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Aliases for C15orf39 Gene

Aliases for C15orf39 Gene

  • Chromosome 15 Open Reading Frame 39 2 3 5

External Ids for C15orf39 Gene

Previous GeneCards Identifiers for C15orf39 Gene

  • GC15P073279
  • GC15P075491
  • GC15P052290

Summaries for C15orf39 Gene

GeneCards Summary for C15orf39 Gene

C15orf39 (Chromosome 15 Open Reading Frame 39) is a Protein Coding gene.

Additional gene information for C15orf39 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf39 Gene

Genomics for C15orf39 Gene

GeneHancer (GH) Regulatory Elements for C15orf39 Gene

Promoters and enhancers for C15orf39 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I075198 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 579.1 +6.2 6193 7.1 CLOCK ZFP64 DMAP1 IRF4 ZNF143 SP3 NFYC SSRP1 ZNF610 GLIS1 C15orf39 RPP25 MAN2C1 CSK PPCDC SIN3A SCAMP2 PIR52818
GH15I075195 Enhancer 1.1 Ensembl ENCODE dbSUPER 550.8 +0.2 204 1.2 KLF1 KLF17 SIN3A ZIC2 ZNF335 ZFHX2 GLIS2 PATZ1 PRDM10 EGR2 C15orf39 PIR52818
GH15I075197 Enhancer 0.5 dbSUPER 550.8 +1.7 1734 0.7 ZNF362 ZNF449 SP2 ZNF600 ZIC2 C15orf39 PIR52818
GH15I075041 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 39 -149.8 -149757 8.2 HDGF PKNOX1 FOXA2 SMAD1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 PPCDC SCAMP5 C15orf39 RPP25 LOC441728 SIN3A DNM1P35 EDC3 ENSG00000203392 ULK3
GH15I074775 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 23.9 -407.5 -407470 26 DMAP1 IRF4 YY1 SLC30A9 ZNF143 ZNF263 SP3 MEF2D GLIS1 RCOR2 CSK MIR4513 EDC3 SIN3A LOC441728 ULK3 ENSG00000260274 C15orf39 DNM1P35 ENSG00000203392
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C15orf39 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C15orf39 gene promoter:

Genomic Locations for C15orf39 Gene

Genomic Locations for C15orf39 Gene
chr15:75,195,643-75,212,169
(GRCh38/hg38)
Size:
16,527 bases
Orientation:
Plus strand
chr15:75,487,984-75,504,510
(GRCh37/hg19)

Genomic View for C15orf39 Gene

Genes around C15orf39 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf39 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf39 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf39 Gene

Proteins for C15orf39 Gene

  • Protein details for C15orf39 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZRI6-CO039_HUMAN
    Recommended name:
    Uncharacterized protein C15orf39
    Protein Accession:
    Q6ZRI6
    Secondary Accessions:
    • B3KWI3
    • C9J888
    • Q71JB1
    • Q7L3S0
    • Q8N3F2
    • Q96FB6
    • Q9NTU5

    Protein attributes for C15orf39 Gene

    Size:
    1047 amino acids
    Molecular mass:
    110673 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAQ06680.1; Type=Frameshift; Positions=267; Evidence={ECO:0000305}; Sequence=CAB55985.3; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD39045.1; Type=Frameshift; Positions=900; Evidence={ECO:0000305};

    Alternative splice isoforms for C15orf39 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C15orf39 Gene

Post-translational modifications for C15orf39 Gene

  • Ubiquitination at posLast=620620 and Lys898
  • Modification sites at PhosphoSitePlus

Other Protein References for C15orf39 Gene

No data available for DME Specific Peptides for C15orf39 Gene

Domains & Families for C15orf39 Gene

Gene Families for C15orf39 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf39 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for C15orf39 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf39: view

No data available for UniProtKB/Swiss-Prot for C15orf39 Gene

Function for C15orf39 Gene

Phenotypes From GWAS Catalog for C15orf39 Gene

genes like me logo Genes that share phenotypes with C15orf39: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf39 Gene

Localization for C15orf39 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C15orf39 gene
Compartment Confidence
cytosol 5
nucleus 2
mitochondrion 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C15orf39 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol IDA --
genes like me logo Genes that share ontologies with C15orf39: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for C15orf39 Gene

