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Aliases for C14orf180 Gene

Aliases for C14orf180 Gene

  • Chromosome 14 Open Reading Frame 180 2 3 5
  • Nutritionally-Regulated Adipose And Cardiac Enriched Protein Homolog 3 4
  • C14orf77 3 4
  • Nutritionally-Regulated Adipose And Cardiac-Enriched 2
  • Chromosome 14 Open Reading Frame 77 2
  • Transmembrane Protein C14orf180 3
  • NRAC 3

External Ids for C14orf180 Gene

Previous HGNC Symbols for C14orf180 Gene

  • C14orf77

Previous GeneCards Identifiers for C14orf180 Gene

  • GC14P104118
  • GC14P105046
  • GC14P085242

Summaries for C14orf180 Gene

GeneCards Summary for C14orf180 Gene

C14orf180 (Chromosome 14 Open Reading Frame 180) is a Protein Coding gene.

Additional gene information for C14orf180 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf180 Gene

Genomics for C14orf180 Gene

GeneHancer (GH) Regulatory Elements for C14orf180 Gene

Promoters and enhancers for C14orf180 Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J104579 Promoter/Enhancer 2 EPDnew Ensembl ENCODE dbSUPER 607.9 +1.7 1710 4.1 ZFX ZNF148 MYC SP1 RXRA ZBTB33 ZNF600 ZIC2 ZNF341 EP300 C14orf180 ENSG00000259037 TMEM179
GH14J104656 Promoter/Enhancer 1.8 FANTOM5 Ensembl ENCODE dbSUPER 9.5 +79.7 79703 6.8 SP1 ZNF121 ZNF687 CREM IKZF1 POLR2A RXRA ZBTB33 PRDM10 BACH1 MTA1 XRCC3 C14orf180 TMEM179 PLD4 INF2 ENSG00000258736 LINC02280
GH14J104290 Enhancer 1.2 FANTOM5 Ensembl ENCODE 10.3 -285.6 -285564 7.5 ZSCAN21 ZNF548 GLIS2 POLR2A CREB1 ZIC2 ZEB2 ZNF629 FOXA2 BRCA1 XRCC3 C14orf180 COA8 TMEM179 LINC02691 LOC105370693 LOC105370694
GH14J104158 Enhancer 1.1 Ensembl ENCODE 11.3 -420.8 -420783 1 CC2D1A CBFA2T2 MLLT1 TRIM24 ZNF639 EGR1 SMARCA4 MTA1 GMEB1 DPF2 KIF26A C14orf180 KLC1 GC14P104161 GC14M104153
GH14J104048 Promoter/Enhancer 1.1 EPDnew Ensembl ENCODE 10 -530.3 -530349 1.7 POLR2A RFX1 CTCF TDRD9 PPP1R13B KIF26A C14orf180 ASPG ATP5MPL LOC105370691 RN7SL634P GC14P104080
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C14orf180 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf180 gene promoter:
  • c-Myc
  • Egr-3
  • HSF2
  • HTF
  • Max1
  • NRF-2
  • PPAR-gamma1
  • PPAR-gamma2
  • RP58
  • Spz1

Genomic Locations for C14orf180 Gene

Genomic Locations for C14orf180 Gene
10,832 bases
Plus strand
10,832 bases
Plus strand

Genomic View for C14orf180 Gene

Genes around C14orf180 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf180 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf180 Gene

Proteins for C14orf180 Gene

  • Protein details for C14orf180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Nutritionally-regulated adipose and cardiac enriched protein homolog
    Protein Accession:

    Protein attributes for C14orf180 Gene

    160 amino acids
    Molecular mass:
    18051 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf180 Gene

Post-translational modifications for C14orf180 Gene

No Post-translational modifications

Other Protein References for C14orf180 Gene

No data available for DME Specific Peptides for C14orf180 Gene

Domains & Families for C14orf180 Gene

Gene Families for C14orf180 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for C14orf180 Gene


Suggested Antigen Peptide Sequences for C14orf180 Gene

GenScript: Design optimal peptide antigens:
  • Transmembrane protein C14orf180 (CN180_HUMAN)

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf180: view

No data available for UniProtKB/Swiss-Prot for C14orf180 Gene

Function for C14orf180 Gene

Phenotypes for C14orf180 Gene

genes like me logo Genes that share phenotypes with C14orf180: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf180

