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Aliases for C14orf93 Gene

Aliases for C14orf93 Gene

  • Chromosome 14 Open Reading Frame 93 2 3 5
  • Regulator Of Thyroid Function And Cancer 2 3
  • Uncharacterized Protein C14orf93 3
  • RTFC 3

External Ids for C14orf93 Gene

Previous GeneCards Identifiers for C14orf93 Gene

  • GC14M017243
  • GC14M021446
  • GC14M022525
  • GC14M023456
  • GC14M003573

Summaries for C14orf93 Gene

GeneCards Summary for C14orf93 Gene

C14orf93 (Chromosome 14 Open Reading Frame 93) is a Protein Coding gene.

Additional gene information for C14orf93 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf93 Gene

Genomics for C14orf93 Gene

GeneHancer (GH) Regulatory Elements for C14orf93 Gene

Promoters and enhancers for C14orf93 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J023005 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 685.7 +1.9 1863 4.9 CLOCK MLX ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF213 E2F8 C14orf93 ENSG00000280129 ACIN1 HAUS4 RBM23 PRMT5 LOC102724814 C14orf119 PRMT5-AS1 THTPA
GH14J022976 Promoter/Enhancer 2.7 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 106.6 +30.3 30295 7.6 MLX ZFP64 FEZF1 DMAP1 YBX1 IRF4 YY1 SLC30A9 E2F8 ZNF143 AJUBA ACIN1 NGDN HAUS4 PRMT5 C14orf93 RBM23 LOC102724814 PABPN1 MMP14
GH14J023067 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 55.3 -60.3 -60261 5.9 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 ACIN1 C14orf93 RBM23 LOC102724814 NGDN HAUS4 PRMT5 PSMB11 PSMB5 C14orf119
GH14J022927 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 38.8 +80.6 80594 3.2 CLOCK MLX DMAP1 IRF4 YY1 SLC30A9 ZNF213 ZNF143 ZNF548 SP3 PRMT5 ENSG00000257285 LOC101926933 TRR-ACG1-3 ACIN1 HAUS4 NGDN LOC102724814 RBM23 C14orf93
GH14J023297 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 33.5 -290.5 -290499 5.5 CLOCK MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ZNF548 HOMEZ BCL2L2 PPP1R3E PIR57322 ACIN1 RNF31 RNA5SP383 PRMT5 RBM23 LOC102724814
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf93 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf93 gene promoter:

Genomic Locations for C14orf93 Gene

Genomic Locations for C14orf93 Gene
24,294 bases
Minus strand

Genomic View for C14orf93 Gene

Genes around C14orf93 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf93 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf93 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf93 Gene

Proteins for C14orf93 Gene

  • Protein details for C14orf93 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C14orf93
    Protein Accession:
    Secondary Accessions:
    • B7WP03
    • D3DS38
    • D3DS39
    • Q86SE6
    • Q96CF7
    • Q9HA68

    Protein attributes for C14orf93 Gene

    538 amino acids
    Molecular mass:
    58697 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf93 Gene


neXtProt entry for C14orf93 Gene

Post-translational modifications for C14orf93 Gene

  • Ubiquitination at posLast=7171
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for C14orf93 Gene

Domains & Families for C14orf93 Gene

Gene Families for C14orf93 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted secreted proteins

Protein Domains for C14orf93 Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf93: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf93 Gene

Function for C14orf93 Gene

Phenotypes From GWAS Catalog for C14orf93 Gene

Gene Ontology (GO) - Molecular Function for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003723 RNA binding HDA 22658674
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with C14orf93: view
genes like me logo Genes that share phenotypes with C14orf93: view

Animal Model Products

miRNA for C14orf93 Gene

miRTarBase miRNAs that target C14orf93

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf93 Gene

Localization for C14orf93 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf93 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf93 gene
Compartment Confidence
extracellular 4
nucleus 3
plasma membrane 2
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C14orf93 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with C14orf93: view

Pathways & Interactions for C14orf93 Gene

SuperPathways for C14orf93 Gene

No Data Available

Interacting Proteins for C14orf93 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q9H972-CN093_HUMAN ENSP00000299088 for C14orf93 Gene via IID UniProtKB STRING

