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Aliases for C15orf38-AP3S2 Gene

Aliases for C15orf38-AP3S2 Gene

  • C15orf38-AP3S2 Readthrough 2 3 5

External Ids for C15orf38-AP3S2 Gene

Previous GeneCards Identifiers for C15orf38-AP3S2 Gene

  • GC15U901312
  • GC15M090378

Summaries for C15orf38-AP3S2 Gene

Entrez Gene Summary for C15orf38-AP3S2 Gene

  • This locus represents naturally occurring read-through transcription between the neighboring C15orf38 (chromosome 15 open reading frame 38) and AP3S2 (adaptor-related protein complex 3, sigma 2 subunit) genes. The read-through transcript encodes a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Nov 2010]

GeneCards Summary for C15orf38-AP3S2 Gene

C15orf38-AP3S2 (C15orf38-AP3S2 Readthrough) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include protein transporter activity. An important paralog of this gene is ARPIN.

Additional gene information for C15orf38-AP3S2 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C15orf38-AP3S2 Gene

Genomics for C15orf38-AP3S2 Gene

GeneHancer (GH) Regulatory Elements for C15orf38-AP3S2 Gene

Promoters and enhancers for C15orf38-AP3S2 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH15I089910 Promoter/Enhancer 2.1 EPDnew FANTOM5 Ensembl ENCODE 550.8 +0.5 477 3.9 HDGF FOXA2 ZSCAN4 ARID4B SIN3A ZNF2 ZNF48 ZNF335 GLIS2 ELK1 ARPIN C15orf38-AP3S2 POLG LOC100631255 GC15P089898
GH15I089855 Enhancer 1.1 ENCODE dbSUPER 12.1 +51.8 51772 10.6 ELF3 PKNOX1 FOXA2 ZFP64 ARID4B THRB RAD21 RARA YY1 ZNF366 AP3S2 RNU6-1111P RNU7-111P C15orf38-AP3S2 ARPIN MESP2 MESP1 ZNF710 PLIN1 ANPEP
GH15I089892 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE 0.4 +19.1 19083 2.3 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 AP3S2 POLG ENSG00000259314 LOC100631255 NIFKP5 FANCI ENSG00000259212 RPL36AP43 KIF7 ARPIN
GH15I089898 Enhancer 1.2 FANTOM5 Ensembl ENCODE 0.4 +13.7 13699 1.4 CTCF RB1 FEZF1 RAD21 RFX5 CC2D1A ZNF121 ZFHX2 ARID2 SCRT2 GC15P089898 RNU7-111P AP3S2 ANPEP ARPIN C15orf38-AP3S2
GH15I089917 Enhancer 0.7 ENCODE 0.4 -5.1 -5074 0.9 ESRRA JUN CTBP1 GATA3 FOS FOSL2 TCF7L2 SMARCE1 SMARCC1 CEBPB ARPIN C15orf38-AP3S2 LOC100421368
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Genomic Locations for C15orf38-AP3S2 Gene

Genomic Locations for C15orf38-AP3S2 Gene
chr15:89,830,599-89,912,990
(GRCh38/hg38)
Size:
82,392 bases
Orientation:
Minus strand
chr15:90,373,831-90,456,222
(GRCh37/hg19)

Genomic View for C15orf38-AP3S2 Gene

Genes around C15orf38-AP3S2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C15orf38-AP3S2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C15orf38-AP3S2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C15orf38-AP3S2 Gene

Proteins for C15orf38-AP3S2 Gene

  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    A0A0A6YYH1
    Recommended name:
    Protein C15orf38-AP3S2
    Protein Accession:
    A0A0A6YYH1

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    394 amino acids
    Molecular mass:
    43882 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YL85
    Recommended name:
    C15orf38-AP3S2 readthrough
    Protein Accession:
    H0YL85

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    185 amino acids
    Molecular mass:
    20448 Da
    Quaternary structure:
    No Data Available
  • Protein details for C15orf38-AP3S2 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    H0YMK0
    Recommended name:
    AP complex subunit sigma
    Protein Accession:
    H0YMK0

    Protein attributes for C15orf38-AP3S2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20721 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C15orf38-AP3S2 Gene

Protein Expression for C15orf38-AP3S2 Gene

Post-translational modifications for C15orf38-AP3S2 Gene

No Post-translational modifications

Other Protein References for C15orf38-AP3S2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for C15orf38-AP3S2 Gene

Domains & Families for C15orf38-AP3S2 Gene

Gene Families for C15orf38-AP3S2 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C15orf38-AP3S2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C15orf38-AP3S2: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Function for C15orf38-AP3S2 Gene

Gene Ontology (GO) - Molecular Function for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008565 protein transporter activity IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

Phenotypes for C15orf38-AP3S2 Gene

GenomeRNAi human phenotypes for C15orf38-AP3S2:
genes like me logo Genes that share phenotypes with C15orf38-AP3S2: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C15orf38-AP3S2 Gene

Localization for C15orf38-AP3S2 Gene

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0030117 membrane coat IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Subcellular locations from COMPARTMENTS for C15orf38-AP3S2 Gene