Pathways & Interactions for C15orf39 Gene

SuperPathways for C15orf39 Gene

No Data Available

Interacting Proteins for C15orf39 Gene

Gene Ontology (GO) - Biological Process for C15orf39 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C15orf39 Gene

Drugs & Compounds for C15orf39 Gene

No Compound Related Data Available

Transcripts for C15orf39 Gene

Unigene Clusters for C15orf39 Gene

Chromosome 15 open reading frame 39:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf39 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b
SP1: -
SP2:
SP3:
SP4: -
SP5: - -
SP6:

Relevant External Links for C15orf39 Gene

GeneLoc Exon Structure for
C15orf39
ECgene alternative splicing isoforms for
C15orf39

Expression for C15orf39 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf39 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for C15orf39 Gene

This gene is overexpressed in Whole Blood (x9.9) and Testis (x4.1).

Protein differential expression in normal tissues from HIPED for C15orf39 Gene

This gene is overexpressed in Saliva (28.9), Pancreatic juice (21.4), Heart (11.7), and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C15orf39 Gene



Protein tissue co-expression partners for C15orf39 Gene

NURSA nuclear receptor signaling pathways regulating expression of C15orf39 Gene:

C15orf39

SOURCE GeneReport for Unigene cluster for C15orf39 Gene:

Hs.17936

Evidence on tissue expression from TISSUES for C15orf39 Gene

  • Spleen(4.2)
  • Muscle(4.1)
  • Eye(4)
  • Nervous system(2.2)
genes like me logo Genes that share expression patterns with C15orf39: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf39 Gene

Orthologs for C15orf39 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf39 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf39 33
  • 99.01 (n)
C15orf39 34
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf39 33
  • 81.82 (n)
C15orf39 34
  • 76 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C30H15orf39 33
  • 79.99 (n)
C15orf39 34
  • 76 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1305464 33
  • 79.55 (n)
mouse
(Mus musculus)
Mammalia 1700017B05Rik 33 16 34
  • 78.48 (n)
oppossum
(Monodelphis domestica)
Mammalia C15orf39 34
  • 45 (a)
OneToOne
chicken
(Gallus gallus)
Aves C15orf39 34
  • 42 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf39 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii C18H15orf39 34
  • 22 (a)
OneToOne
Dr.14401 33
Species where no ortholog for C15orf39 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf39 Gene

ENSEMBL:
Gene Tree for C15orf39 (if available)
TreeFam:
Gene Tree for C15orf39 (if available)

Paralogs for C15orf39 Gene

Pseudogenes.org Pseudogenes for C15orf39 Gene

genes like me logo Genes that share paralogs with C15orf39: view

No data available for Paralogs for C15orf39 Gene

Variants for C15orf39 Gene

Sequence variations from dbSNP and Humsavar for C15orf39 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000487914 -- 75,211,934(+) G/A 3_prime_UTR_variant
rs1000505129 -- 75,200,446(+) A/C upstream_transcript_variant
rs1000532700 -- 75,200,004(+) C/G upstream_transcript_variant
rs1000868442 -- 75,203,365(+) C/T intron_variant
rs1000978321 -- 75,203,676(+) G/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf39 Gene

Variant ID Type Subtype PubMed ID
dgv2621n100 CNV gain 25217958
dgv4627n54 CNV loss 21841781
esv3636921 CNV gain 21293372
nsv1121512 CNV deletion 24896259
nsv833056 CNV gain 17160897
nsv951995 CNV deletion 24416366

Variation tolerance for C15orf39 Gene

Residual Variation Intolerance Score: 92.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.94; 83.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf39 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf39

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf39 Gene

Disorders for C15orf39 Gene

Additional Disease Information for C15orf39

No disorders were found for C15orf39 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf39 Gene

Publications for C15orf39 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PMID: 15498874) Wan D … Gu J (Proceedings of the National Academy of Sciences of the United States of America 2004) 3 4 58
  4. Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S … Poustka A (Genome research 2001) 3 4 58
  5. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58

Products for C15orf39 Gene

Sources for C15orf39 Gene

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