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Aliases for C14orf178 Gene

Aliases for C14orf178 Gene

  • Chromosome 14 Open Reading Frame 178 2 3 5

External Ids for C14orf178 Gene

Previous GeneCards Identifiers for C14orf178 Gene

  • GC14P077297
  • GC14P078226
  • GC14P058393

Summaries for C14orf178 Gene

GeneCards Summary for C14orf178 Gene

C14orf178 (Chromosome 14 Open Reading Frame 178) is a Protein Coding gene.

Additional gene information for C14orf178 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for C14orf178 Gene

Genomics for C14orf178 Gene

GeneHancer (GH) Regulatory Elements for C14orf178 Gene

Promoters and enhancers for C14orf178 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14I077759 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 571.5 +0.1 109 2.5 PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 POLR2B ZNF207 C14orf178 SNW1 RPL21P10 ADCK1 SLIRP
GH14I077799 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 19.6 +39.5 39454 1.5 CLOCK MLX ARID4B SIN3A DMAP1 ZNF2 IRF4 POLR2B E2F8 ZNF207 ADCK1 RPL21P10 C14orf178 ZMYND19P1 IRF2BPL ALKBH1 SNW1 RPL22P2 ENSG00000199440 GC14M077822
GH14I077795 Enhancer 0.9 Ensembl ENCODE 17.6 +35.4 35422 1.5 TEAD1 JUN HLF MAX CEBPB CEBPG EP300 TEAD3 JUND CEBPA C14orf178 SLIRP ADCK1 SNW1
GH14I077663 Enhancer 1 FANTOM5 Ensembl ENCODE 13.4 -97.1 -97127 0.9 PKNOX1 ESRRA CEBPB MNT RFX5 ZFHX2 CTBP1 FOS FOSL2 EGR2 ADCK1 C14orf178 SLIRP SNW1 RPL21P10 GC14P077671 COX6CP11
GH14I077729 Enhancer 0.4 ENCODE 26.5 -29.9 -29940 2 PAF1 MAFK ADCK1 C14orf178 SNW1 SLIRP ALKBH1 RPL21P10
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around C14orf178 on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the C14orf178 gene promoter:

Genomic Locations for C14orf178 Gene

Genomic Locations for C14orf178 Gene
chr14:77,760,830-77,769,742
(GRCh38/hg38)
Size:
8,913 bases
Orientation:
Plus strand
chr14:78,227,173-78,236,085
(GRCh37/hg19)

Genomic View for C14orf178 Gene

Genes around C14orf178 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
C14orf178 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf178 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf178 Gene

Proteins for C14orf178 Gene

  • Protein details for C14orf178 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N769-CN178_HUMAN
    Recommended name:
    Uncharacterized protein C14orf178
    Protein Accession:
    Q8N769
    Secondary Accessions:
    • Q2HIX2
    • Q3KNR7

    Protein attributes for C14orf178 Gene

    Size:
    122 amino acids
    Molecular mass:
    13377 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for C14orf178 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for C14orf178 Gene

Post-translational modifications for C14orf178 Gene

No Post-translational modifications

Other Protein References for C14orf178 Gene

No data available for DME Specific Peptides for C14orf178 Gene

Domains & Families for C14orf178 Gene

Gene Families for C14orf178 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C14orf178 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with C14orf178: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for C14orf178 Gene

Function for C14orf178 Gene

Phenotypes From GWAS Catalog for C14orf178 Gene

genes like me logo Genes that share phenotypes with C14orf178: view

miRNA for C14orf178 Gene

miRTarBase miRNAs that target C14orf178

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for C14orf178 Gene

Localization for C14orf178 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf178 gene
Compartment Confidence
extracellular 2
nucleus 2
peroxisome 1
cytosol 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C14orf178 Gene

Pathways & Interactions for C14orf178 Gene

SuperPathways for C14orf178 Gene

No Data Available

Interacting Proteins for C14orf178 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000348145%0d%0a9606.ENSP00000224140%0d%0a
Selected Interacting proteins: ENSP00000348145 Q8N769-CN178_HUMAN for C14orf178 Gene via STRING IID

Gene Ontology (GO) - Biological Process for C14orf178 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for C14orf178 Gene

Drugs & Compounds for C14orf178 Gene

No Compound Related Data Available

Transcripts for C14orf178 Gene

mRNA/cDNA for C14orf178 Gene

(2) REFSEQ mRNAs :
(2) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf178 Gene

No ASD Table

Relevant External Links for C14orf178 Gene

GeneLoc Exon Structure for
C14orf178
ECgene alternative splicing isoforms for
C14orf178

Expression for C14orf178 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for C14orf178 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf178 Gene

This gene is overexpressed in Testis (x9.8).

NURSA nuclear receptor signaling pathways regulating expression of C14orf178 Gene:

C14orf178

SOURCE GeneReport for Unigene cluster for C14orf178 Gene:

Hs.375834
genes like me logo Genes that share expression patterns with C14orf178: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf178 Gene

Orthologs for C14orf178 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C14orf178 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C14H14orf178 33
  • 97.81 (n)
C14orf178 34
  • 96 (a)
OneToOne
Species where no ortholog for C14orf178 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for C14orf178 Gene

ENSEMBL:
Gene Tree for C14orf178 (if available)
TreeFam:
Gene Tree for C14orf178 (if available)

Paralogs for C14orf178 Gene

genes like me logo Genes that share paralogs with C14orf178: view

No data available for Paralogs for C14orf178 Gene

Variants for C14orf178 Gene

Sequence variations from dbSNP and Humsavar for C14orf178 Gene

SNP ID Clin Chr 14 pos Variation AA Info Type
rs1000131949 -- 77,768,943(+) A/G intron_variant
rs1000324914 -- 77,769,859(+) G/A downstream_transcript_variant
rs1000367442 -- 77,763,762(+) C/T intron_variant
rs1000503936 -- 77,769,276(+) A/G intron_variant
rs1000886780 -- 77,763,405(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for C14orf178 Gene

Variant ID Type Subtype PubMed ID
esv2759998 CNV gain 17122850

Variation tolerance for C14orf178 Gene

Residual Variation Intolerance Score: 64.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.65; 56.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf178 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf178

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf178 Gene

Disorders for C14orf178 Gene

Additional Disease Information for C14orf178

No disorders were found for C14orf178 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for C14orf178 Gene

Publications for C14orf178 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 58
  4. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R … Weissenbach J (Nature 2003) 4 58

Products for C14orf178 Gene

Sources for C14orf178 Gene

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