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Aliases for C14orf37 Gene

Aliases for C14orf37 Gene

  • Chromosome 14 Open Reading Frame 37 2 3 5
  • Upstream Of MTORC2 2 3
  • Uncharacterized Protein C14orf37 3
  • C14_5376 3
  • UT2 3

External Ids for C14orf37 Gene

Previous GeneCards Identifiers for C14orf37 Gene

  • GC14M052267
  • GC14M056460
  • GC14U900322
  • GC14M057540
  • GC14M058470
  • GC14M038636

Summaries for C14orf37 Gene

GeneCards Summary for C14orf37 Gene

C14orf37 (Chromosome 14 Open Reading Frame 37) is a Protein Coding gene.

Additional gene information for C14orf37 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf37 Gene

Genomics for C14orf37 Gene

GeneHancer (GH) Regulatory Elements for C14orf37 Gene

Promoters and enhancers for C14orf37 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I058296 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 550.8 -0.3 -286 4.5 PKNOX1 CLOCK FOXA2 SMAD1 ARNT ARID4B NEUROD1 SIN3A FEZF1 DMAP1 PSMA3-AS1 ARID4A C14orf37 KIAA0586 ENSG00000258682 TIMM9 TOMM20L ACTR10 GC14P058345
GH14I058151 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 560.5 +146.1 146060 1.7 SIN3A ZNF335 GLIS2 EGR1 EGR2 SP3 MTA1 GLIS1 ZNF341 ZBTB26 C14orf37 GC14P058142 RN7SL598P GC14P058110
GH14I058242 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 12.6 +53.5 53534 3.6 HDGF PKNOX1 SMAD1 FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZBTB7B PSMA3 RNU6-341P ARID4A C14orf37 PSMA3-AS1 ENSG00000258682 TRK-CTT1-1 GC14P058110
GH14I058199 Promoter/Enhancer 1.9 EPDnew Ensembl ENCODE 5.9 +97.7 97732 2.4 ATF1 ARID4B SIN3A DMAP1 NCOA2 GLIS2 ZNF207 ZNF143 KLF7 RUNX3 ACTR10 PSMA3-AS1 C14orf37 TRK-CTT1-1 GC14P058110
GH14I058081 Enhancer 0.9 Ensembl ENCODE 10.6 +215.8 215761 1.9 MEIS2 USF1 JUN BACH1 FOSL1 ZNF316 POLR2A NFE2 FOSL2 FOS C14orf37 GC14M058071 LOC100420347 GC14M058040
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf37 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf37 gene promoter:

Genomic Locations for C14orf37 Gene

Genomic Locations for C14orf37 Gene
304,609 bases
Minus strand

Genomic View for C14orf37 Gene

Genes around C14orf37 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf37 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf37 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf37 Gene

Proteins for C14orf37 Gene

  • Protein details for C14orf37 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Uncharacterized protein C14orf37
    Protein Accession:
    Secondary Accessions:
    • A8K8Z8
    • Q6P5Q1
    • Q86TY1

    Protein attributes for C14orf37 Gene

    774 amino acids
    Molecular mass:
    84173 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf37 Gene


neXtProt entry for C14orf37 Gene

Post-translational modifications for C14orf37 Gene

  • Glycosylation at posLast=5757, posLast=9696, Ser135, Asn189, and Ser389

Other Protein References for C14orf37 Gene

No data available for DME Specific Peptides for C14orf37 Gene

Domains & Families for C14orf37 Gene

Gene Families for C14orf37 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C14orf37 Gene


Suggested Antigen Peptide Sequences for C14orf37 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf37: view

No data available for UniProtKB/Swiss-Prot for C14orf37 Gene

Function for C14orf37 Gene

Phenotypes From GWAS Catalog for C14orf37 Gene

Phenotypes for C14orf37 Gene

genes like me logo Genes that share phenotypes with C14orf37: view

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf37 Gene

Localization for C14orf37 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf37 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf37 gene
Compartment Confidence
plasma membrane 2
extracellular 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Plasma membrane (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for C14orf37 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf37: view

Pathways & Interactions for C14orf37 Gene

SuperPathways for C14orf37 Gene

No Data Available

Interacting Proteins for C14orf37 Gene

Gene Ontology (GO) - Biological Process for C14orf37 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf37 Gene

