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Aliases for C15orf40 Gene

Aliases for C15orf40 Gene

  • Chromosome 15 Open Reading Frame 40 2 3 5
  • UPF0235 Protein C15orf40 3

External Ids for C15orf40 Gene

Previous GeneCards Identifiers for C15orf40 Gene

  • GC15M081465
  • GC15M083673
  • GC15M059921
  • GC15M083659

Summaries for C15orf40 Gene

GeneCards Summary for C15orf40 Gene

C15orf40 (Chromosome 15 Open Reading Frame 40) is a Protein Coding gene.

Additional gene information for C15orf40 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf40 Gene

Genomics for C15orf40 Gene

GeneHancer (GH) Regulatory Elements for C15orf40 Gene

Promoters and enhancers for C15orf40 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15J083010 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 717.4 +0.8 838 2.8 HDGF CLOCK ARNT ZFP64 ARID4B NEUROD1 SIN3A DMAP1 ZNF2 ZBTB7B C15orf40 HOMER2 ENSG00000260608 PIR34182 GC15M083024 RAMMET WHAMM EFL1 ENSG00000260579 BTBD1
GH15J083013 Enhancer 0.4 Ensembl 650.7 -0.8 -803 0.2 POLR2A ZBTB33 ENSG00000260608 C15orf40 BTBD1 TM6SF1 ENSG00000273747 LOC105370928
GH15J083060 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 28 -52.4 -52424 7.5 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A FEZF1 DMAP1 ZNF2 BTBD1 C15orf40 SNHG21 TM6SF1 RAMMET AP3B2 GOLGA6L9 WHAMM MIR4515 GC15P083184
GH15J082646 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 40.5 +364.6 364555 1.5 CLOCK ATF1 SIN3A ZNF766 GLIS2 ZFP91 ZNF202 SP3 NCOA1 REST CPEB1 CPEB1-AS1 GC15P082650 C15orf40 WHAMM CSPG4P10 RAMMET GOLGA6L9
GH15J083204 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 34.3 -194.5 -194500 4.3 HDGF SIN3A GLI4 ZNF2 ZBTB7B YY1 GTF3C2 GLIS2 ZNF213 KLF7 HDGFL3 WHAMM C15orf40 RAMMET RPL9P9 GOLGA6L9 EFL1 CSPG4P11 BTBD1 FABP5P8
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C15orf40 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C15orf40 gene promoter:

Genomic Locations for C15orf40 Gene

Genomic Locations for C15orf40 Gene
chr15:82,988,308-83,012,298
(GRCh38/hg38)
Size:
23,991 bases
Orientation:
Minus strand
chr15:83,657,193-83,680,393
(GRCh37/hg19)

Genomic View for C15orf40 Gene

Genes around C15orf40 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf40 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf40 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf40 Gene

Proteins for C15orf40 Gene

  • Protein details for C15orf40 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUR7-CO040_HUMAN
    Recommended name:
    UPF0235 protein C15orf40
    Protein Accession:
    Q8WUR7
    Secondary Accessions:
    • A6NIC9
    • B2R5E7
    • F5GX92
    • F8WD31
    • G5EA00

    Protein attributes for C15orf40 Gene

    Size:
    153 amino acids
    Molecular mass:
    16353 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C15orf40 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf40 Gene

Post-translational modifications for C15orf40 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for C15orf40 Gene

Domains & Families for C15orf40 Gene

Gene Families for C15orf40 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf40 Gene

Suggested Antigen Peptide Sequences for C15orf40 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUR7

UniProtKB/Swiss-Prot:

CO040_HUMAN :
  • Belongs to the UPF0235 family.
Family:
  • Belongs to the UPF0235 family.
genes like me logo Genes that share domains with C15orf40: view

Function for C15orf40 Gene

genes like me logo Genes that share phenotypes with C15orf40: view

Animal Model Products

miRNA for C15orf40 Gene

miRTarBase miRNAs that target C15orf40

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf40 Gene

Localization for C15orf40 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf40 gene
Compartment Confidence
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nucleus (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for C15orf40 Gene

