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Aliases for C15orf59 Gene

Aliases for C15orf59 Gene

  • Chromosome 15 Open Reading Frame 59 2 3 5
  • Inhibitory Synaptic Protein 1 2 3
  • UPF0583 Protein C15orf59 3
  • INSYN1 3

External Ids for C15orf59 Gene

Previous GeneCards Identifiers for C15orf59 Gene

  • GC15M071820
  • GC15M074032
  • GC15M050863

Summaries for C15orf59 Gene

GeneCards Summary for C15orf59 Gene

C15orf59 (Chromosome 15 Open Reading Frame 59) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include transferase activity and cofactor binding. An important paralog of this gene is PRR16.

Additional gene information for C15orf59 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf59 Gene

Genomics for C15orf59 Gene

GeneHancer (GH) Regulatory Elements for C15orf59 Gene

Promoters and enhancers for C15orf59 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I073752 Promoter/Enhancer 1.3 Ensembl ENCODE 550.8 -0.3 -261 1.7 KLF17 ZNF76 SIN3A ZNF335 ZNF121 GLIS2 SCRT2 ZNF391 EGR2 ZBTB11 C15orf59 C15orf59-AS1 CYP1A1 GC15P073700 LOC105370892
GH15I073986 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 5.6 -236.6 -236593 6.8 HDGF PKNOX1 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B IRF4 ZNF766 ZNF213 STOML1 EDC3 UBL7-AS1 CLK3 LOC101929333 C15orf59 LOXL1-AS1
GH15I073682 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 4.9 +67.1 67125 8 SMAD1 ARID4B SIN3A FEZF1 ZBTB7B FOS SP3 SMARCB1 SMARCA4 GLIS1 CD276 NPTN C15orf59 GOLGA6A GC15P073700
GH15I073800 Enhancer 0.8 Ensembl ENCODE 12.1 -48.5 -48530 3 ZNF449 ZNF398 ATF2 ZNF335 FOSL1 JUND ZNF366 ZBTB48 VEZF1 FOSL2 C15orf59 LOC102723657 LOC105370892 GC15P073700
GH15I073964 Enhancer 1.5 FANTOM5 Ensembl ENCODE dbSUPER 2.3 -212.5 -212466 2.6 HDGF PKNOX1 RB1 KLF17 SIN3A BATF ZNF2 KLF5 IRF4 ZNF48 STOML1 PML EDC3 LOC101929333 TBC1D21 LOXL1 CLK3 C15orf59 LOXL1-AS1
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C15orf59 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C15orf59 gene promoter:

Genomic Locations for C15orf59 Gene

Genomic Locations for C15orf59 Gene
17,757 bases
Minus strand

Genomic View for C15orf59 Gene

Genes around C15orf59 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf59 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf59 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf59 Gene

Proteins for C15orf59 Gene

  • Protein details for C15orf59 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    UPF0583 protein C15orf59
    Protein Accession:

    Protein attributes for C15orf59 Gene

    293 amino acids
    Molecular mass:
    31928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf59 Gene

Post-translational modifications for C15orf59 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf59 Gene

No data available for DME Specific Peptides for C15orf59 Gene

Domains & Families for C15orf59 Gene

Gene Families for C15orf59 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf59 Gene


Suggested Antigen Peptide Sequences for C15orf59 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the UPF0583 family.
  • Belongs to the UPF0583 family.
genes like me logo Genes that share domains with C15orf59: view

Function for C15orf59 Gene

Phenotypes From GWAS Catalog for C15orf59 Gene

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf59 Gene

Localization for C15orf59 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf59 gene
Compartment Confidence
nucleus 4
cytosol 2
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf59 Gene

Pathways & Interactions for C15orf59 Gene

SuperPathways for C15orf59 Gene

No Data Available

Interacting Proteins for C15orf59 Gene

Gene Ontology (GO) - Biological Process for C15orf59 Gene


No data available for Pathways by source and SIGNOR curated interactions for C15orf59 Gene

Drugs & Compounds for C15orf59 Gene

No Compound Related Data Available

Transcripts for C15orf59 Gene

mRNA/cDNA for C15orf59 Gene

Unigene Clusters for C15orf59 Gene

Chromosome 15 open reading frame 59:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf59 Gene

No ASD Table

Relevant External Links for C15orf59 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C15orf59 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf59 Gene

mRNA differential expression in normal tissues according to GTEx for C15orf59 Gene

This gene is overexpressed in Heart - Left Ventricle (x4.1).