Drugs & Compounds for C14orf37 Gene

No Compound Related Data Available

Transcripts for C14orf37 Gene

mRNA/cDNA for C14orf37 Gene

(5) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for C14orf37 Gene

Chromosome 14 open reading frame 37:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf37 Gene

ExUns: 1 ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9
SP2: -

Relevant External Links for C14orf37 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf37 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf37 Gene

Protein differential expression in normal tissues from HIPED for C14orf37 Gene

This gene is overexpressed in Serum (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for C14orf37 Gene

Protein tissue co-expression partners for C14orf37 Gene

NURSA nuclear receptor signaling pathways regulating expression of C14orf37 Gene:


SOURCE GeneReport for Unigene cluster for C14orf37 Gene:


Evidence on tissue expression from TISSUES for C14orf37 Gene

  • Kidney(4.3)
  • Intestine(3.8)
  • Stomach(3.6)
  • Lung(2.7)
  • Nervous system(2.5)
genes like me logo Genes that share expression patterns with C14orf37: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf37 Gene

Orthologs for C14orf37 Gene

This gene was present in the common ancestor of chordates.

Orthologs for C14orf37 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf37 33
  • 99.01 (n)
C14ORF37 34
  • 94 (a)
(Canis familiaris)
Mammalia C8H14orf37 33
  • 83.68 (n)
C14orf37 34
  • 69 (a)
(Bos Taurus)
Mammalia C10H14orf37 33
  • 82.14 (n)
C14orf37 34
  • 73 (a)
(Mus musculus)
Mammalia 3632451O06Rik 33 16 34
  • 72.38 (n)
(Rattus norvegicus)
Mammalia RGD1310110 33
  • 71.52 (n)
(Monodelphis domestica)
Mammalia C14orf37 34
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia C14orf37 34
  • 36 (a)
(Gallus gallus)
Aves C5H14ORF37 33
  • 54.11 (n)
C14orf37 34
  • 37 (a)
(Anolis carolinensis)
Reptilia C14orf37 34
  • 88 (a)
Species where no ortholog for C14orf37 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf37 Gene

Gene Tree for C14orf37 (if available)
Gene Tree for C14orf37 (if available)

Paralogs for C14orf37 Gene

No data available for Paralogs for C14orf37 Gene

Variants for C14orf37 Gene

Sequence variations from dbSNP and Humsavar for C14orf37 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000004846 -- 58,149,035(-) T/C intron_variant
rs1000036507 -- 58,080,889(-) G/T genic_downstream_transcript_variant, intron_variant
rs1000043790 -- 58,124,448(-) G/A intron_variant
rs1000050068 -- 58,107,256(-) A/G genic_downstream_transcript_variant, intron_variant
rs1000060433 -- 57,997,585(-) C/T 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant, non_coding_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf37 Gene

Variant ID Type Subtype PubMed ID
nsv826959 CNV loss 20364138
nsv507752 OTHER sequence alteration 20534489
nsv1046422 CNV gain 25217958
nsv1042675 CNV gain 25217958
nsv1038569 CNV gain 25217958
esv3634620 CNV loss 21293372
esv3634619 CNV loss 21293372
esv3634618 CNV loss 21293372
esv34185 CNV loss 18971310
esv3412182 CNV insertion 20981092
esv2677940 CNV deletion 23128226
esv2657771 CNV deletion 23128226
esv2319201 CNV deletion 18987734

Variation tolerance for C14orf37 Gene

Residual Variation Intolerance Score: 89.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.96; 97.46% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf37 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf37 Gene

Disorders for C14orf37 Gene

Additional Disease Information for C14orf37

Genetic Association Database
Human Genome Epidemiology Navigator
ATLAS of Genetics and Cytogenetics in Oncology and Haematology

No disorders were found for C14orf37 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf37 Gene

Publications for C14orf37 Gene

  1. Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. (PMID: 26927669) Lee D … Scadden DT (The Journal of clinical investigation 2016) 2 3 58
  2. Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. (PMID: 25418727) Lee D … Scadden DT (Stem cell reports 2014) 2 3 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Lupus nephritis susceptibility loci in women with systemic lupus erythematosus. (PMID: 24925725) Chung SA … International Consortium for Systemic Lupus Erythematosus Genetics (Journal of the American Society of Nephrology : JASN 2014) 3 58

Products for C14orf37 Gene

Sources for C14orf37 Gene

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