Pathways & Interactions for C15orf40 Gene

SuperPathways for C15orf40 Gene

No Data Available

Interacting Proteins for C15orf40 Gene

Gene Ontology (GO) - Biological Process for C15orf40 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf40 Gene

Drugs & Compounds for C15orf40 Gene

No Compound Related Data Available

Transcripts for C15orf40 Gene

Unigene Clusters for C15orf40 Gene

Chromosome 15 open reading frame 40:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf40 Gene

No ASD Table

Relevant External Links for C15orf40 Gene

GeneLoc Exon Structure for
C15orf40
ECgene alternative splicing isoforms for
C15orf40

Expression for C15orf40 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf40 Gene

Protein differential expression in normal tissues from HIPED for C15orf40 Gene

This gene is overexpressed in Blymphocyte (13.5), Bone marrow stromal cell (12.9), and Pancreas (7.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf40 Gene



NURSA nuclear receptor signaling pathways regulating expression of C15orf40 Gene:

C15orf40

SOURCE GeneReport for Unigene cluster for C15orf40 Gene:

Hs.352541
genes like me logo Genes that share expression patterns with C15orf40: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf40 Gene

Orthologs for C15orf40 Gene

This gene was present in the common ancestor of animals.

Orthologs for C15orf40 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf40 33
  • 99.09 (n)
C15orf40 34
  • 80 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf40 33
  • 89.33 (n)
C21H15ORF40 34
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 3110040N11Rik 16 34 33
  • 83.48 (n)
rat
(Rattus norvegicus)
Mammalia LOC100363116 33
  • 83.48 (n)
dog
(Canis familiaris)
Mammalia C3H15orf40 33
  • 83.21 (n)
-- 34
  • 58 (a)
OneToMany
-- 34
  • 38 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 66 (a)
OneToMany
-- 34
  • 65 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf40 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF40 33
  • 65.17 (n)
C15orf40 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf40 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf40 33
  • 68.5 (n)
zebrafish
(Danio rerio)
Actinopterygii C25H15orf40 34
  • 36 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.6971 33
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001528 33
  • 52.38 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14966 34 33
  • 50.63 (n)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea W01A8.2 34
  • 28 (a)
OneToOne
Species where no ortholog for C15orf40 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for C15orf40 Gene

ENSEMBL:
Gene Tree for C15orf40 (if available)
TreeFam:
Gene Tree for C15orf40 (if available)

Paralogs for C15orf40 Gene

(14) SIMAP similar genes for C15orf40 Gene using alignment to 7 proteins:

  • CO040_HUMAN
  • H0Y996_HUMAN
  • H0Y9H8_HUMAN
  • H0YAC3_HUMAN
  • H3BM85_HUMAN
  • H3BMR1_HUMAN
  • H3BQZ5_HUMAN

Pseudogenes.org Pseudogenes for C15orf40 Gene

genes like me logo Genes that share paralogs with C15orf40: view

No data available for Paralogs for C15orf40 Gene

Variants for C15orf40 Gene

Sequence variations from dbSNP and Humsavar for C15orf40 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000039873 -- 82,997,229(-) T/A genic_downstream_transcript_variant, intron_variant
rs1000065285 -- 83,007,226(-) T/C genic_downstream_transcript_variant, intron_variant
rs1000196119 -- 83,013,882(-) G/A upstream_transcript_variant
rs1000419391 -- 82,998,304(-) G/A genic_downstream_transcript_variant, intron_variant
rs1000443788 -- 83,010,648(-) C/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf40 Gene

Variant ID Type Subtype PubMed ID
esv28659 CNV loss 19812545
esv3637065 CNV gain 21293372
nsv1120052 OTHER inversion 24896259

Variation tolerance for C15orf40 Gene

Residual Variation Intolerance Score: 87.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.48; 64.39% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf40 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf40

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf40 Gene

Disorders for C15orf40 Gene

Additional Disease Information for C15orf40

No disorders were found for C15orf40 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf40 Gene

Publications for C15orf40 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing. (PMID: 26871637) Yang X … Vidal M (Cell 2016) 3 58
  4. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C … Emili A (Nature 2015) 3 58
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H … Mohammed S (Journal of proteome research 2013) 4 58

Products for C15orf40 Gene

Sources for C15orf40 Gene

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