 63.42 (n)
C18H15orf61 31
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000793 30
  • 63.99 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG34148 31 30
  • 56.33 (n)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 31
  • 47 (a)
OneToOne
Species where no ortholog for C15orf61 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf61 Gene

ENSEMBL:
Gene Tree for C15orf61 (if available)
TreeFam:
Gene Tree for C15orf61 (if available)

Paralogs for C15orf61 Gene

No data available for Paralogs for C15orf61 Gene

Variants for C15orf61 Gene

Additional dbSNP identifiers (rs#s) for C15orf61 Gene

Structural Variations from Database of Genomic Variants (DGV) for C15orf61 Gene

Variant ID Type Subtype PubMed ID
esv3636789 CNV loss 21293372
nsv569799 CNV loss 21841781

Variation tolerance for C15orf61 Gene

Gene Damage Index Score: 1.53; 29.74% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf61 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C15orf61 Gene

Disorders for C15orf61 Gene

Additional Disease Information for C15orf61

No disorders were found for C15orf61 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf61 Gene

Publications for C15orf61 Gene

  1. Analysis of the DNA sequence and duplication history of human chromosome 15. (PMID: 16572171) Zody MC … Nusbaum C (Nature 2006) 3 4 54
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 54
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 54
  4. TNIP2 is a Hub Protein in the NF-κB Network with Both Protein and RNA Mediated Interactions. (PMID: 27609421) Banks CA … Washburn MP (Molecular & cellular proteomics : MCP 2016) 3 54
  5. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 3 54

Products for C15orf61 Gene

Sources for C15orf61 Gene