Protein differential expression in normal tissues from HIPED for C15orf59 Gene

This gene is overexpressed in Breast (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C15orf59 Gene

Protein tissue co-expression partners for C15orf59 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf59 Gene:


SOURCE GeneReport for Unigene cluster for C15orf59 Gene:

genes like me logo Genes that share expression patterns with C15orf59: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf59 Gene

Orthologs for C15orf59 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf59 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C15orf59 34
  • 100 (a)
C15H15orf59 33
  • 99.54 (n)
(Bos Taurus)
Mammalia C15orf59 34
  • 92 (a)
C10H15orf59 33
  • 88.93 (n)
(Mus musculus)
Mammalia 6030419C18Rik 33 16 34
  • 86.99 (n)
(Rattus norvegicus)
Mammalia RGD1562618 33
  • 86.48 (n)
(Canis familiaris)
Mammalia C15orf59 34
  • 86 (a)
C30H15orf59 33
  • 85.37 (n)
(Ornithorhynchus anatinus)
Mammalia C15orf59 34
  • 75 (a)
(Monodelphis domestica)
Mammalia C15orf59 34
  • 71 (a)
(Gallus gallus)
Aves C10H15ORF59 33
  • 69.26 (n)
C15orf59 34
  • 62 (a)
(Anolis carolinensis)
Reptilia C15orf59 34
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf59 33
  • 64.57 (n)
(Danio rerio)
Actinopterygii si:dkey-105e17.1 33
  • 60.27 (n)
C18H15orf59 34
  • 51 (a)
Species where no ortholog for C15orf59 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf59 Gene

Gene Tree for C15orf59 (if available)
Gene Tree for C15orf59 (if available)

Paralogs for C15orf59 Gene

Paralogs for C15orf59 Gene

genes like me logo Genes that share paralogs with C15orf59: view

Variants for C15orf59 Gene

Sequence variations from dbSNP and Humsavar for C15orf59 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000059499 -- 73,747,377(-) T/C intron_variant
rs1000334936 -- 73,740,854(-) C/T intron_variant
rs1000475013 -- 73,735,216(-) G/A/C downstream_transcript_variant
rs1000508744 -- 73,739,864(-) TATATTTAT/TAT 3_prime_UTR_variant
rs1000674615 -- 73,744,343(-) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf59 Gene

Variant ID Type Subtype PubMed ID
esv2667170 CNV deletion 23128226
esv2749875 CNV deletion 23290073
esv2749876 CNV deletion 23290073
esv3552674 CNV deletion 23714750
nsv1121512 CNV deletion 24896259
nsv471252 CNV loss 18288195
nsv569970 CNV loss 21841781
nsv951991 CNV deletion 24416366

Variation tolerance for C15orf59 Gene

Residual Variation Intolerance Score: 23.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.34; 26.56% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf59 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf59 Gene

Disorders for C15orf59 Gene

Additional Disease Information for C15orf59

No disorders were found for C15orf59 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf59 Gene

Publications for C15orf59 Gene

  1. Identification of an elaborate complex mediating postsynaptic inhibition. (PMID: 27609886) Uezu A … Soderling SH (Science (New York, N.Y.) 2016) 2 3 58
  2. Open reading frames associated with cancer in the dark matter of the human genome. (PMID: 25048349) Delgado AP … Narayanan R (Cancer genomics & proteomics 2014) 2 3 58
  3. Protein phosphatase 1γ isoforms linked interactions in the brain. (PMID: 23080069) Esteves SL … da Cruz e Silva EF (Journal of molecular neuroscience : MN 2013) 3 58
  4. Identification of the human testis protein phosphatase 1 interactome. (PMID: 21382349) Fardilha M … da Cruz e Silva EF (Biochemical pharmacology 2011) 3 58
  5. Framingham Heart Study genome-wide association: results for pulmonary function measures. (PMID: 17903307) Wilk JB … O'Connor GT (BMC medical genetics 2007) 44 58

Products for C15orf59 Gene

Sources for C15orf59 Gene

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