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf180 Gene

Localization for C14orf180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for C14orf180 Gene

Cell membrane; Single-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf180 gene
Compartment Confidence
plasma membrane 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 0
cytosol 0

Gene Ontology (GO) - Cellular Components for C14orf180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IBA 21873635
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with C14orf180: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for C14orf180 Gene

Pathways & Interactions for C14orf180 Gene

PathCards logo

SuperPathways for C14orf180 Gene

No Data Available

Interacting Proteins for C14orf180 Gene

STRING Interaction Network Preview (showing top 1 STRING interactants - click image to see details)
Selected Interacting proteins: ENSP00000333041 for C14orf180 Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for C14orf180 Gene


No data available for Pathways by source and SIGNOR curated interactions for C14orf180 Gene

Drugs & Compounds for C14orf180 Gene

No Compound Related Data Available

Transcripts for C14orf180 Gene

mRNA/cDNA for C14orf180 Gene

(3) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(15) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

Unigene Clusters for C14orf180 Gene

Chromosome 14 open reading frame 180:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf180

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf180 Gene

No ASD Table

Relevant External Links for C14orf180 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for C14orf180 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf180 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf180 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.0), Heart - Atrial Appendage (x13.3), Adipose - Visceral (Omentum) (x7.4), and Adipose - Subcutaneous (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of C14orf180 Gene:


SOURCE GeneReport for Unigene cluster for C14orf180 Gene:


Evidence on tissue expression from TISSUES for C14orf180 Gene

  • Heart(4.3)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with C14orf180: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf180 Gene

Orthologs for C14orf180 Gene

This gene was present in the common ancestor of mammals.

Orthologs for C14orf180 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia C14H14orf180 34
  • 98.54 (n)
C14orf180 35
  • 98 (a)
(Canis familiaris)
Mammalia LOC612691 34
  • 77.85 (n)
C14orf180 35
  • 66 (a)
(Bos Taurus)
Mammalia NRAC 34
  • 75.47 (n)
C14orf180 35
  • 60 (a)
(Rattus norvegicus)
Mammalia LOC691485 34
  • 69.37 (n)
(Mus musculus)
Mammalia A530016L24Rik 17 35 34
  • 67.1 (n)
(Monodelphis domestica)
Mammalia C14orf180 35
  • 43 (a)
Species where no ortholog for C14orf180 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf180 Gene

Gene Tree for C14orf180 (if available)
Gene Tree for C14orf180 (if available)

Paralogs for C14orf180 Gene

(1) SIMAP similar genes for C14orf180 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with C14orf180: view

No data available for Paralogs for C14orf180 Gene

Variants for C14orf180 Gene

Sequence variations from dbSNP and Humsavar for C14orf180 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000182284 -- 104,578,699(+) G/A/C upstream_transcript_variant
rs1000817289 -- 104,584,771(+) C/T intron_variant
rs1001037569 -- 104,584,950(+) A/G intron_variant
rs1001182520 -- 104,579,757(+) G/A 5_prime_UTR_variant, genic_upstream_transcript_variant, upstream_transcript_variant
rs1001235503 -- 104,586,948(+) C/T intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf180 Gene

Variant ID Type Subtype PubMed ID
esv2749222 CNV deletion 23290073
esv2749223 CNV deletion 23290073
esv2761599 CNV gain 21179565
esv3635623 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv456445 CNV loss 19166990
nsv470676 CNV loss 18288195
nsv566047 CNV loss 21841781
nsv952271 CNV deletion 24416366

Variation tolerance for C14orf180 Gene

Gene Damage Index Score: 1.54; 29.92% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf180 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf180 Gene

Disorders for C14orf180 Gene

Additional Disease Information for C14orf180

No disorders were found for C14orf180 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf180 Gene

Publications for C14orf180 Gene

  1. Nrac, a novel nutritionally-regulated adipose and cardiac-enriched gene. (PMID: 23029450) Zhang R … Abou-Samra AB (PloS one 2012) 2 3 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (PMID: 21873635) Gaudet P … Thomas PD (Briefings in bioinformatics 2011) 3 58
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for C14orf180 Gene

Sources for C14orf180 Gene

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