Pathways & Interactions for C15orf38-AP3S2 Gene

SuperPathways for C15orf38-AP3S2 Gene

No Data Available

Interacting Proteins for C15orf38-AP3S2 Gene

Gene Ontology (GO) - Biological Process for C15orf38-AP3S2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006886 intracellular protein transport IEA --
GO:0015031 protein transport IEA --
GO:0016192 vesicle-mediated transport IEA --
GO:0051126 negative regulation of actin nucleation IEA --
genes like me logo Genes that share ontologies with C15orf38-AP3S2: view

No data available for Pathways by source and SIGNOR curated interactions for C15orf38-AP3S2 Gene

Drugs & Compounds for C15orf38-AP3S2 Gene

No Compound Related Data Available

Transcripts for C15orf38-AP3S2 Gene

mRNA/cDNA for C15orf38-AP3S2 Gene

(1) REFSEQ mRNAs :
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Alternative Splicing Database (ASD) splice patterns (SP) for C15orf38-AP3S2 Gene

No ASD Table

Relevant External Links for C15orf38-AP3S2 Gene

GeneLoc Exon Structure for
C15orf38-AP3S2
ECgene alternative splicing isoforms for
C15orf38-AP3S2

Expression for C15orf38-AP3S2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C15orf38-AP3S2 Gene

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb and MOPED for C15orf38-AP3S2 Gene



genes like me logo Genes that share expression patterns with C15orf38-AP3S2: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C15orf38-AP3S2 Gene

Orthologs for C15orf38-AP3S2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C15orf38-AP3S2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia AP3S2 34
  • 99 (a)
OneToMany
LOC100170757 33
  • 98.96 (n)
cow
(Bos Taurus)
Mammalia C21H15orf38 34
  • 90 (a)
OneToMany
ARPIN 33
  • 88.39 (n)
dog
(Canis familiaris)
Mammalia C3H15orf38 33 34
  • 87.8 (n)
rat
(Rattus norvegicus)
Mammalia RGD1311021 33
  • 85.57 (n)
mouse
(Mus musculus)
Mammalia 2610034B18Rik 33 34
  • 84.37 (n)
Arpin 16
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 73 (a)
ManyToMany
-- 34
  • 70 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 72 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf38 33
  • 62.8 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:112432 33
  • 58.93 (n)
C18H15orf38 34
  • 58 (a)
OneToMany
Species where no ortholog for C15orf38-AP3S2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for C15orf38-AP3S2 Gene

ENSEMBL:
Gene Tree for C15orf38-AP3S2 (if available)
TreeFam:
Gene Tree for C15orf38-AP3S2 (if available)

Paralogs for C15orf38-AP3S2 Gene

Paralogs for C15orf38-AP3S2 Gene

(10) SIMAP similar genes for C15orf38-AP3S2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with C15orf38-AP3S2: view

Variants for C15orf38-AP3S2 Gene

Sequence variations from dbSNP and Humsavar for C15orf38-AP3S2 Gene

SNP ID Clin Chr 15 pos Variation AA Info Type
rs1000050564 -- 89,886,454(-) T/G intron_variant
rs1000141168 -- 89,832,450(-) A/G 3_prime_UTR_variant
rs1000162925 -- 89,857,524(-) C/G/T intron_variant
rs1000183807 -- 89,908,099(-) G/T intron_variant
rs1000230424 -- 89,841,648(-) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C15orf38-AP3S2 Gene

Variant ID Type Subtype PubMed ID
esv1678655 CNV deletion 17803354
esv2667255 CNV deletion 23128226
esv2750010 CNV deletion 23290073
esv3637203 CNV loss 21293372
esv3637204 CNV loss 21293372
esv3637205 CNV gain 21293372
esv3637206 CNV loss 21293372
nsv1661 CNV insertion 18451855
nsv570389 CNV loss 21841781

Variation tolerance for C15orf38-AP3S2 Gene

Residual Variation Intolerance Score: 72% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.42; 42.65% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C15orf38-AP3S2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C15orf38-AP3S2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C15orf38-AP3S2 Gene

Disorders for C15orf38-AP3S2 Gene

Additional Disease Information for C15orf38-AP3S2

No disorders were found for C15orf38-AP3S2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C15orf38-AP3S2 Gene

Publications for C15orf38-AP3S2 Gene

  1. Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility. (PMID: 24509480) DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium … Morris AP (Nature genetics 2014) 3 58
  2. Genome-wide association study identifies three novel loci for type 2 diabetes. (PMID: 23945395) Hara K … Kadowaki T (Human molecular genetics 2014) 3 58
  3. Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci. (PMID: 21874001) Kooner JS … Chambers JC (Nature genetics 2011) 3 58
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T … Taylor TD (PloS one 2010) 3 58
  5. Web-based, participant-driven studies yield novel genetic associations for common traits. (PMID: 20585627) Eriksson N … Mountain J (PLoS genetics 2010) 3 58

Products for C15orf38-AP3S2 Gene

Sources for C15orf38-AP3S2 Gene

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