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Aliases for C15orf54 Gene

Subcategory (RNA class) for C15orf54 Gene

ncRNA

Quality Score for this RNA gene is

3

Aliases for C15orf54 Gene

  • Chromosome 15 Open Reading Frame 54 (Putative) 2 3 5
  • Chromosome 15 Open Reading Frame 54 2

External Ids for C15orf54 Gene

Previous GeneCards Identifiers for C15orf54 Gene

  • GC15P037331
  • GC15P039542
  • GC15P016386

Summaries for C15orf54 Gene

GeneCards Summary for C15orf54 Gene

C15orf54 (Chromosome 15 Open Reading Frame 54 (Putative)) is an RNA Gene, and is affiliated with the ncRNA class.

Additional gene information for C15orf54 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf54 Gene

Genomics for C15orf54 Gene

GeneHancer (GH) Regulatory Elements for C15orf54 Gene

Promoters and enhancers for C15orf54 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I039250 Enhancer 0.9 Ensembl ENCODE dbSUPER 550.8 +0.9 942 2.2 SRF JUND POLR2A JUN IKZF1 C15orf54 THBS1 ENSG00000259447 LOC105370777
GH15I039138 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.5 -110.1 -110056 3.4 ATF1 FOXA2 ARNT SIN3A TCF12 ZNF766 GATA2 FOS NCOA1 MBD2 C15orf54 THBS1 LOC105370780 LOC105370781 LOC105370777
GH15I039269 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +21.2 21151 5.3 PKNOX1 FOXA2 MLX ARID4B ETS1 YY1 ATF7 FOS RXRA SP5 THBS1 C15orf54 ENSG00000259447 LOC105370777
GH15I039190 Enhancer 1.4 FANTOM5 Ensembl ENCODE dbSUPER 11.9 -55.4 -55361 9.6 SOX13 JUN ZNF644 RAD21 RFX5 TEAD3 POLR2A SMC3 RCOR1 FOSL2 ENSG00000259450 C15orf54 BUB1B LOC105370777
GH15I039282 Enhancer 1.1 FANTOM5 Ensembl ENCODE dbSUPER 12.4 +34.9 34893 5.6 JUND JUN FOS THBS1 C15orf54 ENSG00000259447 LOC105370777
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C15orf54 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C15orf54 gene promoter:

Genomic Locations for C15orf54 Gene

Genomic Locations for C15orf54 Gene
chr15:39,250,669-39,254,845
(GRCh38/hg38)
Size:
4,177 bases
Orientation:
Plus strand
chr15:39,542,885-39,547,048
(GRCh37/hg19)

Genomic View for C15orf54 Gene

Genes around C15orf54 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf54 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf54 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf54 Gene

Proteins for C15orf54 Gene

  • Protein details for C15orf54 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N8G6-CO054_HUMAN
    Recommended name:
    Putative uncharacterized protein C15orf54
    Protein Accession:
    Q8N8G6
    Secondary Accessions:
    • B7ZVZ9

    Protein attributes for C15orf54 Gene

    Size:
    183 amino acids
    Molecular mass:
    21040 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf54 Gene

Post-translational modifications for C15orf54 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C15orf54 Gene

REFSEQ proteins:

No data available for DME Specific Peptides for C15orf54 Gene

Domains & Families for C15orf54 Gene

Protein Domains for C15orf54 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf54: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf54 Gene

Function for C15orf54 Gene

Phenotypes From GWAS Catalog for C15orf54 Gene

genes like me logo Genes that share phenotypes with C15orf54: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C15orf54 Gene

Localization for C15orf54 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf54 gene
Compartment Confidence
plasma membrane 1
mitochondrion 1
peroxisome 1
nucleus 1
endoplasmic reticulum 1
cytosol 1
golgi apparatus 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C15orf54 Gene

Pathways & Interactions for C15orf54 Gene

SuperPathways for C15orf54 Gene

No Data Available

Interacting Proteins for C15orf54 Gene

Selected Interacting proteins: Q8N8G6-CO054_HUMAN for C15orf54 Gene via IID

Symbol External ID(s) Details
CRKL

Gene Ontology (GO) - Biological Process for C15orf54 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf54 Gene

Drugs & Compounds for C15orf54 Gene

No Compound Related Data Available

Transcripts for C15orf54 Gene

mRNA/cDNA for C15orf54 Gene

(2) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(4) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C15orf54 Gene

Chromosome 15 open reading frame 54:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf54 Gene

No ASD Table

Relevant External Links for C15orf54 Gene

GeneLoc Exon Structure for
C15orf54
ECgene alternative splicing isoforms for
C15orf54

Expression for C15orf54 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf54 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C15orf54 Gene

This gene is overexpressed in Whole Blood (x5.3) and Minor Salivary Gland (x5.2).

NURSA nuclear receptor signaling pathways regulating expression of C15orf54 Gene:

C15orf54

SOURCE GeneReport for Unigene cluster for C15orf54 Gene:

Hs.376109
genes like me logo Genes that share expression patterns with C15orf54: view

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf54 Gene

Orthologs for C15orf54 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C15orf54 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf54 33
  • 97.81 (n)
dog
(Canis familiaris)
Mammalia C30H15orf54 33
  • 85.42 (n)
Species where no ortholog for C15orf54 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C15orf54 Gene

ENSEMBL:
Gene Tree for C15orf54 (if available)
TreeFam:
Gene Tree for C15orf54 (if available)

Paralogs for C15orf54 Gene

No data available for Paralogs for C15orf54 Gene

Variants for C15orf54 Gene

Sequence variations from dbSNP and Humsavar for C15orf54 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000229717 -- 39,253,017(+) G/A 3_prime_UTR_variant
rs1000680836 -- 39,254,322(+) T/C 3_prime_UTR_variant
rs1001234074 -- 39,251,903(+) G/T intron_variant
rs1001260320 -- 39,252,177(+) A/G coding_sequence_variant, synonymous_variant
rs1001722116 -- 39,250,881(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf54 Gene

Variant ID Type Subtype PubMed ID
esv3569465 CNV gain 25503493
esv3892676 CNV loss 25118596
esv3892677 CNV gain 25118596
nsv569212 CNV gain 21841781

Variation tolerance for C15orf54 Gene

Residual Variation Intolerance Score: 68.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.37; 27.10% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf54 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf54

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf54 Gene

Disorders for C15orf54 Gene

Additional Disease Information for C15orf54

No disorders were found for C15orf54 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf54 Gene

Publications for C15orf54 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 58
  3. Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study. (PMID: 23934736) Yu B … Boerwinkle E (Genetic epidemiology 2013) 3 58
  4. Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality. (PMID: 21348951) Parsa A … Liggett SB (Clinical and translational science 2011) 3 58
  5. Genome-wide association to body mass index and waist circumference: the Framingham Heart Study 100K project. (PMID: 17903300) Fox CS … Atwood LD (BMC medical genetics 2007) 44 58

Products for C15orf54 Gene

Sources for C15orf54 Gene

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