Aliases for C14orf177 Gene

Subcategory (RNA class) for C14orf177 Gene

lncRNA

Number of RNA Genes sources:

2 / 17

Aliases for C14orf177 Gene

  • Chromosome 14 Putative Open Reading Frame 177 2 3 5
  • C14orf177 2 5
  • Putative Uncharacterized Protein C14orf177 4
  • Chromosome 14 Open Reading Frame 177 2
  • HSALNG0103624 164
  • Lnc-CCNK-5 165
  • FLJ25773 2

External Ids for C14orf177 Gene

Previous GeneCards Identifiers for C14orf177 Gene

  • GC14P098250
  • GC14P099177
  • GC14P079360

Summaries for C14orf177 Gene

GeneCards Summary for C14orf177 Gene

C14orf177 (Chromosome 14 Putative Open Reading Frame 177) is an RNA Gene, and is affiliated with the lncRNA class. Diseases associated with C14orf177 include Bardet-Biedl Syndrome 12.

Additional gene information for C14orf177 Gene

No data available for Entrez Gene Summary , CIViC Summary , UniProtKB/Swiss-Prot Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , Rfam classification and piRNA Summary for C14orf177 Gene

Genomics for C14orf177 Gene

GeneHancer (GH) Regulatory Elements Pubs

Promoters and enhancers for C14orf177 Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH14J098711 Enhancer 0.3 Ensembl 600.7 +0.1 88 0.6 GLIS1 C14orf177 piR-60146-042 BCL11B
GH14J098650 Enhancer 0.6 Ensembl ENCODE 11.5 -60.1 -60112 1.4 TEAD4 ETS1 POU5F1 C14orf177 RF00994-348 RF00994-347 BCL11B
GH14J098750 Enhancer 0.5 Ensembl 11.6 +39.3 39288 0.6 CREB1 KDM1A ZBTB17 ZNF366 NFE2L2 C14orf177 piR-60146-042 HSALNG0103626 BCL11B
GH14J098478 Enhancer 0.3 UCNEbase 10.6 -232.8 -232752 0.2 C14orf177 piR-43106-073 ENSG00000258795 BCL11B
GH14J098682 Enhancer 0.3 ENCODE 12.1 -29.4 -29374 0.2 ATF2 C14orf177 RF00994-348 BCL11B
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data from 2017 publication | Request up-to-date GeneHancer data (full dataset)

GeneHancers around C14orf177 on the GeneHancer Hub at the UCSC Golden Path

Cistromic (ChIP-Seq) regulation report from SPP (The Signaling Pathways Project) for C14orf177

Top Transcription factor binding sites by QIAGEN in the C14orf177 gene promoter:
  • CUTL1
  • E47
  • Evi-1
  • FOXJ2
  • FOXJ2 (long isoform)
  • Nkx6-1
  • Pax-4a
  • POU3F2
  • POU3F2 (N-Oct-5a)
  • Sox5

Genomic Locations for C14orf177 Gene

Genomic Locations for C14orf177 Gene
chr14:98,711,613-98,717,766
(GRCh38/hg38)
Size:
6,154 bases
Orientation:
Plus strand
chr14:99,177,950-99,184,103
(GRCh37/hg19)
Size:
6,154 bases
Orientation:
Plus strand

Genomic View for C14orf177 Gene

Genes around C14orf177 on UCSC Golden Path with GeneCards custom track
C14orf177 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Cytogenetic band:
C14orf177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for C14orf177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for C14orf177 Gene

Proteins for C14orf177 Gene

  • Protein details for C14orf177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q52M58-CN177_HUMAN
    Recommended name:
    Putative uncharacterized protein C14orf177
    Protein Accession:
    Q52M58
    Secondary Accessions:
    • Q8N7D2

    Protein attributes for C14orf177 Gene

    Size:
    125 amino acids
    Molecular mass:
    13861 Da
    Quaternary structure:
    No Data Available

neXtProt entry for C14orf177 Gene

Post-translational modifications for C14orf177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for C14orf177 Gene

ENSEMBL proteins:

No data available for DME Specific Peptides for C14orf177 Gene

Domains & Families for C14orf177 Gene

Gene Families for C14orf177 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for C14orf177 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with C14orf177: view

No data available for Suggested Antigen Peptide Sequences , Graphical View of Domain Structure and UniProtKB/Swiss-Prot for C14orf177 Gene

Function for C14orf177 Gene

Phenotypes From GWAS Catalog for C14orf177 Gene

genes like me logo Genes that share phenotypes with C14orf177: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf177

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for C14orf177 Gene

Localization for C14orf177 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for C14orf177 gene
Compartment Confidence
extracellular 2
nucleus 2
cytosol 1
plasma membrane 0
mitochondrion 0
peroxisome 0
golgi apparatus 0

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for C14orf177 Gene

Pathways & Interactions for C14orf177 Gene

PathCards logo

SuperPathways for C14orf177 Gene

No Data Available

Gene Ontology (GO) - Biological Process for C14orf177 Gene

None

No data available for Pathways by source , Interacting Proteins and SIGNOR curated interactions for C14orf177 Gene

Drugs & Compounds for C14orf177 Gene

No Compound Related Data Available

Transcripts for C14orf177 Gene

Non-coding RNA (ncRNA) Transcripts from RNAcentral for C14orf177 Gene

RNAcentral Transcript ID Subcategory Length (nts) # of Sources Source Identifiers and Annotations
URS00008C06E5_9606 lncRNA 484 3

Ensembl: ENST00000546029 (view in UCSC) ,

LncBook: HSALNT0215621,

LNCipedia: lnc-CCNK-5:1,

URS0000E60A72_9606 lncRNA 1289 2

HGNC: 26375,

RefSeq: NR_161368,

URS0000DB781A_9606 lncRNA 467 2

Ensembl: ENST00000541516 (view in UCSC) ,

LncBook: HSALNT0215620,

URS0000E60AAF_9606 lncRNA 1421 1

RefSeq: NR_161367,

URS0000DBA673_9606 lncRNA 1284 1

Ensembl: ENST00000650364 (view in UCSC) ,

C14orf177 in the GeneCards ncRNA compendium hub on the UCSC Golden Path

Additional transcripts not in RNAcentral for C14orf177 Gene

3 REFSEQ mRNAs :
3 NCBI additional mRNA sequence :
1 Ensembl transcripts including schematic representations, and UCSC links to gene/alias where relevant :

CRISPR Products

Inhibitory RNA Products

  • Search GeneCopoeia for shRNA, lentivirus and/or AAV clone products for C14orf177

Alternative Splicing Database (ASD) splice patterns (SP) for C14orf177 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5
SP1: -
SP2:

Relevant External Links for C14orf177 Gene

GeneLoc Exon Structure for
C14orf177

Expression for C14orf177 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for C14orf177 Gene

mRNA differential expression in normal tissues according to GTEx for C14orf177 Gene

This gene is overexpressed in Testis (x50.0).

Transcriptomic regulation report from SPP (The Signaling Pathways Project) for C14orf177

SOURCE GeneReport for Unigene cluster for C14orf177 Gene:

Hs.448754
genes like me logo Genes that share expression patterns with C14orf177: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for C14orf177 Gene

Orthologs for C14orf177 Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for C14orf177 Gene