Gene Ontology (GO) - Biological Process for C14orf93 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf93 Gene

Drugs & Compounds for C14orf93 Gene

No Compound Related Data Available

Transcripts for C14orf93 Gene

Unigene Clusters for C14orf93 Gene

Chromosome 14 open reading frame 93:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf93 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b · 7c · 7d · 7e · 7f · 7g · 7h · 7i ^ 8a · 8b · 8c · 8d ^ 9a · 9b · 9c ^
SP2: - - - - - - -
SP3: - - - - - - - - -
SP4: - - - - - - - - - - - - -
SP5: - - - - - -
SP6: - - - - - - - - - - - - -
SP7: - - - -
SP8: - - - - -
SP9: - - - - - - - - - - -
SP10: - - - - - -
SP11: - - - -
SP12: - - - - - - - -
SP13: - - - - - - - -
SP14: - - - - - - - -
SP15: - - - - - - - - -
SP16: - - - - - - - -

ExUns: 10 ^ 11 ^ 12 ^ 13 ^ 14

Relevant External Links for C14orf93 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf93 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf93 Gene

Protein differential expression in normal tissues from HIPED for C14orf93 Gene

This gene is overexpressed in Tlymphocyte (68.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for C14orf93 Gene

Protein tissue co-expression partners for C14orf93 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf93 Gene:


SOURCE GeneReport for Unigene cluster for C14orf93 Gene:


Evidence on tissue expression from TISSUES for C14orf93 Gene

  • Nervous system(3)
genes like me logo Genes that share expression patterns with C14orf93: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf93 Gene

Orthologs for C14orf93 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf93 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14orf93 34
  • 98 (a)
(Canis familiaris)
Mammalia C14orf93 34
  • 92 (a)
C8H14orf93 33
  • 90.89 (n)
(Bos Taurus)
Mammalia C10H14ORF93 34
  • 91 (a)
C10H14orf93 33
  • 88.97 (n)
(Monodelphis domestica)
Mammalia C14orf93 34
  • 87 (a)
(Rattus norvegicus)
Mammalia RGD1565222 33
  • 85.14 (n)
(Mus musculus)
Mammalia 4931414P19Rik 16 34 33
  • 84.95 (n)
(Ornithorhynchus anatinus)
Mammalia C14orf93 34
  • 82 (a)
(Anolis carolinensis)
Reptilia C14orf93 34
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c14orf93 33
  • 59.29 (n)
Str.14071 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.3310 33
Species where no ortholog for C14orf93 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf93 Gene

Gene Tree for C14orf93 (if available)
Gene Tree for C14orf93 (if available)

Paralogs for C14orf93 Gene

No data available for Paralogs for C14orf93 Gene

Variants for C14orf93 Gene

Sequence variations from dbSNP and Humsavar for C14orf93 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000046493 -- 22,986,528(-) G/A downstream_transcript_variant
rs1000055919 -- 22,994,387(-) T/G intron_variant
rs1000086226 -- 22,993,434(-) A/G intron_variant
rs1000131023 -- 23,011,504(-) T/C upstream_transcript_variant
rs1000267319 -- 23,011,999(-) G/A upstream_transcript_variant

Variation tolerance for C14orf93 Gene

Residual Variation Intolerance Score: 76.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.55; 64.89% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf93 Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for C14orf93 Gene

Disorders for C14orf93 Gene

Additional Disease Information for C14orf93

No disorders were found for C14orf93 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf93 Gene

Publications for C14orf93 Gene

  1. Rtfc (4931414P19Rik) Regulates in vitro Thyroid Differentiation and in vivo Thyroid Function. (PMID: 28230092) Yu Y … Chen L (Scientific reports 2017) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. C14orf93 (RTFC) is identified as a novel susceptibility gene for familial nonmedullary thyroid cancer. (PMID: 27864143) Liu C … Chen L (Biochemical and biophysical research communications 2017) 3 58
  5. Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation. (PMID: 28112733) Hendriks IA … Nielsen ML (Nature structural & molecular biology 2017) 4 58

Products for C14orf93 Gene

Sources for C14orf93 Gene

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