Organism Taxonomy Gene Similarity Type Details
Chimpanzee
(Pan troglodytes)
Mammalia C14orf177 31
  • 98 (a)
OneToOne
C14H14orf177 30
  • 97.87 (n)
Species where no ortholog for C14orf177 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Eremothecium gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • Alpha proteobacteria (Wolbachia pipientis)
  • Amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • Baker's yeast (Saccharomyces cerevisiae)
  • Barley (Hordeum vulgare)
  • Beta proteobacteria (Neisseria meningitidis)
  • Bread mold (Neurospora crassa)
  • Chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • Common water flea (Daphnia pulex)
  • Corn (Zea mays)
  • Cow (Bos Taurus)
  • Dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • Filamentous fungi (Aspergillus nidulans)
  • Firmicute Bacteria (Streptococcus pneumoniae)
  • Fission Yeast (Schizosaccharomyces pombe)
  • Fruit Fly (Drosophila melanogaster)
  • Green Algae (Chlamydomonas reinhardtii)
  • Honey Bee (Apis mellifera)
  • K. Lactis Yeast (Kluyveromyces lactis)
  • Lizard (Anolis carolinensis)
  • Loblloly Pine (Pinus taeda)
  • Malaria Parasite (Plasmodium falciparum)
  • Medicago Trunc (Medicago Truncatula)
  • Moss (Physcomitrella patens)
  • Mouse (Mus musculus)
  • Oppossum (Monodelphis domestica)
  • Orangutan (Pongo pygmaeus)
  • Pig (Sus scrofa)
  • Platypus (Ornithorhynchus anatinus)
  • Rainbow Trout (Oncorhynchus mykiss)
  • Rat (Rattus norvegicus)
  • Rice (Oryza sativa)
  • Rice Blast Fungus (Magnaporthe grisea)
  • Schistosome Parasite (Schistosoma mansoni)
  • Sea Anemone (Nematostella vectensis)
  • Sea Vase (Ciona intestinalis)
  • Sea Squirt (Ciona savignyi)
  • Sea Urchin (Strongylocentrotus purpuratus)
  • Sorghum (Sorghum bicolor)
  • Soybean (Glycine max)
  • Stem Rust Fungus (Puccinia graminis)
  • Sugarcane (Saccharum officinarum)
  • Thale Cress (Arabidopsis thaliana)
  • Tomato (Lycopersicon esculentum)
  • Toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • Tropical Clawed Frog (Silurana tropicalis)
  • Wheat (Triticum aestivum)
  • Worm (Caenorhabditis elegans)
  • Zebrafish (Danio rerio)

Evolution for C14orf177 Gene

ENSEMBL:
Gene Tree for C14orf177 (if available)
TreeFam:
Gene Tree for C14orf177 (if available)

Paralogs for C14orf177 Gene

No data available for Paralogs for C14orf177 Gene

Variants for C14orf177 Gene

Sequence variations, with clinical significance, from ClinVar and Humsavar, with links to dbSNP for C14orf177 Gene

SNP ID Clinical significance and condition Chr 14 pos Variation AA Info Type
rs17097718 - p.Arg3Trp
rs4905757 - p.Val33Ala

Additional dbSNP identifiers (rs#s) for C14orf177 Gene

Structural Variations from Database of Genomic Variants (DGV) for C14orf177 Gene

Variant ID Type Subtype PubMed ID
dgv1968n100 CNV loss 25217958
dgv3870n54 CNV loss 21841781
dgv3871n54 CNV loss 21841781
dgv419e214 CNV loss 21293372
esv2665034 CNV deletion 23128226
esv2761555 CNV loss 21179565
esv3552032 CNV deletion 23714750
esv3581403 CNV loss 25503493
esv3635469 CNV gain 21293372
esv3635472 CNV gain 21293372
nsv456417 CNV loss 19166990
nsv516436 CNV loss 19592680

Variation tolerance for C14orf177 Gene

Residual Variation Intolerance Score: 78.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.00; 49.85% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for C14orf177 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
C14orf177

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for C14orf177 Gene

Disorders for C14orf177 Gene

MalaCards: The human disease database

(1) MalaCards diseases for C14orf177 Gene - From: DISEASES

Disorder Aliases PubMed IDs
bardet-biedl syndrome 12
  • bbs12
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for C14orf177

genes like me logo Genes that share disorders with C14orf177: view

No data available for UniProtKB/Swiss-Prot and Genatlas for C14orf177 Gene

Publications for C14orf177 Gene

  1. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease. (PMID: 26365416) Kunkle BW … Pericak-Vance MA (Alzheimer's & dementia : the journal of the Alzheimer's Association 2016) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3
  5. Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy. (PMID: 23118302) Chu AY … Ridker PM (Circulation. Cardiovascular genetics 2012) 3

Products for C14orf177 Gene

Sources for C14orf177 Gene